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Search term: YLR234W


Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name TOP3
SGD link S000004224
Alternative ID YLR234W
Description DNA Topoisomerase III, conserved protein that functions in a complex with Sgs1p and Rmi1p to relax single-stranded negatively-supercoiled DNA preferentially, involved in telomere stability and regulation of mitotic recombination
Synonyms YLR234W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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Query species:

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Search for GO info:  

GO info in one table:


KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG1956 ACDHYPE

KOGs classification KOGs description
INFORMATION STORAGE AND PROCESSING DNA topoisomerase III alpha

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At4g31210_2 GI:15235852
Arabidopsis thaliana (Ath) At5g63920 GI:15237561
Caenorhabditis elegans (Cel) CE28138
(WBGene00006596)
GI:17555378 O61660
Drosophila melanogaster (Dme) 7298596 GI:7298596
Homo sapiens (Hsa) Hs10835218
(TOP3A)
GI:10835218 Q13472
Saccharomyces cerevisiae (Sce) YLR234w
(S000004224)
GI:6323263 P13099
Schizosaccharomyces pombe (Spo) SPBC16G5.12c GI:19113553 O60126
Encephalitozoon cuniculi (Ecu) ECU04g1070 GI:19074185 Q8SS31


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IC
SceS000004224
ISS
SpoSPBC16G5.12c
TAS
HsaTOP3A
GO:0005739 mitochondrion C
IDA
SpoSPBC16G5.12c
GO:0016605 PML body C
IDA
HsaTOP3A
GO:0031422 RecQ helicase-Topo III complex C
IDA
SceS000004224
IPI
SceS000004224
TAS
SpoSPBC16G5.12c
GO:0003677 DNA binding F
ISS
AthAt5g63920
At4g31210
TAS
HsaTOP3A
GO:0003916 DNA topoisomerase activity F
ISS
AthAt5g63920
TAS
HsaTOP3A
GO:0003917 DNA topoisomerase type I activity F
IDA
SceS000004224
ISS
AthAt4g31210
TAS
SpoSPBC16G5.12c
GO:0005515 protein binding F
IPI
HsaTOP3A
SpoSPBC16G5.12c
GO:0000018 regulation of DNA recombination P
IMP
SceS000004224
GO:0000280 nuclear division P
IMP
SpoSPBC16G5.12c
GO:0000712 resolution of meiotic recombination
intermediates
P
IMP
AthAt5g63920
TAS
SpoSPBC16G5.12c
GO:0006259 DNA metabolic process P
IGI
SpoSPBC16G5.12c
GO:0006260 DNA replication P
RCA
SceS000004224
GO:0006261 DNA-dependent DNA replication P
IMP
SpoSPBC16G5.12c
GO:0006265 DNA topological change P
ISS
AthAt5g63920
At4g31210
GO:0006268 DNA unwinding involved in replication P
ISS
AthAt5g63920
At4g31210
GO:0006281 DNA repair P
IMP
AthAt5g63920
RCA
SceS000004224
GO:0006974 response to DNA damage stimulus P
RCA
SceS000004224
GO:0007000 nucleolus organization P
IMP
SpoSPBC16G5.12c
GO:0007004 telomere maintenance via telomerase P
IMP
SceS000004224
GO:0007059 chromosome segregation P
IMP
AthAt5g63920
SpoSPBC16G5.12c
GO:0007064 mitotic sister chromatid cohesion P
IMP
SceS000004224
GO:0007067 mitosis P
IMP
AthAt5g63920
GO:0007126 meiosis P
IMP
AthAt5g63920
CelWBGene00006596
TAS
HsaTOP3A
GO:0007131 reciprocal meiotic recombination P
IGI
SceS000004224
IMP
SceS000004224
GO:0007276 gamete generation P
IMP
CelWBGene00006596
GO:0031297 replication fork processing P
NAS
SpoSPBC16G5.12c
GO:0043007 maintenance of rDNA P
IMP
SpoSPBC16G5.12c
GO:0045910 negative regulation of DNA recombination P
TAS
SpoSPBC16G5.12c
GO:0051052 regulation of DNA metabolic process P
RCA
SceS000004224
GO:0051321 meiotic cell cycle P
RCA
SceS000004224

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
101621

Species Gene ID NCBI link UniProt link
Schizosaccharomyces pombe (Spo) top3
(SPBC16G5.12c)
GI:19113553 O60126
Saccharomyces cerevisiae (Sce) TOP3
(S000004224)
GI:6323263 P13099
Kluyveromyces lactis (Kla) KLLA0F20724g GI:50311957
Eremothecium gossypii (Ego) AGOS_AGL101C GI:45200996
Magnaporthe grisea (Mgr) MGG_11342 GI:145614352
Neurospora crassa (Ncr) NCU00081.1 GI:32403108


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IC
SceS000004224
ISS
SpoSPBC16G5.12c
GO:0005739 mitochondrion C
IDA
SpoSPBC16G5.12c
GO:0031422 RecQ helicase-Topo III complex C
IDA
SceS000004224
IPI
SceS000004224
TAS
SpoSPBC16G5.12c
GO:0003917 DNA topoisomerase type I activity F
IDA
SceS000004224
TAS
SpoSPBC16G5.12c
GO:0005515 protein binding F
IPI
SpoSPBC16G5.12c
GO:0000018 regulation of DNA recombination P
IMP
SceS000004224
GO:0000280 nuclear division P
IMP
SpoSPBC16G5.12c
GO:0000712 resolution of meiotic recombination
intermediates
P
TAS
SpoSPBC16G5.12c
GO:0006259 DNA metabolic process P
IGI
SpoSPBC16G5.12c
GO:0006260 DNA replication P
RCA
SceS000004224
GO:0006261 DNA-dependent DNA replication P
IMP
SpoSPBC16G5.12c
GO:0006281 DNA repair P
RCA
SceS000004224
GO:0006974 response to DNA damage stimulus P
RCA
SceS000004224
GO:0007000 nucleolus organization P
IMP
SpoSPBC16G5.12c
GO:0007004 telomere maintenance via telomerase P
IMP
SceS000004224
GO:0007059 chromosome segregation P
IMP
SpoSPBC16G5.12c
GO:0007064 mitotic sister chromatid cohesion P
IMP
SceS000004224
GO:0007131 reciprocal meiotic recombination P
IGI
SceS000004224
IMP
SceS000004224
GO:0031297 replication fork processing P
NAS
SpoSPBC16G5.12c
GO:0043007 maintenance of rDNA P
IMP
SpoSPBC16G5.12c
GO:0045910 negative regulation of DNA recombination P
TAS
SpoSPBC16G5.12c
GO:0051052 regulation of DNA metabolic process P
RCA
SceS000004224
GO:0051321 meiotic cell cycle P
RCA
SceS000004224

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_405

Species OrthoMCL
sequence
Model organism
protein page
UniProt link
Anopheles gambiae (Aga) aga12325 ENSANGP00000011926
Anopheles gambiae (Aga) aga14176 ENSANGP00000027829
Anopheles gambiae (Aga) aga13415 ENSANGP00000027934
Ashbya gossypii (Ago) ago4211 AGL101C
Arabidopsis thaliana (Ath) ath21195 At4g31210.1
Arabidopsis thaliana (Ath) ath28519 At5g63920.1
Caenorhabditis elegans (Cel) cel19947 Y56A3A.27
(CE28138;
WBGene00006596)
Candida glabrata (Cgl) cgl1993 CAGL0G08470g
Cryptococcus neoformans (Cne) cne3807 185.m02384
Dictyostelium discoideum (Ddi) ddi2335 DDB0217608
Debaryomyces hansenii (Dha) dha6334 DEHA0G14234g
Drosophila melanogaster (Dme) dme3008 CG10123-PA
(FBgn0040268)
Danio rerio (Dre) dre19922 ENSDARP00000020883
Danio rerio (Dre) dre17738 ENSDARP00000028876
Escherichia coli (Eco) eco1237 16129235
Encephalitozoon cuniculi (Ecu) ecu823 19074185
Takifugu rubripes (Fru) fru30884 SINFRUP00000136008
Takifugu rubripes (Fru) fru30885 SINFRUP00000169687
Takifugu rubripes (Fru) fru30886 SINFRUP00000175685
Takifugu rubripes (Fru) fru30887 SINFRUP00000177210
Gallus gallus (Gga) gga6510 ENSGALP00000008033
Gallus gallus (Gga) gga6511 ENSGALP00000008034
Gallus gallus (Gga) gga6512 ENSGALP00000008035
Gallus gallus (Gga) gga6509 ENSGALP00000008036
(TOP3A)
Q4W5X0
Homo sapiens (Hsa) hsa13184 ENSP00000321636
(TOP3A)
Q13472-1
Homo sapiens (Hsa) hsa13185 ENSP00000353166
Kluyveromyces lactis (Kla) kla5010 KLLA0F20724g
Mus musculus (Mmu) mmu3847 ENSMUSP00000002891
(MGI:1197527)
O70157
Neurospora crassa (Ncr) ncr79 NCU00081.2
Oryza sativa (Osa) osa30914 4359.m00163
Oryza sativa (Osa) osa31271 4380.m00111
Oryza sativa (Osa) osa52190 5934.m00047
Oryza sativa (Osa) osa63275 6618.m00230
Oryza sativa (Osa) osa63321 6618.m00514
Plasmodium falciparum (Pfa) pfa4433 PF13_0251
Rattus norvegicus (Rno) rno5184 ENSRNOP00000006848
(RGD:1309320)
Saccharomyces cerevisiae (Sce) sce4337 YLR234W
(S000004224)
Schizosaccharomyces pombe (Spo) spo342 SPBC16G5.12c O60126
Yarrowia lipolytica (Yli) yli6292 YALI0F22495g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IC
SceS000004224
ISS
SpoSPBC16G5.12c
GO:0005739 mitochondrion C
IDA
SpoSPBC16G5.12c
GO:0031422 RecQ helicase-Topo III complex C
IDA
SceS000004224
IPI
SceS000004224
TAS
SpoSPBC16G5.12c
GO:0003677 DNA binding F
ISS
AthAt5g63920
At4g31210
GO:0003916 DNA topoisomerase activity F
IDA
DmeFBgn0040268
ISS
AthAt5g63920
GO:0003917 DNA topoisomerase type I activity F
IDA
SceS000004224
ISS
AthAt4g31210
DmeFBgn0040268
NAS
DmeFBgn0040268
TAS
SpoSPBC16G5.12c
GO:0003918 DNA topoisomerase (ATP-hydrolyzing)
activity
F
ISS
PfaPF13_0251
GO:0005515 protein binding F
IPI
SpoSPBC16G5.12c
GO:0000018 regulation of DNA recombination P
IMP
SceS000004224
GO:0000280 nuclear division P
IMP
SpoSPBC16G5.12c
GO:0000712 resolution of meiotic recombination
intermediates
P
IMP
AthAt5g63920
TAS
SpoSPBC16G5.12c
GO:0000724 double-strand break repair via homologous
recombination
P
IMP
DmeFBgn0040268
GO:0006259 DNA metabolic process P
IGI
SpoSPBC16G5.12c
GO:0006260 DNA replication P
RCA
SceS000004224
GO:0006261 DNA-dependent DNA replication P
IMP
SpoSPBC16G5.12c
GO:0006265 DNA topological change P
ISS
AthAt5g63920
At4g31210
GO:0006268 DNA unwinding involved in replication P
ISS
AthAt5g63920
At4g31210
GO:0006281 DNA repair P
IMP
AthAt5g63920
RCA
SceS000004224
GO:0006974 response to DNA damage stimulus P
RCA
SceS000004224
GO:0007000 nucleolus organization P
IMP
SpoSPBC16G5.12c
GO:0007004 telomere maintenance via telomerase P
IMP
SceS000004224
GO:0007059 chromosome segregation P
IMP
AthAt5g63920
SpoSPBC16G5.12c
GO:0007064 mitotic sister chromatid cohesion P
IMP
SceS000004224
GO:0007067 mitosis P