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Search term: YLR262C

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name YPT6
SGD link S000004252
Alternative ID YLR262C
Description GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6
Synonyms YLR262C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG0094 ACDHYPE

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALING GTPase Rab6/YPT6/Ryh1, small G protein superfamily

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At2g22290 GI:15227173
Arabidopsis thaliana (Ath) At2g44610 GI:15224916
Arabidopsis thaliana (Ath) At4g39890 GI:15236081
Arabidopsis thaliana (Ath) At5g10260 GI:15238112
Arabidopsis thaliana (Ath) At5g64990 GI:15238317
Caenorhabditis elegans (Cel) CE00234
(WBGene00004269)		 GI:17553774 P34213
Caenorhabditis elegans (Cel) CE04274 GI:17532587
Caenorhabditis elegans (Cel) CE07541
(WBGene00004270)		 GI:17570073 Q22782
Drosophila melanogaster (Dme) 7292134 GI:7292134
Drosophila melanogaster (Dme) 7297923
(FBgn0015797)		 GI:17137220
Homo sapiens (Hsa) Hs4758998 GI:4758998
Homo sapiens (Hsa) Hs7706675 GI:7706675
Homo sapiens (Hsa) Hs13994318 GI:13994318
Homo sapiens (Hsa) Hs14149799 GI:14149799
Homo sapiens (Hsa) Hs19923231
(RAB6A)		 GI:19923231 P20340
Saccharomyces cerevisiae (Sce) YLR262c
(S000004252)		 GI:6323291 Q99260
Schizosaccharomyces pombe (Spo) SPAC4C5.02c GI:19114161 P17608
Encephalitozoon cuniculi (Ecu) ECU09g0170 GI:19173137
Arabidopsis thaliana (Ath) At2g22290 GI:15227173
Arabidopsis thaliana (Ath) At2g44610 GI:15224916
Arabidopsis thaliana (Ath) At4g39890 GI:15236081
Arabidopsis thaliana (Ath) At5g10260 GI:15238112
Arabidopsis thaliana (Ath) At5g64990 GI:15238317
Caenorhabditis elegans (Cel) CE00234
(WBGene00004269)		 GI:17553774 P34213
Caenorhabditis elegans (Cel) CE04274 GI:17532587
Caenorhabditis elegans (Cel) CE07541
(WBGene00004270)		 GI:17570073 Q22782
Drosophila melanogaster (Dme) 7292134 GI:7292134
Drosophila melanogaster (Dme) 7297923
(FBgn0015797)		 GI:17137220
Homo sapiens (Hsa) Hs4758998 GI:4758998
Homo sapiens (Hsa) Hs7706675 GI:7706675
Homo sapiens (Hsa) Hs13994318 GI:13994318
Homo sapiens (Hsa) Hs14149799 GI:14149799
Homo sapiens (Hsa) Hs19923231
(RAB6A)		 GI:19923231 P20340
Saccharomyces cerevisiae (Sce) YLR262c
(S000004252)		 GI:6323291 Q99260
Schizosaccharomyces pombe (Spo) SPAC4C5.02c GI:19114161 P17608
Encephalitozoon cuniculi (Ecu) ECU09g0170 GI:19173137
Arabidopsis thaliana (Ath) At2g22290 GI:15227173
Arabidopsis thaliana (Ath) At2g44610 GI:15224916
Arabidopsis thaliana (Ath) At4g39890 GI:15236081
Arabidopsis thaliana (Ath) At5g10260 GI:15238112
Arabidopsis thaliana (Ath) At5g64990 GI:15238317
Caenorhabditis elegans (Cel) CE00234
(WBGene00004269)		 GI:17553774 P34213
Caenorhabditis elegans (Cel) CE04274 GI:17532587
Caenorhabditis elegans (Cel) CE07541
(WBGene00004270)		 GI:17570073 Q22782
Drosophila melanogaster (Dme) 7292134 GI:7292134
Drosophila melanogaster (Dme) 7297923
(FBgn0015797)		 GI:17137220
Homo sapiens (Hsa) Hs4758998 GI:4758998
Homo sapiens (Hsa) Hs7706675 GI:7706675
Homo sapiens (Hsa) Hs13994318 GI:13994318
Homo sapiens (Hsa) Hs14149799 GI:14149799
Homo sapiens (Hsa) Hs19923231
(RAB6A)		 GI:19923231 P20340
Saccharomyces cerevisiae (Sce) YLR262c
(S000004252)		 GI:6323291 Q99260
Schizosaccharomyces pombe (Spo) SPAC4C5.02c GI:19114161 P17608
Encephalitozoon cuniculi (Ecu) ECU09g0170 GI:19173137


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005624 membrane fraction C
IDA
AthAt2g44610
GO:0005634 nucleus C
IDA
SpoSPAC4C5.02c
GO:0005739 mitochondrion C
IDA
AthAt2g22290
At5g64990
GO:0005794 Golgi apparatus C
IDA
HsaRAB6A
ISS
SpoSPAC4C5.02c
TAS
SceS000004252
GO:0005829 cytosol C
IDA
SpoSPAC4C5.02c
GO:0005886 plasma membrane C
IDA
AthAt2g44610
GO:0003924 GTPase activity F
IDA
HsaRAB6A
SceS000004252
ISS
DmeFBgn0015797
SceS000004252
SpoSPAC4C5.02c
TAS
SceS000004252
GO:0005515 protein binding F
IPI
AthAt4g39890
At2g44610
DmeFBgn0015797
HsaRAB6A
GO:0005525 GTP binding F
IDA
AthAt2g44610
HsaRAB6A
ISS
AthAt5g10260
At2g44610
At4g39890
At2g22290
At5g64990
TAS
SpoSPAC4C5.02c
GO:0000003 reproduction P
IMP
CelWBGene00004269
GO:0001745 compound eye morphogenesis P
IGI
DmeFBgn0015797
GO:0006184 GTP catabolic process P
ISS
SpoSPAC4C5.02c
GO:0006605 protein targeting P
RCA
SceS000004252
GO:0006886 intracellular protein transport P
IGI
SceS000004252
ISS
SpoSPAC4C5.02c
TAS
SceS000004252
GO:0006887 exocytosis P
IMP
DmeFBgn0015797
GO:0006970 response to osmotic stress P
IMP
SpoSPAC4C5.02c
GO:0007264 small GTPase mediated signal transduction P
IC
SpoSPAC4C5.02c
GO:0007293 germarium-derived egg chamber formation P
IMP
DmeFBgn0015797
GO:0008103 oocyte microtubule cytoskeleton
polarization		 P
IMP
DmeFBgn0015797
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00004270
GO:0016192 vesicle-mediated transport P
RCA
SceS000004252
GO:0018125 peptidyl-cysteine methylation P
IDA
HsaRAB6A
GO:0032940 secretion by cell P
IGI
AthAt2g44610
GO:0042147 retrograde transport, endosome to
Golgi		 P
IMP
SceS000004252
ISS
SpoSPAC4C5.02c
TAS
SceS000004252
GO:0045184 establishment of protein localization P
RCA
SceS000004252
GO:0045451 pole plasm oskar mRNA localization P
IMP
DmeFBgn0015797

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
39749

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) RAB6B GI:96975097
Pan troglodytes (Ptr) RAB6B GI:114589479
Canis familiaris (Cfa) RAB6B GI:73990587
Mus musculus (Mmu) Rab6b
(MGI:107283)		 GI:30424655 P61294
Rattus norvegicus (Rno) Rab6b GI:109483890
Caenorhabditis elegans (Cel) rab-6.1
(CE00234;
WBGene00004269)		 GI:17553774 P34213
Schizosaccharomyces pombe (Spo) hos1 GI:19114161
Saccharomyces cerevisiae (Sce) YPT6
(S000004252)		 GI:6323291 Q99260
Kluyveromyces lactis (Kla) KLLA0F20471g GI:50311935
Eremothecium gossypii (Ego) AGOS_AGR257C GI:45201353
Magnaporthe grisea (Mgr) MGG_04143 GI:145607295
Arabidopsis thaliana (Ath) RAB6A GI:15224916
Oryza sativa (Osa) Os07g0496000 GI:115472201
Plasmodium falciparum (Pfa) PF11_0461 GI:124804843


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
MmuMGI:107283
GO:0005794 Golgi apparatus C
IDA
HsaRAB6A
NAS
HsaRAB6B
TAS
PfaPF11_0461
SceS000004252
GO:0003674 molecular_function F
ND
MmuMGI:107283
GO:0003924 GTPase activity F
IDA
HsaRAB6A
SceS000004252
ISS
SceS000004252
NAS
HsaRAB6B
TAS
SceS000004252
GO:0005515 protein binding F
IPI
HsaRAB6B
RAB6A
GO:0005525 GTP binding F
IDA
HsaRAB6A
GO:0000003 reproduction P
IMP
CelWBGene00004269
GO:0006605 protein targeting P
RCA
SceS000004252
GO:0006886 intracellular protein transport P
IGI
SceS000004252
TAS
SceS000004252
GO:0006890 retrograde vesicle-mediated transport, Golgi to
ER		 P
NAS
HsaRAB6B
GO:0008150 biological_process P
ND
MmuMGI:107283
GO:0016192 vesicle-mediated transport P
RCA
SceS000004252
GO:0018125 peptidyl-cysteine methylation P
IDA
HsaRAB6A
GO:0042147 retrograde transport, endosome to
Golgi		 P
IMP
SceS000004252
TAS
SceS000004252
GO:0045184 establishment of protein localization P
RCA
SceS000004252

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_985

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga8429 ENSANGP00000020507
Ashbya gossypii (Ago) ago4568 AGR257C
Arabidopsis thaliana (Ath) ath9124 At2g22290.1
Arabidopsis thaliana (Ath) ath11677 At2g44610.1
Arabidopsis thaliana (Ath) ath22206 At4g39890.1
Arabidopsis thaliana (Ath) ath23227 At5g10260.1
Caenorhabditis elegans (Cel) cel11060 F59B2.7
(CE00234;
WBGene00004269)
Caenorhabditis elegans (Cel) cel16360 T25G12.4
(CE07541;
WBGene00004270)
Candida glabrata (Cgl) cgl3779 CAGL0K06017g
Cryptococcus neoformans (Cne) cne1667 164.m02015
Dictyostelium discoideum (Ddi) ddi11538 DDB0229392
Debaryomyces hansenii (Dha) dha3536 DEHA0E06699g
Drosophila melanogaster (Dme) dme2099 CG6601-PA
(FBgn0015797)
Danio rerio (Dre) dre20436 ENSDARP00000042254
(zgc:112018)		 Q5BJD1
Danio rerio (Dre) dre5729 ENSDARP00000045554
(zgc:63637)		 Q6PEH6
Takifugu rubripes (Fru) fru11363 SINFRUP00000160354
Takifugu rubripes (Fru) fru30703 SINFRUP00000162675
Gallus gallus (Gga) gga16644 ENSGALP00000006694
Gallus gallus (Gga) gga16645 ENSGALP00000006695
(RAB6B)
Homo sapiens (Hsa) hsa23172 ENSP00000285208
(RAB6B)		 Q9NRW1
Homo sapiens (Hsa) hsa6210 ENSP00000311449
(RAB6A)		 P20340-2
Homo sapiens (Hsa) hsa6209 ENSP00000336850
(RAB6A)		 P20340-1
Homo sapiens (Hsa) hsa6211 ENSP00000347674
Kluyveromyces lactis (Kla) kla4999 KLLA0F20471g
Mus musculus (Mmu) mmu24525 ENSMUSP00000032946
(MGI:894313)		 P35279-1
Mus musculus (Mmu) mmu28164 ENSMUSP00000035155
(MGI:107283)		 P61294
Neurospora crassa (Ncr) ncr5081 NCU05234.2
Oryza sativa (Osa) osa30126 4342.m00120
Oryza sativa (Osa) osa30143 4342.m00152
Oryza sativa (Osa) osa58693 6274.m00096
Plasmodium falciparum (Pfa) pfa908 PF11_0461
Rattus norvegicus (Rno) rno29167 ENSRNOP00000012219
(RGD:1309958)
Rattus norvegicus (Rno) rno2420 ENSRNOP00000025104
(RGD:619737)		 Q9WVB1
Rattus norvegicus (Rno) rno2421 ENSRNOP00000043537
(RGD:619737)
Saccharomyces cerevisiae (Sce) sce4366 YLR262C
(S000004252)
Schizosaccharomyces pombe (Spo) spo4328 SPAC4C5.02c P17608
Yarrowia lipolytica (Yli) yli1664 YALI0B22154g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
MmuMGI:107283
GO:0005624 membrane fraction C
IDA
AthAt2g44610
GO:0005625 soluble fraction C
ISO
MmuMGI:894313
GO:0005626 insoluble fraction C
ISO
MmuMGI:894313
GO:0005634 nucleus C
IDA
SpoSPAC4C5.02c
GO:0005739 mitochondrion C
IDA
AthAt2g22290
GO:0005794 Golgi apparatus C
IDA
MmuMGI:894313
ISO
MmuMGI:894313
ISS
SpoSPAC4C5.02c
TAS
PfaPF11_0461
SceS000004252
GO:0005829 cytosol C
IDA
SpoSPAC4C5.02c
GO:0005886 plasma membrane C
IDA
AthAt2g44610
GO:0001671 ATPase activator activity F
ISO
MmuMGI:894313
GO:0003674 molecular_function F
ND
MmuMGI:107283
GO:0003924 GTPase activity F
IDA
SceS000004252
ISS
DmeFBgn0015797
SceS000004252
SpoSPAC4C5.02c
TAS
SceS000004252
GO:0005515 protein binding F
IPI
AthAt4g39890
At2g44610
DmeFBgn0015797
MmuMGI:894313
GO:0005525 GTP binding F
IDA
AthAt2g44610
ISO
MmuMGI:894313
ISS
AthAt5g10260
At2g44610
At4g39890
At2g22290
TAS
SpoSPAC4C5.02c
GO:0047485 protein N-terminus binding F
ISO
MmuMGI:894313
GO:0000003 reproduction P
IMP
CelWBGene00004269
GO:0001745 compound eye morphogenesis P
IGI
DmeFBgn0015797
GO:0006184 GTP catabolic process P
ISS
SpoSPAC4C5.02c
GO:0006605 protein targeting P
RCA
SceS000004252
GO:0006886 intracellular protein transport P
IGI
SceS000004252
ISS
SpoSPAC4C5.02c
TAS
MmuMGI:894313
SceS000004252
GO:0006887 exocytosis P
IMP
DmeFBgn0015797
GO:0006970 response to osmotic stress P
IMP
SpoSPAC4C5.02c
GO:0007264 small GTPase mediated signal transduction P
IC
SpoSPAC4C5.02c
GO:0007293 germarium-derived egg chamber formation P
IMP
DmeFBgn0015797
GO:0008103 oocyte microtubule cytoskeleton
polarization		 P
IMP
DmeFBgn0015797
GO:0008150 biological_process P
ND
MmuMGI:107283
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00004270
GO:0016192 vesicle-mediated transport P
RCA
SceS000004252
GO:0018125 peptidyl-cysteine methylation P
ISO
MmuMGI:894313
GO:0032940 secretion by cell P
IGI
AthAt2g44610
GO:0042147 retrograde transport, endosome to
Golgi		 P
IMP
SceS000004252
ISS
SpoSPAC4C5.02c
TAS
SceS000004252
GO:0045184 establishment of protein localization P
RCA
SceS000004252
GO:0045451 pole plasm oskar mRNA localization P
IMP
DmeFBgn0015797

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPAC4C5.02c
(P17608)		 YLR262C
(S000004252)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SpoSPAC4C5.02c
GO:0005794 Golgi apparatus C
ISS
SpoSPAC4C5.02c
TAS
SceS000004252
GO:0005829 cytosol C
IDA
SpoSPAC4C5.02c
GO:0003924 GTPase activity F
IDA
SceS000004252
ISS
SceS000004252
SpoSPAC4C5.02c
TAS
SceS000004252
GO:0005525 GTP binding F
TAS
SpoSPAC4C5.02c
GO:0006184 GTP catabolic process P
ISS
SpoSPAC4C5.02c
GO:0006605 protein targeting P
RCA
SceS000004252
GO:0006886 intracellular protein transport P
IGI
SceS000004252
ISS
SpoSPAC4C5.02c
TAS
SceS000004252
GO:0006970 response to osmotic stress P
IMP
SpoSPAC4C5.02c
GO:0007264 small GTPase mediated signal transduction P
IC
SpoSPAC4C5.02c
GO:0016192 vesicle-mediated transport P
RCA
SceS000004252
GO:0042147 retrograde transport, endosome to
Golgi		 P
IMP
SceS000004252
ISS
SpoSPAC4C5.02c
TAS
SceS000004252
GO:0045184 establishment of protein localization P
RCA
SceS000004252

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