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Search term: YLR274W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name MCM5
SGD link S000004264
Alternative ID YLR274W
Description Component of the hexameric MCM complex, which is important for priming origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation when activated by Cdc7p-Dbf4p in S-phase
Synonyms YLR274W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG0481 ACDHYPE

KOGs classification KOGs description
INFORMATION STORAGE AND PROCESSING DNA replication licensing factor, MCM5 component

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At2g07690 GI:15226146
Caenorhabditis elegans (Cel) CE03558
(WBGene00003157)		 GI:17554306 Q21902
Drosophila melanogaster (Dme) 7299365 GI:7299365
Homo sapiens (Hsa) Hs11418031 GI:11418031
Homo sapiens (Hsa) Hs6981192 GI:6981192
Saccharomyces cerevisiae (Sce) YLR274w
(S000004264)		 GI:6323304 P29496
Schizosaccharomyces pombe (Spo) SPAC3F10.01 GI:19114845
Encephalitozoon cuniculi (Ecu) ECU06g0340 GI:19074284 Q8SRS4
Arabidopsis thaliana (Ath) At2g07690 GI:15226146
Caenorhabditis elegans (Cel) CE03558
(WBGene00003157)		 GI:17554306 Q21902
Drosophila melanogaster (Dme) 7299365 GI:7299365
Homo sapiens (Hsa) Hs11418031 GI:11418031
Homo sapiens (Hsa) Hs6981192 GI:6981192
Saccharomyces cerevisiae (Sce) YLR274w
(S000004264)		 GI:6323304 P29496
Schizosaccharomyces pombe (Spo) SPAC3F10.01 GI:19114845
Encephalitozoon cuniculi (Ecu) ECU06g0340 GI:19074284 Q8SRS4
Arabidopsis thaliana (Ath) At2g07690 GI:15226146
Caenorhabditis elegans (Cel) CE03558
(WBGene00003157)		 GI:17554306 Q21902
Drosophila melanogaster (Dme) 7299365 GI:7299365
Homo sapiens (Hsa) Hs11418031 GI:11418031
Homo sapiens (Hsa) Hs6981192 GI:6981192
Saccharomyces cerevisiae (Sce) YLR274w
(S000004264)		 GI:6323304 P29496
Schizosaccharomyces pombe (Spo) SPAC3F10.01 GI:19114845
Encephalitozoon cuniculi (Ecu) ECU06g0340 GI:19074284 Q8SRS4


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000784 nuclear chromosome, telomeric region C
IDA
SceS000004264
GO:0005634 nucleus C
IDA
AthAt2g07690
SceS000004264
GO:0005656 pre-replicative complex C
IDA
SceS000004264
GO:0005737 cytoplasm C
IDA
AthAt2g07690
SceS000004264
GO:0031261 DNA replication preinitiation complex C
IPI
SceS000004264
GO:0031298 replication fork protection complex C
IDA
SceS000004264
GO:0042555 MCM complex C
IDA
SceS000004264
GO:0003677 DNA binding F
ISS
AthAt2g07690
GO:0003682 chromatin binding F
IDA
SceS000004264
GO:0003688 DNA replication origin binding F
IDA
SceS000004264
GO:0003697 single-stranded DNA binding F
IMP
SceS000004264
GO:0004003 ATP-dependent DNA helicase activity F
RCA
SceS000004264
GO:0005524 ATP binding F
ISS
AthAt2g07690
GO:0008094 DNA-dependent ATPase activity F
ISS
AthAt2g07690
GO:0009378 four-way junction helicase activity F
RCA
SceS000004264
GO:0016887 ATPase activity F
RCA
SceS000004264
GO:0042623 ATPase activity, coupled F
RCA
SceS000004264
GO:0043138 3'-5' DNA helicase activity F
RCA
SceS000004264
GO:0000084 S phase of mitotic cell cycle P
IGI
SceS000004264
IMP
SceS000004264
GO:0000727 double-strand break repair via break-induced
replication		 P
IMP
SceS000004264
GO:0000910 cytokinesis P
IMP
CelWBGene00003157
GO:0001703 gastrulation with mouth forming
first		 P
IMP
CelWBGene00003157
GO:0006260 DNA replication P
RCA
SceS000004264
GO:0006267 pre-replicative complex assembly P
IDA
SceS000004264
IPI
SceS000004264
GO:0006268 DNA unwinding involved in replication P
TAS
AthAt2g07690
GO:0006270 DNA-dependent DNA replication initiation P
IMP
SceS000004264
ISS
AthAt2g07690
GO:0006271 DNA strand elongation involved in DNA
replication		 P
RCA
SceS000004264
GO:0006343 establishment of chromatin silencing P
IMP
SceS000004264
GO:0006348 chromatin silencing at telomere P
IMP
SceS000004264
GO:0007369 gastrulation P
IMP
CelWBGene00003157
GO:0009790 embryo development P
IMP
CelWBGene00003157
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00003157
GO:0022616 DNA strand elongation P
RCA
SceS000004264
GO:0030174 regulation of DNA-dependent DNA replication
initiation		 P
IMP
SceS000004264
GO:0031939 negative regulation of chromatin silencing at
telomere		 P
IMP
SceS000004264
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00003157
GO:0051301 cell division P
IMP
CelWBGene00003157

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
4904

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) MCM5 GI:23510448
Pan troglodytes (Ptr) MCM5 GI:114686124
Canis familiaris (Cfa) MCM5 GI:73969862
Mus musculus (Mmu) Mcm5
(MGI:103197)		 GI:112293273 P49718
Rattus norvegicus (Rno) Mcm5 GI:109507773
Gallus gallus (Gga) MCM5 GI:57525409
Drosophila melanogaster (Dme) Mcm5
(FBgn0017577)		 GI:24645774
Anopheles gambiae (Aga) AgaP_AGAP004408 GI:58385070
Caenorhabditis elegans (Cel) mcm-5
(CE03558;
WBGene00003157)		 GI:17554306 Q21902
Saccharomyces cerevisiae (Sce) MCM5
(S000004264)		 GI:6323304 P29496
Kluyveromyces lactis (Kla) KLLA0D09262g GI:50306995
Eremothecium gossypii (Ego) AGOS_AGR276W GI:45201372
Magnaporthe grisea (Mgr) MGG_08646 GI:39948003
Neurospora crassa (Ncr) NCU01171.1 GI:32412368
Arabidopsis thaliana (Ath) AT2G07690 GI:15226146
Oryza sativa (Osa) Os02g0797400 GI:115449233
Plasmodium falciparum (Pfa) PFL0580w GI:124805740


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000784 nuclear chromosome, telomeric region C
IDA
SceS000004264
GO:0005634 nucleus C
IDA
AthAt2g07690
SceS000004264
GO:0005654 nucleoplasm C
EXP
HsaMCM5
GO:0005656 pre-replicative complex C
IDA
SceS000004264
ISS
DmeFBgn0017577
PfaPFL0580w
GO:0005737 cytoplasm C
IDA
AthAt2g07690
SceS000004264
GO:0031261 DNA replication preinitiation complex C
IPI
SceS000004264
GO:0031298 replication fork protection complex C
IDA
SceS000004264
GO:0042555 MCM complex C
IDA
SceS000004264
GO:0003677 DNA binding F
ISS
AthAt2g07690
GO:0003682 chromatin binding F
IDA
SceS000004264
ISS
DmeFBgn0017577
GO:0003688 DNA replication origin binding F
IDA
SceS000004264
GO:0003697 single-stranded DNA binding F
IMP
SceS000004264
GO:0004003 ATP-dependent DNA helicase activity F
ISS
PfaPFL0580w
RCA
SceS000004264
GO:0005515 protein binding F
IPI
HsaMCM5
GO:0005524 ATP binding F
ISS
AthAt2g07690
GO:0008094 DNA-dependent ATPase activity F
ISS
AthAt2g07690
GO:0009378 four-way junction helicase activity F
RCA
SceS000004264
GO:0016887 ATPase activity F
RCA
SceS000004264
GO:0042623 ATPase activity, coupled F
RCA
SceS000004264
GO:0043138 3'-5' DNA helicase activity F
IDA
DmeFBgn0017577
RCA
SceS000004264
GO:0000084 S phase of mitotic cell cycle P
IGI
SceS000004264
IMP
SceS000004264
GO:0000712 resolution of meiotic recombination
intermediates		 P
IMP
DmeFBgn0017577
GO:0000727 double-strand break repair via break-induced
replication		 P
IMP
SceS000004264
GO:0000910 cytokinesis P
IMP
CelWBGene00003157
GO:0001703 gastrulation with mouth forming
first		 P
IMP
CelWBGene00003157
GO:0006260 DNA replication P
EXP
HsaMCM5
RCA
SceS000004264
GO:0006267 pre-replicative complex assembly P
IDA
SceS000004264
IPI
SceS000004264
ISS
DmeFBgn0017577
GO:0006268 DNA unwinding involved in replication P
TAS
AthAt2g07690
GO:0006270 DNA-dependent DNA replication initiation P
IMP
SceS000004264
ISS
AthAt2g07690
GO:0006271 DNA strand elongation involved in DNA
replication		 P
RCA
SceS000004264
TAS
PfaPFL0580w
GO:0006343 establishment of chromatin silencing P
IMP
SceS000004264
GO:0006348 chromatin silencing at telomere P
IMP
SceS000004264
GO:0007126 meiosis P
IMP
DmeFBgn0017577
GO:0007369 gastrulation P
IMP
CelWBGene00003157
GO:0009790 embryo development P
IMP
CelWBGene00003157
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00003157
GO:0022616 DNA strand elongation P
RCA
SceS000004264
GO:0030174 regulation of DNA-dependent DNA replication
initiation		 P
IMP
SceS000004264
GO:0030261 chromosome condensation P
IMP
DmeFBgn0017577
GO:0031939 negative regulation of chromatin silencing at
telomere		 P
IMP
SceS000004264
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00003157
GO:0042023 DNA endoreduplication P
IMP
DmeFBgn0017577
GO:0051301 cell division P
IMP
CelWBGene00003157

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_2371

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga6951 ENSANGP00000013133
Ashbya gossypii (Ago) ago4587 AGR276W
Arabidopsis thaliana (Ath) ath8074 At2g07690.1
Caenorhabditis elegans (Cel) cel13783 R10E4.4
(CE03558;
WBGene00003157)
Candida glabrata (Cgl) cgl1444 CAGL0F04939g
Cryptococcus neoformans (Cne) cne5051 186.m03980
Dictyostelium discoideum (Ddi) ddi10696 DDB0219794
Debaryomyces hansenii (Dha) dha4492 DEHA0F02376g
Drosophila melanogaster (Dme) dme11944 CG4082-PA
(FBgn0017577)
Danio rerio (Dre) dre17327 ENSDARP00000018877
(mcm5)		 Q6NV07
Encephalitozoon cuniculi (Ecu) ecu1511 19074284
Takifugu rubripes (Fru) fru31864 SINFRUP00000154343
Gallus gallus (Gga) gga982 ENSGALP00000020463
(MCM5)		 Q5ZKL0
Homo sapiens (Hsa) hsa21557 ENSP00000216122
(MCM5)		 P33992
Kluyveromyces lactis (Kla) kla2474 KLLA0D09262g
Mus musculus (Mmu) mmu26220 ENSMUSP00000005545
(MGI:103197)		 P49718
Neurospora crassa (Ncr) ncr1134 NCU01171.2
Oryza sativa (Osa) osa5783 2428.m00165
Plasmodium falciparum (Pfa) pfa4902 PFL0580w
Rattus norvegicus (Rno) rno14609 ENSRNOP00000019677
(RGD:1306616)
Saccharomyces cerevisiae (Sce) sce4380 YLR274W
(S000004264)
Schizosaccharomyces pombe (Spo) spo3973 SPAC1B2.05 P41389
Yarrowia lipolytica (Yli) yli46 YALI0A01353g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000784 nuclear chromosome, telomeric region C
IDA
SceS000004264
GO:0005634 nucleus C
IDA
AthAt2g07690
SceS000004264
SpoSPAC1B2.05
GO:0005656 pre-replicative complex C
IC
SpoSPAC1B2.05
IDA
SceS000004264
ISS
DmeFBgn0017577
PfaPFL0580w
GO:0005657 replication fork C
NAS
SpoSPAC1B2.05
GO:0005737 cytoplasm C
IDA
AthAt2g07690
SceS000004264
SpoSPAC1B2.05
GO:0005829 cytosol C
IDA
SpoSPAC1B2.05
GO:0031261 DNA replication preinitiation complex C
IC
SpoSPAC1B2.05
IPI
SceS000004264
GO:0031298 replication fork protection complex C
IDA
SceS000004264
GO:0031390 Ctf18 RFC-like complex C
IC
SpoSPAC1B2.05
GO:0042555 MCM complex C
IDA
SceS000004264
SpoSPAC1B2.05
GO:0003677 DNA binding F
ISS
AthAt2g07690
GO:0003682 chromatin binding F
IDA
SceS000004264
ISS
DmeFBgn0017577
GO:0003688 DNA replication origin binding F
IDA
SceS000004264
GO:0003697 single-stranded DNA binding F
IMP
SceS000004264
GO:0004003 ATP-dependent DNA helicase activity F
ISS
PfaPFL0580w
RCA
SceS000004264
TAS
SpoSPAC1B2.05
GO:0005515 protein binding F
IPI
SpoSPAC1B2.05
GO:0005524 ATP binding F
ISS
AthAt2g07690
GO:0008094 DNA-dependent ATPase activity F
ISS
AthAt2g07690
GO:0009378 four-way junction helicase activity F
RCA
SceS000004264
GO:0016887 ATPase activity F
RCA
SceS000004264
GO:0042623 ATPase activity, coupled F
RCA
SceS000004264
GO:0043138 3'-5' DNA helicase activity F
IDA
DmeFBgn0017577
RCA
SceS000004264
GO:0000084 S phase of mitotic cell cycle P
IC
SpoSPAC1B2.05
IGI
SceS000004264
IMP
SceS000004264
GO:0000712 resolution of meiotic recombination
intermediates		 P
IMP
DmeFBgn0017577
GO:0000727 double-strand break repair via break-induced
replication		 P
IMP
SceS000004264
GO:0000910 cytokinesis P
IMP
CelWBGene00003157
GO:0001703 gastrulation with mouth forming
first		 P
IMP
CelWBGene00003157
GO:0006260 DNA replication P
RCA
SceS000004264
GO:0006267 pre-replicative complex assembly P
IDA
SceS000004264
IPI
SceS000004264
ISS
DmeFBgn0017577
GO:0006268 DNA unwinding involved in replication P
TAS
AthAt2g07690
GO:0006270 DNA-dependent DNA replication initiation P
IDA
SpoSPAC1B2.05
IMP
SceS000004264
ISS
AthAt2g07690
GO:0006271 DNA strand elongation involved in DNA
replication		 P
RCA
SceS000004264
TAS
PfaPFL0580w
SpoSPAC1B2.05
GO:0006343 establishment of chromatin silencing P
IMP
SceS000004264
GO:0006348 chromatin silencing at telomere P
IMP
SceS000004264
GO:0007126 meiosis P
IMP
DmeFBgn0017577
GO:0007369 gastrulation P
IMP
CelWBGene00003157
GO:0009790 embryo development P
IMP
CelWBGene00003157
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00003157
GO:0022616 DNA strand elongation P
RCA
SceS000004264
GO:0030174 regulation of DNA-dependent DNA replication
initiation		 P
IMP
SceS000004264
GO:0030261 chromosome condensation P
IMP
DmeFBgn0017577
GO:0031939 negative regulation of chromatin silencing at
telomere		 P
IMP
SceS000004264
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00003157
GO:0042023 DNA endoreduplication P
IMP
DmeFBgn0017577
GO:0051301 cell division P
IMP
CelWBGene00003157

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPAC1B2.05
(P41389)		 YLR274W
(S000004264)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000784 nuclear chromosome, telomeric region C
IDA
SceS000004264
GO:0005634 nucleus C
IDA
SceS000004264
SpoSPAC1B2.05
GO:0005656 pre-replicative complex C
IC
SpoSPAC1B2.05
IDA
SceS000004264
GO:0005657 replication fork C
NAS
SpoSPAC1B2.05
GO:0005737 cytoplasm C
IDA
SceS000004264
SpoSPAC1B2.05
GO:0005829 cytosol C
IDA
SpoSPAC1B2.05
GO:0031261 DNA replication preinitiation complex C
IC
SpoSPAC1B2.05
IPI
SceS000004264
GO:0031298 replication fork protection complex C
IDA
SceS000004264
GO:0031390 Ctf18 RFC-like complex C
IC
SpoSPAC1B2.05
GO:0042555 MCM complex C
IDA
SceS000004264
SpoSPAC1B2.05
GO:0003682 chromatin binding F
IDA
SceS000004264
GO:0003688 DNA replication origin binding F
IDA
SceS000004264
GO:0003697 single-stranded DNA binding F
IMP
SceS000004264
GO:0004003 ATP-dependent DNA helicase activity F
RCA
SceS000004264
TAS
SpoSPAC1B2.05
GO:0005515 protein binding F
IPI
SpoSPAC1B2.05
GO:0009378 four-way junction helicase activity F
RCA
SceS000004264
GO:0016887 ATPase activity F
RCA
SceS000004264
GO:0042623 ATPase activity, coupled F
RCA
SceS000004264
GO:0043138 3'-5' DNA helicase activity F
RCA
SceS000004264
GO:0000084 S phase of mitotic cell cycle P
IC
SpoSPAC1B2.05
IGI
SceS000004264
IMP
SceS000004264
GO:0000727 double-strand break repair via break-induced
replication		 P
IMP
SceS000004264
GO:0006260 DNA replication P
RCA
SceS000004264
GO:0006267 pre-replicative complex assembly P
IDA
SceS000004264
IPI
SceS000004264
GO:0006270 DNA-dependent DNA replication initiation P
IDA
SpoSPAC1B2.05
IMP
SceS000004264
GO:0006271 DNA strand elongation involved in DNA
replication		 P
RCA
SceS000004264
TAS
SpoSPAC1B2.05
GO:0006343 establishment of chromatin silencing P
IMP
SceS000004264
GO:0006348 chromatin silencing at telomere P
IMP
SceS000004264
GO:0022616 DNA strand elongation P
RCA
SceS000004264
GO:0030174 regulation of DNA-dependent DNA replication
initiation		 P
IMP
SceS000004264
GO:0031939 negative regulation of chromatin silencing at
telomere		 P
IMP
SceS000004264

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Query species:

Include wild-cards:   

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GO info in one table:

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