YOGY Home YOGY Help

Search term: YLR291C

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name GCD7
SGD link S000004282
Alternative ID YLR291C
Description Beta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
Synonyms YLR291C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

Search for gene by ID or name:

Query species:

Include wild-cards:   

Search for GO info:  

GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG1465 ACDHYP-

KOGs classification KOGs description
INFORMATION STORAGE AND PROCESSING Translation initiation factor 2B, beta subunit (eIF-2Bbeta/GCD7)

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At3g07300 GI:15231439
Caenorhabditis elegans (Cel) CE20267
(WBGene00012950)		 GI:17510061 Q9XWD5
Drosophila melanogaster (Dme) 7290350
(eIF2B-beta)		 GI:18543295
Homo sapiens (Hsa) Hs7657058
(EIF2B2)		 GI:7657058 P49770
Saccharomyces cerevisiae (Sce) YLR291c
(S000004282)		 GI:6323322 P32502
Schizosaccharomyces pombe (Spo) SPAC343.14c GI:19114347 Q9UT76


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005737 cytoplasm C
IDA
HsaEIF2B2
GO:0005739 mitochondrion C
IDA
SceS000004282
GO:0005829 cytosol C
IDA
SpoSPAC343.14c
ISS
DmeeIF2B-beta
GO:0005851 eukaryotic translation initiation factor 2B
complex		 C
IDA
HsaEIF2B2
SceS000004282
IGI
SceS000004282
IMP
SceS000004282
IPI
SceS000004282
ISS
AthAt3g07300
DmeeIF2B-beta
SpoSPAC343.14c
GO:0032045 guanyl-nucleotide exchange factor
complex		 C
IDA
SceS000004282
IPI
SceS000004282
GO:0003743 translation initiation factor activity F
IDA
HsaEIF2B2
IGI
SceS000004282
IPI
SceS000004282
ISS
AthAt3g07300
DmeeIF2B-beta
SpoSPAC343.14c
GO:0005085 guanyl-nucleotide exchange factor
activity		 F
IDA
HsaEIF2B2
SceS000004282
IMP
HsaEIF2B2
IPI
SceS000004282
GO:0005515 protein binding F
IPI
HsaEIF2B2
GO:0005524 ATP binding F
IDA
HsaEIF2B2
GO:0005525 GTP binding F
IDA
HsaEIF2B2
ISS
AthAt3g07300
GO:0030234 enzyme regulator activity F
IGI
SceS000004282
IMP
SceS000004282
IPI
SceS000004282
GO:0000003 reproduction P
IMP
CelWBGene00012950
GO:0001541 ovarian follicle development P
IMP
HsaEIF2B2
GO:0002119 nematode larval development P
IMP
CelWBGene00012950
GO:0006413 translational initiation P
IDA
HsaEIF2B2
ISS
AthAt3g07300
DmeeIF2B-beta
SpoSPAC343.14c
GO:0006417 regulation of translation P
RCA
SceS000004282
GO:0006446 regulation of translational initiation P
IDA
SceS000004282
IGI
SceS000004282
IMP
SceS000004282
IPI
SceS000004282
TAS
HsaEIF2B2
GO:0006898 receptor-mediated endocytosis P
IMP
CelWBGene00012950
GO:0007417 central nervous system development P
IMP
HsaEIF2B2
GO:0009408 response to heat P
ISS
HsaEIF2B2
TAS
HsaEIF2B2
GO:0009749 response to glucose stimulus P
ISS
HsaEIF2B2
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00012950
GO:0010171 body morphogenesis P
IMP
CelWBGene00012950
GO:0014003 oligodendrocyte development P
IMP
HsaEIF2B2
GO:0040007 growth P
IMP
CelWBGene00012950
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00012950
GO:0040018 positive regulation of multicellular organism
growth		 P
IMP
CelWBGene00012950
GO:0042552 myelination P
IMP
HsaEIF2B2
GO:0043434 response to peptide hormone stimulus P
ISS
HsaEIF2B2
GO:0045948 positive regulation of translational
initiation		 P
ISS
SpoSPAC343.14c
GO:0051716 cellular response to stimulus P
IDA
HsaEIF2B2

Back to the top

HomoloGene results:

HomoloGene cluster Phylogenetic pattern
6507

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) EIF2B2 GI:7657058 P49770
Pan troglodytes (Ptr) EIF2B2 GI:114653987
Canis familiaris (Cfa) EIF2B2 GI:73963645
Mus musculus (Mmu) Eif2b2
(MGI:2145118)		 GI:21703888 Q8BK57
Rattus norvegicus (Rno) Eif2b2
(RGD:620820)		 GI:14091738
Gallus gallus (Gga) EIF2B2 GI:57529951
Drosophila melanogaster (Dme) eIF2B-beta GI:18543295
Anopheles gambiae (Aga) AgaP_AGAP007097 GI:118778494
Schizosaccharomyces pombe (Spo) SPAC343.14c GI:19114347 Q9UT76
Saccharomyces cerevisiae (Sce) GCD7
(S000004282)		 GI:6323322 P32502
Kluyveromyces lactis (Kla) KLLA0C05082g GI:50304939
Kluyveromyces lactis (Kla) KLLA0A04433g GI:50302519
Eremothecium gossypii (Ego) AGOS_AGR292C GI:45201388
Arabidopsis thaliana (Ath) AT3G07300 GI:79313151
Oryza sativa (Osa) Os10g0392700 GI:115481846
Plasmodium falciparum (Pfa) PFL2430c GI:124807029


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005737 cytoplasm C
IDA
HsaEIF2B2
GO:0005739 mitochondrion C
IDA
SceS000004282
GO:0005829 cytosol C
IDA
SpoSPAC343.14c
ISS
DmeeIF2B-beta
GO:0005851 eukaryotic translation initiation factor 2B
complex		 C
IDA
HsaEIF2B2
SceS000004282
IGI
SceS000004282
IMP
SceS000004282
IPI
SceS000004282
ISO
MmuMGI:2145118
ISS
AthAt3g07300
DmeeIF2B-beta
PfaPFL2430c
SpoSPAC343.14c
GO:0032045 guanyl-nucleotide exchange factor
complex		 C
IDA
SceS000004282
IPI
SceS000004282
GO:0003743 translation initiation factor activity F
IDA
HsaEIF2B2
IGI
SceS000004282
IPI
SceS000004282
ISS
AthAt3g07300
DmeeIF2B-beta
SpoSPAC343.14c
GO:0005085 guanyl-nucleotide exchange factor
activity		 F
IDA
HsaEIF2B2
SceS000004282
IMP
HsaEIF2B2
IPI
SceS000004282
ISO
MmuMGI:2145118
MGI:2145118
GO:0005515 protein binding F
IPI
HsaEIF2B2
GO:0005524 ATP binding F
IDA
HsaEIF2B2
GO:0005525 GTP binding F
IDA
HsaEIF2B2
ISO
MmuMGI:2145118
ISS
AthAt3g07300
PfaPFL2430c
GO:0030234 enzyme regulator activity F
IGI
SceS000004282
IMP
SceS000004282
IPI
SceS000004282
GO:0001541 ovarian follicle development P
IMP
HsaEIF2B2
GO:0006413 translational initiation P
IDA
HsaEIF2B2
ISS
AthAt3g07300
DmeeIF2B-beta
PfaPFL2430c
SpoSPAC343.14c
GO:0006417 regulation of translation P
RCA
SceS000004282
GO:0006446 regulation of translational initiation P
IDA
SceS000004282
IGI
SceS000004282
IMP
SceS000004282
IPI
SceS000004282
TAS
HsaEIF2B2
GO:0007417 central nervous system development P
IMP
HsaEIF2B2
GO:0009408 response to heat P
ISO
MmuMGI:2145118
ISS
HsaEIF2B2
TAS
HsaEIF2B2
GO:0009749 response to glucose stimulus P
ISO
MmuMGI:2145118
ISS
HsaEIF2B2
GO:0014003 oligodendrocyte development P
IMP
HsaEIF2B2
GO:0042552 myelination P
IMP
HsaEIF2B2
GO:0043434 response to peptide hormone stimulus P
ISO
MmuMGI:2145118
ISS
HsaEIF2B2
GO:0045948 positive regulation of translational
initiation		 P
ISS
SpoSPAC343.14c
GO:0051716 cellular response to stimulus P
IDA
HsaEIF2B2

Back to the top

OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_2285

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga2550 ENSANGP00000011225
Ashbya gossypii (Ago) ago4603 AGR292C
Arabidopsis thaliana (Ath) ath12817 At3g07300.1
Caenorhabditis elegans (Cel) cel19173 Y47H9C.7
(CE20267;
WBGene00012950)
Candida glabrata (Cgl) cgl2041 CAGL0G09669g
Dictyostelium discoideum (Ddi) ddi13506 DDB0231373
Debaryomyces hansenii (Dha) dha2832 DEHA0D12056g
Drosophila melanogaster (Dme) dme16289 CG2677-PA
(FBgn0024996)
Danio rerio (Dre) dre13105 ENSDARP00000039651
Danio rerio (Dre) dre13108 ENSDARP00000044390
Takifugu rubripes (Fru) fru22901 SINFRUP00000133481
Gallus gallus (Gga) gga19560 ENSGALP00000016737
(EIF2B2)		 Q5ZL25
Gallus gallus (Gga) gga19561 ENSGALP00000016738
Homo sapiens (Hsa) hsa9834 ENSP00000266126
(EIF2B2)		 P49770
Kluyveromyces lactis (Kla) kla191 KLLA0A04433g
Kluyveromyces lactis (Kla) kla1426 KLLA0C05082g
Mus musculus (Mmu) mmu6001 ENSMUSP00000004910
(MGI:2145118)		 Q99LD9
Neurospora crassa (Ncr) ncr8725 NCU08952.2
Oryza sativa (Osa) osa17582 3167.m00161
Oryza sativa (Osa) osa17597 3167.m00197
Oryza sativa (Osa) osa17598 3167.m00198
Plasmodium falciparum (Pfa) pfa5267 PFL2430c
Rattus norvegicus (Rno) rno25443 ENSRNOP00000008730
(RGD:620820)		 Q6IRS8
Saccharomyces cerevisiae (Sce) sce4400 YLR291C
(S000004282)
Schizosaccharomyces pombe (Spo) spo503 SPAC343.14c Q9UT76
Yarrowia lipolytica (Yli) yli6364 YALI0F24321g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005739 mitochondrion C
IDA
SceS000004282
GO:0005829 cytosol C
IDA
SpoSPAC343.14c
ISS
DmeFBgn0024996
GO:0005851 eukaryotic translation initiation factor 2B
complex		 C
IDA
SceS000004282
IGI
SceS000004282
IMP
SceS000004282
IPI
SceS000004282
ISO
MmuMGI:2145118
ISS
AthAt3g07300
DmeFBgn0024996
PfaPFL2430c
SpoSPAC343.14c
GO:0032045 guanyl-nucleotide exchange factor
complex		 C
IDA
SceS000004282
IPI
SceS000004282
GO:0003743 translation initiation factor activity F
IGI
SceS000004282
IPI
SceS000004282
ISS
AthAt3g07300
DmeFBgn0024996
SpoSPAC343.14c
GO:0005085 guanyl-nucleotide exchange factor
activity		 F
IDA
SceS000004282
IPI
SceS000004282
ISO
MmuMGI:2145118
MGI:2145118
GO:0005525 GTP binding F
ISO
MmuMGI:2145118
ISS
AthAt3g07300
PfaPFL2430c
GO:0030234 enzyme regulator activity F
IGI
SceS000004282
IMP
SceS000004282
IPI
SceS000004282
GO:0000003 reproduction P
IMP
CelWBGene00012950
GO:0002119 nematode larval development P
IMP
CelWBGene00012950
GO:0006413 translational initiation P
ISS
AthAt3g07300
DmeFBgn0024996
PfaPFL2430c
SpoSPAC343.14c
GO:0006417 regulation of translation P
RCA
SceS000004282
GO:0006446 regulation of translational initiation P
IDA
SceS000004282
IGI
SceS000004282
IMP
SceS000004282
IPI
SceS000004282
GO:0006898 receptor-mediated endocytosis P
IMP
CelWBGene00012950
GO:0009408 response to heat P
ISO
MmuMGI:2145118
GO:0009749 response to glucose stimulus P
ISO
MmuMGI:2145118
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00012950
GO:0010171 body morphogenesis P
IMP
CelWBGene00012950
GO:0040007 growth P
IMP
CelWBGene00012950
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00012950
GO:0040018 positive regulation of multicellular organism
growth		 P
IMP
CelWBGene00012950
GO:0043434 response to peptide hormone stimulus P
ISO
MmuMGI:2145118
GO:0045948 positive regulation of translational
initiation		 P
ISS
SpoSPAC343.14c

Back to the top

Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPAC343.14c
(Q9UT76)		 YLR291C
(S000004282)