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Search term: YLR310C

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name CDC25
SGD link S000004301
Alternative ID YLR310C
Description Membrane bound guanine nucleotide exchange factor (GEF or GDP-release factor); indirectly regulates adenylate cyclase through activation of Ras1p and Ras2p by stimulating the exchange of GDP for GTP; required for progression through G1
Synonyms YLR310C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG3417 -CDHYPE

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALING Ras1 guanine nucleotide exchange factor

Species KOG link NCBI link UniProt link
Caenorhabditis elegans (Cel) CE05713 GI:17560110
Caenorhabditis elegans (Cel) CE21520
(WBGene00021320)		 GI:17570353
Caenorhabditis elegans (Cel) CE28779 GI:17563288
Drosophila melanogaster (Dme) 7290754 GI:7290754
Drosophila melanogaster (Dme) 7298097 GI:7298097
Drosophila melanogaster (Dme) 7302878
(FBgn0034158)		 GI:20130059 Q0E949
Drosophila melanogaster (Dme) 7302879 GI:7302879 Q0E949
Homo sapiens (Hsa) Hs15529996
(SOS1)		 GI:15529996 Q07889
Homo sapiens (Hsa) Hs19923151 GI:19923151
Homo sapiens (Hsa) Hs20149570 GI:20149570
Homo sapiens (Hsa) Hs20482804 GI:20482804
Homo sapiens (Hsa) Hs20546742 GI:20546742
Homo sapiens (Hsa) Hs22048159 GI:22048159
Homo sapiens (Hsa) Hs4885357 GI:4885357
Homo sapiens (Hsa) Hs5032025 GI:5032025
Homo sapiens (Hsa) Hs7662070
(RALGPS1)		 GI:7662070 Q9NZ16
Homo sapiens (Hsa) Hs7662334 GI:7662334 Q8IV61
Homo sapiens (Hsa) Hs8922307 GI:8922307
Saccharomyces cerevisiae (Sce) YAL024c
(S000000022)		 GI:6319295 P07866
Saccharomyces cerevisiae (Sce) YCL068c GI:10383751 P25593
Saccharomyces cerevisiae (Sce) YCR038c
(S000000634)		 GI:10383799 P25300
Saccharomyces cerevisiae (Sce) YLR310c
(S000004301)		 GI:6323341 P04821
Schizosaccharomyces pombe (Spo) SPBC336.03 GI:19112915 Q9USU1
Schizosaccharomyces pombe (Spo) SPCC1442.01 GI:19075816 P26674
Encephalitozoon cuniculi (Ecu) ECU07g0270 GI:19074449 Q8SV40


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000131 incipient cellular bud site C
IDA
SceS000000634
GO:0005575 cellular_component C
ND
HsaRALGPS1
SceYCL068c
GO:0005634 nucleus C
IDA
SceS000004301
GO:0005737 cytoplasm C
IDA
SceS000004301
GO:0005829 cytosol C
EXP
HsaSOS1
IDA
SceS000004301
SpoSPBC336.03
SPCC1442.01
GO:0005886 plasma membrane C
IDA
SceS000004301
GO:0005933 cellular bud C
IDA
SceS000000022
GO:0005935 cellular bud neck C
IDA
SceS000000634
GO:0003674 molecular_function F
ND
SceYCL068c
GO:0005083 small GTPase regulator activity F
RCA
SceS000000022
GO:0005085 guanyl-nucleotide exchange factor
activity		 F
EXP
HsaSOS1
ISS
DmeFBgn0034158
SceS000000022
NAS
HsaRALGPS1
TAS
SceS000000634
GO:0005088 Ras guanyl-nucleotide exchange factor
activity		 F
EXP
HsaSOS1
RCA
SceS000000022
TAS
SceS000000634
S000004301
SpoSPBC336.03
GO:0005100 Rho GTPase activator activity F
TAS
HsaSOS1
GO:0005515 protein binding F
IPI
HsaSOS1
GO:0000003 reproduction P
RCA
SceS000000634
GO:0000282 cellular bud site selection P
TAS
SceS000000634
GO:0000747 conjugation with cellular fusion P
IMP
SpoSPCC1442.01
GO:0001302 replicative cell aging P
IMP
SceS000004301
GO:0006915 apoptosis P
EXP
HsaSOS1
GO:0007089 traversing start control point of mitotic cell
cycle		 P
IMP
SceS000004301
GO:0007096 regulation of exit from mitosis P
TAS
SceS000000022
GO:0007120 axial cellular bud site selection P
TAS
SceS000000634
GO:0007121 bipolar cellular bud site selection P
TAS
SceS000000634
GO:0007124 pseudohyphal growth P
TAS
SceS000000634
GO:0007154 cell communication P
RCA
SceS000000022
GO:0007163 establishment or maintenance of cell
polarity		 P
IGI
SpoSPBC336.03
GO:0007165 signal transduction P
NAS
HsaSOS1
RCA
SceS000000022
GO:0007264 small GTPase mediated signal transduction P
RCA
SceS000000022
TAS
SceS000000634
GO:0007265 Ras protein signal transduction P
EXP
HsaSOS1
TAS
SceS000004301
GO:0007568 aging P
RCA
SceS000004301
GO:0008150 biological_process P
ND
SceYCL068c
GO:0008624 induction of apoptosis by extracellular
signals		 P
EXP
HsaSOS1
GO:0016192 vesicle-mediated transport P
IGI
SceS000000022
GO:0019932 second-messenger-mediated signaling P
RCA
SceS000004301
GO:0019953 sexual reproduction P
RCA
SceS000000634
GO:0023034 intracellular signaling pathway P
NAS
HsaRALGPS1
GO:0030435 sporulation resulting in formation of a cellular
spore		 P
RCA
SceS000004301
GO:0031578 mitotic cell cycle spindle orientation
checkpoint		 P
TAS
SceS000000022
GO:0032489 regulation of Cdc42 protein signal
transduction		 P
TAS
SpoSPBC336.03
GO:0050790 regulation of catalytic activity P
RCA
SceS000000022
S000004301
GO:0051181 cofactor transport P
RCA
SceS000000634
GO:0051301 cell division P
RCA
SceS000000634
GO:0051726 regulation of cell cycle P
IMP
SceS000004301
RCA
SceS000000022

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
39765

Species Gene ID NCBI link UniProt link
Saccharomyces cerevisiae (Sce) CDC25
(S000004301)		 GI:6323341 P04821
Kluyveromyces lactis (Kla) KLLA0D09306g GI:50306999
Eremothecium gossypii (Ego) AGOS_ADL038W GI:45187835


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SceS000004301
GO:0005737 cytoplasm C
IDA
SceS000004301
GO:0005829 cytosol C
IDA
SceS000004301
GO:0005886 plasma membrane C
IDA
SceS000004301
GO:0005088 Ras guanyl-nucleotide exchange factor
activity		 F
TAS
SceS000004301
GO:0001302 replicative cell aging P
IMP
SceS000004301
GO:0007089 traversing start control point of mitotic cell
cycle		 P
IMP
SceS000004301
GO:0007265 Ras protein signal transduction P
TAS
SceS000004301
GO:0007568 aging P
RCA
SceS000004301
GO:0019932 second-messenger-mediated signaling P
RCA
SceS000004301
GO:0030435 sporulation resulting in formation of a cellular
spore		 P
RCA
SceS000004301
GO:0050790 regulation of catalytic activity P
RCA
SceS000004301
GO:0051726 regulation of cell cycle P
IMP
SceS000004301

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_1180

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga11307 ENSANGP00000016641
Ashbya gossypii (Ago) ago1703 ADL038W
Caenorhabditis elegans (Cel) cel16642 T28F12.3
(CE36328;
WBGene00004947)
Candida glabrata (Cgl) cgl1091 CAGL0E03476g
Cryptococcus neoformans (Cne) cne2808 183.m01747
Dictyostelium discoideum (Ddi) ddi11731 DDB0185196
Dictyostelium discoideum (Ddi) ddi11681 DDB0185198
Dictyostelium discoideum (Ddi) ddi951 DDB0189445
Dictyostelium discoideum (Ddi) ddi13196 DDB0191187
Dictyostelium discoideum (Ddi) ddi11774 DDB0191324
Dictyostelium discoideum (Ddi) ddi12893 DDB0191357
Dictyostelium discoideum (Ddi) ddi12471 DDB0215006
Dictyostelium discoideum (Ddi) ddi12470 DDB0215008
Dictyostelium discoideum (Ddi) ddi13528 DDB0215365
Debaryomyces hansenii (Dha) dha557 DEHA0A12485g
Drosophila melanogaster (Dme) dme2323 CG7793-PA
(FBgn0001965)
Danio rerio (Dre) dre5124 ENSDARP00000019860
Danio rerio (Dre) dre5125 ENSDARP00000049198
Takifugu rubripes (Fru) fru15797 SINFRUP00000143939
Takifugu rubripes (Fru) fru15794 SINFRUP00000143940
Takifugu rubripes (Fru) fru15796 SINFRUP00000169119
Takifugu rubripes (Fru) fru15795 SINFRUP00000171411
Gallus gallus (Gga) gga20041 ENSGALP00000020023
(SOS2)
Gallus gallus (Gga) gga26249 ENSGALP00000021567
(LOC431192)
Gallus gallus (Gga) gga26250 ENSGALP00000021568
Gallus gallus (Gga) gga26251 ENSGALP00000021569
Homo sapiens (Hsa) hsa9498 ENSP00000216373
(SOS2)		 Q07890
Homo sapiens (Hsa) hsa17729 ENSP00000263879
(SOS1)		 Q59GG9
Homo sapiens (Hsa) hsa9499 ENSP00000346183
Kluyveromyces lactis (Kla) kla2476 KLLA0D09306g
Mus musculus (Mmu) mmu5789 ENSMUSP00000044866
(MGI:98355)		 Q02384
Mus musculus (Mmu) mmu12148 ENSMUSP00000067786
(MGI:98354)		 Q62245
Neurospora crassa (Ncr) ncr6318 NCU06500.2
Rattus norvegicus (Rno) rno25206 ENSRNOP00000006425
(RGD:620435)		 Q9Z1I1
Rattus norvegicus (Rno) rno24634 ENSRNOP00000009359
(RGD:1310949)		 Q497A5
Saccharomyces cerevisiae (Sce) sce4024 YLL016W
Saccharomyces cerevisiae (Sce) sce4421 YLR310C
(S000004301)
Schizosaccharomyces pombe (Spo) spo2330 SPBC336.03 Q9USU1
Yarrowia lipolytica (Yli) yli3639 YALI0D22286g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SceS000004301
GO:0005737 cytoplasm C
IDA
SceS000004301
GO:0005829 cytosol C
IDA
SceS000004301
SpoSPBC336.03
GO:0005886 plasma membrane C
IDA
SceS000004301
ISO
MmuMGI:98354
GO:0014069 postsynaptic density C
ISO
MmuMGI:98354
GO:0043025 neuronal cell body C
ISO
MmuMGI:98354
GO:0005085 guanyl-nucleotide exchange factor
activity		 F
IDA
MmuMGI:98355
GO:0005088 Ras guanyl-nucleotide exchange factor
activity		 F
IMP
MmuMGI:98355
MGI:98354
ISS
CelWBGene00004947
DmeFBgn0001965
NAS
DmeFBgn0001965
TAS
SceS000004301
SpoSPBC336.03
GO:0005515 protein binding F
IPI
DmeFBgn0001965
MmuMGI:98355
MGI:98354
GO:0005516 calmodulin binding F
IPI
CelWBGene00004947
GO:0017124 SH3 domain binding F
ISO
MmuMGI:98354
GO:0000003 reproduction P
IMP
CelWBGene00004947
GO:0001302 replicative cell aging P
IMP
SceS000004301
GO:0007015 actin filament organization P
IMP
DmeFBgn0001965
GO:0007089 traversing start control point of mitotic cell
cycle		 P
IMP
SceS000004301
GO:0007163 establishment or maintenance of cell
polarity		 P
IGI
SpoSPBC336.03
GO:0007264 small GTPase mediated signal transduction P
IMP
MmuMGI:98355
MGI:98354
GO:0007265 Ras protein signal transduction P
ISO
MmuMGI:98354
ISS
DmeFBgn0001965
TAS
SceS000004301
GO:0007292 female gamete generation P
IMP
CelWBGene00004947
GO:0007399 nervous system development P
NAS
DmeFBgn0001965
GO:0007426 tracheal outgrowth, open tracheal
system		 P
IMP
DmeFBgn0001965
GO:0007568 aging P
RCA
SceS000004301
GO:0008293 torso signaling pathway P
TAS
DmeFBgn0001965
GO:0008360 regulation of cell shape P
IMP
DmeFBgn0001965
GO:0008543 fibroblast growth factor receptor signaling
pathway		 P
IGI
MmuMGI:98354
GO:0008595 anterior/posterior axis specification,
embryo		 P
TAS
DmeFBgn0001965
GO:0009790 embryo development P
IMP
CelWBGene00004947
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00004947
GO:0010171 body morphogenesis P
IMP
CelWBGene00004947
GO:0016477 cell migration P
IMP
CelWBGene00004947
GO:0018991 oviposition P
IMP
CelWBGene00004947
GO:0019932 second-messenger-mediated signaling P
RCA
SceS000004301
GO:0030435 sporulation resulting in formation of a cellular
spore		 P
RCA
SceS000004301
GO:0032489 regulation of Cdc42 protein signal
transduction		 P
TAS
SpoSPBC336.03
GO:0032940 secretion by cell P
IMP
CelWBGene00004947
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00004947
GO:0040026 positive regulation of vulval development P
IGI
CelWBGene00004947
GO:0045500 sevenless signaling pathway P
TAS
DmeFBgn0001965
GO:0045749 negative regulation of S phase of mitotic cell
cycle		 P
IMP
DmeFBgn0001965
GO:0048011 nerve growth factor receptor signaling
pathway		 P
ISO
MmuMGI:98354
GO:0050790 regulation of catalytic activity P
IDA
MmuMGI:98355
IMP
MmuMGI:98355
MGI:98354
RCA
SceS000004301
GO:0051726 regulation of cell cycle P
IMP
SceS000004301

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPCC1442.01
(P26674)		 YLR310C
(S000004301)
SPBC336.03
(Q9USU1)		 YLR310C
(S000004301)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SceS000004301
GO:0005737 cytoplasm C
IDA
SceS000004301
GO:0005829 cytosol C
IDA
SceS000004301
SpoSPBC336.03
SPCC1442.01
GO:0005886 plasma membrane C
IDA
SceS000004301
GO:0005088 Ras guanyl-nucleotide exchange factor
activity		 F
TAS
SceS000004301
SpoSPBC336.03
GO:0000747 conjugation with cellular fusion P
IMP
SpoSPCC1442.01
GO:0001302 replicative cell aging P
IMP
SceS000004301
GO:0007089 traversing start control point of mitotic cell
cycle		 P
IMP
SceS000004301
GO:0007163 establishment or maintenance of cell
polarity		 P
IGI
SpoSPBC336.03
GO:0007265 Ras protein signal transduction P
TAS
SceS000004301
GO:0007568 aging P
RCA
SceS000004301
GO:0019932 second-messenger-mediated signaling P
RCA
SceS000004301
GO:0030435 sporulation resulting in formation of a cellular
spore		 P
RCA
SceS000004301
GO:0032489 regulation of Cdc42 protein signal
transduction		 P
TAS
SpoSPBC336.03
GO:0050790 regulation of catalytic activity P
RCA
SceS000004301
GO:0051726 regulation of cell cycle P
IMP
SceS000004301

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s.khadayate@ucl.ac.uk