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Search term: YLR318W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name EST2
SGD link S000004310
Alternative ID YLR318W
Description Reverse transcriptase subunit of the telomerase holoenzyme, essential for telomerase core catalytic activity, involved in other aspects of telomerase assembly and function; mutations in human homolog are associated with aplastic anemia
Synonyms YLR318W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG1005 AC-HYPE

KOGs classification KOGs description
INFORMATION STORAGE AND PROCESSINGINFORMATION STORAGE AND PROCESSING Telomerase catalytic subunit/reverse transcriptase TERT

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At5g16850 GI:15237420
Caenorhabditis elegans (Cel) CE15748
(WBGene00006618)		 GI:17506433 O45321
Caenorhabditis elegans (Cel) CE27901 GI:17506435 O45321
Homo sapiens (Hsa) Hs4507439 GI:4507439
Saccharomyces cerevisiae (Sce) YLR318w
(S000004310)		 GI:6323350 Q06163
Schizosaccharomyces pombe (Spo) SPBC29A3.14c GI:19112634 O13339
Encephalitozoon cuniculi (Ecu) ECU09g0310 GI:19173151
Arabidopsis thaliana (Ath) At5g16850 GI:15237420
Caenorhabditis elegans (Cel) CE15748
(WBGene00006618)		 GI:17506433 O45321
Caenorhabditis elegans (Cel) CE27901 GI:17506435 O45321
Homo sapiens (Hsa) Hs4507439 GI:4507439
Saccharomyces cerevisiae (Sce) YLR318w
(S000004310)		 GI:6323350 Q06163
Schizosaccharomyces pombe (Spo) SPBC29A3.14c GI:19112634 O13339
Encephalitozoon cuniculi (Ecu) ECU09g0310 GI:19173151


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000228 nuclear chromosome C
IC
SpoSPBC29A3.14c
GO:0000333 telomerase catalytic core complex C
IDA
SceS000004310
SpoSPBC29A3.14c
IPI
SceS000004310
GO:0000781 chromosome, telomeric region C
IC
SpoSPBC29A3.14c
GO:0005634 nucleus C
IDA
SceS000004310
SpoSPBC29A3.14c
GO:0005697 telomerase holoenzyme complex C
IDA
SceS000004310
IPI
SceS000004310
GO:0005730 nucleolus C
IDA
SceS000004310
GO:0003720 telomerase activity F
IDA
AthAt5g16850
SceS000004310
GO:0003721 telomeric template RNA reverse transcriptase
activity		 F
IMP
SpoSPBC29A3.14c
ISS
AthAt5g16850
TAS
SceS000004310
GO:0003723 RNA binding F
IPI
SpoSPBC29A3.14c
GO:0005515 protein binding F
IPI
SpoSPBC29A3.14c
GO:0042162 telomeric DNA binding F
IDA
SceS000004310
GO:0001302 replicative cell aging P
IGI
SceS000004310
GO:0006278 RNA-dependent DNA replication P
IC
SpoSPBC29A3.14c
GO:0007000 nucleolus organization P
IMP
AthAt5g16850
GO:0007004 telomere maintenance via telomerase P
IDA
SceS000004310
IGI
AthAt5g16850
IMP
AthAt5g16850
CelWBGene00006618
SceS000004310
SpoSPBC29A3.14c
GO:0050000 chromosome localization P
IMP
AthAt5g16850
GO:0051276 chromosome organization P
IGI
AthAt5g16850

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
39767

Species Gene ID NCBI link UniProt link
Saccharomyces cerevisiae (Sce) EST2
(S000004310)		 GI:6323350 Q06163
Kluyveromyces lactis (Kla) KLLA0C18381g GI:50306115
Eremothecium gossypii (Ego) AGOS_AFR494W GI:45199012


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000333 telomerase catalytic core complex C
IDA
SceS000004310
IPI
SceS000004310
GO:0005634 nucleus C
IDA
SceS000004310
GO:0005697 telomerase holoenzyme complex C
IDA
SceS000004310
IPI
SceS000004310
GO:0005730 nucleolus C
IDA
SceS000004310
GO:0003720 telomerase activity F
IDA
SceS000004310
GO:0003721 telomeric template RNA reverse transcriptase
activity		 F
TAS
SceS000004310
GO:0042162 telomeric DNA binding F
IDA
SceS000004310
GO:0001302 replicative cell aging P
IGI
SceS000004310
GO:0007004 telomere maintenance via telomerase P
IDA
SceS000004310
IMP
SceS000004310

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_3729

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Ashbya gossypii (Ago) ago3686 AFR494W
Arabidopsis thaliana (Ath) ath23917 At5g16850.1
Candida glabrata (Cgl) cgl33 CAGL0A00869g
Cryptococcus neoformans (Cne) cne3060 167.m05925
Dictyostelium discoideum (Ddi) ddi10894 DDB0192195
Debaryomyces hansenii (Dha) dha1963 DEHA0C12045g
Encephalitozoon cuniculi (Ecu) ecu1302 19173151
Takifugu rubripes (Fru) fru83 SINFRUP00000149754
Gallus gallus (Gga) gga10757 ENSGALP00000021505
Gallus gallus (Gga) gga10758 ENSGALP00000021506
(TERT)		 Q537V4
Gallus gallus (Gga) gga10759 ENSGALP00000021507
Homo sapiens (Hsa) hsa24994 ENSP00000296820
(TERT)		 O14746-2
Homo sapiens (Hsa) hsa24993 ENSP00000309572
(TERT)		 O14746-1
Homo sapiens (Hsa) hsa24996 ENSP00000324616
Homo sapiens (Hsa) hsa24995 ENSP00000334346
(TERT)		 O14746-3
Kluyveromyces lactis (Kla) kla2018 KLLA0C18381g
Mus musculus (Mmu) mmu7240 ENSMUSP00000022104
(MGI:1202709)		 O70372
Neurospora crassa (Ncr) ncr2701 NCU02791.2
Oryza sativa (Osa) osa64066 6791.m00095
Rattus norvegicus (Rno) rno356 ENSRNOP00000022683
(RGD:70494)		 Q673L6-1
Saccharomyces cerevisiae (Sce) sce4431 YLR318W
(S000004310)
Schizosaccharomyces pombe (Spo) spo2692 SPBC29A3.14c O13339
Yarrowia lipolytica (Yli) yli3216 YALI0D12188g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000228 nuclear chromosome C
IC
SpoSPBC29A3.14c
GO:0000333 telomerase catalytic core complex C
IDA
SceS000004310
SpoSPBC29A3.14c
IPI
SceS000004310
GO:0000781 chromosome, telomeric region C
IC
SpoSPBC29A3.14c
GO:0005634 nucleus C
IDA
SceS000004310
SpoSPBC29A3.14c
ISO
MmuMGI:1202709
GO:0005697 telomerase holoenzyme complex C
IDA
SceS000004310
IPI
SceS000004310
GO:0005730 nucleolus C
IDA
SceS000004310
GO:0005737 cytoplasm C
ISO
MmuMGI:1202709
GO:0003720 telomerase activity F
IDA
AthAt5g16850
MmuMGI:1202709
SceS000004310
GO:0003721 telomeric template RNA reverse transcriptase
activity		 F
IMP
SpoSPBC29A3.14c
ISS
AthAt5g16850
TAS
SceS000004310
GO:0003723 RNA binding F
IPI
SpoSPBC29A3.14c
GO:0005515 protein binding F
IPI
MmuMGI:1202709
SpoSPBC29A3.14c
GO:0042162 telomeric DNA binding F
IDA
SceS000004310
GO:0001302 replicative cell aging P
IGI
SceS000004310
GO:0006278 RNA-dependent DNA replication P
IC
SpoSPBC29A3.14c
GO:0007000 nucleolus organization P
IMP
AthAt5g16850
GO:0007004 telomere maintenance via telomerase P
IDA
SceS000004310
IGI
AthAt5g16850
IMP
AthAt5g16850
SceS000004310
SpoSPBC29A3.14c
GO:0008152 metabolic process P
IDA
MmuMGI:1202709
GO:0050000 chromosome localization P
IMP
AthAt5g16850
GO:0051276 chromosome organization P
IGI
AthAt5g16850

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPBC29A3.14c
(O13339)		 YLR318W
(S000004310)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000228 nuclear chromosome C
IC
SpoSPBC29A3.14c
GO:0000333 telomerase catalytic core complex C
IDA
SceS000004310
SpoSPBC29A3.14c
IPI
SceS000004310
GO:0000781 chromosome, telomeric region C
IC
SpoSPBC29A3.14c
GO:0005634 nucleus C
IDA
SceS000004310
SpoSPBC29A3.14c
GO:0005697 telomerase holoenzyme complex C
IDA
SceS000004310
IPI
SceS000004310
GO:0005730 nucleolus C
IDA
SceS000004310
GO:0003720 telomerase activity F
IDA
SceS000004310
GO:0003721 telomeric template RNA reverse transcriptase
activity		 F
IMP
SpoSPBC29A3.14c
TAS
SceS000004310
GO:0003723 RNA binding F
IPI
SpoSPBC29A3.14c
GO:0005515 protein binding F
IPI
SpoSPBC29A3.14c
GO:0042162 telomeric DNA binding F
IDA
SceS000004310
GO:0001302 replicative cell aging P
IGI
SceS000004310
GO:0006278 RNA-dependent DNA replication P
IC
SpoSPBC29A3.14c
GO:0007004 telomere maintenance via telomerase P
IDA
SceS000004310
IMP
SceS000004310
SpoSPBC29A3.14c

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