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Search term: YLR359W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name ADE13
SGD link S000004351
Alternative ID YLR359W
Description Adenylosuccinate lyase, catalyzes two steps in the 'de novo' purine nucleotide biosynthetic pathway; expression is repressed by adenine and activated by Bas1p and Pho2p; mutations in human ortholog ADSL cause adenylosuccinase deficiency
Synonyms YLR359W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG2700 ACDHYP-

KOGs classification KOGs description
METABOLISM Adenylosuccinate lyase

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At1g36280 GI:15220375
Arabidopsis thaliana (Ath) At4g18440 GI:15233876
Caenorhabditis elegans (Cel) CE06248 GI:17508577 Q21774
Drosophila melanogaster (Dme) 7300210 GI:7300210
Homo sapiens (Hsa) Hs4557269
(ADSL)		 GI:4557269 P30566
Homo sapiens (Hsa) Hs7705660 GI:7705660
Saccharomyces cerevisiae (Sce) YLR359w
(S000004351)		 GI:6323391 Q05911
Schizosaccharomyces pombe (Spo) SPBC14F5.09c GI:19113527 O60105
Schizosaccharomyces pombe (Spo) SPBC8E4.05c GI:19113634 O42889


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
SceS000004351
GO:0005634 nucleus C
IDA
SpoSPBC14F5.09c
SPBC8E4.05c
GO:0005737 cytoplasm C
IDA
HsaADSL
GO:0005829 cytosol C
EXP
HsaADSL
IDA
SpoSPBC14F5.09c
SPBC8E4.05c
GO:0009507 chloroplast C
IDA
AthAt4g18440
GO:0009570 chloroplast stroma C
IDA
AthAt4g18440
GO:0003674 molecular_function F
ND
SpoSPBC8E4.05c
GO:0004018 N6-(1,2-dicarboxyethyl)AMP AMP-lyase
(fumarate-forming) activity		 F
EXP
HsaADSL
IDA
HsaADSL
IMP
SceS000004351
ISS
AthAt4g18440
At1g36280
SpoSPBC14F5.09c
GO:0006164 purine nucleotide biosynthetic
process		 P
IC
HsaADSL
IMP
SceS000004351
GO:0006167 AMP biosynthetic process P
IDA
HsaADSL
GO:0006189 'de novo' IMP biosynthetic process P
IGI
SceS000004351
IMP
SceS000004351
ISS
SpoSPBC14F5.09c
GO:0009168 purine ribonucleoside monophosphate biosynthetic
process		 P
EXP
HsaADSL
GO:0033554 cellular response to stress P
IEP
SpoSPBC8E4.05c
GO:0051262 protein tetramerization P
IDA
HsaADSL

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
12

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) ADSL GI:4557269 P30566
Canis familiaris (Cfa) ADSL GI:73969028
Mus musculus (Mmu) Adsl
(MGI:103202)		 GI:29788764 P54822
Rattus norvegicus (Rno) Adsl GI:62652759
Gallus gallus (Gga) ADSL GI:45382981
Drosophila melanogaster (Dme) CG3590
(FBgn0038467)		 GI:24647570
Anopheles gambiae (Aga) AgaP_AGAP002378 GI:118782913
Schizosaccharomyces pombe (Spo) ade8
(SPBC14F5.09c)		 GI:19113527 O60105
Saccharomyces cerevisiae (Sce) ADE13
(S000004351)		 GI:6323391 Q05911
Kluyveromyces lactis (Kla) KLLA0B13189g GI:50304339
Eremothecium gossypii (Ego) AGOS_ABL006C GI:45185224
Magnaporthe grisea (Mgr) MGG_03645 GI:145615982
Neurospora crassa (Ncr) NCU06187.1 GI:32411123


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
SceS000004351
GO:0005625 soluble fraction C
ISO
MmuMGI:103202
GO:0005634 nucleus C
IDA
SpoSPBC14F5.09c
GO:0005737 cytoplasm C
IDA
HsaADSL
GO:0005739 mitochondrion C
IDA
MmuMGI:103202
GO:0005829 cytosol C
EXP
HsaADSL
IDA
SpoSPBC14F5.09c
ISO
MmuMGI:103202
ISS
DmeFBgn0038467
GO:0004018 N6-(1,2-dicarboxyethyl)AMP AMP-lyase
(fumarate-forming) activity		 F
EXP
HsaADSL
IDA
HsaADSL
IMP
SceS000004351
ISA
MmuMGI:103202
ISO
MmuMGI:103202
ISS
DmeFBgn0038467
SpoSPBC14F5.09c
GO:0006163 purine nucleotide metabolic process P
ISO
MmuMGI:103202
ISS
DmeFBgn0038467
GO:0006164 purine nucleotide biosynthetic
process		 P
IC
HsaADSL
IMP
SceS000004351
GO:0006167 AMP biosynthetic process P
IDA
HsaADSL
ISA
MmuMGI:103202
GO:0006189 'de novo' IMP biosynthetic process P
IGI
SceS000004351
IMP
SceS000004351
ISS
SpoSPBC14F5.09c
GO:0007584 response to nutrient P
ISO
MmuMGI:103202
GO:0009060 aerobic respiration P
ISO
MmuMGI:103202
GO:0009168 purine ribonucleoside monophosphate biosynthetic
process		 P
EXP
HsaADSL
GO:0051262 protein tetramerization P
IDA
HsaADSL

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_2083

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga4547 ENSANGP00000014908
Ashbya gossypii (Ago) ago586 ABL006C
Caenorhabditis elegans (Cel) cel13441 R06C7.5a
Candida glabrata (Cgl) cgl327 CAGL0B02794g
Cryptococcus neoformans (Cne) cne4394 177.m03145
Debaryomyces hansenii (Dha) dha5030 DEHA0F14487g
Drosophila melanogaster (Dme) dme13011 CG3590-PA
(FBgn0038467)
Danio rerio (Dre) dre17288 ENSDARP00000022310
Takifugu rubripes (Fru) fru9847 SINFRUP00000167543
Gallus gallus (Gga) gga864 ENSGALP00000019613
(ADSL)		 P21265
Homo sapiens (Hsa) hsa21715 ENSP00000216194
(ADSL)		 P30566-1
Kluyveromyces lactis (Kla) kla1117 KLLA0B13189g
Mus musculus (Mmu) mmu9341 ENSMUSP00000023043
(MGI:103202)		 Q3TMB8
Neurospora crassa (Ncr) ncr6012 NCU06187.2
Rattus norvegicus (Rno) rno27440 ENSRNOP00000025193
(RGD:1307617)
Saccharomyces cerevisiae (Sce) sce4474 YLR359W
(S000004351)
Schizosaccharomyces pombe (Spo) spo3486 SPBC14F5.09c O60105
Schizosaccharomyces pombe (Spo) spo2156 SPBC8E4.05c O42889
Yarrowia lipolytica (Yli) yli1470 YALI0B17402g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
SceS000004351
GO:0005625 soluble fraction C
ISO
MmuMGI:103202
GO:0005634 nucleus C
IDA
SpoSPBC14F5.09c
SPBC8E4.05c
GO:0005739 mitochondrion C
IDA
MmuMGI:103202
GO:0005829 cytosol C
IDA
SpoSPBC14F5.09c
SPBC8E4.05c
ISO
MmuMGI:103202
ISS
DmeFBgn0038467
GO:0003674 molecular_function F
ND
SpoSPBC8E4.05c
GO:0004018 N6-(1,2-dicarboxyethyl)AMP AMP-lyase
(fumarate-forming) activity		 F
IMP
SceS000004351
ISA
MmuMGI:103202
ISO
MmuMGI:103202
ISS
DmeFBgn0038467
SpoSPBC14F5.09c
GO:0006163 purine nucleotide metabolic process P
ISO
MmuMGI:103202
ISS
DmeFBgn0038467
GO:0006164 purine nucleotide biosynthetic
process		 P
IMP
SceS000004351
GO:0006167 AMP biosynthetic process P
ISA
MmuMGI:103202
GO:0006189 'de novo' IMP biosynthetic process P
IGI
SceS000004351
IMP
SceS000004351
ISS
SpoSPBC14F5.09c
GO:0007584 response to nutrient P
ISO
MmuMGI:103202
GO:0009060 aerobic respiration P
ISO
MmuMGI:103202
GO:0033554 cellular response to stress P
IEP
SpoSPBC8E4.05c

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPBC14F5.09c
(O60105)		 YLR359W
(S000004351)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
SceS000004351
GO:0005634 nucleus C
IDA
SpoSPBC14F5.09c
GO:0005829 cytosol C
IDA
SpoSPBC14F5.09c
GO:0004018 N6-(1,2-dicarboxyethyl)AMP AMP-lyase
(fumarate-forming) activity		 F
IMP
SceS000004351
ISS
SpoSPBC14F5.09c
GO:0006164 purine nucleotide biosynthetic
process		 P
IMP
SceS000004351
GO:0006189 'de novo' IMP biosynthetic process P
IGI
SceS000004351
IMP
SceS000004351
ISS
SpoSPBC14F5.09c

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GO info in one table:

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