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Search term: YLR378C

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name SEC61
SGD link S000004370
Alternative ID YLR378C
Description Essential subunit of Sec61 complex (Sec61p, Sbh1p, and Sss1p); forms a channel for SRP-dependent protein import and retrograde transport of misfolded proteins out of the ER; with Sec63 complex allows SRP-independent protein import into ER
Synonyms YLR378C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG1373 ACDHYPE

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALINGCELLULAR PROCESSES AND SIGNALING Transport protein Sec61, alpha subunit

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At1g29310 GI:15218887
Arabidopsis thaliana (Ath) At1g78720 GI:15219158
Arabidopsis thaliana (Ath) At2g34250 GI:15226261
Caenorhabditis elegans (Cel) CE14954
(WBGene00013311)		 GI:17543770 O18239
Drosophila melanogaster (Dme) 7297121 GI:7297121
Homo sapiens (Hsa) Hs7019415
(SEC61A1)		 GI:7019415 P61619
Homo sapiens (Hsa) Hs17449156 GI:17449156
Homo sapiens (Hsa) Hs14589847 GI:10946604
Saccharomyces cerevisiae (Sce) YBR283c
(S000000487)		 GI:6319760 P38353
Saccharomyces cerevisiae (Sce) YLR378c
(S000004370)		 GI:6323411 P32915
Schizosaccharomyces pombe (Spo) SPBC19G7.17 GI:19112775 O42965
Schizosaccharomyces pombe (Spo) SPBC354.02c GI:19112018 P79088
Encephalitozoon cuniculi (Ecu) ECU09g0130 GI:19173133


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005739 mitochondrion C
IDA
AthAt1g29310
GO:0005783 endoplasmic reticulum C
IDA
SpoSPBC354.02c
GO:0005784 Sec61 translocon complex C
IDA
SceS000004370
ISS
SpoSPBC19G7.17
SPBC354.02c
GO:0005794 Golgi apparatus C
IDA
SpoSPBC354.02c
GO:0005886 plasma membrane C
IDA
AthAt1g29310
GO:0016020 membrane C
IDA
AthAt1g29310
ISS
AthAt2g34250
At1g78720
At1g29310
GO:0030176 integral to endoplasmic reticulum
membrane		 C
ISS
HsaSEC61A1
GO:0071261 Ssh1 translocon complex C
IDA
SceS000000487
GO:0005048 signal sequence binding F
IDA
SceS000000487
S000004370
GO:0005515 protein binding F
IPI
HsaSEC61A1
GO:0008320 protein transmembrane transporter
activity		 F
ISA
SceS000000487
GO:0008565 protein transporter activity F
ISS
SpoSPBC19G7.17
SPBC354.02c
GO:0015197 peptide transporter activity F
IMP
SceS000004370
GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane
transporter activity		 F
IDA
SceS000004370
IMP
SceS000004370
ISS
AthAt2g34250
At1g78720
At1g29310
GO:0043022 ribosome binding F
ISS
HsaSEC61A1
NAS
SpoSPBC354.02c
GO:0000003 reproduction P
IMP
CelWBGene00013311
GO:0006614 SRP-dependent cotranslational protein targeting to
membrane		 P
IGI
SceS000000487
IMP
SceS000000487
GO:0006616 SRP-dependent cotranslational protein targeting to
membrane, translocation		 P
IDA
SceS000004370
ISS
SpoSPBC354.02c
SPBC19G7.17
GO:0006620 posttranslational protein targeting to
membrane		 P
ISS
SpoSPBC354.02c
GO:0009306 protein secretion P
ISS
AthAt2g34250
At1g78720
At1g29310
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00013311
GO:0015833 peptide transport P
IMP
SceS000004370
GO:0018193 peptidyl-amino acid modification P
RCA
SceS000000487
GO:0030970 retrograde protein transport, ER to
cytosol		 P
IMP
SceS000004370
GO:0031204 posttranslational protein targeting to membrane,
translocation		 P
IDA
SceS000004370
IMP
SceS000004370
GO:0044262 cellular carbohydrate metabolic
process		 P
RCA
SceS000004370
GO:0045047 protein targeting to ER P
ISS
HsaSEC61A1

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
55537

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) SEC61A1 GI:7019415 P61619
Pan troglodytes (Ptr) SEC61A1 GI:114589143
Canis familiaris (Cfa) SEC61A1 GI:50979146
Mus musculus (Mmu) Sec61a1
(MGI:1858417)		 GI:8394252 P61620
Rattus norvegicus (Rno) Sec61a1
(RGD:68321)		 GI:40538882
Gallus gallus (Gga) SEC61A1 GI:118096920
Schizosaccharomyces pombe (Spo) sec61
(SPBC354.02c)		 GI:19112018 P79088
Saccharomyces cerevisiae (Sce) SEC61
(S000004370)		 GI:6323411 P32915
Kluyveromyces lactis (Kla) KLLA0E01144g GI:50307999
Eremothecium gossypii (Ego) AGOS_AFR596W GI:45199114
Magnaporthe grisea (Mgr) MGG_04856 GI:145602502
Neurospora crassa (Ncr) NCU08897.1 GI:32421691
Arabidopsis thaliana (Ath) AT1G29310 GI:186479015
Arabidopsis thaliana (Ath) AT2G34250 GI:15226261
Oryza sativa (Osa) Os03g0213100 GI:115451517
Oryza sativa (Osa) Os09g0347700 GI:115478703
Plasmodium falciparum (Pfa) MAL13P1.231 GI:124513638


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005739 mitochondrion C
IDA
AthAt1g29310
GO:0005783 endoplasmic reticulum C
IDA
SpoSPBC354.02c
GO:0005784 Sec61 translocon complex C
IDA
SceS000004370
ISS
SpoSPBC354.02c
GO:0005794 Golgi apparatus C
IDA
SpoSPBC354.02c
GO:0005886 plasma membrane C
IDA
AthAt1g29310
GO:0016020 membrane C
IDA
AthAt1g29310
ISS
AthAt2g34250
At1g29310
GO:0019718 rough microsome C
ISO
MmuMGI:1858417
GO:0030176 integral to endoplasmic reticulum
membrane		 C
ISS
HsaSEC61A1
GO:0005048 signal sequence binding F
IDA
SceS000004370
GO:0005515 protein binding F
IPI
HsaSEC61A1
GO:0008565 protein transporter activity F
ISS
SpoSPBC354.02c
GO:0015197 peptide transporter activity F
IMP
SceS000004370
GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane
transporter activity		 F
IDA
SceS000004370
IMP
SceS000004370
ISS
AthAt2g34250
At1g29310
GO:0043022 ribosome binding F
IDA
MmuMGI:1858417
ISS
HsaSEC61A1
NAS
SpoSPBC354.02c
GO:0006616 SRP-dependent cotranslational protein targeting to
membrane, translocation		 P
IDA
SceS000004370
ISS
SpoSPBC354.02c
GO:0006620 posttranslational protein targeting to
membrane		 P
ISS
SpoSPBC354.02c
GO:0009306 protein secretion P
ISS
AthAt2g34250
At1g29310
GO:0015833 peptide transport P
IMP
SceS000004370
GO:0030970 retrograde protein transport, ER to
cytosol		 P
IMP
SceS000004370
GO:0031204 posttranslational protein targeting to membrane,
translocation		 P
IDA
SceS000004370
IMP
SceS000004370
GO:0044262 cellular carbohydrate metabolic
process		 P
RCA
SceS000004370
GO:0045047 protein targeting to ER P
ISS
HsaSEC61A1

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_781

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga11311 ENSANGP00000016786
Ashbya gossypii (Ago) ago3788 AFR596W
Arabidopsis thaliana (Ath) ath3058 At1g29310.1
Arabidopsis thaliana (Ath) ath7223 At1g78720.1
Arabidopsis thaliana (Ath) ath10464 At2g34250.1
Caenorhabditis elegans (Cel) cel20037 Y57G11C.15
(CE14954;
WBGene00013311)
Candida glabrata (Cgl) cgl2278 CAGL0H04961g
Cryptococcus neoformans (Cne) cne182 162.m02595
Dictyostelium discoideum (Ddi) ddi6569 DDB0206262
Debaryomyces hansenii (Dha) dha4445 DEHA0F01353g
Drosophila melanogaster (Dme) dme1068 CG9539-PA
(FBgn0026571)
Danio rerio (Dre) dre20720 ENSDARP00000027967
Danio rerio (Dre) dre20719 ENSDARP00000039772
Danio rerio (Dre) dre20721 ENSDARP00000049424
(sec61b)		 Q90YL4
Encephalitozoon cuniculi (Ecu) ecu1284 19173133
Takifugu rubripes (Fru) fru5598 SINFRUP00000145654
Takifugu rubripes (Fru) fru5671 SINFRUP00000157389
Gallus gallus (Gga) gga5248 ENSGALP00000009577
(SEC61A1)
Gallus gallus (Gga) gga26963 ENSGALP00000022602
(SEC61A2)
Homo sapiens (Hsa) hsa23090 ENSP00000243253
(SEC61A1)		 P61619-1
Homo sapiens (Hsa) hsa3509 ENSP00000298428
(SEC61A2)		 Q9H9S3-1
Homo sapiens (Hsa) hsa3510 ENSP00000344775
Kluyveromyces lactis (Kla) kla2999 KLLA0E01144g
Mus musculus (Mmu) mmu14040 ENSMUSP00000026926
(MGI:1931071)		 A2ATT9
Mus musculus (Mmu) mmu22304 ENSMUSP00000032168
(MGI:1858417)		 P61620
Neurospora crassa (Ncr) ncr8670 NCU08897.2
Oryza sativa (Osa) osa38167 4887.m00284
Oryza sativa (Osa) osa38170 4887.m00285
Oryza sativa (Osa) osa36710 4963.m00136
Oryza sativa (Osa) osa73923 7283.m00095
Plasmodium falciparum (Pfa) pfa3975 MAL13P1.231
Rattus norvegicus (Rno) rno21817 ENSRNOP00000018455
(RGD:68321)		 P61621
Rattus norvegicus (Rno) rno13620 ENSRNOP00000036212
(RGD:1305948)
Saccharomyces cerevisiae (Sce) sce4496 YLR378C
(S000004370)
Schizosaccharomyces pombe (Spo) spo863 SPBC354.02c P79088
Yarrowia lipolytica (Yli) yli4766 YALI0E21912g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
MmuMGI:1931071
GO:0005739 mitochondrion C
IDA
AthAt1g29310
GO:0005783 endoplasmic reticulum C
IDA
SpoSPBC354.02c
GO:0005784 Sec61 translocon complex C
IDA
SceS000004370
ISS
SpoSPBC354.02c
GO:0005794 Golgi apparatus C
IDA
SpoSPBC354.02c
GO:0005886 plasma membrane C
IDA
AthAt1g29310
GO:0016020 membrane C
IDA
AthAt1g29310
ISS
AthAt2g34250
At1g78720
At1g29310
GO:0019718 rough microsome C
ISO
MmuMGI:1858417
GO:0005048 signal sequence binding F
IDA
SceS000004370
GO:0008565 protein transporter activity F
ISS
SpoSPBC354.02c
GO:0015197 peptide transporter activity F
IMP
SceS000004370
GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane
transporter activity		 F
IDA
SceS000004370
IMP
SceS000004370
ISS
AthAt2g34250
At1g78720
At1g29310
GO:0043022 ribosome binding F
IDA
MmuMGI:1858417
MGI:1931071
NAS
SpoSPBC354.02c
GO:0000003 reproduction P
IMP
CelWBGene00013311
GO:0006616 SRP-dependent cotranslational protein targeting to
membrane, translocation		 P
IDA
SceS000004370
ISS
SpoSPBC354.02c
GO:0006620 posttranslational protein targeting to
membrane		 P
ISS
SpoSPBC354.02c
GO:0008150 biological_process P
ND
MmuMGI:1931071
GO:0009306 protein secretion P
ISS
AthAt2g34250
At1g78720
At1g29310
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00013311
GO:0015833 peptide transport P
IMP
SceS000004370
GO:0030970 retrograde protein transport, ER to
cytosol		 P
IMP
SceS000004370
GO:0031204 posttranslational protein targeting to membrane,
translocation		 P
IDA
SceS000004370
IMP
SceS000004370
GO:0044262 cellular carbohydrate metabolic
process		 P
RCA
SceS000004370

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPBC354.02c
(P79088)		 YLR378C
(S000004370)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005783 endoplasmic reticulum C
IDA
SpoSPBC354.02c
GO:0005784 Sec61 translocon complex C
IDA
SceS000004370
ISS
SpoSPBC354.02c
GO:0005794 Golgi apparatus C
IDA
SpoSPBC354.02c
GO:0005048 signal sequence binding F
IDA
SceS000004370
GO:0008565 protein transporter activity F
ISS
SpoSPBC354.02c
GO:0015197 peptide transporter activity F
IMP
SceS000004370
GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane
transporter activity		 F
IDA
SceS000004370
IMP
SceS000004370
GO:0043022 ribosome binding F
NAS
SpoSPBC354.02c
GO:0006616 SRP-dependent cotranslational protein targeting to
membrane, translocation		 P
IDA
SceS000004370
ISS
SpoSPBC354.02c
GO:0006620 posttranslational protein targeting to
membrane		 P
ISS
SpoSPBC354.02c
GO:0015833 peptide transport P
IMP
SceS000004370
GO:0030970 retrograde protein transport, ER to
cytosol		 P
IMP
SceS000004370
GO:0031204 posttranslational protein targeting to membrane,
translocation		 P
IDA
SceS000004370
IMP
SceS000004370
GO:0044262 cellular carbohydrate metabolic
process		 P
RCA
SceS000004370

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