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Search term: YLR386W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name VAC14
SGD link S000004378
Alternative ID YLR386W
Description Protein involved in regulated synthesis of PtdIns(3,5)P(2), in control of trafficking of some proteins to the vacuole lumen via the MVB, and in maintenance of vacuole size and acidity; interacts with Fig4p; activator of Fab1p
Synonyms YLR386W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG0212 ACDHYP-

KOGs classification KOGs description
POORLY CHARACTERIZED Uncharacterized conserved protein

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At2g01690 GI:15226335
Caenorhabditis elegans (Cel) CE06100
(WBGene00010565)		 GI:17508059 Q21225
Drosophila melanogaster (Dme) 7299645 GI:7299645
Homo sapiens (Hsa) Hs20070299 GI:20070299
Homo sapiens (Hsa) Hs22067514 GI:22067514
Homo sapiens (Hsa) Hs22069041 GI:22069041
Saccharomyces cerevisiae (Sce) YLR386w
(S000004378)		 GI:6323418 Q06708
Schizosaccharomyces pombe (Spo) SPBC25H2.03 GI:19113155 P87145
Arabidopsis thaliana (Ath) At2g01690 GI:15226335
Caenorhabditis elegans (Cel) CE06100
(WBGene00010565)		 GI:17508059 Q21225
Drosophila melanogaster (Dme) 7299645 GI:7299645
Homo sapiens (Hsa) Hs20070299 GI:20070299
Homo sapiens (Hsa) Hs22067514 GI:22067514
Homo sapiens (Hsa) Hs22069041 GI:22069041
Saccharomyces cerevisiae (Sce) YLR386w
(S000004378)		 GI:6323418 Q06708
Schizosaccharomyces pombe (Spo) SPBC25H2.03 GI:19113155 P87145
Arabidopsis thaliana (Ath) At2g01690 GI:15226335
Caenorhabditis elegans (Cel) CE06100
(WBGene00010565)		 GI:17508059 Q21225
Drosophila melanogaster (Dme) 7299645 GI:7299645
Homo sapiens (Hsa) Hs20070299 GI:20070299
Homo sapiens (Hsa) Hs22067514 GI:22067514
Homo sapiens (Hsa) Hs22069041 GI:22069041
Saccharomyces cerevisiae (Sce) YLR386w
(S000004378)		 GI:6323418 Q06708
Schizosaccharomyces pombe (Spo) SPBC25H2.03 GI:19113155 P87145


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000306 extrinsic to vacuolar membrane C
IDA
SceS000004378
GO:0000329 fungal-type vacuole membrane C
IDA
SceS000004378
ISS
SpoSPBC25H2.03
GO:0005737 cytoplasm C
IDA
SpoSPBC25H2.03
GO:0005886 plasma membrane C
IDA
AthAt2g01690
GO:0043234 protein complex C
NAS
SpoSPBC25H2.03
GO:0070772 PAS complex C
IDA
SceS000004378
IPI
SceS000004378
GO:0003674 molecular_function F
ND
SpoSPBC25H2.03
GO:0030674 protein binding, bridging F
IDA
SceS000004378
IMP
SceS000004378
GO:0000011 vacuole inheritance P
ISS
SpoSPBC25H2.03
GO:0006644 phospholipid metabolic process P
ISS
SpoSPBC25H2.03
GO:0006661 phosphatidylinositol biosynthetic
process		 P
IGI
SceS000004378
IMP
SceS000004378
GO:0008150 biological_process P
ND
AthAt2g01690
GO:0030384 phosphoinositide metabolic process P
NAS
SpoSPBC25H2.03
GO:0033674 positive regulation of kinase activity P
IGI
SceS000004378
IMP
SceS000004378
GO:0048015 phosphoinositide-mediated signaling P
NAS
SpoSPBC25H2.03

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
6528

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) VAC14 GI:39780552
Pan troglodytes (Ptr) VAC14 GI:114663513
Canis familiaris (Cfa) VAC14 GI:73957055
Mus musculus (Mmu) Vac14
(MGI:2157980)		 GI:31542488 Q80WQ2
Rattus norvegicus (Rno) Vac14
(RGD:631410)		 GI:29293817
Gallus gallus (Gga) VAC14 GI:71895589
Drosophila melanogaster (Dme) CG5608
(FBgn0038058)		 GI:24646316
Anopheles gambiae (Aga) AgaP_AGAP000770 GI:158289625
Caenorhabditis elegans (Cel) K04G2.6
(CE06100;
WBGene00010565)		 GI:17508059 Q21225
Schizosaccharomyces pombe (Spo) SPBC25H2.03 GI:19113155 P87145
Saccharomyces cerevisiae (Sce) VAC14
(S000004378)		 GI:6323418 Q06708
Kluyveromyces lactis (Kla) KLLA0E05137g GI:50308355
Eremothecium gossypii (Ego) AGOS_AER049W GI:45190655
Magnaporthe grisea (Mgr) MGG_03568 GI:145616108
Neurospora crassa (Ncr) NCU02409.1 GI:32421483
Arabidopsis thaliana (Ath) AT2G01690 GI:42570643
Oryza sativa (Osa) Os03g0223700 GI:115451649


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000306 extrinsic to vacuolar membrane C
IDA
SceS000004378
GO:0000329 fungal-type vacuole membrane C
IDA
SceS000004378
ISS
SpoSPBC25H2.03
GO:0005737 cytoplasm C
IDA
SpoSPBC25H2.03
GO:0005774 vacuolar membrane C
ISA
MmuMGI:2157980
GO:0005886 plasma membrane C
IDA
AthAt2g01690
GO:0010008 endosome membrane C
IDA
HsaVAC14
GO:0043234 protein complex C
NAS
SpoSPBC25H2.03
GO:0070772 PAS complex C
IDA
SceS000004378
IPI
SceS000004378
GO:0003674 molecular_function F
ND
SpoSPBC25H2.03
GO:0004872 receptor activity F
NAS
HsaVAC14
GO:0005515 protein binding F
IPI
HsaVAC14
GO:0019209 kinase activator activity F
ISA
MmuMGI:2157980
GO:0030674 protein binding, bridging F
IDA
SceS000004378
IMP
SceS000004378
GO:0000011 vacuole inheritance P
ISS
SpoSPBC25H2.03
GO:0006644 phospholipid metabolic process P
ISS
SpoSPBC25H2.03
GO:0006661 phosphatidylinositol biosynthetic
process		 P
IGI
SceS000004378
IMP
SceS000004378
GO:0006970 response to osmotic stress P
ISA
MmuMGI:2157980
GO:0007165 signal transduction P
NAS
HsaVAC14
GO:0008150 biological_process P
ND
AthAt2g01690
GO:0030384 phosphoinositide metabolic process P
NAS
SpoSPBC25H2.03
GO:0033674 positive regulation of kinase activity P
IGI
SceS000004378
IMP
SceS000004378
GO:0042327 positive regulation of phosphorylation P
ISA
MmuMGI:2157980
GO:0048015 phosphoinositide-mediated signaling P
NAS
SpoSPBC25H2.03
GO:0050790 regulation of catalytic activity P
ISA
MmuMGI:2157980

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_2051

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga15438 ENSANGP00000017485
Ashbya gossypii (Ago) ago2554 AER049W
Arabidopsis thaliana (Ath) ath7572 At2g01690.1
Arabidopsis thaliana (Ath) ath7573 At2g01690.2
Caenorhabditis elegans (Cel) cel11907 K04G2.6
(CE06100;
WBGene00010565)
Candida glabrata (Cgl) cgl2345 CAGL0H06501g
Cryptococcus neoformans (Cne) cne966 163.m06434
Dictyostelium discoideum (Ddi) ddi8883 DDB0188326
Debaryomyces hansenii (Dha) dha541 DEHA0A12067g
Drosophila melanogaster (Dme) dme12278 CG5608-PA
(FBgn0038058)
Danio rerio (Dre) dre30005 ENSDARP00000003288
(vac14)		 Q66L58
Danio rerio (Dre) dre30006 ENSDARP00000019530
Danio rerio (Dre) dre30007 ENSDARP00000029573
Takifugu rubripes (Fru) fru30770 SINFRUP00000150615
Takifugu rubripes (Fru) fru30769 SINFRUP00000167357
Takifugu rubripes (Fru) fru30771 SINFRUP00000170979
Gallus gallus (Gga) gga4465 ENSGALP00000003868
Gallus gallus (Gga) gga4466 ENSGALP00000003869
(VAC14)		 Q5ZIW5
Homo sapiens (Hsa) hsa12456 ENSP00000261776
(VAC14)		 Q08AM6
Kluyveromyces lactis (Kla) kla3178 KLLA0E05137g
Mus musculus (Mmu) mmu26693 ENSMUSP00000034190
(MGI:2157980)		 Q80WQ2
Mus musculus (Mmu) mmu26692 ENSMUSP00000041935
Neurospora crassa (Ncr) ncr2342 NCU02409.2
Oryza sativa (Osa) osa51042 5864.m00149
Plasmodium falciparum (Pfa) pfa5031 PFL1240c
Rattus norvegicus (Rno) rno14999 ENSRNOP00000023383
(RGD:631410)		 Q80W92
Saccharomyces cerevisiae (Sce) sce4504 YLR386W
(S000004378)
Schizosaccharomyces pombe (Spo) spo2448 SPBC25H2.03 P87145
Yarrowia lipolytica (Yli) yli1687 YALI0B22682g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000306 extrinsic to vacuolar membrane C
IDA
SceS000004378
GO:0000329 fungal-type vacuole membrane C
IDA
SceS000004378
ISS
SpoSPBC25H2.03
GO:0005737 cytoplasm C
IDA
SpoSPBC25H2.03
GO:0005774 vacuolar membrane C
ISA
MmuMGI:2157980
GO:0005886 plasma membrane C
IDA
AthAt2g01690
GO:0043234 protein complex C
NAS
SpoSPBC25H2.03
GO:0070772 PAS complex C
IDA
SceS000004378
IPI
SceS000004378
GO:0003674 molecular_function F
ND
PfaPFL1240c
SpoSPBC25H2.03
GO:0019209 kinase activator activity F
ISA
MmuMGI:2157980
GO:0030674 protein binding, bridging F
IDA
SceS000004378
IMP
SceS000004378
GO:0000011 vacuole inheritance P
ISS
SpoSPBC25H2.03
GO:0006644 phospholipid metabolic process P
ISS
SpoSPBC25H2.03
GO:0006661 phosphatidylinositol biosynthetic
process		 P
IGI
SceS000004378
IMP
SceS000004378
GO:0006970 response to osmotic stress P
ISA
MmuMGI:2157980
GO:0008150 biological_process P
ND
AthAt2g01690
PfaPFL1240c
GO:0030384 phosphoinositide metabolic process P
NAS
SpoSPBC25H2.03
GO:0033674 positive regulation of kinase activity P
IGI
SceS000004378
IMP
SceS000004378
GO:0042327 positive regulation of phosphorylation P
ISA
MmuMGI:2157980
GO:0048015 phosphoinositide-mediated signaling P
NAS
SpoSPBC25H2.03
GO:0050790 regulation of catalytic activity P
ISA
MmuMGI:2157980

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPBC25H2.03
(P87145)		 YLR386W
(S000004378)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000306 extrinsic to vacuolar membrane C
IDA
SceS000004378
GO:0000329 fungal-type vacuole membrane C
IDA
SceS000004378
ISS
SpoSPBC25H2.03
GO:0005737 cytoplasm C
IDA
SpoSPBC25H2.03
GO:0043234 protein complex C
NAS
SpoSPBC25H2.03
GO:0070772 PAS complex C
IDA
SceS000004378
IPI
SceS000004378
GO:0003674 molecular_function F
ND
SpoSPBC25H2.03
GO:0030674 protein binding, bridging F
IDA
SceS000004378
IMP
SceS000004378
GO:0000011 vacuole inheritance P
ISS
SpoSPBC25H2.03
GO:0006644 phospholipid metabolic process P
ISS
SpoSPBC25H2.03
GO:0006661 phosphatidylinositol biosynthetic
process		 P
IGI
SceS000004378
IMP
SceS000004378
GO:0030384 phosphoinositide metabolic process P
NAS
SpoSPBC25H2.03
GO:0033674 positive regulation of kinase activity P
IGI
SceS000004378
IMP
SceS000004378
GO:0048015 phosphoinositide-mediated signaling P
NAS
SpoSPBC25H2.03

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Search for gene by ID or name:

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GO info in one table:

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