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Search term: YLR396C

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name VPS33
SGD link S000004388
Alternative ID YLR396C
Description ATP-binding protein that is a subunit of the HOPS complex and the CORVET tethering complex; essential for membrane docking and fusion at both the Golgi-to-endosome and endosome-to-vacuole stages of protein transport
Synonyms YLR396C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG1302 ACDHYP-

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALING Vacuolar sorting protein VPS33/slp1 (Sec1 family)

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At3g54860 GI:7488419
Caenorhabditis elegans (Cel) CE00012 GI:17551812
Caenorhabditis elegans (Cel) CE27890 GI:17532561
Drosophila melanogaster (Dme) 7293600
(FBgn0000257)		 GI:17647233 A4V4S5
Drosophila melanogaster (Dme) 7301340 GI:7301340 Q9VBR1
Homo sapiens (Hsa) Hs18105056
(VPS33A)		 GI:18105056 Q9H6C4
Homo sapiens (Hsa) Hs18105058 GI:18105058
Saccharomyces cerevisiae (Sce) YLR396c
(S000004388)		 GI:6323428 P20795
Schizosaccharomyces pombe (Spo) SPBC1703.15c GI:19113002 Q9P7V6


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000324 fungal-type vacuole C
IDA
SceS000004388
GO:0000329 fungal-type vacuole membrane C
IDA
SceS000004388
IPI
SceS000004388
GO:0005634 nucleus C
IDA
SpoSPBC1703.15c
GO:0005764 lysosome C
IDA
DmeFBgn0000257
GO:0005769 early endosome C
IDA
HsaVPS33A
GO:0005770 late endosome C
IDA
HsaVPS33A
GO:0005829 cytosol C
IDA
SceS000004388
SpoSPBC1703.15c
TAS
DmeFBgn0000257
GO:0009705 plant-type vacuole membrane C
IDA
AthAt3g54860
GO:0016020 membrane C
TAS
DmeFBgn0000257
GO:0030897 HOPS complex C
IDA
HsaVPS33A
IPI
SceS000004388
ISS
SpoSPBC1703.15c
GO:0033263 CORVET complex C
IDA
SceS000004388
GO:0048471 perinuclear region of cytoplasm C
IDA
HsaVPS33A
GO:0000149 SNARE binding F
ISS
DmeFBgn0000257
GO:0005515 protein binding F
IPI
DmeFBgn0000257
HsaVPS33A
GO:0005524 ATP binding F
IDA
SceS000004388
IMP
SceS000004388
ISS
SpoSPBC1703.15c
GO:0008565 protein transporter activity F
ISS
AthAt3g54860
GO:0035091 phosphoinositide binding F
IDA
SceS000004388
GO:0000046 autophagic vacuole fusion P
IMP
DmeFBgn0000257
GO:0006622 protein targeting to lysosome P
IMP
DmeFBgn0000257
GO:0006623 protein targeting to vacuole P
IMP
SceS000004388
SpoSPBC1703.15c
GO:0006727 ommochrome biosynthetic process P
IMP
DmeFBgn0000257
GO:0006895 Golgi to endosome transport P
ISS
SpoSPBC1703.15c
GO:0006896 Golgi to vacuole transport P
IMP
SceS000004388
GO:0006897 endocytosis P
IMP
SceS000004388
GO:0007032 endosome organization P
IMP
DmeFBgn0000257
GO:0007033 vacuole organization P
IMP
SceS000004388
SpoSPBC1703.15c
RCA
SceS000004388
TAS
AthAt3g54860
GO:0007040 lysosome organization P
NAS
DmeFBgn0000257
GO:0008057 eye pigment granule organization P
IMP
DmeFBgn0000257
GO:0008333 endosome to lysosome transport P
IMP
DmeFBgn0000257
TAS
DmeFBgn0000257
GO:0008340 determination of adult lifespan P
IMP
DmeFBgn0000257
GO:0009306 protein secretion P
ISS
AthAt3g54860
GO:0016192 vesicle-mediated transport P
IDA
HsaVPS33A
ISS
DmeFBgn0000257
GO:0030220 platelet formation P
ISS
HsaVPS33A
GO:0031396 regulation of protein ubiquitination P
IMP
DmeFBgn0000257
GO:0032400 melanosome localization P
IDA
HsaVPS33A
GO:0032418 lysosome localization P
IDA
HsaVPS33A
GO:0032889 regulation of vacuole fusion, non-autophagic P
IDA
SceS000004388
GO:0034727 piecemeal microautophagy of nucleus P
IMP
SceS000004388
GO:0035542 regulation of SNARE complex assembly P
IDA
SceS000004388
GO:0042144 vacuole fusion, non-autophagic P
IMP
SceS000004388
ISS
SpoSPBC1703.15c
GO:0045324 late endosome to vacuole transport P
ISS
SpoSPBC1703.15c
GO:0046907 intracellular transport P
TAS
DmeFBgn0000257
GO:0048070 regulation of developmental pigmentation P
ISS
HsaVPS33A
GO:0048072 compound eye pigmentation P
IMP
DmeFBgn0000257
TAS
DmeFBgn0000257
GO:0048278 vesicle docking P
IGI
SceS000004388
ISS
SpoSPBC1703.15c
GO:0050801 ion homeostasis P
RCA
SceS000004388
GO:0051469 vesicle fusion with vacuole P
IGI
SceS000004388

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
68847

Species Gene ID NCBI link UniProt link
Saccharomyces cerevisiae (Sce) VPS33
(S000004388)		 GI:6323428 P20795
Kluyveromyces lactis (Kla) KLLA0B03267g GI:50303475
Eremothecium gossypii (Ego) AGOS_AER064C GI:45190670


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000324 fungal-type vacuole C
IDA
SceS000004388
GO:0000329 fungal-type vacuole membrane C
IDA
SceS000004388
IPI
SceS000004388
GO:0005829 cytosol C
IDA
SceS000004388
GO:0030897 HOPS complex C
IPI
SceS000004388
GO:0033263 CORVET complex C
IDA
SceS000004388
GO:0005524 ATP binding F
IDA
SceS000004388
IMP
SceS000004388
GO:0035091 phosphoinositide binding F
IDA
SceS000004388
GO:0006623 protein targeting to vacuole P
IMP
SceS000004388
GO:0006896 Golgi to vacuole transport P
IMP
SceS000004388
GO:0006897 endocytosis P
IMP
SceS000004388
GO:0007033 vacuole organization P
IMP
SceS000004388
RCA
SceS000004388
GO:0032889 regulation of vacuole fusion, non-autophagic P
IDA
SceS000004388
GO:0034727 piecemeal microautophagy of nucleus P
IMP
SceS000004388
GO:0035542 regulation of SNARE complex assembly P
IDA
SceS000004388
GO:0042144 vacuole fusion, non-autophagic P
IMP
SceS000004388
GO:0048278 vesicle docking P
IGI
SceS000004388
GO:0050801 ion homeostasis P
RCA
SceS000004388
GO:0051469 vesicle fusion with vacuole P
IGI
SceS000004388

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_2380

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga5499 ENSANGP00000014711
Ashbya gossypii (Ago) ago2569 AER064C
Arabidopsis thaliana (Ath) ath16857 At3g54860.1
Caenorhabditis elegans (Cel) cel327 B0303.9
(CE00539;
WBGene00015130)
Candida glabrata (Cgl) cgl530 CAGL0C02607g
Cryptococcus neoformans (Cne) cne3025 167.m03328
Dictyostelium discoideum (Ddi) ddi11287 DDB0189239
Dictyostelium discoideum (Ddi) ddi3259 DDB0217762
Debaryomyces hansenii (Dha) dha3736 DEHA0E11198g
Drosophila melanogaster (Dme) dme18644 CG12230-PA
(FBgn0000257)
Drosophila melanogaster (Dme) dme18643 CG12230-PB
(FBgn0000257)
Danio rerio (Dre) dre3291 ENSDARP00000013152
Takifugu rubripes (Fru) fru15077 SINFRUP00000142336
Gallus gallus (Gga) gga7237 ENSGALP00000007052
(VPS33A)
Homo sapiens (Hsa) hsa8370 ENSP00000267199
(VPS33A)		 Q96AX1
Kluyveromyces lactis (Kla) kla677 KLLA0B03267g
Mus musculus (Mmu) mmu20916 ENSMUSP00000031388
(MGI:1924823)		 Q80XK7
Neurospora crassa (Ncr) ncr8889 NCU09121.2
Oryza sativa (Osa) osa44287 5588.m00127
Plasmodium falciparum (Pfa) pfa4807 PFI1700c
Rattus norvegicus (Rno) rno8557 ENSRNOP00000011458
(RGD:620643)
Saccharomyces cerevisiae (Sce) sce4514 YLR396C
(S000004388)
Schizosaccharomyces pombe (Spo) spo28 SPBC1703.15c Q9P7V6
Yarrowia lipolytica (Yli) yli5516 YALI0F04125g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000324 fungal-type vacuole C
IDA
SceS000004388
GO:0000329 fungal-type vacuole membrane C
IDA
SceS000004388
IPI
SceS000004388
GO:0005634 nucleus C
IDA
SpoSPBC1703.15c
GO:0005764 lysosome C
IDA
DmeFBgn0000257
GO:0005829 cytosol C
IDA
SceS000004388
SpoSPBC1703.15c
TAS
DmeFBgn0000257
GO:0009705 plant-type vacuole membrane C
IDA
AthAt3g54860
GO:0016020 membrane C
TAS
DmeFBgn0000257
GO:0030897 HOPS complex C
IPI
SceS000004388
ISS
SpoSPBC1703.15c
GO:0033263 CORVET complex C
IDA
SceS000004388
GO:0000149 SNARE binding F
ISS
DmeFBgn0000257
GO:0005515 protein binding F
IPI
DmeFBgn0000257
GO:0005524 ATP binding F
IDA
SceS000004388
IMP
SceS000004388
ISS
SpoSPBC1703.15c
GO:0008565 protein transporter activity F
ISS
AthAt3g54860
GO:0035091 phosphoinositide binding F
IDA
SceS000004388
GO:0000046 autophagic vacuole fusion P
IMP
DmeFBgn0000257
GO:0006622 protein targeting to lysosome P
IMP
DmeFBgn0000257
GO:0006623 protein targeting to vacuole P
IMP
SceS000004388
SpoSPBC1703.15c
GO:0006727 ommochrome biosynthetic process P
IMP
DmeFBgn0000257
GO:0006895 Golgi to endosome transport P
ISS
SpoSPBC1703.15c
GO:0006896 Golgi to vacuole transport P
IMP
SceS000004388
GO:0006897 endocytosis P
IMP
SceS000004388
GO:0007032 endosome organization P
IMP
DmeFBgn0000257
GO:0007033 vacuole organization P
IMP
SceS000004388
SpoSPBC1703.15c
RCA
SceS000004388
TAS
AthAt3g54860
GO:0007040 lysosome organization P
NAS
DmeFBgn0000257
GO:0008057 eye pigment granule organization P
IMP
DmeFBgn0000257
GO:0008333 endosome to lysosome transport P
IMP
DmeFBgn0000257
TAS
DmeFBgn0000257
GO:0008340 determination of adult lifespan P
IMP
CelWBGene00015130
DmeFBgn0000257
GO:0009306 protein secretion P
ISS
AthAt3g54860
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00015130
GO:0010171 body morphogenesis P
IMP
CelWBGene00015130
GO:0016192 vesicle-mediated transport P
ISA
MmuMGI:1924823
ISS
DmeFBgn0000257
GO:0030220 platelet formation P
IMP
MmuMGI:1924823
GO:0031396 regulation of protein ubiquitination P
IMP
DmeFBgn0000257
GO:0032889 regulation of vacuole fusion, non-autophagic P
IDA
SceS000004388
GO:0034727 piecemeal microautophagy of nucleus P
IMP
SceS000004388
GO:0035542 regulation of SNARE complex assembly P
IDA
SceS000004388
GO:0042144 vacuole fusion, non-autophagic P
IMP
SceS000004388
ISS
SpoSPBC1703.15c
GO:0043473 pigmentation P
IMP
MmuMGI:1924823
GO:0045324 late endosome to vacuole transport P
ISS
SpoSPBC1703.15c
GO:0046907 intracellular transport P
TAS
DmeFBgn0000257
GO:0048070 regulation of developmental pigmentation P
IMP
MmuMGI:1924823
GO:0048072 compound eye pigmentation P
IMP
DmeFBgn0000257
TAS
DmeFBgn0000257
GO:0048278 vesicle docking P
IGI
SceS000004388
ISS
SpoSPBC1703.15c
GO:0050801 ion homeostasis P
RCA
SceS000004388
GO:0051469 vesicle fusion with vacuole P
IGI
SceS000004388

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPBC1703.15c
(Q9P7V6)		 YLR396C
(S000004388)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000324 fungal-type vacuole C
IDA
SceS000004388
GO:0000329 fungal-type vacuole membrane C
IDA
SceS000004388
IPI
SceS000004388
GO:0005634 nucleus C
IDA
SpoSPBC1703.15c
GO:0005829 cytosol C
IDA
SceS000004388
SpoSPBC1703.15c
GO:0030897 HOPS complex C
IPI
SceS000004388
ISS
SpoSPBC1703.15c
GO:0033263 CORVET complex C
IDA
SceS000004388
GO:0005524 ATP binding F
IDA
SceS000004388
IMP
SceS000004388
ISS
SpoSPBC1703.15c
GO:0035091 phosphoinositide binding F
IDA
SceS000004388
GO:0006623 protein targeting to vacuole P
IMP
SceS000004388
SpoSPBC1703.15c
GO:0006895 Golgi to endosome transport P
ISS
SpoSPBC1703.15c
GO:0006896 Golgi to vacuole transport P
IMP
SceS000004388
GO:0006897 endocytosis P
IMP
SceS000004388
GO:0007033 vacuole organization P
IMP
SceS000004388
SpoSPBC1703.15c
RCA
SceS000004388
GO:0032889 regulation of vacuole fusion, non-autophagic P
IDA
SceS000004388
GO:0034727 piecemeal microautophagy of nucleus P
IMP
SceS000004388
GO:0035542 regulation of SNARE complex assembly P
IDA
SceS000004388
GO:0042144 vacuole fusion, non-autophagic P
IMP
SceS000004388
ISS
SpoSPBC1703.15c
GO:0045324 late endosome to vacuole transport P
ISS
SpoSPBC1703.15c
GO:0048278 vesicle docking P
IGI
SceS000004388
ISS
SpoSPBC1703.15c
GO:0050801 ion homeostasis P
RCA
SceS000004388
GO:0051469 vesicle fusion with vacuole P
IGI
SceS000004388

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