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Search term: YLR397C

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name AFG2
SGD link S000004389
Alternative ID YLR397C
Description ATPase of the CDC48/PAS1/SEC18 (AAA) family, forms a hexameric complex; is essential for pre-60S maturation and release of several preribosome maturation factors; may be involved in degradation of aberrant mRNAs
Synonyms YLR397C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG0730 ACDHYPE

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALING AAA+-type ATPase

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At2g03670 GI:15227690
Arabidopsis thaliana (Ath) At3g09840 GI:15232776
Arabidopsis thaliana (Ath) At3g24530 GI:15230128
Arabidopsis thaliana (Ath) At3g53230 GI:15231775
Arabidopsis thaliana (Ath) At4g04180 GI:15233417
Arabidopsis thaliana (Ath) At5g03340 GI:11265361
Caenorhabditis elegans (Cel) CE02114
(WBGene00007352)		 GI:17531535 P54811
Caenorhabditis elegans (Cel) CE05402
(WBGene00008053)		 GI:17532375 P54812
Caenorhabditis elegans (Cel) CE06097
(WBGene00010562)		 GI:17508053 Q21222
Drosophila melanogaster (Dme) 7292363 GI:7292363 Q9VZQ0
Drosophila melanogaster (Dme) 7297973
(FBgn0032450)		 GI:19921202
Drosophila melanogaster (Dme) 7303816 GI:17137560
Homo sapiens (Hsa) Hs13129040
(SPATA5L1)		 GI:13129040
Homo sapiens (Hsa) Hs18583802 GI:18583802
Homo sapiens (Hsa) Hs20532580 GI:20532580
Homo sapiens (Hsa) Hs21624654 GI:19880131 Q8NB90
Homo sapiens (Hsa) Hs6005942
(VCP)		 GI:6005942 P55072
Saccharomyces cerevisiae (Sce) YDL126c
(S000002284)		 GI:6320077 P25694
Saccharomyces cerevisiae (Sce) YLR397c
(S000004389)		 GI:6323429 P32794
Schizosaccharomyces pombe (Spo) SPAC1565.08 GI:19114199 Q9P3A7
Schizosaccharomyces pombe (Spo) SPBC56F2.07c GI:19113502 O60058
Encephalitozoon cuniculi (Ecu) ECU01g1230 GI:19075136
Encephalitozoon cuniculi (Ecu) ECU05g1140 GI:19173654 Q8SRV6
Arabidopsis thaliana (Ath) At2g03670 GI:15227690
Arabidopsis thaliana (Ath) At3g09840 GI:15232776
Arabidopsis thaliana (Ath) At3g24530 GI:15230128
Arabidopsis thaliana (Ath) At3g53230 GI:15231775
Arabidopsis thaliana (Ath) At4g04180 GI:15233417
Arabidopsis thaliana (Ath) At5g03340 GI:11265361
Caenorhabditis elegans (Cel) CE02114
(WBGene00007352)		 GI:17531535 P54811
Caenorhabditis elegans (Cel) CE05402
(WBGene00008053)		 GI:17532375 P54812
Caenorhabditis elegans (Cel) CE06097
(WBGene00010562)		 GI:17508053 Q21222
Drosophila melanogaster (Dme) 7292363 GI:7292363 Q9VZQ0
Drosophila melanogaster (Dme) 7297973
(FBgn0032450)		 GI:19921202
Drosophila melanogaster (Dme) 7303816 GI:17137560
Homo sapiens (Hsa) Hs13129040
(SPATA5L1)		 GI:13129040
Homo sapiens (Hsa) Hs18583802 GI:18583802
Homo sapiens (Hsa) Hs20532580 GI:20532580
Homo sapiens (Hsa) Hs21624654 GI:19880131 Q8NB90
Homo sapiens (Hsa) Hs6005942
(VCP)		 GI:6005942 P55072
Saccharomyces cerevisiae (Sce) YDL126c
(S000002284)		 GI:6320077 P25694
Saccharomyces cerevisiae (Sce) YLR397c
(S000004389)		 GI:6323429 P32794
Schizosaccharomyces pombe (Spo) SPAC1565.08 GI:19114199 Q9P3A7
Schizosaccharomyces pombe (Spo) SPBC56F2.07c GI:19113502 O60058
Encephalitozoon cuniculi (Ecu) ECU01g1230 GI:19075136
Encephalitozoon cuniculi (Ecu) ECU05g1140 GI:19173654 Q8SRV6


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000502 proteasome complex C
IDA
HsaVCP
GO:0000790 nuclear chromatin C
IDA
SpoSPAC1565.08
GO:0000837 Doa10p ubiquitin ligase complex C
IDA
SceS000002284
GO:0005618 cell wall C
IDA
AthAt3g09840
At5g03340
GO:0005622 intracellular C
IDA
SceS000004389
GO:0005634 nucleus C
IDA
AthAt3g09840
CelWBGene00008053
WBGene00007352
HsaVCP
SceS000002284
SpoSPAC1565.08
TAS
HsaVCP
GO:0005635 nuclear envelope C
IDA
AthAt3g09840
GO:0005730 nucleolus C
IDA
AthAt3g53230
At3g09840
GO:0005737 cytoplasm C
IDA
AthAt3g09840
HsaVCP
SpoSPAC1565.08
GO:0005783 endoplasmic reticulum C
IDA
HsaVCP
ISS
DmeFBgn0032450
GO:0005789 endoplasmic reticulum membrane C
IDA
SceS000002284
ISS
SpoSPAC1565.08
GO:0005792 microsome C
IDA
SceS000002284
ISS
HsaVCP
GO:0005819 spindle C
IDA
AthAt3g09840
GO:0005829 cytosol C
IDA
AthAt3g53230
HsaVCP
SceS000002284
SpoSPAC1565.08
SPBC56F2.07c
GO:0005886 plasma membrane C
IDA
AthAt3g09840
At3g53230
GO:0009507 chloroplast C
IDA
AthAt3g24530
GO:0009524 phragmoplast C
IDA
AthAt3g09840
GO:0022626 cytosolic ribosome C
IDA
AthAt3g09840
GO:0030687 preribosome, large subunit precursor C
IDA
SceS000004389
IMP
SceS000004389
GO:0034098 Cdc48p-Npl4p-Ufd1p AAA ATPase complex C
IDA
SceS000002284
IPI
CelWBGene00008053
WBGene00007352
ISS
SpoSPAC1565.08
GO:0043332 mating projection tip C
IDA
SceS000002284
GO:0005515 protein binding F
IPI
AthAt5g03340
HsaVCP
SpoSPAC1565.08
GO:0005524 ATP binding F
ISS
AthAt3g53230
SpoSPBC56F2.07c
GO:0016887 ATPase activity F
IDA
CelWBGene00010562
SceS000002284
S000004389
ISS
AthAt4g04180
At5g03340
At3g09840
At3g24530
At2g03670
DmeFBgn0032450
SpoSPAC1565.08
SPBC56F2.07c
TAS
HsaVCP
GO:0019901 protein kinase binding F
IPI
CelWBGene00010562
GO:0019903 protein phosphatase binding F
IPI
HsaVCP
GO:0019904 protein domain specific binding F
IPI
HsaVCP
GO:0031593 polyubiquitin binding F
IDA
HsaVCP
GO:0042802 identical protein binding F
IPI
AthAt3g09840
GO:0000003 reproduction P
IMP
CelWBGene00007352
WBGene00010562
GO:0000278 mitotic cell cycle P
IMP
SceS000002284
GO:0000910 cytokinesis P
IMP
CelWBGene00007352
WBGene00008053
GO:0002119 nematode larval development P
IMP
CelWBGene00008053
WBGene00007352
WBGene00010562
GO:0006200 ATP catabolic process P
ISS
SpoSPAC1565.08
SPBC56F2.07c
GO:0006281 DNA repair P
NAS
HsaVCP
GO:0006302 double-strand break repair P
IDA
HsaVCP
GO:0006469 negative regulation of protein kinase
activity		 P
IDA
CelWBGene00010562
GO:0006508 proteolysis P
RCA
SceS000002284
GO:0006511 ubiquitin-dependent protein catabolic
process		 P
IDA
SceS000002284
IGI
SpoSPAC1565.08
IPI
SceS000002284
GO:0006898 receptor-mediated endocytosis P
IMP
CelWBGene00010562
GO:0006906 vesicle fusion P
IDA
SceS000002284
ISS
SpoSPAC1565.08
GO:0006919 activation of caspase activity P
ISS
HsaVCP
GO:0006974 response to DNA damage stimulus P
IDA
HsaVCP
GO:0007052 mitotic spindle organization P
IMP
CelWBGene00010562
GO:0007059 chromosome segregation P
IGI
SpoSPAC1565.08
GO:0007067 mitosis P
IMP
CelWBGene00010562
GO:0007091 mitotic metaphase/anaphase transition P
IMP
CelWBGene00010562
GO:0007126 meiosis P
IMP
CelWBGene00008053
WBGene00007352
GO:0007346 regulation of mitotic cell cycle P
NAS
SpoSPAC1565.08
GO:0008219 cell death P
RCA
SceS000002284
GO:0009792 embryo development ending in birth or egg
hatching		 P
IGI
CelWBGene00008053
WBGene00007352
IMP
CelWBGene00008053
WBGene00010562
WBGene00007352
GO:0009846 pollen germination P
IMP
AthAt3g09840
GO:0009860 pollen tube growth P
IMP
AthAt3g09840
GO:0015031 protein transport P
IDA
SceS000002284
GO:0016567 protein ubiquitination P
NAS
HsaVCP
GO:0019538 protein metabolic process P
ISS
AthAt3g24530
GO:0030433 ER-associated protein catabolic
process		 P
IMP
SceS000002284
ISS
SpoSPAC1565.08
TAS
HsaVCP
GO:0030435 sporulation resulting in formation of a cellular
spore		 P
RCA
SceS000002284
GO:0030968 endoplasmic reticulum unfolded protein
response		 P
IMP
CelWBGene00007352
WBGene00008053
TAS
HsaVCP
GO:0030970 retrograde protein transport, ER to
cytosol		 P
IDA
HsaVCP
ISS
SpoSPAC1565.08
GO:0031134 sister chromatid biorientation P
IMP
SceS000002284
GO:0032436 positive regulation of proteasomal
ubiquitin-dependent protein catabolic
process		 P
IDA
HsaVCP
GO:0033554 cellular response to stress P
IGI
SpoSPAC1565.08
GO:0040002 collagen and cuticulin-based cuticle
development		 P
IMP
CelWBGene00007352
GO:0040007 growth P
IMP
CelWBGene00010562
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00008053
WBGene00010562
GO:0040011 locomotion P
IMP
CelWBGene00007352
WBGene00008053
GO:0040018 positive regulation of multicellular organism
growth		 P
IMP
CelWBGene00007352
GO:0042254 ribosome biogenesis P
ISS
SpoSPBC56F2.07c
GO:0042273 ribosomal large subunit biogenesis P
IMP
SceS000004389
GO:0042493 response to drug P
IMP
SceS000004389
GO:0042981 regulation of apoptosis P
TAS
HsaVCP
GO:0043161 proteasomal ubiquitin-dependent protein catabolic
process		 P
NAS
HsaVCP
GO:0045184 establishment of protein localization P
TAS
HsaVCP
GO:0045732 positive regulation of protein catabolic
process		 P
IDA
HsaVCP
GO:0046686 response to cadmium ion P
IEP
AthAt3g09840
At3g53230
GO:0051230 spindle disassembly P
TAS
SpoSPAC1565.08
GO:0051301 cell division P
IMP
AthAt3g09840
CelWBGene00007352
WBGene00008053
GO:0061166 establishment of endoplasmic reticulum
localization involved in endoplasmic reticulum
polarization at cell division site		 P
IMP
SpoSPAC1565.08
GO:0071712 ER-associated misfolded protein catabolic
process		 P
IGI
CelWBGene00007352
WBGene00008053

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
56920

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) SPATA5 GI:157671927
Pan troglodytes (Ptr) SPATA5 GI:114595942
Canis familiaris (Cfa) SPATA5 GI:73984095
Mus musculus (Mmu) Spata5
(MGI:1927170)		 GI:10946660 B7ZNK9
Rattus norvegicus (Rno) Spata5 GI:62643360
Gallus gallus (Gga) SPATA5 GI:118090312
Schizosaccharomyces pombe (Spo) SPBC56F2.07c GI:19113502 O60058
Saccharomyces cerevisiae (Sce) AFG2
(S000004389)		 GI:6323429 P32794
Kluyveromyces lactis (Kla) KLLA0B03234g GI:50303471


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005622 intracellular C
IDA
SceS000004389
GO:0005737 cytoplasm C
IDA
HsaSPATA5
GO:0005829 cytosol C
IDA
SpoSPBC56F2.07c
GO:0030687 preribosome, large subunit precursor C
IDA
SceS000004389
IMP
SceS000004389
GO:0005524 ATP binding F
ISS
SpoSPBC56F2.07c
GO:0016887 ATPase activity F
IDA
SceS000004389
ISS
SpoSPBC56F2.07c
GO:0006200 ATP catabolic process P
ISS
SpoSPBC56F2.07c
GO:0042254 ribosome biogenesis P
ISS
SpoSPBC56F2.07c
GO:0042273 ribosomal large subunit biogenesis P
IMP
SceS000004389
GO:0042493 response to drug P
IMP
SceS000004389

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_6378

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Ashbya gossypii (Ago) ago2570 AER065C
Arabidopsis thaliana (Ath) ath17061 At3g56690.1
Candida glabrata (Cgl) cgl529 CAGL0C02585g
Cryptococcus neoformans (Cne) cne4286 177.m03043
Dictyostelium discoideum (Ddi) ddi6524 DDB0205453
Debaryomyces hansenii (Dha) dha527 DEHA0A11759g
Takifugu rubripes (Fru) fru1421 SINFRUP00000156837
Gallus gallus (Gga) gga17825 ENSGALP00000019284
(SPATA5)
Gallus gallus (Gga) gga17826 ENSGALP00000019285
Homo sapiens (Hsa) hsa24613 ENSP00000274008
(SPATA5)		 Q8NB90-1
Kluyveromyces lactis (Kla) kla675 KLLA0B03234g
Mus musculus (Mmu) mmu16533 ENSMUSP00000029277
(MGI:1927170)		 Q9Z2U6
Rattus norvegicus (Rno) rno15972 ENSRNOP00000023584
(RGD:1310478)
Saccharomyces cerevisiae (Sce) sce4515 YLR397C
(S000004389)
Schizosaccharomyces pombe (Spo) spo2127 SPBC56F2.07c O60058
Yarrowia lipolytica (Yli) yli4141 YALI0E06655g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005622 intracellular C
IDA
SceS000004389
GO:0005829 cytosol C
IDA
SpoSPBC56F2.07c
GO:0009507 chloroplast C
IDA
AthAt3g56690
GO:0009535 chloroplast thylakoid membrane C
IDA
AthAt3g56690
GO:0030687 preribosome, large subunit precursor C
IDA
SceS000004389
IMP
SceS000004389
GO:0005516 calmodulin binding F
IDA
AthAt3g56690
TAS
AthAt3g56690
GO:0005524 ATP binding F
ISS
SpoSPBC56F2.07c
GO:0016887 ATPase activity F
IDA
SceS000004389
ISS
AthAt3g56690
SpoSPBC56F2.07c
GO:0006200 ATP catabolic process P
ISS
SpoSPBC56F2.07c
GO:0042254 ribosome biogenesis P
ISS
SpoSPBC56F2.07c
GO:0042273 ribosomal large subunit biogenesis P
IMP
SceS000004389
GO:0042493 response to drug P
IMP
SceS000004389

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPBC56F2.07c
(O60058)		 YLR397C
(S000004389)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005622 intracellular C
IDA
SceS000004389
GO:0005829 cytosol C
IDA
SpoSPBC56F2.07c
GO:0030687 preribosome, large subunit precursor C
IDA
SceS000004389
IMP
SceS000004389
GO:0005524 ATP binding F
ISS
SpoSPBC56F2.07c
GO:0016887 ATPase activity F
IDA
SceS000004389
ISS
SpoSPBC56F2.07c
GO:0006200 ATP catabolic process P
ISS
SpoSPBC56F2.07c
GO:0042254 ribosome biogenesis P
ISS
SpoSPBC56F2.07c
GO:0042273 ribosomal large subunit biogenesis P
IMP
SceS000004389
GO:0042493 response to drug P
IMP
SceS000004389

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