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Search term: YLR425W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name TUS1
SGD link S000004417
Alternative ID YLR425W
Description Guanine nucleotide exchange factor (GEF) that functions to modulate Rho1p activity as part of the cell integrity signaling pathway; multicopy suppressor of tor2 mutation and ypk1 ypk2 double mutation; potential Cdc28p substrate
Synonyms YLR425W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG4305 --DHYPE

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALING RhoGEF GTPase

Species KOG link NCBI link UniProt link
Drosophila melanogaster (Dme) 7292538 GI:7292538
Homo sapiens (Hsa) Hs11128045_2 GI:11128045
Homo sapiens (Hsa) Hs19923327 GI:19923327 Q7Z628
Homo sapiens (Hsa) Hs22060844 GI:22060844
Homo sapiens (Hsa) Hs4504797_2 GI:4504797
Homo sapiens (Hsa) Hs9506401 GI:9506401 Q9NR81
Saccharomyces cerevisiae (Sce) YGR070w
(S000003302)		 GI:6321507 P53046
Saccharomyces cerevisiae (Sce) YLR371w
(S000004363)		 GI:6323403 P51862
Saccharomyces cerevisiae (Sce) YLR425w
(S000004417)		 GI:6323457 Q06412
Schizosaccharomyces pombe (Spo) SPAC1006.06 GI:19115765 Q9UTR5
Schizosaccharomyces pombe (Spo) SPCC645.06c GI:19075615 Q9Y7U5
Schizosaccharomyces pombe (Spo) SPCC645.07 GI:19075616 Q9Y7U6
Encephalitozoon cuniculi (Ecu) ECU03g0550 GI:19173015 Q8SW55


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000935 barrier septum C
IDA
SpoSPAC1006.06
SPCC645.07
GO:0005575 cellular_component C
ND
SceS000004417
GO:0005622 intracellular C
TAS
SceS000003302
GO:0005634 nucleus C
IDA
SpoSPCC645.07
GO:0005829 cytosol C
IDA
SpoSPAC1006.06
SPCC645.06c
GO:0005934 cellular bud tip C
TAS
SceS000004363
GO:0005935 cellular bud neck C
RCA
SceS000004363
GO:0030428 cell septum C
IDA
SpoSPCC645.07
GO:0032153 cell division site C
IDA
SpoSPCC645.06c
GO:0051285 cell cortex of cell tip C
IDA
SpoSPAC1006.06
SPCC645.07
GO:0051286 cell tip C
IDA
SpoSPCC645.07
GO:0004871 signal transducer activity F
RCA
SceS000004363
TAS
SceS000003302
GO:0005089 Rho guanyl-nucleotide exchange factor
activity		 F
IDA
SceS000004363
S000004417
IGI
SpoSPAC1006.06
SPCC645.07
SPCC645.06c
IPI
SceS000004363
ISA
SceS000003302
GO:0005515 protein binding F
IPI
SpoSPAC1006.06
SPCC645.07
SPCC645.06c
GO:0005546 phosphatidylinositol-4,5-bisphosphate
binding		 F
IDA
SceS000004363
GO:0060089 molecular transducer activity F
RCA
SceS000004363
GO:0000003 reproduction P
RCA
SceS000004363
GO:0000918 selection of site for barrier septum
formation		 P
IMP
SpoSPAC1006.06
GO:0006950 response to stress P
IMP
SceS000004363
GO:0006984 ER-nucleus signaling pathway P
RCA
SceS000004363
GO:0007015 actin filament organization P
TAS
SceS000003302
S000004363
GO:0007047 cellular cell wall organization P
RCA
SceS000004417
S000004363
GO:0007117 budding cell bud growth P
TAS
SceS000003302
S000004363
GO:0007165 signal transduction P
IGI
SceS000004417
IMP
SceS000004417
GO:0007264 small GTPase mediated signal transduction P
TAS
SceS000003302
S000004363
GO:0008360 regulation of cell shape P
IGI
SpoSPCC645.07
GO:0009272 fungal-type cell wall biogenesis P
IGI
SpoSPCC645.07
SPAC1006.06
GO:0009966 regulation of signal transduction P
RCA
SceS000004363
GO:0010590 regulation of cytokinetic cell
separation		 P
IMP
SpoSPCC645.06c
GO:0030010 establishment of cell polarity P
TAS
SceS000003302
S000004363
GO:0030994 primary cell septum disassembly P
IMP
SpoSPCC645.06c
GO:0031505 fungal-type cell wall organization P
IGI
SceS000004417
IMP
SceS000004417
TAS
SceS000003302
S000004363
GO:0032319 regulation of Rho GTPase activity P
IC
SpoSPCC645.06c
SPAC1006.06
IGI
SpoSPCC645.07
GO:0032953 regulation of 1,3-beta-glucan biosynthetic
process		 P
IGI
SpoSPCC645.07
IMP
SpoSPCC645.06c
GO:0035023 regulation of Rho protein signal
transduction		 P
IGI
SpoSPCC645.06c
SPAC1006.06
GO:0035025 positive regulation of Rho protein signal
transduction		 P
IGI
SpoSPCC645.07
GO:0045807 positive regulation of endocytosis P
IMP
SceS000004363
GO:0051049 regulation of transport P
RCA
SceS000004363
GO:0051301 cell division P
RCA
SceS000004363
GO:0051666 actin cortical patch localization P
IMP
SpoSPAC1006.06
SPCC645.07
SPCC645.06c
GO:0060624 regulation of ascospore wall 1,3-beta-glucan
biosynthetic process		 P
IC
SpoSPCC645.06c

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
117878

Species Gene ID NCBI link UniProt link
Saccharomyces cerevisiae (Sce) TUS1
(S000004417)		 GI:6323457 Q06412
Kluyveromyces lactis (Kla) KLLA0D02618g GI:50306423
Eremothecium gossypii (Ego) AGOS_AER110W GI:45190716


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
SceS000004417
GO:0005089 Rho guanyl-nucleotide exchange factor
activity		 F
IDA
SceS000004417
GO:0007047 cellular cell wall organization P
RCA
SceS000004417
GO:0007165 signal transduction P
IGI
SceS000004417
IMP
SceS000004417
GO:0031505 fungal-type cell wall organization P
IGI
SceS000004417
IMP
SceS000004417

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_15231

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Ashbya gossypii (Ago) ago2615 AER110W
Candida glabrata (Cgl) cgl3195 CAGL0J04752g
Debaryomyces hansenii (Dha) dha1076 DEHA0B08943g
Kluyveromyces lactis (Kla) kla2184 KLLA0D02618g
Neurospora crassa (Ncr) ncr2073 NCU02131.2
Saccharomyces cerevisiae (Sce) sce4548 YLR425W
(S000004417)
Schizosaccharomyces pombe (Spo) spo1873 SPCC645.06c Q9Y7U5
Yarrowia lipolytica (Yli) yli4367 YALI0E12155g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
SceS000004417
GO:0005829 cytosol C
IDA
SpoSPCC645.06c
GO:0032153 cell division site C
IDA
SpoSPCC645.06c
GO:0005089 Rho guanyl-nucleotide exchange factor
activity		 F
IDA
SceS000004417
IGI
SpoSPCC645.06c
GO:0005515 protein binding F
IPI
SpoSPCC645.06c
GO:0007047 cellular cell wall organization P
RCA
SceS000004417
GO:0007165 signal transduction P
IGI
SceS000004417
IMP
SceS000004417
GO:0010590 regulation of cytokinetic cell
separation		 P
IMP
SpoSPCC645.06c
GO:0030994 primary cell septum disassembly P
IMP
SpoSPCC645.06c
GO:0031505 fungal-type cell wall organization P
IGI
SceS000004417
IMP
SceS000004417
GO:0032319 regulation of Rho GTPase activity P
IC
SpoSPCC645.06c
GO:0032953 regulation of 1,3-beta-glucan biosynthetic
process		 P
IMP
SpoSPCC645.06c
GO:0035023 regulation of Rho protein signal
transduction		 P
IGI
SpoSPCC645.06c
GO:0051666 actin cortical patch localization P
IMP
SpoSPCC645.06c
GO:0060624 regulation of ascospore wall 1,3-beta-glucan
biosynthetic process		 P
IC
SpoSPCC645.06c

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPCC645.06c
(Q9Y7U5)		 YLR425W
(S000004417)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
SceS000004417
GO:0005829 cytosol C
IDA
SpoSPCC645.06c
GO:0032153 cell division site C
IDA
SpoSPCC645.06c
GO:0005089 Rho guanyl-nucleotide exchange factor
activity		 F
IDA
SceS000004417
IGI
SpoSPCC645.06c
GO:0005515 protein binding F
IPI
SpoSPCC645.06c
GO:0007047 cellular cell wall organization P
RCA
SceS000004417
GO:0007165 signal transduction P
IGI
SceS000004417
IMP
SceS000004417
GO:0010590 regulation of cytokinetic cell
separation		 P
IMP
SpoSPCC645.06c
GO:0030994 primary cell septum disassembly P
IMP
SpoSPCC645.06c
GO:0031505 fungal-type cell wall organization P
IGI
SceS000004417
IMP
SceS000004417
GO:0032319 regulation of Rho GTPase activity P
IC
SpoSPCC645.06c
GO:0032953 regulation of 1,3-beta-glucan biosynthetic
process		 P
IMP
SpoSPCC645.06c
GO:0035023 regulation of Rho protein signal
transduction		 P
IGI
SpoSPCC645.06c
GO:0051666 actin cortical patch localization P
IMP
SpoSPCC645.06c
GO:0060624 regulation of ascospore wall 1,3-beta-glucan
biosynthetic process		 P
IC
SpoSPCC645.06c

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