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Search term: YML075C

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name HMG1
SGD link S000004540
Alternative ID YML075C
Description One of two isozymes of HMG-CoA reductase that catalyzes the conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; localizes to the nuclear envelope; overproduction induces the formation of karmellae
Synonyms YML075C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG2480 ACDHYPE

KOGs classification KOGs description
METABOLISM 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At1g76490 GI:15223072
Arabidopsis thaliana (Ath) At2g17370 GI:15227821
Caenorhabditis elegans (Cel) CE02598 GI:17552940
Drosophila melanogaster (Dme) 7301039 GI:7301039 P14773
Homo sapiens (Hsa) Hs4557643
(HMGCR)		 GI:4557643 P04035
Saccharomyces cerevisiae (Sce) YLR450w
(S000004442)		 GI:6323483 P12684
Saccharomyces cerevisiae (Sce) YML075c
(S000004540)		 GI:6323565 P12683
Schizosaccharomyces pombe (Spo) SPCC162.09c GI:19075735 Q10283
Encephalitozoon cuniculi (Ecu) ECU10g1720 GI:19074783 Q8SQZ9


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005635 nuclear envelope C
IDA
SceS000004540
S000004442
GO:0005783 endoplasmic reticulum C
IDA
AthAt1g76490
SpoSPCC162.09c
GO:0005789 endoplasmic reticulum membrane C
EXP
HsaHMGCR
IDA
SceS000004442
S000004540
SpoSPCC162.09c
GO:0005792 microsome C
IDA
AthAt2g17370
GO:0016020 membrane C
TAS
AthAt1g76490
GO:0016021 integral to membrane C
ISM
SceS000004540
S000004442
GO:0031965 nuclear membrane C
ISS
SpoSPCC162.09c
GO:0042175 nuclear membrane-endoplasmic reticulum
network		 C
IDA
SpoSPCC162.09c
GO:0004420 hydroxymethylglutaryl-CoA reductase (NADPH)
activity		 F
IDA
SceS000004540
SpoSPCC162.09c
IMP
SceS000004540
SpoSPCC162.09c
ISA
SceS000004442
GO:0005515 protein binding F
IPI
SpoSPCC162.09c
GO:0042282 hydroxymethylglutaryl-CoA reductase
activity		 F
IGI
AthAt1g76490
ISS
AthAt2g17370
At1g76490
GO:0006066 alcohol metabolic process P
RCA
SceS000004540
GO:0006696 ergosterol biosynthetic process P
IMP
SceS000004540
SpoSPCC162.09c
ISA
SceS000004442
GO:0007047 cellular cell wall organization P
IMP
SpoSPCC162.09c
GO:0008299 isoprenoid biosynthetic process P
ISS
AthAt1g76490
TAS
AthAt2g17370
At1g76490
GO:0008354 germ cell migration P
TAS
HsaHMGCR
GO:0008406 gonad development P
TAS
HsaHMGCR
GO:0010142 farnesyl diphosphate biosynthetic process,
mevalonate pathway		 P
ISS
SpoSPCC162.09c
GO:0016104 triterpenoid biosynthetic process P
IMP
AthAt2g17370
GO:0016126 sterol biosynthetic process P
IMP
AthAt2g17370
At1g76490
GO:0019287 isopentenyl diphosphate biosynthetic process,
mevalonate pathway		 P
IC
SceS000004540
GO:0045184 establishment of protein localization P
RCA
SceS000004442
S000004540

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
30994

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) HMGCR GI:4557643 P04035
Pan troglodytes (Ptr) HMGCR GI:114599627
Canis familiaris (Cfa) HMGCR GI:73952215
Mus musculus (Mmu) Hmgcr
(MGI:96159)		 GI:56119096 Q01237
Rattus norvegicus (Rno) Hmgcr
(RGD:2803)		 GI:40538852 44412
Gallus gallus (Gga) HMGCR GI:45383193
Drosophila melanogaster (Dme) Hmgcr
(FBgn0001205)		 GI:24649399
Anopheles gambiae (Aga) AgaP_AGAP002288 GI:158284797
Caenorhabditis elegans (Cel) F08F8.2
(CE30649;
WBGene00017268)		 GI:25144592
Schizosaccharomyces pombe (Spo) hmg1
(SPCC162.09c)		 GI:19075735 Q10283
Saccharomyces cerevisiae (Sce) HMG1
(S000004540)		 GI:6323565 P12683
Saccharomyces cerevisiae (Sce) HMG2
(S000004442)		 GI:6323483 P12684
Kluyveromyces lactis (Kla) KLLA0B04642g GI:50303597
Eremothecium gossypii (Ego) AGOS_AER152W GI:45190756
Magnaporthe grisea (Mgr) MGG_08975 GI:145614090
Neurospora crassa (Ncr) NCU00712.1 GI:32408825
Arabidopsis thaliana (Ath) HMG1 GI:79382641
Oryza sativa (Osa) Os09g0492700 GI:115479895


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005622 intracellular C
TAS
DmeFBgn0001205
GO:0005635 nuclear envelope C
IDA
SceS000004540
S000004442
GO:0005783 endoplasmic reticulum C
IDA
AthHMG1
SpoSPCC162.09c
GO:0005789 endoplasmic reticulum membrane C
EXP
HsaHMGCR
IDA
SceS000004442
S000004540
SpoSPCC162.09c
NAS
DmeFBgn0001205
GO:0005792 microsome C
IDA
MmuMGI:96159
ISO
MmuMGI:96159
GO:0016020 membrane C
TAS
AthHMG1
GO:0016021 integral to membrane C
ISM
SceS000004540
S000004442
GO:0031965 nuclear membrane C
ISS
SpoSPCC162.09c
GO:0042175 nuclear membrane-endoplasmic reticulum
network		 C
IDA
SpoSPCC162.09c
GO:0004420 hydroxymethylglutaryl-CoA reductase (NADPH)
activity		 F
IDA
MmuMGI:96159
SceS000004540
SpoSPCC162.09c
IMP
SceS000004540
SpoSPCC162.09c
ISA
SceS000004442
ISS
DmeFBgn0001205
GO:0005515 protein binding F
IPI
SpoSPCC162.09c
GO:0042282 hydroxymethylglutaryl-CoA reductase
activity		 F
IGI
AthHMG1
ISO
MmuMGI:96159
ISS
AthHMG1
GO:0042803 protein homodimerization activity F
ISO
MmuMGI:96159
GO:0000003 reproduction P
IMP
CelWBGene00017268
GO:0002119 nematode larval development P
IMP
CelWBGene00017268
GO:0006066 alcohol metabolic process P
RCA
SceS000004540
GO:0006695 cholesterol biosynthetic process P
IDA
MmuMGI:96159
ISO
MmuMGI:96159
GO:0006696 ergosterol biosynthetic process P
IMP
SceS000004540
SpoSPCC162.09c
ISA
SceS000004442
GO:0006898 receptor-mediated endocytosis P
IMP
CelWBGene00017268
GO:0007047 cellular cell wall organization P
IMP
SpoSPCC162.09c
GO:0007280 pole cell migration P
IGI
DmeFBgn0001205
IMP
DmeFBgn0001205
TAS
DmeFBgn0001205
GO:0008299 isoprenoid biosynthetic process P
ISO
MmuMGI:96159
ISS
AthHMG1
NAS
DmeFBgn0001205
TAS
AthHMG1
DmeFBgn0001205
GO:0008354 germ cell migration P
IMP
DmeFBgn0001205
TAS
DmeFBgn0001205
HsaHMGCR
GO:0008406 gonad development P
TAS
DmeFBgn0001205
HsaHMGCR
GO:0008542 visual learning P
IGI
MmuMGI:96159
GO:0009790 embryo development P
IMP
MmuMGI:96159
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00017268
GO:0010142 farnesyl diphosphate biosynthetic process,
mevalonate pathway		 P
ISS
SpoSPCC162.09c
GO:0016126 sterol biosynthetic process P
IMP
AthHMG1
GO:0019287 isopentenyl diphosphate biosynthetic process,
mevalonate pathway		 P
IC
SceS000004540
GO:0019915 lipid storage P
IMP
CelWBGene00017268
GO:0035050 embryonic heart tube development P
IMP
DmeFBgn0001205
GO:0035232 germ cell attraction P
TAS
DmeFBgn0001205
GO:0040007 growth P
IMP
CelWBGene00017268
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00017268
GO:0040011 locomotion P
IMP
CelWBGene00017268
GO:0043407 negative regulation of MAP kinase
activity		 P
IGI
MmuMGI:96159
GO:0045184 establishment of protein localization P
RCA
SceS000004442
S000004540
GO:0048643 positive regulation of skeletal muscle tissue
development		 P
ISO
MmuMGI:96159

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_1286

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga4437 ENSANGP00000006223
Ashbya gossypii (Ago) ago2655 AER152W
Arabidopsis thaliana (Ath) ath6971 At1g76490.1
Arabidopsis thaliana (Ath) ath8581 At2g17370.1
Caenorhabditis elegans (Cel) cel5684 F08F8.2
(CE30649;
WBGene00017268)
Candida glabrata (Cgl) cgl4576 CAGL0L11506g
Cryptococcus neoformans (Cne) cne1293 180.m00238
Dictyostelium discoideum (Ddi) ddi11373 DDB0191125
Dictyostelium discoideum (Ddi) ddi11860 DDB0215357
Debaryomyces hansenii (Dha) dha2753 DEHA0D10307g
Drosophila melanogaster (Dme) dme14062 CG10367-PA
(FBgn0001205)
Drosophila melanogaster (Dme) dme14063 CG10367-PB
(FBgn0001205)
Danio rerio (Dre) dre19823 ENSDARP00000011999
Danio rerio (Dre) dre19822 ENSDARP00000022691
Danio rerio (Dre) dre13212 ENSDARP00000041880
Danio rerio (Dre) dre13215 ENSDARP00000043198
Danio rerio (Dre) dre13214 ENSDARP00000044157
Danio rerio (Dre) dre13213 ENSDARP00000045493
Danio rerio (Dre) dre19824 ENSDARP00000047695
Encephalitozoon cuniculi (Ecu) ecu699 19074783
Takifugu rubripes (Fru) fru3042 SINFRUP00000130864
Takifugu rubripes (Fru) fru3044 SINFRUP00000130867
Takifugu rubripes (Fru) fru10341 SINFRUP00000151948
Takifugu rubripes (Fru) fru10340 SINFRUP00000151950
Takifugu rubripes (Fru) fru10342 SINFRUP00000171635
Takifugu rubripes (Fru) fru3043 SINFRUP00000175692
Gallus gallus (Gga) gga27688 ENSGALP00000024068
(HMGCR)
Homo sapiens (Hsa) hsa25396 ENSP00000287936
(HMGCR)		 P04035-1
Homo sapiens (Hsa) hsa25395 ENSP00000340816
(HMGCR)		 P04035-2
Kluyveromyces lactis (Kla) kla738 KLLA0B04642g
Mus musculus (Mmu) mmu7416 ENSMUSP00000070103
Neurospora crassa (Ncr) ncr690 NCU00712.2
Oryza sativa (Osa) osa16280 3130.m00142
Oryza sativa (Osa) osa19908 3509.m00221
Rattus norvegicus (Rno) rno15387 ENSRNOP00000022055
(RGD:2803)		 P51639
Saccharomyces cerevisiae (Sce) sce4575 YLR450W
(S000004442)
Saccharomyces cerevisiae (Sce) sce4679 YML075C
(S000004540)
Schizosaccharomyces pombe (Spo) spo1242 SPCC162.09c Q10283
Yarrowia lipolytica (Yli) yli4062 YALI0E04807g