Bahler Lab

Search term: YML087C

Gene summary:

Species Saccharomyces cerevisiae (Sce)

Primary name AIM33

SGD link S000004552

Alternative ID YML087C

Description Putative protein of unknown function, highly conserved across species and orthologous to human CYB5R4; null mutant displays reduced frequency of mitochondrial genome loss

Synonyms YML087C

Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

Search for gene by ID or name:

Query species:

Include wild-cards: Yes No

Search for GO info: Yes No

GO info in one table: Yes No

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)

KOG0534 ACDHYP-

KOGs classification KOGs description

METABOLISMMETABOLISM NADH-cytochrome b-5 reductase

GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations

GO:0005575 cellular_component C
ND
Sce S000004552

GO:0005739 mitochondrion C
IDA
Ath At5g20080
Sce S000001305
S000001633
S000005563
Spo SPAC17H9.12c

GO:0005741 mitochondrial outer membrane C
IDA
Sce S000001305
S000001633
ISS
Spo SPAC17H9.12c

GO:0005758 mitochondrial intermembrane space C
IDA
Sce S000001633
ISS
Spo SPAC17H9.12c

GO:0005773 vacuole C
IDA
Ath At1g37130

GO:0005783 endoplasmic reticulum C
IDA
Ath At5g17770
Hsa CYB5R3
Sce S000004594
Spo SPCC970.03

GO:0005789 endoplasmic reticulum membrane C
IC
Spo SPCC970.03

GO:0005792 microsome C
IDA
Sce S000001305

GO:0005829 cytosol C
TAS
Ath At1g77760

GO:0005833 hemoglobin complex C
TAS
Hsa CYB5R3

GO:0005886 plasma membrane C
IDA
Ath At1g37130
At5g17770
Sce S000004594

GO:0009505 plant-type cell wall C
IDA
Ath At5g17770
At5g20080

GO:0031307 integral to mitochondrial outer
membrane C
IDA
Sce S000001633

GO:0031314 extrinsic to mitochondrial inner
membrane C
IDA
Sce S000005563

GO:0003674 molecular_function F
ND
Sce S000004552
S000004594

GO:0004128 cytochrome-b5 reductase activity F
IDA
Ath At5g17770
Sce S000001305
S000001633
ISS
Ath At5g20080
Spo SPAC17H9.12c
SPCC970.03

GO:0005507 copper ion binding F
IDA
Ath At5g20080

GO:0005515 protein binding F
IPI
Ath At1g77760

GO:0008940 nitrate reductase activity F
IDA
Ath At1g37130
IMP
Ath At1g77760
ISS
Ath At1g37130

GO:0009703 nitrate reductase (NADH) activity F
IDA
Ath At1g37130

GO:0016491 oxidoreductase activity F
IDA
Sce S000005563
RCA
Sce S000004594

GO:0050660 FAD binding F
ISS
Spo SPCC970.03

GO:0051287 NAD or NADH binding F
ISS
Spo SPCC970.03

GO:0001300 chronological cell aging P
IMP
Sce S000004594

GO:0001302 replicative cell aging P
IMP
Sce S000004594

GO:0002119 nematode larval development P
IMP
Cel WBGene00020268

GO:0006696 ergosterol biosynthetic process P
IDA
Sce S000001633
ISS
Spo SPAC17H9.12c

GO:0006809 nitric oxide biosynthetic process P
IMP
Ath At1g37130
At1g77760

GO:0006886 intracellular protein transport P
ISS
Spo SPCC970.03

GO:0006898 receptor-mediated endocytosis P
IMP
Cel WBGene00020268

GO:0007006 mitochondrial membrane organization P
IMP
Sce S000005563

GO:0008015 blood circulation P
TAS
Hsa CYB5R3

GO:0008150 biological_process P
ND
Sce S000001305
S000004552

GO:0009416 response to light stimulus P
IMP
Ath At1g77760
At1g37130

GO:0009610 response to symbiotic fungus P
IEP
Ath At1g37130

GO:0009651 response to salt stress P
IEP
Ath At5g20080

GO:0009792 embryo development ending in birth or egg
hatching P
IMP
Cel WBGene00020268

GO:0015031 protein transport P
IMP
Sce S000004594

GO:0016192 vesicle-mediated transport P
IC
Spo SPCC970.03

GO:0018063 cytochrome c-heme linkage P
IGI
Sce S000005563

GO:0018193 peptidyl-amino acid modification P
RCA
Sce S000004594

GO:0022900 electron transport chain P
IDA
Ath At5g17770

GO:0031329 regulation of cellular catabolic
process P
RCA
Sce S000005563

GO:0032940 secretion by cell P
IMP
Cel WBGene00020267

GO:0034599 cellular response to oxidative
stress P
IMP
Sce S000001633
ISS
Spo SPAC17H9.12c

GO:0040007 growth P
IMP
Cel WBGene00020268

GO:0040010 positive regulation of growth rate P
IMP
Cel WBGene00020267
WBGene00020268

GO:0042128 nitrate assimilation P
IMP
Ath At1g77760
At1g37130

GO:0055114 oxidation reduction P
RCA
Sce S000001633

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern

OG1_1036

Species OrthoMCL
sequence Model organism
protein page UniProt link

Anopheles gambiae (Aga) aga8375 ENSANGP00000008218

Arabidopsis thaliana (Ath) ath23162 At5g09680.1

Caenorhabditis elegans (Cel) cel19568 Y52B11A.3a
(CE41283;
WBGene00013123)

Caenorhabditis elegans (Cel) cel19569 Y52B11A.3b
(CE41284)

Candida glabrata (Cgl) cgl3653 CAGL0K03069g

Cryptococcus neoformans (Cne) cne2871 183.m01880

Dictyostelium discoideum (Ddi) ddi2353 DDB0167227

Dictyostelium discoideum (Ddi) ddi9781 DDB0219593

Debaryomyces hansenii (Dha) dha2586 DEHA0D06501g

Drosophila melanogaster (Dme) dme6028 CG11257-PA
(FBgn0034442)

Danio rerio (Dre) dre6647 ENSDARP00000003991

Danio rerio (Dre) dre6648 ENSDARP00000048688

Encephalitozoon cuniculi (Ecu) ecu1761 19075124

Takifugu rubripes (Fru) fru10044 SINFRUP00000150852

Takifugu rubripes (Fru) fru10045 SINFRUP00000165954

Takifugu rubripes (Fru) fru10046 SINFRUP00000174874

Gallus gallus (Gga) gga15732 ENSGALP00000025496

Gallus gallus (Gga) gga15733 ENSGALP00000025497
(CYB5R4)

Gallus gallus (Gga) gga15734 ENSGALP00000025498

Homo sapiens (Hsa) hsa27454 ENSP00000265287

Kluyveromyces lactis (Kla) kla3783 KLLA0E18535g

Mus musculus (Mmu) mmu28041 ENSMUSP00000059660
(MGI:2386848) Q3TDX8-3

Mus musculus (Mmu) mmu28042 ENSMUSP00000074778

Mus musculus (Mmu) mmu28043 ENSMUSP00000075958

Mus musculus (Mmu) mmu28044 ENSMUSP00000077121

Neurospora crassa (Ncr) ncr5881 NCU06051.2

Neurospora crassa (Ncr) ncr7852 NCU08060.2

Oryza sativa (Osa) osa3221 2011.m00135

Oryza sativa (Osa) osa20475 3411.m00153

Oryza sativa (Osa) osa68456 7018.m00158

Plasmodium falciparum (Pfa) pfa4644 PFI0885w

Rattus norvegicus (Rno) rno29036 ENSRNOP00000013909
(RGD:621834) Q68EJ0-1

Rattus norvegicus (Rno) rno29037 ENSRNOP00000013975
(RGD:621834)

Rattus norvegicus (Rno) rno29034 ENSRNOP00000039062
(RGD:621834)

Rattus norvegicus (Rno) rno29035 ENSRNOP00000051230

Saccharomyces cerevisiae (Sce) sce4692 YML087C
(S000004552)

Saccharomyces cerevisiae (Sce) sce4825 YMR073C
(S000004677)

Schizosaccharomyces pombe (Spo) spo2252 SPAC1F12.10c Q10352

Schizosaccharomyces pombe (Spo) spo4742 SPCC330.03c O74875

Yarrowia lipolytica (Yli) yli2201 YALI0C11627g

GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations

GO:0005575 cellular_component C
ND
Sce S000004552

GO:0005634 nucleus C
IDA
Spo SPAC1F12.10c

GO:0005737 cytoplasm C
IDA
Sce S000004677
Spo SPCC330.03c
ISA
Mmu MGI:2386848

GO:0005783 endoplasmic reticulum C
IDA
Mmu MGI:2386848

GO:0005829 cytosol C
IDA
Ath At5g09680
Spo SPAC1F12.10c

GO:0003674 molecular_function F
ND
Sce S000004677
S000004552

GO:0003958 NADPH-hemoprotein reductase activity F
ISO
Mmu MGI:2386848
ISS
Spo SPCC330.03c
SPAC1F12.10c

GO:0004128 cytochrome-b5 reductase activity F
IDA
Mmu MGI:2386848
ISA
Mmu MGI:2386848

GO:0005515 protein binding F
IPI
Mmu MGI:2386848

GO:0020037 heme binding F
ISA
Mmu MGI:2386848
ISO
Mmu MGI:2386848
ISS
Spo SPAC1F12.10c
SPCC330.03c

GO:0050660 FAD binding F
ISO
Mmu MGI:2386848

GO:0006414 translational elongation P
RCA
Sce S000004677

GO:0006739 NADP metabolic process P
ISO
Mmu MGI:2386848

GO:0008150 biological_process P
ND
Sce S000004552

GO:0008152 metabolic process P
IDA
Mmu MGI:2386848

GO:0010311 lateral root formation P
IMP
Ath At5g09680

GO:0030073 insulin secretion P
IMP
Mmu MGI:2386848

GO:0033554 cellular response to stress P
IEP
Spo SPCC330.03c

GO:0040007 growth P
IMP
Cel WBGene00013123

GO:0042168 heme metabolic process P
IC
Spo SPAC1F12.10c
SPCC330.03c
ISA
Mmu MGI:2386848

GO:0042493 response to drug P
IMP
Sce S000004677

GO:0042593 glucose homeostasis P
IMP
Mmu MGI:2386848

GO:0046677 response to antibiotic P
IMP
Mmu MGI:2386848

GO:0048468 cell development P
IMP
Mmu MGI:2386848

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Curated yeast ortholog results:

S. pombe
systematic ID S. cerevisiae
systematic ID

SPCC970.03
(O74557) YML087C
(S000004552)

GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations

GO:0005575 cellular_component C
ND
Sce S000004552

GO:0005783 endoplasmic reticulum C
IDA
Spo SPCC970.03

GO:0005789 endoplasmic reticulum membrane C
IC
Spo SPCC970.03

GO:0003674 molecular_function F
ND
Sce S000004552

GO:0004128 cytochrome-b5 reductase activity F
ISS
Spo SPCC970.03

GO:0050660 FAD binding F
ISS
Spo SPCC970.03

GO:0051287 NAD or NADH binding F
ISS
Spo SPCC970.03

GO:0006886 intracellular protein transport P
ISS
Spo SPCC970.03

GO:0008150 biological_process P
ND
Sce S000004552

GO:0016192 vesicle-mediated transport P
IC
Spo SPCC970.03

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YOGY Home

YOGY Help

Search for gene by ID or name:

Query species:

Include wild-cards: Yes No

Search for GO info: Yes No

GO info in one table: Yes No

s.khadayate@ucl.ac.uk

KOG name	Phylogenetic pattern (and link to KOGs with this pattern)
KOG0534	ACDHYP-

KOGs classification	KOGs description
METABOLISMMETABOLISM	NADH-cytochrome b-5 reductase

Species	KOG link	NCBI link	UniProt link
Arabidopsis thaliana (Ath)	At1g37130_3	GI:15221314
Arabidopsis thaliana (Ath)	At1g77760_3	GI:15218104
Arabidopsis thaliana (Ath)	At5g17770	GI:15238025
Arabidopsis thaliana (Ath)	At5g20080	GI:15241263
Caenorhabditis elegans (Cel)	CE13275 (WBGene00020267)	GI:17563926	O16522
Caenorhabditis elegans (Cel)	CE13277 (WBGene00020268)	GI:17563928	O16521
Caenorhabditis elegans (Cel)	CE20292_2	GI:17510203
Drosophila melanogaster (Dme)	7293557	GI:7293557	Q9VWK8
Drosophila melanogaster (Dme)	7294666	GI:7294666	Q0E8F5
Drosophila melanogaster (Dme)	7302484_2	GI:7302484	A1ZBK6
Homo sapiens (Hsa)	Hs7705899_2	GI:7705899
Homo sapiens (Hsa)	Hs7706443	GI:7706443
Homo sapiens (Hsa)	Hs7706455	GI:7706455
Homo sapiens (Hsa)	Hs4503327 (CYB5R3)	GI:4503327	P00387
Homo sapiens (Hsa)	Hs14735899	GI:14735899
Homo sapiens (Hsa)	Hs20474889	GI:20474889
Homo sapiens (Hsa)	Hs19923907 (OXNAD1)	GI:19923907	Q96HP4
Homo sapiens (Hsa)	Hs6552328	GI:6552328	P00387
Saccharomyces cerevisiae (Sce)	YIL043c (S000001305)	GI:6322146
Saccharomyces cerevisiae (Sce)	YKL150w (S000001633)	GI:6322699	P36060
Saccharomyces cerevisiae (Sce)	YML087c (S000004552)	GI:6323552	Q04516
Saccharomyces cerevisiae (Sce)	YML125c (S000004594)	GI:6323510	Q12746
Saccharomyces cerevisiae (Sce)	YOR037w (S000005563)	GI:6324611
Schizosaccharomyces pombe (Spo)	SPAC17H9.12c	GI:19114494	O13809
Schizosaccharomyces pombe (Spo)	SPCC970.03	GI:19075352	O74557
Arabidopsis thaliana (Ath)	At1g37130_3	GI:15221314
Arabidopsis thaliana (Ath)	At1g77760_3	GI:15218104
Arabidopsis thaliana (Ath)	At5g17770	GI:15238025
Arabidopsis thaliana (Ath)	At5g20080	GI:15241263
Caenorhabditis elegans (Cel)	CE13275 (WBGene00020267)	GI:17563926	O16522
Caenorhabditis elegans (Cel)	CE13277 (WBGene00020268)	GI:17563928	O16521
Caenorhabditis elegans (Cel)	CE20292_2	GI:17510203
Drosophila melanogaster (Dme)	7293557	GI:7293557	Q9VWK8
Drosophila melanogaster (Dme)	7294666	GI:7294666	Q0E8F5
Drosophila melanogaster (Dme)	7302484_2	GI:7302484	A1ZBK6
Homo sapiens (Hsa)	Hs7705899_2	GI:7705899
Homo sapiens (Hsa)	Hs7706443	GI:7706443
Homo sapiens (Hsa)	Hs7706455	GI:7706455
Homo sapiens (Hsa)	Hs4503327 (CYB5R3)	GI:4503327	P00387
Homo sapiens (Hsa)	Hs14735899	GI:14735899
Homo sapiens (Hsa)	Hs20474889	GI:20474889
Homo sapiens (Hsa)	Hs19923907 (OXNAD1)	GI:19923907	Q96HP4
Homo sapiens (Hsa)	Hs6552328	GI:6552328	P00387
Saccharomyces cerevisiae (Sce)	YIL043c (S000001305)	GI:6322146
Saccharomyces cerevisiae (Sce)	YKL150w (S000001633)	GI:6322699	P36060
Saccharomyces cerevisiae (Sce)	YML087c (S000004552)	GI:6323552	Q04516
Saccharomyces cerevisiae (Sce)	YML125c (S000004594)	GI:6323510	Q12746
Saccharomyces cerevisiae (Sce)	YOR037w (S000005563)	GI:6324611
Schizosaccharomyces pombe (Spo)	SPAC17H9.12c	GI:19114494	O13809
Schizosaccharomyces pombe (Spo)	SPCC970.03	GI:19075352	O74557
Arabidopsis thaliana (Ath)	At1g37130_3	GI:15221314
Arabidopsis thaliana (Ath)	At1g77760_3	GI:15218104
Arabidopsis thaliana (Ath)	At5g17770	GI:15238025
Arabidopsis thaliana (Ath)	At5g20080	GI:15241263
Caenorhabditis elegans (Cel)	CE13275 (WBGene00020267)	GI:17563926	O16522
Caenorhabditis elegans (Cel)	CE13277 (WBGene00020268)	GI:17563928	O16521
Caenorhabditis elegans (Cel)	CE20292_2	GI:17510203
Drosophila melanogaster (Dme)	7293557	GI:7293557	Q9VWK8
Drosophila melanogaster (Dme)	7294666	GI:7294666	Q0E8F5
Drosophila melanogaster (Dme)	7302484_2	GI:7302484	A1ZBK6
Homo sapiens (Hsa)	Hs7705899_2	GI:7705899
Homo sapiens (Hsa)	Hs7706443	GI:7706443
Homo sapiens (Hsa)	Hs7706455	GI:7706455
Homo sapiens (Hsa)	Hs4503327 (CYB5R3)	GI:4503327	P00387
Homo sapiens (Hsa)	Hs14735899	GI:14735899
Homo sapiens (Hsa)	Hs20474889	GI:20474889
Homo sapiens (Hsa)	Hs19923907 (OXNAD1)	GI:19923907	Q96HP4
Homo sapiens (Hsa)	Hs6552328	GI:6552328	P00387
Saccharomyces cerevisiae (Sce)	YIL043c (S000001305)	GI:6322146
Saccharomyces cerevisiae (Sce)	YKL150w (S000001633)	GI:6322699	P36060
Saccharomyces cerevisiae (Sce)	YML087c (S000004552)	GI:6323552	Q04516
Saccharomyces cerevisiae (Sce)	YML125c (S000004594)	GI:6323510	Q12746
Saccharomyces cerevisiae (Sce)	YOR037w (S000005563)	GI:6324611
Schizosaccharomyces pombe (Spo)	SPAC17H9.12c	GI:19114494	O13809
Schizosaccharomyces pombe (Spo)	SPCC970.03	GI:19075352	O74557

Species	OrthoMCL sequence	Model organism protein page	UniProt link
Anopheles gambiae (Aga)	aga8375	ENSANGP00000008218
Arabidopsis thaliana (Ath)	ath23162	At5g09680.1
Caenorhabditis elegans (Cel)	cel19568	Y52B11A.3a (CE41283; WBGene00013123)
Caenorhabditis elegans (Cel)	cel19569	Y52B11A.3b (CE41284)
Candida glabrata (Cgl)	cgl3653	CAGL0K03069g
Cryptococcus neoformans (Cne)	cne2871	183.m01880
Dictyostelium discoideum (Ddi)	ddi2353	DDB0167227
Dictyostelium discoideum (Ddi)	ddi9781	DDB0219593
Debaryomyces hansenii (Dha)	dha2586	DEHA0D06501g
Drosophila melanogaster (Dme)	dme6028	CG11257-PA (FBgn0034442)
Danio rerio (Dre)	dre6647	ENSDARP00000003991
Danio rerio (Dre)	dre6648	ENSDARP00000048688
Encephalitozoon cuniculi (Ecu)	ecu1761	19075124
Takifugu rubripes (Fru)	fru10044	SINFRUP00000150852
Takifugu rubripes (Fru)	fru10045	SINFRUP00000165954
Takifugu rubripes (Fru)	fru10046	SINFRUP00000174874
Gallus gallus (Gga)	gga15732	ENSGALP00000025496
Gallus gallus (Gga)	gga15733	ENSGALP00000025497 (CYB5R4)
Gallus gallus (Gga)	gga15734	ENSGALP00000025498
Homo sapiens (Hsa)	hsa27454	ENSP00000265287
Kluyveromyces lactis (Kla)	kla3783	KLLA0E18535g
Mus musculus (Mmu)	mmu28041	ENSMUSP00000059660 (MGI:2386848)	Q3TDX8-3
Mus musculus (Mmu)	mmu28042	ENSMUSP00000074778
Mus musculus (Mmu)	mmu28043	ENSMUSP00000075958
Mus musculus (Mmu)	mmu28044	ENSMUSP00000077121
Neurospora crassa (Ncr)	ncr5881	NCU06051.2
Neurospora crassa (Ncr)	ncr7852	NCU08060.2
Oryza sativa (Osa)	osa3221	2011.m00135
Oryza sativa (Osa)	osa20475	3411.m00153
Oryza sativa (Osa)	osa68456	7018.m00158
Plasmodium falciparum (Pfa)	pfa4644	PFI0885w
Rattus norvegicus (Rno)	rno29036	ENSRNOP00000013909 (RGD:621834)	Q68EJ0-1
Rattus norvegicus (Rno)	rno29037	ENSRNOP00000013975 (RGD:621834)
Rattus norvegicus (Rno)	rno29034	ENSRNOP00000039062 (RGD:621834)
Rattus norvegicus (Rno)	rno29035	ENSRNOP00000051230
Saccharomyces cerevisiae (Sce)	sce4692	YML087C (S000004552)
Saccharomyces cerevisiae (Sce)	sce4825	YMR073C (S000004677)
Schizosaccharomyces pombe (Spo)	spo2252	SPAC1F12.10c	Q10352
Schizosaccharomyces pombe (Spo)	spo4742	SPCC330.03c	O74875
Yarrowia lipolytica (Yli)	yli2201	YALI0C11627g

S. pombe systematic ID	S. cerevisiae systematic ID
SPCC970.03 (O74557)	YML087C (S000004552)