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Search term: YML121W


Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name GTR1
SGD link S000004590
Alternative ID YML121W
Description Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB
Synonyms YML121W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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Query species:

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GO info in one table:


KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG3886 -CDHYP-

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALING GTP-binding protein

Species KOG link NCBI link UniProt link
Caenorhabditis elegans (Cel) CE02361
(WBGene00006414)
GI:17536467 Q22743
Caenorhabditis elegans (Cel) CE28471
(WBGene00019014)
GI:17568261 Q20940
Drosophila melanogaster (Dme) 7299113 GI:7299113
Homo sapiens (Hsa) Hs4504669
(IL4)
GI:4504669 P05112
Homo sapiens (Hsa) Hs5729999
(RRAGA)
GI:5729999 Q7L523
Homo sapiens (Hsa) Hs8051627 GI:8051627
Homo sapiens (Hsa) Hs8051629 GI:8051629
Saccharomyces cerevisiae (Sce) YML121w
(S000004590)
GI:6323514 Q00582
Schizosaccharomyces pombe (Spo) SPBC337.13c GI:19112206 O74824


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000322 storage vacuole C
RCA
SceS000004590
GO:0000323 lytic vacuole C
RCA
SceS000004590
GO:0000324 fungal-type vacuole C
RCA
SceS000004590
GO:0000329 fungal-type vacuole membrane C
RCA
SceS000004590
GO:0005615 extracellular space C
TAS
HsaIL4
GO:0005634 nucleus C
IDA
HsaRRAGA
SceS000004590
SpoSPBC337.13c
ISS
SpoSPBC337.13c
GO:0005737 cytoplasm C
IDA
HsaRRAGA
SceS000004590
ISS
SpoSPBC337.13c
GO:0005774 vacuolar membrane C
IDA
SceS000004590
GO:0005794 Golgi apparatus C
IDA
HsaRRAGA
GO:0005829 cytosol C
IDA
SpoSPBC337.13c
GO:0031902 late endosome membrane C
IDA
SceS000004590
GO:0034449 GSE complex C
IDA
SceS000004590
GO:0043231 intracellular membrane-bounded
organelle
C
IDA
HsaRRAGA
GO:0005136 interleukin-4 receptor binding F
TAS
HsaIL4
GO:0005515 protein binding F
IPI
HsaRRAGA
IL4
GO:0005525 GTP binding F
IDA
HsaRRAGA
SceS000004590
ISS
SpoSPBC337.13c
GO:0008083 growth factor activity F
NAS
HsaIL4
GO:0016563 transcription activator activity F
IDA
HsaIL4
GO:0016564 transcription repressor activity F
IDA
HsaIL4
GO:0019003 GDP binding F
IDA
SceS000004590
GO:0042803 protein homodimerization activity F
IDA
HsaRRAGA
GO:0046982 protein heterodimerization activity F
IPI
HsaRRAGA
GO:0051219 phosphoprotein binding F
IDA
HsaRRAGA
GO:0006348 chromatin silencing at telomere P
IMP
SceS000004590
GO:0006360 transcription from RNA polymerase I
promoter
P
IMP
SceS000004590
IPI
SceS000004590
GO:0006383 transcription from RNA polymerase III
promoter
P
IMP
SceS000004590
IPI
SceS000004590
GO:0006811 ion transport P
RCA
SceS000004590
GO:0006817 phosphate transport P
IMP
SceS000004590
GO:0006935 chemotaxis P
TAS
HsaIL4
GO:0006955 immune response P
TAS
HsaIL4
GO:0006968 cellular defense response P
TAS
HsaIL4
GO:0006974 response to DNA damage stimulus P
IMP
CelWBGene00019014
GO:0007264 small GTPase mediated signal transduction P
NAS
SpoSPBC337.13c
GO:0008203 cholesterol metabolic process P
ISS
HsaIL4
GO:0008219 cell death P
IDA
HsaRRAGA
GO:0016481 negative regulation of transcription P
IDA
HsaIL4
GO:0019048 virus-host interaction P
IDA
HsaRRAGA
GO:0030183 B cell differentiation P
TAS
HsaIL4
GO:0030890 positive regulation of B cell proliferation P
ISS
HsaIL4
GO:0042092 T-helper 2 type immune response P
TAS
HsaIL4
GO:0042102 positive regulation of T cell proliferation P
ISS
HsaIL4
GO:0042325 regulation of phosphorylation P
ISS
HsaIL4
GO:0043066 negative regulation of apoptosis P
ISS
HsaIL4
GO:0045189 connective tissue growth factor biosynthetic
process
P
TAS
HsaIL4
GO:0045191 regulation of isotype switching P
TAS
HsaIL4
GO:0045348 positive regulation of MHC class II biosynthetic
process
P
ISS
HsaIL4
GO:0045671 negative regulation of osteoclast
differentiation
P
ISS
HsaIL4
GO:0045919 positive regulation of cytolysis P
IDA
HsaRRAGA
GO:0045941 positive regulation of transcription P
IDA
HsaIL4
GO:0045944 positive regulation of transcription from RNA
polymerase II promoter
P
ISS
HsaIL4
GO:0048295 positive regulation of isotype switching to IgE
isotypes
P
ISS
HsaIL4
GO:0048304 positive regulation of isotype switching to IgG
isotypes
P
ISS
HsaIL4
GO:0050776 regulation of immune response P
ISS
HsaIL4
GO:0050801 ion homeostasis P
RCA
SceS000004590

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
68852

Species Gene ID NCBI link UniProt link
Saccharomyces cerevisiae (Sce) GTR1
(S000004590)
GI:6323514 Q00582
Kluyveromyces lactis (Kla) KLLA0C06358g GI:50305047
Eremothecium gossypii (Ego) AGOS_AFR446W GI:45198964
Magnaporthe grisea (Mgr) MGG_04881 GI:39940718
Neurospora crassa (Ncr) NCU01099.1 GI:32412224


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000322 storage vacuole C
RCA
SceS000004590
GO:0000323 lytic vacuole C
RCA
SceS000004590
GO:0000324 fungal-type vacuole C
RCA
SceS000004590
GO:0000329 fungal-type vacuole membrane C
RCA
SceS000004590
GO:0005634 nucleus C
IDA
SceS000004590
GO:0005737 cytoplasm C
IDA
SceS000004590
GO:0005774 vacuolar membrane C
IDA
SceS000004590
GO:0031902 late endosome membrane C
IDA
SceS000004590
GO:0034449 GSE complex C
IDA
SceS000004590
GO:0005525 GTP binding F
IDA
SceS000004590
GO:0019003 GDP binding F
IDA
SceS000004590
GO:0006348 chromatin silencing at telomere P
IMP
SceS000004590
GO:0006360 transcription from RNA polymerase I
promoter
P
IMP
SceS000004590
IPI
SceS000004590
GO:0006383 transcription from RNA polymerase III
promoter
P
IMP
SceS000004590
IPI
SceS000004590
GO:0006811 ion transport P
RCA
SceS000004590
GO:0006817 phosphate transport P
IMP
SceS000004590
GO:0050801 ion homeostasis P
RCA
SceS000004590

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_2660

Species OrthoMCL
sequence
Model organism
protein page
UniProt link
Anopheles gambiae (Aga) aga5244 ENSANGP00000018255
Ashbya gossypii (Ago) ago3638 AFR446W
Caenorhabditis elegans (Cel) cel16271 T24F1.1
(CE02361;
WBGene00006414)
Candida glabrata (Cgl) cgl311 CAGL0B02453g
Cryptococcus neoformans (Cne) cne2482 181.m08523
Dictyostelium discoideum (Ddi) ddi13144 DDB0230043
Debaryomyces hansenii (Dha) dha2441 DEHA0D03267g
Drosophila melanogaster (Dme) dme11607 CG11968-PA
(FBgn0037647)
Takifugu rubripes (Fru) fru27482 SINFRUP00000150511
Takifugu rubripes (Fru) fru27481 SINFRUP00000171847
Gallus gallus (Gga) gga16995 ENSGALP00000012233
(RRAGB)
Gallus gallus (Gga) gga16994 ENSGALP00000012234
(RRAGB)
Homo sapiens (Hsa) hsa32881 ENSP00000262850
(RRAGB)
Q5VZM2-1
Homo sapiens (Hsa) hsa32882 ENSP00000262851
Homo sapiens (Hsa) hsa31054 ENSP00000286334
Kluyveromyces lactis (Kla) kla1480 KLLA0C06358g
Mus musculus (Mmu) mmu29750 ENSMUSP00000039013
(MGI:3038613)
Q6NTA4
Mus musculus (Mmu) mmu18370 ENSMUSP00000057660
Mus musculus (Mmu) mmu29751 ENSMUSP00000077401
Neurospora crassa (Ncr) ncr1063 NCU01099.2
Rattus norvegicus (Rno) rno31144 ENSRNOP00000004235
(RGD:619805)
Q63487-1
Rattus norvegicus (Rno) rno23372 ENSRNOP00000009225
(RGD:619804)
Q63486
Rattus norvegicus (Rno) rno31145 ENSRNOP00000044934
Saccharomyces cerevisiae (Sce) sce4731 YML121W
(S000004590)
Schizosaccharomyces pombe (Spo) spo3453 SPBC337.13c O74824
Yarrowia lipolytica (Yli) yli335 YALI0A10098g