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Search term: YML124C

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name TUB3
SGD link S000004593
Alternative ID YML124C
Description Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; expressed at lower level than Tub1p
Synonyms YML124C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG1376 ACDHYPE

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALING Alpha tubulin

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At1g04820 GI:15220329
Arabidopsis thaliana (Ath) At1g50010 GI:15222856
Arabidopsis thaliana (Ath) At1g64740 GI:15217737
Arabidopsis thaliana (Ath) At4g14960 GI:15233627
Arabidopsis thaliana (Ath) At5g19770 GI:15241168
Arabidopsis thaliana (Ath) At5g19780 GI:15241179
Caenorhabditis elegans (Cel) CE03837 GI:17570755
Caenorhabditis elegans (Cel) CE04535 GI:17567599
Caenorhabditis elegans (Cel) CE09434
(WBGene00006531)		 GI:17506673 Q19490
Caenorhabditis elegans (Cel) CE09692
(WBGene00006528)		 GI:17509355 O18688
Caenorhabditis elegans (Cel) CE09884 GI:17509357
Caenorhabditis elegans (Cel) CE16521
(WBGene00006533)		 GI:17555336 O18154
Caenorhabditis elegans (Cel) CE17563
(WBGene00006529)		 GI:17506073
Caenorhabditis elegans (Cel) CE18680
(WBGene00006530)		 GI:17534029 Q20409
Caenorhabditis elegans (Cel) CE19055
(WBGene00012489)		 GI:17536957 Q9XXH2
Caenorhabditis elegans (Cel) CE24843
(WBGene00003175)		 GI:17554312 P91910
Caenorhabditis elegans (Cel) CE27866 GI:14530380
Drosophila melanogaster (Dme) 7294896 GI:17647151
Drosophila melanogaster (Dme) 7298798
(alphaTub84D)		 GI:17737821 A4V2J2
Drosophila melanogaster (Dme) 7299237
(alphaTub85E)		 GI:17865841
Drosophila melanogaster (Dme) 7300328 GI:7300328
Homo sapiens (Hsa) Hs13376181
(TUBAL3)		 GI:13376181 A6NHL2
Homo sapiens (Hsa) Hs13376539 GI:13376539
Homo sapiens (Hsa) Hs14389309
(TUBA1C)		 GI:14389309 Q9BQE3
Homo sapiens (Hsa) Hs15317880 GI:15317880
Homo sapiens (Hsa) Hs17437683 GI:17437683
Homo sapiens (Hsa) Hs17442820 GI:17442820
Homo sapiens (Hsa) Hs17477766 GI:17477766
Homo sapiens (Hsa) Hs17477991 GI:17477991
Homo sapiens (Hsa) Hs17921989 GI:6678467
Homo sapiens (Hsa) Hs17921991 GI:17921991
Homo sapiens (Hsa) Hs17921993 GI:6678465
Homo sapiens (Hsa) Hs17986283 GI:6755901
Homo sapiens (Hsa) Hs20480498 GI:20480498
Homo sapiens (Hsa) Hs20532817 GI:20532817
Homo sapiens (Hsa) Hs20535366 GI:20535366
Homo sapiens (Hsa) Hs20553809 GI:20553809
Homo sapiens (Hsa) Hs21450790 GI:14603022
Homo sapiens (Hsa) Hs22041015 GI:22041015
Homo sapiens (Hsa) Hs22041892_1 GI:22041892
Homo sapiens (Hsa) Hs22047212 GI:22047212
Homo sapiens (Hsa) Hs22059625 GI:22059625
Homo sapiens (Hsa) Hs22065448 GI:22065448
Homo sapiens (Hsa) Hs5174477 GI:5174477
Homo sapiens (Hsa) Hs9507215
(TUBA8)		 GI:9507215 Q9NY65
Saccharomyces cerevisiae (Sce) YML085c
(S000004550)		 GI:6323554 P09733
Saccharomyces cerevisiae (Sce) YML124c
(S000004593)		 GI:6323511 P09734
Schizosaccharomyces pombe (Spo) SPBC16A3.15c GI:19113566 P04688
Schizosaccharomyces pombe (Spo) SPBC800.05c GI:19111898 P04689
Encephalitozoon cuniculi (Ecu) ECU07g1190 GI:19074542 Q8SRI6


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005618 cell wall C
IDA
AthAt4g14960
At5g19770
At5g19780
At1g50010
At1g04820
GO:0005634 nucleus C
IDA
SpoSPBC800.05c
GO:0005730 nucleolus C
IDA
AthAt4g14960
GO:0005773 vacuole C
IDA
AthAt4g14960
GO:0005811 lipid particle C
IDA
DmealphaTub84D
GO:0005816 spindle pole body C
IDA
SceS000004593
S000004550
GO:0005827 polar microtubule C
TAS
SceS000004593
S000004550
GO:0005828 kinetochore microtubule C
TAS
SceS000004593
S000004550
GO:0005829 cytosol C
IDA
AthAt1g50010
At5g19770
At5g19780
At1g64740
At4g14960
At1g04820
SpoSPBC800.05c
GO:0005874 microtubule C
IDA
AthAt4g14960
CelWBGene00003175
ISS
DmealphaTub84D
alphaTub85E
NAS
DmealphaTub84D
alphaTub85E
TAS
SpoSPBC16A3.15c
SPBC800.05c
GO:0005880 nuclear microtubule C
TAS
SceS000004550
S000004593
GO:0005881 cytoplasmic microtubule C
TAS
SceS000004593
S000004550
GO:0005886 plasma membrane C
IDA
AthAt5g19770
At4g14960
At1g04820
At1g64740
GO:0009507 chloroplast C
IDA
AthAt1g04820
GO:0015630 microtubule cytoskeleton C
ISS
AthAt1g64740
GO:0016020 membrane C
IDA
AthAt4g14960
At1g50010
At5g19780
GO:0045298 tubulin complex C
IDA
AthAt4g14960
ISS
AthAt1g04820
At5g19770
At1g50010
At5g19780
NAS
DmealphaTub84D
alphaTub85E
TAS
SceS000004593
S000004550
GO:0005200 structural constituent of cytoskeleton F
IC
SpoSPBC16A3.15c
SPBC800.05c
ISS
AthAt5g19770
At1g04820
At4g14960
At5g19780
At1g50010
At1g64740
CelWBGene00003175
DmealphaTub85E
alphaTub84D
TAS
SceS000004593
S000004550
GO:0005515 protein binding F
IPI
AthAt4g14960
DmealphaTub84D
HsaTUBA1C
GO:0005525 GTP binding F
IC
SpoSPBC16A3.15c
SPBC800.05c
NAS
DmealphaTub84D
alphaTub85E
GO:0046982 protein heterodimerization activity F
IPI
SpoSPBC16A3.15c
SPBC800.05c
GO:0000003 reproduction P
IMP
CelWBGene00006529
WBGene00006530
WBGene00006528
WBGene00012489
GO:0000070 mitotic sister chromatid segregation P
TAS
SceS000004550
S000004593
GO:0000132 establishment of mitotic spindle
orientation		 P
IGI
CelWBGene00006529
WBGene00006528
GO:0000226 microtubule cytoskeleton organization P
IC
SpoSPBC16A3.15c
SPBC800.05c
IMP
AthAt4g14960
RCA
SceS000004550
GO:0000278 mitotic cell cycle P
RCA
SceS000004550
S000004593
GO:0000279 M phase P
RCA
SceS000004550
S000004593
GO:0000743 nuclear migration involved in conjugation with
cellular fusion		 P
TAS
SceS000004550
S000004593
GO:0000910 cytokinesis P
IMP
CelWBGene00006528
WBGene00006529
DmealphaTub84D
GO:0002009 morphogenesis of an epithelium P
IMP
CelWBGene00012489
WBGene00006530
GO:0002119 nematode larval development P
IMP
CelWBGene00006530
WBGene00006528
WBGene00006529
GO:0006898 receptor-mediated endocytosis P
IMP
CelWBGene00006530
WBGene00012489
GO:0007017 microtubule-based process P
IMP
CelWBGene00003175
ISS
AthAt1g64740
CelWBGene00003175
DmealphaTub84D
TAS
AthAt1g50010
At1g04820
At5g19780
GO:0007052 mitotic spindle organization P
IMP
CelWBGene00006528
WBGene00006529
DmealphaTub85E
GO:0007067 mitosis P
IMP
CelWBGene00006529
GO:0007094 mitotic cell cycle spindle assembly
checkpoint		 P
IDA
DmealphaTub85E
GO:0007163 establishment or maintenance of cell
polarity		 P
IMP
SpoSPBC800.05c
GO:0007416 synapse assembly P
IMP
CelWBGene00006528
GO:0007638 mechanosensory behavior P
IMP
CelWBGene00003175
GO:0008104 protein localization P
IMP
CelWBGene00006529
GO:0008340 determination of adult lifespan P
IMP
CelWBGene00006533
GO:0009415 response to water P
RCA
SceS000004593
GO:0009612 response to mechanical stimulus P
IMP
CelWBGene00003175
GO:0009651 response to salt stress P
IEP
AthAt1g50010
At4g14960
GO:0009792 embryo development ending in birth or egg
hatching		 P
IGI
CelWBGene00006529
WBGene00006528
IMP
CelWBGene00006530
WBGene00012489
WBGene00006528
WBGene00006529
GO:0009987 cellular process P
IMP
DmealphaTub84D
alphaTub85E
GO:0019915 lipid storage P
IMP
CelWBGene00006533
GO:0030473 nuclear migration along microtubule P
TAS
SceS000004550
S000004593
GO:0032465 regulation of cytokinesis P
IGI
CelWBGene00006528
WBGene00006529
GO:0035046 pronuclear migration P
IMP
CelWBGene00012489
WBGene00006530
WBGene00006528
WBGene00006529
GO:0040007 growth P
IMP
CelWBGene00006530
WBGene00006528
WBGene00006529
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00012489
WBGene00006530
GO:0040011 locomotion P
IMP
CelWBGene00012489
WBGene00006530
WBGene00006528
GO:0040017 positive regulation of locomotion P
IMP
CelWBGene00006530
GO:0040039 inductive cell migration P
IMP
CelWBGene00006530
WBGene00006528
WBGene00006529
WBGene00012489
GO:0045143 homologous chromosome segregation P
TAS
SceS000004550
S000004593
GO:0046686 response to cadmium ion P
IEP
AthAt1g04820
At5g19780
GO:0048311 mitochondrion distribution P
IMP
SpoSPBC800.05c
GO:0048675 axon extension P
IMP
CelWBGene00006528
GO:0051642 centrosome localization P
IMP
CelWBGene00006529
GO:0071258 cellular response to gravity P
IMP
AthAt5g19770
At4g14960
At1g04820

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
68498

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) TUBA1A GI:17986283
Pan troglodytes (Ptr) TUBA1A GI:55637947
Canis familiaris (Cfa) TUBA1A GI:57106374
Mus musculus (Mmu) Tuba1a
(MGI:98869)		 GI:6755901 P68369
Rattus norvegicus (Rno) Tuba1a GI:11560133
Drosophila melanogaster (Dme) alphaTub84B GI:17136564
Anopheles gambiae (Aga) AgaP_AGAP010971 GI:158287825
Caenorhabditis elegans (Cel) mec-12
(CE24843;
WBGene00003175)		 GI:17554312 P91910
Saccharomyces cerevisiae (Sce) TUB3
(S000004593)		 GI:6323511 P09734


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005816 spindle pole body C
IDA
SceS000004593
GO:0005819 spindle C
IDA
DmealphaTub84B
GO:0005827 polar microtubule C
TAS
SceS000004593
GO:0005828 kinetochore microtubule C
TAS
SceS000004593
GO:0005829 cytosol C
EXP
HsaTUBA1A
GO:0005874 microtubule C
IDA
CelWBGene00003175
ISS
DmealphaTub84B
NAS
DmealphaTub84B
GO:0005880 nuclear microtubule C
TAS
SceS000004593
GO:0005881 cytoplasmic microtubule C
IDA
MmuMGI:98869
TAS
SceS000004593
GO:0045298 tubulin complex C
NAS
DmealphaTub84B
TAS
SceS000004593
GO:0005200 structural constituent of cytoskeleton F
ISS
CelWBGene00003175
DmealphaTub84B
TAS
SceS000004593
GO:0005525 GTP binding F
NAS
DmealphaTub84B
GO:0019904 protein domain specific binding F
ISO
MmuMGI:98869
GO:0000070 mitotic sister chromatid segregation P
TAS
SceS000004593
GO:0000278 mitotic cell cycle P
RCA
SceS000004593
GO:0000279 M phase P
RCA
SceS000004593
GO:0000743 nuclear migration involved in conjugation with
cellular fusion		 P
TAS
SceS000004593
GO:0007017 microtubule-based process P
IMP
CelWBGene00003175
ISS
CelWBGene00003175
GO:0007052 mitotic spindle organization P
IMP
DmealphaTub84B
GO:0007094 mitotic cell cycle spindle assembly
checkpoint		 P
IDA
DmealphaTub84B
GO:0007638 mechanosensory behavior P
IMP
CelWBGene00003175
GO:0009415 response to water P
RCA
SceS000004593
GO:0009612 response to mechanical stimulus P
IMP
CelWBGene00003175
GO:0009987 cellular process P
IMP
DmealphaTub84B
GO:0019730 antimicrobial humoral response P
IMP
DmealphaTub84B
GO:0030473 nuclear migration along microtubule P
TAS
SceS000004593
GO:0045143 homologous chromosome segregation P
TAS
SceS000004593

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPBC800.05c
(P04689)		 YML124C
(S000004593)
SPBC16A3.15c
(P04688)		 YML124C
(S000004593)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SpoSPBC800.05c
GO:0005816 spindle pole body C
IDA
SceS000004593
GO:0005827 polar microtubule C
TAS
SceS000004593
GO:0005828 kinetochore microtubule C
TAS
SceS000004593
GO:0005829 cytosol C
IDA
SpoSPBC800.05c
GO:0005874 microtubule C
TAS
SpoSPBC16A3.15c
SPBC800.05c
GO:0005880 nuclear microtubule C
TAS
SceS000004593
GO:0005881 cytoplasmic microtubule C
TAS
SceS000004593
GO:0045298 tubulin complex C
TAS
SceS000004593
GO:0005200 structural constituent of cytoskeleton F
IC
SpoSPBC16A3.15c
SPBC800.05c
TAS
SceS000004593
GO:0005525 GTP binding F
IC
SpoSPBC16A3.15c
SPBC800.05c
GO:0046982 protein heterodimerization activity F
IPI
SpoSPBC16A3.15c
SPBC800.05c
GO:0000070 mitotic sister chromatid segregation P
TAS
SceS000004593
GO:0000226 microtubule cytoskeleton organization P
IC
SpoSPBC16A3.15c
SPBC800.05c
GO:0000278 mitotic cell cycle P
RCA
SceS000004593
GO:0000279 M phase P
RCA
SceS000004593
GO:0000743 nuclear migration involved in conjugation with
cellular fusion		 P
TAS
SceS000004593
GO:0007163 establishment or maintenance of cell
polarity		 P
IMP
SpoSPBC800.05c
GO:0009415 response to water P
RCA
SceS000004593
GO:0030473 nuclear migration along microtubule P
TAS
SceS000004593
GO:0045143 homologous chromosome segregation P
TAS
SceS000004593
GO:0048311 mitochondrion distribution P
IMP
SpoSPBC800.05c

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s.khadayate@ucl.ac.uk