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Search term: YML125C

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name PGA3
SGD link S000004594
Alternative ID YML125C
Description Putative cytochrome b5 reductase, localized to the plasma membrane; may be involved in regulation of lifespan; required for maturation of Gas1p and Pho8p, proposed to be involved in protein trafficking
Synonyms YML125C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG0534 ACDHYP-

KOGs classification KOGs description
METABOLISMMETABOLISM NADH-cytochrome b-5 reductase

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At1g37130_3 GI:15221314
Arabidopsis thaliana (Ath) At1g77760_3 GI:15218104
Arabidopsis thaliana (Ath) At5g17770 GI:15238025
Arabidopsis thaliana (Ath) At5g20080 GI:15241263
Caenorhabditis elegans (Cel) CE13275
(WBGene00020267)		 GI:17563926 O16522
Caenorhabditis elegans (Cel) CE13277
(WBGene00020268)		 GI:17563928 O16521
Caenorhabditis elegans (Cel) CE20292_2 GI:17510203
Drosophila melanogaster (Dme) 7293557 GI:7293557 Q9VWK8
Drosophila melanogaster (Dme) 7294666 GI:7294666 Q0E8F5
Drosophila melanogaster (Dme) 7302484_2 GI:7302484 A1ZBK6
Homo sapiens (Hsa) Hs7705899_2 GI:7705899
Homo sapiens (Hsa) Hs7706443 GI:7706443
Homo sapiens (Hsa) Hs7706455 GI:7706455
Homo sapiens (Hsa) Hs4503327
(CYB5R3)		 GI:4503327 P00387
Homo sapiens (Hsa) Hs14735899 GI:14735899
Homo sapiens (Hsa) Hs20474889 GI:20474889
Homo sapiens (Hsa) Hs19923907
(OXNAD1)		 GI:19923907 Q96HP4
Homo sapiens (Hsa) Hs6552328 GI:6552328 P00387
Saccharomyces cerevisiae (Sce) YIL043c
(S000001305)		 GI:6322146
Saccharomyces cerevisiae (Sce) YKL150w
(S000001633)		 GI:6322699 P36060
Saccharomyces cerevisiae (Sce) YML087c
(S000004552)		 GI:6323552 Q04516
Saccharomyces cerevisiae (Sce) YML125c
(S000004594)		 GI:6323510 Q12746
Saccharomyces cerevisiae (Sce) YOR037w
(S000005563)		 GI:6324611
Schizosaccharomyces pombe (Spo) SPAC17H9.12c GI:19114494 O13809
Schizosaccharomyces pombe (Spo) SPCC970.03 GI:19075352 O74557
Arabidopsis thaliana (Ath) At1g37130_3 GI:15221314
Arabidopsis thaliana (Ath) At1g77760_3 GI:15218104
Arabidopsis thaliana (Ath) At5g17770 GI:15238025
Arabidopsis thaliana (Ath) At5g20080 GI:15241263
Caenorhabditis elegans (Cel) CE13275
(WBGene00020267)		 GI:17563926 O16522
Caenorhabditis elegans (Cel) CE13277
(WBGene00020268)		 GI:17563928 O16521
Caenorhabditis elegans (Cel) CE20292_2 GI:17510203
Drosophila melanogaster (Dme) 7293557 GI:7293557 Q9VWK8
Drosophila melanogaster (Dme) 7294666 GI:7294666 Q0E8F5
Drosophila melanogaster (Dme) 7302484_2 GI:7302484 A1ZBK6
Homo sapiens (Hsa) Hs7705899_2 GI:7705899
Homo sapiens (Hsa) Hs7706443 GI:7706443
Homo sapiens (Hsa) Hs7706455 GI:7706455
Homo sapiens (Hsa) Hs4503327
(CYB5R3)		 GI:4503327 P00387
Homo sapiens (Hsa) Hs14735899 GI:14735899
Homo sapiens (Hsa) Hs20474889 GI:20474889
Homo sapiens (Hsa) Hs19923907
(OXNAD1)		 GI:19923907 Q96HP4
Homo sapiens (Hsa) Hs6552328 GI:6552328 P00387
Saccharomyces cerevisiae (Sce) YIL043c
(S000001305)		 GI:6322146
Saccharomyces cerevisiae (Sce) YKL150w
(S000001633)		 GI:6322699 P36060
Saccharomyces cerevisiae (Sce) YML087c
(S000004552)		 GI:6323552 Q04516
Saccharomyces cerevisiae (Sce) YML125c
(S000004594)		 GI:6323510 Q12746
Saccharomyces cerevisiae (Sce) YOR037w
(S000005563)		 GI:6324611
Schizosaccharomyces pombe (Spo) SPAC17H9.12c GI:19114494 O13809
Schizosaccharomyces pombe (Spo) SPCC970.03 GI:19075352 O74557
Arabidopsis thaliana (Ath) At1g37130_3 GI:15221314
Arabidopsis thaliana (Ath) At1g77760_3 GI:15218104
Arabidopsis thaliana (Ath) At5g17770 GI:15238025
Arabidopsis thaliana (Ath) At5g20080 GI:15241263
Caenorhabditis elegans (Cel) CE13275
(WBGene00020267)		 GI:17563926 O16522
Caenorhabditis elegans (Cel) CE13277
(WBGene00020268)		 GI:17563928 O16521
Caenorhabditis elegans (Cel) CE20292_2 GI:17510203
Drosophila melanogaster (Dme) 7293557 GI:7293557 Q9VWK8
Drosophila melanogaster (Dme) 7294666 GI:7294666 Q0E8F5
Drosophila melanogaster (Dme) 7302484_2 GI:7302484 A1ZBK6
Homo sapiens (Hsa) Hs7705899_2 GI:7705899
Homo sapiens (Hsa) Hs7706443 GI:7706443
Homo sapiens (Hsa) Hs7706455 GI:7706455
Homo sapiens (Hsa) Hs4503327
(CYB5R3)		 GI:4503327 P00387
Homo sapiens (Hsa) Hs14735899 GI:14735899
Homo sapiens (Hsa) Hs20474889 GI:20474889
Homo sapiens (Hsa) Hs19923907
(OXNAD1)		 GI:19923907 Q96HP4
Homo sapiens (Hsa) Hs6552328 GI:6552328 P00387
Saccharomyces cerevisiae (Sce) YIL043c
(S000001305)		 GI:6322146
Saccharomyces cerevisiae (Sce) YKL150w
(S000001633)		 GI:6322699 P36060
Saccharomyces cerevisiae (Sce) YML087c
(S000004552)		 GI:6323552 Q04516
Saccharomyces cerevisiae (Sce) YML125c
(S000004594)		 GI:6323510 Q12746
Saccharomyces cerevisiae (Sce) YOR037w
(S000005563)		 GI:6324611
Schizosaccharomyces pombe (Spo) SPAC17H9.12c GI:19114494 O13809
Schizosaccharomyces pombe (Spo) SPCC970.03 GI:19075352 O74557


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
SceS000004552
GO:0005739 mitochondrion C
IDA
AthAt5g20080
SceS000001305
S000001633
S000005563
SpoSPAC17H9.12c
GO:0005741 mitochondrial outer membrane C
IDA
SceS000001305
S000001633
ISS
SpoSPAC17H9.12c
GO:0005758 mitochondrial intermembrane space C
IDA
SceS000001633
ISS
SpoSPAC17H9.12c
GO:0005773 vacuole C
IDA
AthAt1g37130
GO:0005783 endoplasmic reticulum C
IDA
AthAt5g17770
HsaCYB5R3
SceS000004594
SpoSPCC970.03
GO:0005789 endoplasmic reticulum membrane C
IC
SpoSPCC970.03
GO:0005792 microsome C
IDA
SceS000001305
GO:0005829 cytosol C
TAS
AthAt1g77760
GO:0005833 hemoglobin complex C
TAS
HsaCYB5R3
GO:0005886 plasma membrane C
IDA
AthAt1g37130
At5g17770
SceS000004594
GO:0009505 plant-type cell wall C
IDA
AthAt5g17770
At5g20080
GO:0031307 integral to mitochondrial outer
membrane		 C
IDA
SceS000001633
GO:0031314 extrinsic to mitochondrial inner
membrane		 C
IDA
SceS000005563
GO:0003674 molecular_function F
ND
SceS000004552
S000004594
GO:0004128 cytochrome-b5 reductase activity F
IDA
AthAt5g17770
SceS000001305
S000001633
ISS
AthAt5g20080
SpoSPAC17H9.12c
SPCC970.03
GO:0005507 copper ion binding F
IDA
AthAt5g20080
GO:0005515 protein binding F
IPI
AthAt1g77760
GO:0008940 nitrate reductase activity F
IDA
AthAt1g37130
IMP
AthAt1g77760
ISS
AthAt1g37130
GO:0009703 nitrate reductase (NADH) activity F
IDA
AthAt1g37130
GO:0016491 oxidoreductase activity F
IDA
SceS000005563
RCA
SceS000004594
GO:0050660 FAD binding F
ISS
SpoSPCC970.03
GO:0051287 NAD or NADH binding F
ISS
SpoSPCC970.03
GO:0001300 chronological cell aging P
IMP
SceS000004594
GO:0001302 replicative cell aging P
IMP
SceS000004594
GO:0002119 nematode larval development P
IMP
CelWBGene00020268
GO:0006696 ergosterol biosynthetic process P
IDA
SceS000001633
ISS
SpoSPAC17H9.12c
GO:0006809 nitric oxide biosynthetic process P
IMP
AthAt1g37130
At1g77760
GO:0006886 intracellular protein transport P
ISS
SpoSPCC970.03
GO:0006898 receptor-mediated endocytosis P
IMP
CelWBGene00020268
GO:0007006 mitochondrial membrane organization P
IMP
SceS000005563
GO:0008015 blood circulation P
TAS
HsaCYB5R3
GO:0008150 biological_process P
ND
SceS000001305
S000004552
GO:0009416 response to light stimulus P
IMP
AthAt1g77760
At1g37130
GO:0009610 response to symbiotic fungus P
IEP
AthAt1g37130
GO:0009651 response to salt stress P
IEP
AthAt5g20080
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00020268
GO:0015031 protein transport P
IMP
SceS000004594
GO:0016192 vesicle-mediated transport P
IC
SpoSPCC970.03
GO:0018063 cytochrome c-heme linkage P
IGI
SceS000005563
GO:0018193 peptidyl-amino acid modification P
RCA
SceS000004594
GO:0022900 electron transport chain P
IDA
AthAt5g17770
GO:0031329 regulation of cellular catabolic
process		 P
RCA
SceS000005563
GO:0032940 secretion by cell P
IMP
CelWBGene00020267
GO:0034599 cellular response to oxidative
stress		 P
IMP
SceS000001633
ISS
SpoSPAC17H9.12c
GO:0040007 growth P
IMP
CelWBGene00020268
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00020267
WBGene00020268
GO:0042128 nitrate assimilation P
IMP
AthAt1g77760
At1g37130
GO:0055114 oxidation reduction P
RCA
SceS000001633

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
74764

Species Gene ID NCBI link UniProt link
Saccharomyces cerevisiae (Sce) PGA3
(S000004594)		 GI:6323510 Q12746
Kluyveromyces lactis (Kla) KLLA0C16918g GI:50305993
Eremothecium gossypii (Ego) AGOS_AFR439C GI:45198957


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005783 endoplasmic reticulum C
IDA
SceS000004594
GO:0005886 plasma membrane C
IDA
SceS000004594
GO:0003674 molecular_function F
ND
SceS000004594
GO:0016491 oxidoreductase activity F
RCA
SceS000004594
GO:0001300 chronological cell aging P
IMP
SceS000004594
GO:0001302 replicative cell aging P
IMP
SceS000004594
GO:0015031 protein transport P
IMP
SceS000004594
GO:0018193 peptidyl-amino acid modification P
RCA
SceS000004594

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_24647

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Ashbya gossypii (Ago) ago3631 AFR439C
Candida glabrata (Cgl) cgl314 CAGL0B02519g
Debaryomyces hansenii (Dha) dha155 DEHA0A03487g
Kluyveromyces lactis (Kla) kla1956 KLLA0C16918g
Saccharomyces cerevisiae (Sce) sce4735 YML125C
(S000004594)


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005783 endoplasmic reticulum C
IDA
SceS000004594
GO:0005886 plasma membrane C
IDA
SceS000004594
GO:0003674 molecular_function F
ND
SceS000004594
GO:0016491 oxidoreductase activity F
RCA
SceS000004594
GO:0001300 chronological cell aging P
IMP
SceS000004594
GO:0001302 replicative cell aging P
IMP
SceS000004594
GO:0015031 protein transport P
IMP
SceS000004594
GO:0018193 peptidyl-amino acid modification P
RCA
SceS000004594

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPCC970.03
(O74557)		 YML125C
(S000004594)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005783 endoplasmic reticulum C
IDA
SceS000004594
SpoSPCC970.03
GO:0005789 endoplasmic reticulum membrane C
IC
SpoSPCC970.03
GO:0005886 plasma membrane C
IDA
SceS000004594
GO:0003674 molecular_function F
ND
SceS000004594
GO:0004128 cytochrome-b5 reductase activity F
ISS
SpoSPCC970.03
GO:0016491 oxidoreductase activity F
RCA
SceS000004594
GO:0050660 FAD binding F
ISS
SpoSPCC970.03
GO:0051287 NAD or NADH binding F
ISS
SpoSPCC970.03
GO:0001300 chronological cell aging P
IMP
SceS000004594
GO:0001302 replicative cell aging P
IMP
SceS000004594
GO:0006886 intracellular protein transport P
ISS
SpoSPCC970.03
GO:0015031 protein transport P
IMP
SceS000004594
GO:0016192 vesicle-mediated transport P
IC
SpoSPCC970.03
GO:0018193 peptidyl-amino acid modification P
RCA
SceS000004594

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