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Search term: YML126C

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name ERG13
SGD link S000004595
Alternative ID YML126C
Description 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase, catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA; involved in the second step in mevalonate biosynthesis
Synonyms YML126C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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Query species:

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG1393 ACDHYPE

KOGs classification KOGs description
METABOLISM Hydroxymethylglutaryl-CoA synthase

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At4g11820 GI:15234313
Caenorhabditis elegans (Cel) CE09624
(WBGene00017769)		 GI:17560126 P54871
Drosophila melanogaster (Dme) 7302938
(FBgn0010611)		 GI:17933694
Homo sapiens (Hsa) Hs5031751
(HMGCS2)		 GI:5031751 P54868
Homo sapiens (Hsa) Hs4504429 GI:4504429
Homo sapiens (Hsa) Hs17449881 GI:17449881
Saccharomyces cerevisiae (Sce) YML126c
(S000004595)		 GI:6323509 P54839
Schizosaccharomyces pombe (Spo) SPAC4F8.14c GI:19114771 P54874
Encephalitozoon cuniculi (Ecu) ECU10g0510 GI:19074660 Q8SR61


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
AthAt4g11820
GO:0005634 nucleus C
IDA
SpoSPAC4F8.14c
GO:0005759 mitochondrial matrix C
EXP
HsaHMGCS2
GO:0005783 endoplasmic reticulum C
IC
SpoSPAC4F8.14c
TAS
SceS000004595
GO:0005829 cytosol C
IDA
SpoSPAC4F8.14c
GO:0004421 hydroxymethylglutaryl-CoA synthase
activity		 F
EXP
HsaHMGCS2
IGI
AthAt4g11820
IMP
SceS000004595
SpoSPAC4F8.14c
ISS
AthAt4g11820
DmeFBgn0010611
GO:0000003 reproduction P
IMP
CelWBGene00017769
GO:0001700 embryonic development via the syncytial
blastoderm		 P
IMP
DmeFBgn0010611
GO:0002119 nematode larval development P
IMP
CelWBGene00017769
GO:0006066 alcohol metabolic process P
RCA
SceS000004595
GO:0006084 acetyl-CoA metabolic process P
IMP
SpoSPAC4F8.14c
GO:0006696 ergosterol biosynthetic process P
IMP
SceS000004595
SpoSPAC4F8.14c
GO:0006898 receptor-mediated endocytosis P
IMP
CelWBGene00017769
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00017769
GO:0010142 farnesyl diphosphate biosynthetic process,
mevalonate pathway		 P
IMP
SpoSPAC4F8.14c
GO:0010171 body morphogenesis P
IMP
CelWBGene00017769
GO:0018996 molting cycle, collagen and cuticulin-based
cuticle		 P
IMP
CelWBGene00017769
GO:0019287 isopentenyl diphosphate biosynthetic process,
mevalonate pathway		 P
TAS
AthAt4g11820
GO:0040007 growth P
IMP
CelWBGene00017769
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00017769
GO:0040011 locomotion P
IMP
CelWBGene00017769
GO:0043094 cellular metabolic compound salvage P
RCA
SceS000004595
GO:0070317 negative regulation of G0 to G1
transition		 P
IMP
SpoSPAC4F8.14c

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
1609

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) HMGCS1 GI:148298764
Pan troglodytes (Ptr) HMGCS1 GI:114600409
Canis familiaris (Cfa) HMGCS1 GI:73954270
Mus musculus (Mmu) Hmgcs1
(MGI:107592)		 GI:31981842 Q3UJ70
Mus musculus (Mmu) LOC100040592 GI:149264816
Rattus norvegicus (Rno) Hmgcs1
(RGD:70970)		 GI:8393538
Gallus gallus (Gga) HMGCS1 GI:45382279
Drosophila melanogaster (Dme) Hmgs
(FBgn0010611)		 GI:17933694
Anopheles gambiae (Aga) AgaP_AGAP005847 GI:118787138
Schizosaccharomyces pombe (Spo) hcs
(SPAC4F8.14c)		 GI:19114771 P54874
Saccharomyces cerevisiae (Sce) ERG13
(S000004595)		 GI:6323509 P54839
Kluyveromyces lactis (Kla) KLLA0D10505g GI:50307101
Eremothecium gossypii (Ego) AGOS_ADL356C GI:45187516
Magnaporthe grisea (Mgr) MGG_01026 GI:39973655
Neurospora crassa (Ncr) NCU03922.1 GI:32405256
Arabidopsis thaliana (Ath) MVA1 GI:15234313
Oryza sativa (Osa) Os03g0118800 GI:115450347
Oryza sativa (Osa) Os09g0521400 GI:115480225
Oryza sativa (Osa) Os08g0544900 GI:115477629


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
AthMVA1
GO:0005625 soluble fraction C
TAS
HsaHMGCS1
GO:0005634 nucleus C
IDA
SpoSPAC4F8.14c
GO:0005783 endoplasmic reticulum C
IC
SpoSPAC4F8.14c
TAS
SceS000004595
GO:0005829 cytosol C
EXP
HsaHMGCS1
IDA
SpoSPAC4F8.14c
ISO
MmuMGI:107592
GO:0004421 hydroxymethylglutaryl-CoA synthase
activity		 F
EXP
HsaHMGCS1
IGI
AthMVA1
IMP
SceS000004595
SpoSPAC4F8.14c
ISO
MmuMGI:107592
ISS
AthMVA1
DmeFBgn0010611
GO:0008144 drug binding F
ISO
MmuMGI:107592
GO:0016853 isomerase activity F
ISO
MmuMGI:107592
GO:0042803 protein homodimerization activity F
ISO
MmuMGI:107592
GO:0043177 organic acid binding F
ISO
MmuMGI:107592
GO:0001700 embryonic development via the syncytial
blastoderm		 P
IMP
DmeFBgn0010611
GO:0006066 alcohol metabolic process P
RCA
SceS000004595
GO:0006084 acetyl-CoA metabolic process P
IMP
SpoSPAC4F8.14c
GO:0006629 lipid metabolic process P
NAS
HsaHMGCS1
GO:0006696 ergosterol biosynthetic process P
IMP
SceS000004595
SpoSPAC4F8.14c
GO:0010142 farnesyl diphosphate biosynthetic process,
mevalonate pathway		 P
IMP
SpoSPAC4F8.14c
GO:0010243 response to organic nitrogen P
ISO
MmuMGI:107592
GO:0019287 isopentenyl diphosphate biosynthetic process,
mevalonate pathway		 P
TAS
AthMVA1
GO:0043094 cellular metabolic compound salvage P
RCA
SceS000004595
GO:0070317 negative regulation of G0 to G1
transition		 P
IMP
SpoSPAC4F8.14c
GO:0071445 cellular response to protein stimulus P
ISO
MmuMGI:107592

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_1457

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga1291 ENSANGP00000017491
Ashbya gossypii (Ago) ago1384 ADL356C
Arabidopsis thaliana (Ath) ath18923 At4g11820.1
Arabidopsis thaliana (Ath) ath18924 At4g11820.2
Caenorhabditis elegans (Cel) cel7182 F25B4.6
(CE09624;
WBGene00017769)
Candida glabrata (Cgl) cgl2239 CAGL0H04081g
Cryptococcus neoformans (Cne) cne4354 177.m03107
Cryptococcus neoformans (Cne) cne5575 179.m00435
Dictyostelium discoideum (Ddi) ddi3856 DDB0217522
Dictyostelium discoideum (Ddi) ddi12855 DDB0219924
Debaryomyces hansenii (Dha) dha151 DEHA0A03399g
Drosophila melanogaster (Dme) dme5430 CG4311-PA
(FBgn0010611)
Drosophila melanogaster (Dme) dme5431 CG4311-PB
(FBgn0010611)
Drosophila melanogaster (Dme) dme5432 CG4311-PC
(FBgn0010611)
Drosophila melanogaster (Dme) dme5433 CG4311-PD
(FBgn0010611)
Drosophila melanogaster (Dme) dme5434 CG4311-PE
(FBgn0010611)
Danio rerio (Dre) dre32013 ENSDARP00000024048
Danio rerio (Dre) dre28988 ENSDARP00000024552
Encephalitozoon cuniculi (Ecu) ecu576 19074660
Takifugu rubripes (Fru) fru29108 SINFRUP00000149024
Gallus gallus (Gga) gga22201 ENSGALP00000004672
(HMGCS2)
Gallus gallus (Gga) gga22200 ENSGALP00000004673
Gallus gallus (Gga) gga27640 ENSGALP00000023936
(HMGCS1)		 P23228
Homo sapiens (Hsa) hsa1818 ENSP00000256633
Homo sapiens (Hsa) hsa25199 ENSP00000322706
(HMGCS1)		 Q01581
Kluyveromyces lactis (Kla) kla2528 KLLA0D10505g
Mus musculus (Mmu) mmu17228 ENSMUSP00000029468
Mus musculus (Mmu) mmu30777 ENSMUSP00000064279
Mus musculus (Mmu) mmu30778 ENSMUSP00000066683
Neurospora crassa (Ncr) ncr3811 NCU03922.2
Oryza sativa (Osa) osa25997 3908.m00135
Oryza sativa (Osa) osa69919 6975.m00099
Rattus norvegicus (Rno) rno15558 ENSRNOP00000023554
(RGD:70970)		 P17425
Rattus norvegicus (Rno) rno16687 ENSRNOP00000026122
(RGD:2804)		 P22791
Saccharomyces cerevisiae (Sce) sce4736 YML126C
(S000004595)
Schizosaccharomyces pombe (Spo) spo4522 SPAC4F8.14c P54874
Yarrowia lipolytica (Yli) yli6594 YALI0F30481g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
AthAt4g11820
GO:0005634 nucleus C
IDA
SpoSPAC4F8.14c
GO:0005783 endoplasmic reticulum C
IC
SpoSPAC4F8.14c
TAS
SceS000004595
GO:0005829 cytosol C
IDA
SpoSPAC4F8.14c
GO:0004421 hydroxymethylglutaryl-CoA synthase
activity		 F
IGI
AthAt4g11820
IMP
SceS000004595
SpoSPAC4F8.14c
ISS
AthAt4g11820
DmeFBgn0010611
GO:0000003 reproduction P
IMP
CelWBGene00017769
GO:0001700 embryonic development via the syncytial
blastoderm		 P
IMP
DmeFBgn0010611
GO:0002119 nematode larval development P
IMP
CelWBGene00017769
GO:0006066 alcohol metabolic process P
RCA
SceS000004595
GO:0006084 acetyl-CoA metabolic process P
IMP
SpoSPAC4F8.14c
GO:0006696 ergosterol biosynthetic process P
IMP
SceS000004595
SpoSPAC4F8.14c
GO:0006898 receptor-mediated endocytosis P
IMP
CelWBGene00017769
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00017769
GO:0010142 farnesyl diphosphate biosynthetic process,
mevalonate pathway		 P
IMP
SpoSPAC4F8.14c
GO:0010171 body morphogenesis P
IMP
CelWBGene00017769
GO:0018996 molting cycle, collagen and cuticulin-based
cuticle		 P
IMP
CelWBGene00017769
GO:0019287 isopentenyl diphosphate biosynthetic process,
mevalonate pathway		 P
TAS
AthAt4g11820
GO:0040007 growth P
IMP
CelWBGene00017769
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00017769
GO:0040011 locomotion P
IMP
CelWBGene00017769
GO:0043094 cellular metabolic compound salvage P
RCA
SceS000004595
GO:0070317 negative regulation of G0 to G1
transition		 P
IMP
SpoSPAC4F8.14c

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPAC4F8.14c
(P54874)		 YML126C
(S000004595)