Bahler Lab

Search term: YMR015C

Gene summary:

Species Saccharomyces cerevisiae (Sce)

Primary name ERG5

SGD link S000004617

Alternative ID YMR015C

Description C-22 sterol desaturase, a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs

Synonyms YMR015C

Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

Search for gene by ID or name:

Query species:

Include wild-cards: Yes No

Search for GO info: Yes No

GO info in one table: Yes No

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)

KOG0157 ACDHYP-

KOGs classification KOGs description

METABOLISMMETABOLISM Cytochrome P450 CYP4/CYP19/CYP26 subfamilies

GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations

GO:0005575 cellular_component C
ND
Ath At1g55940
At1g69500
At3g30290
At5g08250
At5g14400
At5g36130
Sce S000002810

GO:0005624 membrane fraction C
TAS
Hsa CYP19A1

GO:0005773 vacuole C
IDA
Ath At5g58860

GO:0005783 endoplasmic reticulum C
IDA
Ath At1g57750
At1g05160
At3g50660
At2g32440
At2g45510
At3g14610
At5g23190
At5g48000
Hsa CYP19A1
Sce S000004617
ISS
Spo SPAC19A8.04
NAS
Hsa CYP26B1

GO:0005789 endoplasmic reticulum membrane C
EXP
Hsa CYP26B1
CYP4F2

GO:0005792 microsome C
IDA
Ath At2g27690
Hsa CYP26B1
NAS
Dme FBgn0010019
FBgn0011576
FBgn0030304
FBgn0015032
FBgn0015037
FBgn0015034
FBgn0031693
FBgn0015035

GO:0005811 lipid particle C
IDA
Dme FBgn0015035

GO:0009507 chloroplast C
IDA
Ath At1g31800
At4g15110
At3g53130
TAS
Ath At3g53130

GO:0009570 chloroplast stroma C
IDA
Ath At4g15110

GO:0009941 chloroplast envelope C
IDA
Ath At3g53130

GO:0016020 membrane C
NAS
Dme FBgn0015034
FBgn0010019
FBgn0015035
FBgn0011576
FBgn0015037
FBgn0030304
FBgn0015032
FBgn0031693

GO:0000249 C-22 sterol desaturase activity F
IDA
Ath At2g34500
At2g34490
Sce S000004617
ISS
Spo SPAC19A8.04

GO:0001972 retinoic acid binding F
IDA
Hsa CYP26B1

GO:0004497 monooxygenase activity F
IDA
Ath At3g30180
At5g38970

GO:0005515 protein binding F
IPI
Ath At4g00360
Hsa CYP4F2
CYP4F8
Spo SPAC19A8.04

GO:0008270 zinc ion binding F
IDA
Ath At3g30290

GO:0008395 steroid hydroxylase activity F
IMP
Ath At2g26710
TAS
Ath At4g36380
Hsa CYP46A1

GO:0008401 retinoic acid 4-hydroxylase activity F
EXP
Hsa CYP26B1
IDA
Hsa CYP26B1

GO:0009055 electron carrier activity F
ISS
Dme FBgn0015035
FBgn0010019
FBgn0011576
FBgn0030304
FBgn0031693
FBgn0015037
FBgn0015034
NAS
Dme FBgn0010019
FBgn0015034
FBgn0015035
FBgn0015037
FBgn0011576
FBgn0030304
FBgn0015032
FBgn0031693
TAS
Hsa CYP19A1

GO:0009974 epsilon hydroxylase activity F
IMP
Ath At3g53130

GO:0010012 steroid 22-alpha hydroxylase activity F
IDA
Ath At3g50660

GO:0010291 carotene beta-ring hydroxylase
activity F
IMP
Ath At1g31800

GO:0010295 (+)-abscisic acid 8'-hydroxylase
activity F
IDA
Ath At4g19230
At2g29090
At3g19270
At5g45340

GO:0016491 oxidoreductase activity F
ISS
Sce S000002810

GO:0016709 oxidoreductase activity, acting on paired donors,
with incorporation or reduction of molecular
oxygen, NADH or NADPH as one donor, and
incorporation of one atom of oxygen F
IDA
Ath At3g13730
At4g36380

GO:0016712 oxidoreductase activity, acting on paired donors,
with incorporation or reduction of molecular
oxygen, reduced flavin or flavoprotein as one
donor, and incorporation of one atom of
oxygen F
TAS
Hsa CYP19A1

GO:0018685 alkane 1-monooxygenase activity F
IDA
Ath At1g63710
At1g69500
At1g01600
At2g27690
At2g45970
At4g00360
At5g58860
Hsa CYP4F2
TAS
Hsa CYP4F8

GO:0019825 oxygen binding F
EXP
Hsa CYP4F2
ISS
Ath At1g55940
At1g47620
At1g57750
At1g65670
At1g13150
At1g69500
At1g17060
At1g24540
At1g63710
At1g75130
At1g12740
At1g05160
At1g01600
At2g21910
At1g13140
At1g65340
At1g34540
At1g67110
At1g19630
At2g23180
At1g78490
At1g73340
At2g26710
At1g31800
At2g29090
At2g28860
At2g34500
At2g27690
At3g44970
At2g28850
At2g44890
At2g32440
At3g13730
At2g45510
At2g34490
At2g45970
At2g42850
At2g46960
At3g14630
At3g01900
At3g14680
At2g46950
At3g14610
At3g14660
At3g14690
At3g14620
At3g19270
At3g14640
At3g14650
At3g30180
At4g19230
At3g26125
At3g53130
At3g48520
At3g30290
At3g56630
At4g00360
At4g39500
At4g15110
At4g15300
At4g36380
At4g27710
At4g32170
At4g39510
At4g39480
At5g02900
At5g05690
At5g08250
At5g36110
At5g14400
At5g23190
At5g24900
At5g24910
At5g36130
At5g38970
At5g52400
At5g38450
At5g45340
At5g48000
At5g58860
At5g51900
At5g52320
At5g63450
TAS
Hsa CYP19A1

GO:0020037 heme binding F
IDA
Hsa CYP19A1
NAS
Hsa CYP26B1

GO:0051777 ent-kaurenoate oxidase activity F
IDA
Ath At1g05160
At2g32440

GO:0070330 aromatase activity F
IDA
Hsa CYP19A1

GO:0080014 thalianol hydroxylase activity F
IMP
Ath At5g48000

GO:0080133 midchain alkane hydroxylase activity F
IMP
Ath At1g57750

GO:0000038 very long-chain fatty acid metabolic
process P
IDA
Hsa CYP4F2

GO:0001676 long-chain fatty acid metabolic
process P
IDA
Hsa CYP4F2

GO:0001709 cell fate determination P
ISS
Hsa CYP26B1

GO:0006066 alcohol metabolic process P
RCA
Sce S000004617

GO:0006629 lipid metabolic process P
IMP
Dme FBgn0010019

GO:0006631 fatty acid metabolic process P
IDA
Ath At1g63710
At1g01600
At2g45970
At4g00360
At5g58860

GO:0006691 leukotriene metabolic process P
TAS
Hsa CYP4F2

GO:0006693 prostaglandin metabolic process P
TAS
Hsa CYP4F8

GO:0006694 steroid biosynthetic process P
EXP
Hsa CYP19A1
NAS
Dme FBgn0030304

GO:0006696 ergosterol biosynthetic process P
IDA
Sce S000004617
IEP
Spo SPAC19A8.04
IMP
Sce S000004617
Spo SPAC19A8.04

GO:0006707 cholesterol catabolic process P
TAS
Hsa CYP46A1

GO:0007140 male meiosis P
ISS
Hsa CYP26B1

GO:0007283 spermatogenesis P
ISS
Hsa CYP26B1

GO:0007399 nervous system development P
TAS
Hsa CYP46A1

GO:0008150 biological_process P
ND
Ath At1g55940
At1g75130
At2g42850
At3g30290
At3g56630
At5g02900
At5g36130
At5g14400
At5g24900

GO:0009414 response to water deprivation P
IMP
Ath At5g45340

GO:0009416 response to light stimulus P
IGI
Ath At1g17060
At2g26710

GO:0009639 response to red or far red light P
IEP
Ath At2g29090
At4g19230
At5g45340

GO:0009686 gibberellin biosynthetic process P
ISS
Ath At2g32440
TAS
Ath At1g05160
At2g32440

GO:0009687 abscisic acid metabolic process P
IMP
Ath At2g29090
At4g19230

GO:0009741 response to brassinosteroid stimulus P
IEP
Ath At3g50660
At2g26710
IMP
Ath At3g50660

GO:0009753 response to jasmonic acid stimulus P
IMP
Ath At3g50660

GO:0009826 unidimensional cell growth P
IMP
Ath At1g17060
At3g50660
At5g05690

GO:0009867 jasmonic acid mediated signaling
pathway P
IGI
Ath At3g50660

GO:0009911 positive regulation of flower development P
IGI
Ath At5g05690

GO:0009954 proximal/distal pattern formation P
ISS
Hsa CYP26B1

GO:0009965 leaf morphogenesis P
IMP
Ath At4g36380

GO:0010025 wax biosynthetic process P
IMP
Ath At1g57750

GO:0010114 response to red light P
IEP
Ath At2g29090

GO:0010224 response to UV-B P
IGI
Ath At5g05690

GO:0010268 brassinosteroid homeostasis P
IEP
Ath At2g26710
At4g36380
At5g05690
At5g38970

GO:0010345 suberin biosynthetic process P
IMP
Ath At5g23190
At5g58860

GO:0010358 leaf shaping P
IMP
Ath At3g50660

GO:0010584 pollen exine formation P
IMP
Ath At1g69500
At5g05690

GO:0016117 carotenoid biosynthetic process P
IMP
Ath At1g31800
At3g53130

GO:0016123 xanthophyll biosynthetic process P
IGI
Ath At1g31800

GO:0016131 brassinosteroid metabolic process P
IDA
Ath At2g26710
IMP
Ath At1g17060
At2g26710

GO:0016132 brassinosteroid biosynthetic process P
IDA
Ath At3g30180
At5g38970
IMP
Ath At3g50660
At3g13730
At4g36380
At5g05690
TAS
Ath At5g38970

GO:0030326 embryonic limb morphogenesis P
ISS
Hsa CYP26B1

GO:0030476 ascospore wall assembly P
IDA
Sce S000002810
IMP
Sce S000002810

GO:0034653 retinoic acid catabolic process P
IDA
Hsa CYP26B1

GO:0042445 hormone metabolic process P
NAS
Dme FBgn0031693

GO:0042761 very long-chain fatty acid biosynthetic
process P
IMP
Ath At5g23190

GO:0042814 monopolar cell growth P
IMP
Ath At4g36380

GO:0043094 cellular metabolic compound salvage P
RCA
Sce S000004617

GO:0044255 cellular lipid metabolic process P
RCA
Sce S000004617

GO:0046345 abscisic acid catabolic process P
TAS
Ath At5g45340

GO:0046701 insecticide catabolic process P
NAS
Dme FBgn0031693

GO:0048364 root development P
IMP
Ath At5g48000

GO:0048366 leaf development P
IGI
Ath At3g13730
At4g36380
IMP
Ath At3g50660

GO:0048387 negative regulation of retinoic acid receptor
signaling pathway P
TAS
Hsa CYP26B1

GO:0048441 petal development P
IGI
Ath At3g13730
At4g36380

GO:0048443 stamen development P
IGI
Ath At3g13730
At4g36380

GO:0048657 tapetal cell differentiation P
IMP
Ath At5g05690

GO:0048838 release of seed from dormancy P
IMP
Ath At2g29090
At4g19230

GO:0050832 defense response to fungus P
IEP
Ath At4g19230

GO:0055114 oxidation reduction P
IDA
Hsa CYP26B1

GO:0071210 protein insertion into membrane
raft P
IMP
Spo SPAC19A8.04

GO:0080003 thalianol metabolic process P
IMP
Ath At5g48000

GO:0080110 sporopollenin biosynthetic process P
IMP
Ath At1g69500

GO:0090002 establishment of protein localization in plasma
membrane P
IMP
Spo SPAC19A8.04

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern

20212

Species Gene ID NCBI link UniProt link

Schizosaccharomyces pombe (Spo) erg5
(SPAC19A8.04) GI:19114700 O13820

Saccharomyces cerevisiae (Sce) ERG5
(S000004617) GI:6323657 P54781

Kluyveromyces lactis (Kla) KLLA0D11242g GI:50307167

Magnaporthe grisea (Mgr) MGG_06047 GI:145603444

Neurospora crassa (Ncr) NCU05278.1 GI:32408307

Arabidopsis thaliana (Ath) CYP710A3 GI:15226974

Arabidopsis thaliana (Ath) CYP710A4 GI:15226976

Arabidopsis thaliana (Ath) CYP710A1 GI:15226758

Arabidopsis thaliana (Ath) CYP710A2 GI:15226756

Oryza sativa (Osa) Os01g0210900 GI:115435228

Oryza sativa (Osa) Os01g0211200 GI:115435230

Oryza sativa (Osa) Os01g0211600 GI:115435232

GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations

GO:0005783 endoplasmic reticulum C
IDA
Sce S000004617
ISS
Spo SPAC19A8.04

GO:0000249 C-22 sterol desaturase activity F
IDA
Ath CYP710A2
CYP710A1
Sce S000004617
ISS
Spo SPAC19A8.04

GO:0005515 protein binding F
IPI
Spo SPAC19A8.04

GO:0019825 oxygen binding F
ISS
Ath CYP710A1
CYP710A4
CYP710A3
CYP710A2

GO:0006066 alcohol metabolic process P
RCA
Sce S000004617

GO:0006696 ergosterol biosynthetic process P
IDA
Sce S000004617
IEP
Spo SPAC19A8.04
IMP
Sce S000004617
Spo SPAC19A8.04

GO:0043094 cellular metabolic compound salvage P
RCA
Sce S000004617

GO:0044255 cellular lipid metabolic process P
RCA
Sce S000004617

GO:0071210 protein insertion into membrane
raft P
IMP
Spo SPAC19A8.04

GO:0090002 establishment of protein localization in plasma
membrane P
IMP
Spo SPAC19A8.04

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern

OG1_4319

GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations

GO:0005783 endoplasmic reticulum C
IDA
Sce S000004617
ISS
Spo SPAC19A8.04

GO:0000249 C-22 sterol desaturase activity F
IDA
Ath At2g34500
At2g34490
Sce S000004617
ISS
Spo SPAC19A8.04

GO:0005515 protein binding F
IPI
Spo SPAC19A8.04

GO:0019825 oxygen binding F
ISS
Ath At2g28860
At2g34500
At2g28850
At2g34490

GO:0006066 alcohol metabolic process P
RCA
Sce S000004617

GO:0006696 ergosterol biosynthetic process P
IDA
Sce S000004617
IEP
Spo SPAC19A8.04
IMP
Sce S000004617
Spo SPAC19A8.04

GO:0043094 cellular metabolic compound salvage P
RCA
Sce S000004617

GO:0044255 cellular lipid metabolic process P
RCA
Sce S000004617

GO:0071210 protein insertion into membrane
raft P
IMP
Spo SPAC19A8.04

GO:0090002 establishment of protein localization in plasma
membrane P
IMP
Spo SPAC19A8.04

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Curated yeast ortholog results:

S. pombe
systematic ID S. cerevisiae
systematic ID

SPAC19A8.04
(O13820) YMR015C
(S000004617)

GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations

GO:0005783 endoplasmic reticulum C
IDA
Sce S000004617
ISS
Spo SPAC19A8.04

GO:0000249 C-22 sterol desaturase activity F
IDA
Sce S000004617
ISS
Spo SPAC19A8.04

GO:0005515 protein binding F
IPI
Spo SPAC19A8.04

GO:0006066 alcohol metabolic process P
RCA
Sce S000004617

GO:0006696 ergosterol biosynthetic process P
IDA
Sce S000004617
IEP
Spo SPAC19A8.04
IMP
Sce S000004617
Spo SPAC19A8.04

GO:0043094 cellular metabolic compound salvage P
RCA
Sce S000004617

GO:0044255 cellular lipid metabolic process P
RCA
Sce S000004617

GO:0071210 protein insertion into membrane
raft P
IMP
Spo SPAC19A8.04

GO:0090002 establishment of protein localization in plasma
membrane P
IMP
Spo SPAC19A8.04

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YOGY Home

YOGY Help

Search for gene by ID or name:

Query species:

Include wild-cards: Yes No

Search for GO info: Yes No

GO info in one table: Yes No

s.khadayate@ucl.ac.uk

KOG name	Phylogenetic pattern (and link to KOGs with this pattern)
KOG0157	ACDHYP-

KOGs classification	KOGs description
METABOLISMMETABOLISM	Cytochrome P450 CYP4/CYP19/CYP26 subfamilies

Species	Gene ID	NCBI link	UniProt link
Schizosaccharomyces pombe (Spo)	erg5 (SPAC19A8.04)	GI:19114700	O13820
Saccharomyces cerevisiae (Sce)	ERG5 (S000004617)	GI:6323657	P54781
Kluyveromyces lactis (Kla)	KLLA0D11242g	GI:50307167
Magnaporthe grisea (Mgr)	MGG_06047	GI:145603444
Neurospora crassa (Ncr)	NCU05278.1	GI:32408307
Arabidopsis thaliana (Ath)	CYP710A3	GI:15226974
Arabidopsis thaliana (Ath)	CYP710A4	GI:15226976
Arabidopsis thaliana (Ath)	CYP710A1	GI:15226758
Arabidopsis thaliana (Ath)	CYP710A2	GI:15226756
Oryza sativa (Osa)	Os01g0210900	GI:115435228
Oryza sativa (Osa)	Os01g0211200	GI:115435230
Oryza sativa (Osa)	Os01g0211600	GI:115435232

Species	OrthoMCL sequence	Model organism protein page	UniProt link
Ashbya gossypii (Ago)	ago644	ABR053C
Arabidopsis thaliana (Ath)	ath9854	At2g28850.1
Arabidopsis thaliana (Ath)	ath9855	At2g28860.1
Arabidopsis thaliana (Ath)	ath10496	At2g34490.1
Arabidopsis thaliana (Ath)	ath10497	At2g34500.1
Candida glabrata (Cgl)	cgl4991	CAGL0M07656g
Cryptococcus neoformans (Cne)	cne1236	180.m00174
Dictyostelium discoideum (Ddi)	ddi888	DDB0202357
Debaryomyces hansenii (Dha)	dha2600	DEHA0D06842g
Kluyveromyces lactis (Kla)	kla2561	KLLA0D11242g
Neurospora crassa (Ncr)	ncr5123	NCU05278.2
Oryza sativa (Osa)	osa9838	2739.m00161
Oryza sativa (Osa)	osa9839	2739.m00162
Oryza sativa (Osa)	osa9843	2739.m00164
Oryza sativa (Osa)	osa9847	2739.m00168
Oryza sativa (Osa)	osa10719	2754.m00151
Oryza sativa (Osa)	osa10720	2754.m00152
Oryza sativa (Osa)	osa10724	2754.m00154
Oryza sativa (Osa)	osa10732	2754.m00158
Saccharomyces cerevisiae (Sce)	sce4763	YMR015C (S000004617)
Schizosaccharomyces pombe (Spo)	spo2341	SPAC19A8.04	O13820
Yarrowia lipolytica (Yli)	yli598	YALI0A18062g

S. pombe systematic ID	S. cerevisiae systematic ID
SPAC19A8.04 (O13820)	YMR015C (S000004617)