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Search term: YMR026C


Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name PEX12
SGD link S000004628
Alternative ID YMR026C
Description C3HC4-type RING-finger peroxisomal membrane peroxin required for peroxisome biogenesis and peroxisomal matrix protein import; forms translocation subcomplex with Pex2p and Pex10p; mutations in human homolog cause peroxisomal disorders
Synonyms YMR026C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:


KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG0826 ACDHY--

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALING Predicted E3 ubiquitin ligase involved in peroxisome organization

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At3g04460 GI:15229300
Caenorhabditis elegans (Cel) CE03163
(WBGene00004197)
GI:17551466 Q19189
Drosophila melanogaster (Dme) 7296163 GI:12585327
Homo sapiens (Hsa) Hs18581171 GI:18581171
Homo sapiens (Hsa) Hs4505721
(PEX12)
GI:4505721 O00623
Saccharomyces cerevisiae (Sce) YMR026c
(S000004628)
GI:6323668 Q04370
Arabidopsis thaliana (Ath) At3g04460 GI:15229300
Caenorhabditis elegans (Cel) CE03163
(WBGene00004197)
GI:17551466 Q19189
Drosophila melanogaster (Dme) 7296163 GI:12585327
Homo sapiens (Hsa) Hs18581171 GI:18581171
Homo sapiens (Hsa) Hs4505721
(PEX12)
GI:4505721 O00623
Saccharomyces cerevisiae (Sce) YMR026c
(S000004628)
GI:6323668 Q04370


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005777 peroxisome C
IDA
AthAt3g04460
HsaPEX12
GO:0005778 peroxisomal membrane C
IDA
AthAt3g04460
GO:0005779 integral to peroxisomal membrane C
IDA
HsaPEX12
SceS000004628
TAS
HsaPEX12
GO:0004842 ubiquitin-protein ligase activity F
IDA
SceS000004628
GO:0005515 protein binding F
IPI
HsaPEX12
SceS000004628
GO:0008022 protein C-terminus binding F
IPI
HsaPEX12
GO:0008270 zinc ion binding F
IMP
HsaPEX12
GO:0002119 nematode larval development P
IMP
CelWBGene00004197
GO:0006625 protein targeting to peroxisome P
NAS
HsaPEX12
GO:0006635 fatty acid beta-oxidation P
IMP
AthAt3g04460
GO:0007031 peroxisome organization P
IMP
AthAt3g04460
CelWBGene00004197
HsaPEX12
GO:0009792 embryo development ending in birth or egg
hatching
P
IMP
CelWBGene00004197
GO:0016558 protein import into peroxisome
matrix
P
IDA
AthAt3g04460
IMP
AthAt3g04460
HsaPEX12
SceS000004628
NAS
HsaPEX12
GO:0040007 growth P
IMP
CelWBGene00004197
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00004197
GO:0048598 embryonic morphogenesis P
IMP
AthAt3g04460

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
39888

Species Gene ID NCBI link UniProt link
Saccharomyces cerevisiae (Sce) PEX12
(S000004628)
GI:6323668 Q04370
Kluyveromyces lactis (Kla) KLLA0E07568g GI:50308577
Eremothecium gossypii (Ego) AGOS_ABR067C GI:45185296


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005779 integral to peroxisomal membrane C
IDA
SceS000004628
GO:0004842 ubiquitin-protein ligase activity F
IDA
SceS000004628
GO:0005515 protein binding F
IPI
SceS000004628
GO:0016558 protein import into peroxisome
matrix
P
IMP
SceS000004628

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_4318

Species OrthoMCL
sequence
Model organism
protein page
UniProt link
Ashbya gossypii (Ago) ago658 ABR067C
Arabidopsis thaliana (Ath) ath12484 At3g04460.1
Caenorhabditis elegans (Cel) cel5613 F08B12.2
(CE03163;
WBGene00004197)
Candida glabrata (Cgl) cgl4983 CAGL0M07469g
Dictyostelium discoideum (Ddi) ddi8708 DDB0186545
Debaryomyces hansenii (Dha) dha71 DEHA0A01683g
Drosophila melanogaster (Dme) dme146 CG3639-PA
(FBgn0031282)
Danio rerio (Dre) dre20046 ENSDARP00000009146
Takifugu rubripes (Fru) fru7924 SINFRUP00000145935
Gallus gallus (Gga) gga8786 ENSGALP00000003367
(PEX12)
Homo sapiens (Hsa) hsa13470 ENSP00000225873
(PEX12)
O00623
Kluyveromyces lactis (Kla) kla3290 KLLA0E07568g
Mus musculus (Mmu) mmu4421 ENSMUSP00000018877
(MGI:2144177)
Q8VC48
Neurospora crassa (Ncr) ncr5091 NCU05245.2
Oryza sativa (Osa) osa639 873.m00165
Rattus norvegicus (Rno) rno5741 ENSRNOP00000013233
(RGD:620757)
O88177
Saccharomyces cerevisiae (Sce) sce4774 YMR026C
(S000004628)
Schizosaccharomyces pombe (Spo) spo4532 SPAPB17E12.03 Q8TFH8
Yarrowia lipolytica (Yli) yli3828 YALI0D26642g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005777 peroxisome C
IDA
AthAt3g04460
ISO
MmuMGI:2144177
GO:0005778 peroxisomal membrane C
IDA
AthAt3g04460
ISO
MmuMGI:2144177
ISS
SpoSPAPB17E12.03
GO:0005779 integral to peroxisomal membrane C
IDA
SceS000004628
NAS
DmeFBgn0031282
GO:0004842 ubiquitin-protein ligase activity F
IDA
SceS000004628
ISS
SpoSPAPB17E12.03
GO:0005515 protein binding F
IPI
SceS000004628
GO:0008270 zinc ion binding F
ISS
SpoSPAPB17E12.03
GO:0002119 nematode larval development P
IMP
CelWBGene00004197
GO:0006625 protein targeting to peroxisome P
NAS
DmeFBgn0031282
GO:0006635 fatty acid beta-oxidation P
IMP
AthAt3g04460
GO:0007031 peroxisome organization P
IMP
AthAt3g04460
CelWBGene00004197
ISO
MmuMGI:2144177
ISS
SpoSPAPB17E12.03
NAS
DmeFBgn0031282
GO:0007286 spermatid development P
IMP
DmeFBgn0031282
GO:0009792 embryo development ending in birth or egg
hatching
P
IMP
CelWBGene00004197
GO:0016558 protein import into peroxisome
matrix
P
IDA
AthAt3g04460
IMP
AthAt3g04460
SceS000004628
GO:0016567 protein ubiquitination P
ISS
SpoSPAPB17E12.03
GO:0040007 growth P
IMP
CelWBGene00004197
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00004197
GO:0048137 spermatocyte division P
IMP
DmeFBgn0031282
GO:0048598 embryonic morphogenesis P
IMP
AthAt3g04460

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Curated yeast ortholog results:

S. pombe
systematic ID
S. cerevisiae
systematic ID
SPAPB17E12.03
(Q8TFH8)
YMR026C
(S000004628)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005778 peroxisomal membrane C
ISS
SpoSPAPB17E12.03
GO:0005779 integral to peroxisomal membrane C
IDA
SceS000004628
GO:0004842 ubiquitin-protein ligase activity F
IDA
SceS000004628
ISS
SpoSPAPB17E12.03
GO:0005515 protein binding F
IPI
SceS000004628
GO:0008270 zinc ion binding F
ISS
SpoSPAPB17E12.03
GO:0007031 peroxisome organization P
ISS
SpoSPAPB17E12.03
GO:0016558 protein import into peroxisome
matrix
P
IMP
SceS000004628
GO:0016567 protein ubiquitination P
ISS
SpoSPAPB17E12.03

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GO info in one table:

s.khadayate@ucl.ac.uk