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Search term: YMR165C

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name PAH1
SGD link S000004775
Alternative ID YMR165C
Description Mg2+-dependent phosphatidate (PA) phosphatase, catalyzes the dephosphorylation of PA to yield diacylglycerol and Pi, responsible for de novo lipid synthesis; homologous to mammalian lipin 1
Synonyms YMR165C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG2116 ACDHYPE

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALINGMETABOLISM Protein involved in plasmid maintenance/nuclear protein involved in lipid metabolism

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At3g09560 GI:15232716
Arabidopsis thaliana (Ath) At5g42870 GI:15239098
Caenorhabditis elegans (Cel) CE19946
(WBGene00010425)		 GI:17561970 Q9XXT5
Drosophila melanogaster (Dme) 7304087 GI:20129779
Homo sapiens (Hsa) Hs20559103 GI:20559103
Homo sapiens (Hsa) Hs22027648
(LPIN1)		 GI:22027648 Q14693
Homo sapiens (Hsa) Hs22044754 GI:22044754
Homo sapiens (Hsa) Hs7662022
(LPIN2)		 GI:7662022 Q92539
Saccharomyces cerevisiae (Sce) YMR165c
(S000004775)		 GI:6323817 P32567
Schizosaccharomyces pombe (Spo) SPAC1952.13 GI:19115727 Q9UUJ6
Encephalitozoon cuniculi (Ecu) ECU02g0200 GI:19073941 Q8SWG3


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
AthAt3g09560
GO:0005624 membrane fraction C
IDA
SceS000004775
GO:0005634 nucleus C
ISS
HsaLPIN1
GO:0005635 nuclear envelope C
IDA
CelWBGene00010425
GO:0005654 nucleoplasm C
IDA
CelWBGene00010425
GO:0005737 cytoplasm C
IDA
CelWBGene00010425
SceS000004775
ISS
HsaLPIN1
SpoSPAC1952.13
GO:0005783 endoplasmic reticulum C
IDA
CelWBGene00010425
GO:0005829 cytosol C
IDA
SpoSPAC1952.13
GO:0016020 membrane C
IDA
AthAt5g42870
GO:0048046 apoplast C
IDA
AthAt5g42870
GO:0000287 magnesium ion binding F
ISS
SpoSPAC1952.13
GO:0003674 molecular_function F
ND
HsaLPIN1
GO:0003713 transcription coactivator activity F
ISS
HsaLPIN2
GO:0005515 protein binding F
IPI
SpoSPAC1952.13
GO:0008195 phosphatidate phosphatase activity F
IDA
SceS000004775
IGI
AthAt5g42870
At3g09560
IMP
SceS000004775
ISS
HsaLPIN2
SpoSPAC1952.13
GO:0000070 mitotic sister chromatid segregation P
IMP
CelWBGene00010425
GO:0000910 cytokinesis P
IMP
CelWBGene00010425
GO:0002119 nematode larval development P
IMP
CelWBGene00010425
GO:0006276 plasmid maintenance P
IMP
SceS000004775
RCA
SceS000004775
GO:0006629 lipid metabolic process P
IGI
AthAt5g42870
At3g09560
ISS
HsaLPIN2
GO:0006642 triglyceride mobilization P
ISS
HsaLPIN1
GO:0006997 nucleus organization P
IMP
CelWBGene00010425
SpoSPAC1952.13
GO:0006998 nuclear envelope organization P
ISS
SpoSPAC1952.13
GO:0007029 endoplasmic reticulum organization P
IMP
CelWBGene00010425
SpoSPAC1952.13
GO:0007052 mitotic spindle organization P
IMP
CelWBGene00010425
GO:0007078 lamin depolymerization P
IMP
CelWBGene00010425
GO:0008610 lipid biosynthetic process P
IMP
SceS000004775
GO:0008654 phospholipid biosynthetic process P
ISS
SpoSPAC1952.13
GO:0009060 aerobic respiration P
IMP
SceS000004775
GO:0009062 fatty acid catabolic process P
ISS
HsaLPIN1
GO:0009790 embryo development P
IMP
CelWBGene00010425
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00010425
GO:0016036 cellular response to phosphate
starvation		 P
IGI
AthAt5g42870
At3g09560
GO:0016043 cellular component organization P
IMP
CelWBGene00010425
GO:0019915 lipid storage P
IMP
CelWBGene00010425
GO:0030437 ascospore formation P
IMP
SpoSPAC1952.13
GO:0031468 nuclear envelope reassembly P
IMP
CelWBGene00010425
GO:0032940 secretion by cell P
IMP
CelWBGene00010425
GO:0033554 cellular response to stress P
IEP
SpoSPAC1952.13
GO:0034504 protein localization in nucleus P
IMP
CelWBGene00010425
GO:0040007 growth P
IMP
CelWBGene00010425
GO:0040011 locomotion P
IMP
CelWBGene00010425
GO:0040018 positive regulation of multicellular organism
growth		 P
IMP
CelWBGene00010425
GO:0045944 positive regulation of transcription from RNA
polymerase II promoter		 P
ISS
HsaLPIN2
GO:0051081 nuclear envelope disassembly P
IMP
CelWBGene00010425
GO:0051276 chromosome organization P
IMP
SpoSPAC1952.13
GO:0051301 cell division P
IMP
CelWBGene00010425

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
31840

Species Gene ID NCBI link UniProt link
Schizosaccharomyces pombe (Spo) ned1
(SPAC1952.13)		 GI:19115727 Q9UUJ6
Saccharomyces cerevisiae (Sce) PAH1
(S000004775)		 GI:6323817 P32567
Kluyveromyces lactis (Kla) KLLA0D09867g GI:50307045
Eremothecium gossypii (Ego) AGOS_AFL195W GI:45198326
Magnaporthe grisea (Mgr) MGG_01311 GI:39951337
Neurospora crassa (Ncr) NCU03137.1 GI:32420259


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005624 membrane fraction C
IDA
SceS000004775
GO:0005737 cytoplasm C
IDA
SceS000004775
ISS
SpoSPAC1952.13
GO:0005829 cytosol C
IDA
SpoSPAC1952.13
GO:0000287 magnesium ion binding F
ISS
SpoSPAC1952.13
GO:0005515 protein binding F
IPI
SpoSPAC1952.13
GO:0008195 phosphatidate phosphatase activity F
IDA
SceS000004775
IMP
SceS000004775
ISS
SpoSPAC1952.13
GO:0006276 plasmid maintenance P
IMP
SceS000004775
RCA
SceS000004775
GO:0006997 nucleus organization P
IMP
SpoSPAC1952.13
GO:0006998 nuclear envelope organization P
ISS
SpoSPAC1952.13
GO:0007029 endoplasmic reticulum organization P
IMP
SpoSPAC1952.13
GO:0008610 lipid biosynthetic process P
IMP
SceS000004775
GO:0008654 phospholipid biosynthetic process P
ISS
SpoSPAC1952.13
GO:0009060 aerobic respiration P
IMP
SceS000004775
GO:0030437 ascospore formation P
IMP
SpoSPAC1952.13
GO:0033554 cellular response to stress P
IEP
SpoSPAC1952.13
GO:0051276 chromosome organization P
IMP
SpoSPAC1952.13

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_313

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga3056 ENSANGP00000009316
Ashbya gossypii (Ago) ago3000 AFL195W
Arabidopsis thaliana (Ath) ath13035 At3g09560.1
Arabidopsis thaliana (Ath) ath13036 At3g09560.2
Arabidopsis thaliana (Ath) ath26087 At5g42870.1
Caenorhabditis elegans (Cel) cel11486 H37A05.1
(CE19946;
WBGene00010425)
Candida glabrata (Cgl) cgl1560 CAGL0F07689g
Cryptococcus neoformans (Cne) cne492 163.m06330
Dictyostelium discoideum (Ddi) ddi1215 DDB0168507
Debaryomyces hansenii (Dha) dha2520 DEHA0D04972g
Drosophila melanogaster (Dme) dme3828 CG8709-PA
(FBgn0033269)
Danio rerio (Dre) dre11300 ENSDARP00000018903
Danio rerio (Dre) dre11302 ENSDARP00000019852
Danio rerio (Dre) dre11303 ENSDARP00000025443
Danio rerio (Dre) dre4332 ENSDARP00000038311
Danio rerio (Dre) dre23090 ENSDARP00000040487
Danio rerio (Dre) dre23093 ENSDARP00000041277
Danio rerio (Dre) dre11301 ENSDARP00000042864
Danio rerio (Dre) dre23089 ENSDARP00000044614
Danio rerio (Dre) dre11299 ENSDARP00000047108
Danio rerio (Dre) dre23092 ENSDARP00000048503
Danio rerio (Dre) dre23091 ENSDARP00000050023
Encephalitozoon cuniculi (Ecu) ecu20 19073941
Takifugu rubripes (Fru) fru17087 SINFRUP00000130208
Takifugu rubripes (Fru) fru8147 SINFRUP00000131947
Takifugu rubripes (Fru) fru5451 SINFRUP00000134836
Takifugu rubripes (Fru) fru5453 SINFRUP00000134841
Takifugu rubripes (Fru) fru19824 SINFRUP00000142452
Takifugu rubripes (Fru) fru32509 SINFRUP00000164112
Takifugu rubripes (Fru) fru8142 SINFRUP00000166285
Takifugu rubripes (Fru) fru17088 SINFRUP00000166905
Takifugu rubripes (Fru) fru17089 SINFRUP00000167693
Takifugu rubripes (Fru) fru5452 SINFRUP00000172935
Takifugu rubripes (Fru) fru8145 SINFRUP00000173738
Takifugu rubripes (Fru) fru17086 SINFRUP00000175920
Takifugu rubripes (Fru) fru8144 SINFRUP00000176510
Takifugu rubripes (Fru) fru8143 SINFRUP00000176814
Gallus gallus (Gga) gga10972 ENSGALP00000023902
(LPIN2)
Gallus gallus (Gga) gga10973 ENSGALP00000023903
Gallus gallus (Gga) gga10974 ENSGALP00000023904
Gallus gallus (Gga) gga15992 ENSGALP00000026499
Gallus gallus (Gga) gga15993 ENSGALP00000026500
Gallus gallus (Gga) gga15991 ENSGALP00000026501
(LPIN1)
Homo sapiens (Hsa) hsa20220 ENSP00000255145
Homo sapiens (Hsa) hsa17481 ENSP00000256720
(LPIN1)		 B7Z858
Homo sapiens (Hsa) hsa14673 ENSP00000261596
(LPIN2)		 Q92539
Kluyveromyces lactis (Kla) kla2499 KLLA0D09867g
Mus musculus (Mmu) mmu12073 ENSMUSP00000024848
Mus musculus (Mmu) mmu5493 ENSMUSP00000039197
(MGI:1891340)		 Q3U3C3
Mus musculus (Mmu) mmu15928 ENSMUSP00000043053
(MGI:1891342)		 Q99PI4
Mus musculus (Mmu) mmu12074 ENSMUSP00000053756
(MGI:1891341)		 Q99PI5-1
Mus musculus (Mmu) mmu5494 ENSMUSP00000070583
(MGI:1891340)		 Q91ZP3-1
Neurospora crassa (Ncr) ncr3041 NCU03137.2
Oryza sativa (Osa) osa23389 3729.m00150
Oryza sativa (Osa) osa30644 4352.m00200
Oryza sativa (Osa) osa30649 4352.m00237
Oryza sativa (Osa) osa71360 6998.m00169
Plasmodium falciparum (Pfa) pfa2685 PFC0150w
Rattus norvegicus (Rno) rno24904 ENSRNOP00000005863
(RGD:1307646)		 Q5XIM8
Rattus norvegicus (Rno) rno30631 ENSRNOP00000020476
(RGD:1304588)
Rattus norvegicus (Rno) rno20177 ENSRNOP00000022403
(RGD:1588534)		 Q5EBA5
Rattus norvegicus (Rno) rno24905 ENSRNOP00000035585
(RGD:1307646)
Saccharomyces cerevisiae (Sce) sce4927 YMR165C
(S000004775)
Schizosaccharomyces pombe (Spo) spo4447 SPAC1952.13 Q9UUJ6
Yarrowia lipolytica (Yli) yli3845 YALI0D27016g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
AthAt3g09560
GO:0005624 membrane fraction C
IDA
SceS000004775
GO:0005634 nucleus C
IDA
MmuMGI:1891340
ISA
MmuMGI:1891342
GO:0005635 nuclear envelope C
IDA
CelWBGene00010425
GO:0005654 nucleoplasm C
IDA
CelWBGene00010425
GO:0005737 cytoplasm C
IDA
CelWBGene00010425
MmuMGI:1891340
SceS000004775
ISS
SpoSPAC1952.13
GO:0005783 endoplasmic reticulum C
IDA
CelWBGene00010425
GO:0005789 endoplasmic reticulum membrane C
IDA
MmuMGI:1891341
GO:0005829 cytosol C
IDA
MmuMGI:1891341
SpoSPAC1952.13
GO:0016020 membrane C
IDA
AthAt5g42870
GO:0048046 apoplast C
IDA
AthAt5g42870
GO:0000287 magnesium ion binding F
ISS
SpoSPAC1952.13
GO:0003713 transcription coactivator activity F
IDA
MmuMGI:1891340
MGI:1891341
GO:0005515 protein binding F
IPI
MmuMGI:1891340
SpoSPAC1952.13
GO:0008195 phosphatidate phosphatase activity F
IDA
MmuMGI:1891342
MGI:1891341
MGI:1891340
SceS000004775
IGI
AthAt5g42870
At3g09560
IMP
SceS000004775
ISS
SpoSPAC1952.13
GO:0042975 peroxisome proliferator activated receptor
binding		 F
IPI
MmuMGI:1891340
GO:0000070 mitotic sister chromatid segregation P
IMP
CelWBGene00010425
GO:0000910 cytokinesis P
IMP
CelWBGene00010425
GO:0002119 nematode larval development P
IMP
CelWBGene00010425
GO:0006276 plasmid maintenance P
IMP
SceS000004775
RCA
SceS000004775
GO:0006629 lipid metabolic process P
IDA
MmuMGI:1891341
IGI
AthAt5g42870
At3g09560
IMP
MmuMGI:1891340
GO:0006642 triglyceride mobilization P
IDA
MmuMGI:1891340
GO:0006997 nucleus organization P
IMP
CelWBGene00010425
SpoSPAC1952.13
GO:0006998 nuclear envelope organization P
ISS
SpoSPAC1952.13
GO:0007029 endoplasmic reticulum organization P
IMP
CelWBGene00010425
SpoSPAC1952.13
GO:0007052 mitotic spindle organization P
IMP
CelWBGene00010425
GO:0007078 lamin depolymerization P
IMP
CelWBGene00010425
GO:0008610 lipid biosynthetic process P
IMP
SceS000004775
GO:0008654 phospholipid biosynthetic process P
ISS
SpoSPAC1952.13
GO:0009060 aerobic respiration P
IMP
SceS000004775
GO:0009062 fatty acid catabolic process P
IDA
MmuMGI:1891340
GO:0009790 embryo development P
IMP
CelWBGene00010425
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00010425
GO:0016036 cellular response to phosphate
starvation		 P
IGI
AthAt5g42870
At3g09560
GO:0016043 cellular component organization P
IMP
CelWBGene00010425
GO:0016311 dephosphorylation P
IDA
MmuMGI:1891341
MGI:1891340
MGI:1891342
GO:0019915 lipid storage P
IMP
CelWBGene00010425
GO:0030437 ascospore formation P
IMP
SpoSPAC1952.13
GO:0031468 nuclear envelope reassembly P
IMP
CelWBGene00010425
GO:0031529 ruffle organization P
IMP
MmuMGI:1891340
GO:0031532 actin cytoskeleton reorganization P
IMP
MmuMGI:1891340
GO:0032869 cellular response to insulin stimulus P
IMP
MmuMGI:1891340
ISO
MmuMGI:1891340
GO:0032940 secretion by cell P
IMP
CelWBGene00010425
GO:0033554 cellular response to stress P
IEP
SpoSPAC1952.13
GO:0034504 protein localization in nucleus P
IMP
CelWBGene00010425
GO:0040007 growth P
IMP
CelWBGene00010425
GO:0040011 locomotion P
IMP
CelWBGene00010425
GO:0040018 positive regulation of multicellular organism
growth		 P
IMP
CelWBGene00010425
GO:0045444 fat cell differentiation P
NAS
MmuMGI:1891340
GO:0045598 regulation of fat cell differentiation P
IMP
MmuMGI:1891340
GO:0045944 positive regulation of transcription from RNA
polymerase II promoter		 P
IDA
MmuMGI:1891341
MGI:1891340
GO:0051081 nuclear envelope disassembly P
IMP
CelWBGene00010425
GO:0051276 chromosome organization P
IMP
SpoSPAC1952.13
GO:0051301 cell division P
IMP
CelWBGene00010425

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPAC1952.13
(Q9UUJ6)		 YMR165C
(S000004775)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005624 membrane fraction C
IDA
SceS000004775
GO:0005737 cytoplasm C
IDA
SceS000004775
ISS
SpoSPAC1952.13
GO:0005829 cytosol C
IDA
SpoSPAC1952.13
GO:0000287 magnesium ion binding F
ISS
SpoSPAC1952.13
GO:0005515 protein binding F
IPI
SpoSPAC1952.13
GO:0008195 phosphatidate phosphatase activity F
IDA
SceS000004775
IMP
SceS000004775
ISS
SpoSPAC1952.13
GO:0006276 plasmid maintenance P
IMP
SceS000004775
RCA
SceS000004775
GO:0006997 nucleus organization P
IMP
SpoSPAC1952.13
GO:0006998 nuclear envelope organization P
ISS
SpoSPAC1952.13
GO:0007029 endoplasmic reticulum organization P
IMP
SpoSPAC1952.13
GO:0008610 lipid biosynthetic process P
IMP
SceS000004775
GO:0008654 phospholipid biosynthetic process P
ISS
SpoSPAC1952.13
GO:0009060 aerobic respiration P
IMP
SceS000004775
GO:0030437 ascospore formation P
IMP
SpoSPAC1952.13
GO:0033554 cellular response to stress P
IEP
SpoSPAC1952.13
GO:0051276 chromosome organization P
IMP
SpoSPAC1952.13

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