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Search term: YMR202W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name ERG2
SGD link S000004815
Alternative ID YMR202W
Description C-8 sterol isomerase, catalyzes the isomerization of the delta-8 double bond to the delta-7 position at an intermediate step in ergosterol biosynthesis
Synonyms YMR202W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG4143 ---HYP-

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALING Sigma receptor and C-8 sterol isomerase

Species KOG link NCBI link UniProt link
Homo sapiens (Hsa) Hs5032117
(SIGMAR1)		 GI:5032117 Q8N7H3
Saccharomyces cerevisiae (Sce) YMR202w
(S000004815)		 GI:6323858 P32352
Schizosaccharomyces pombe (Spo) SPAC20G8.07c GI:19114236 P87113


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005635 nuclear envelope C
IDA
HsaSIGMAR1
GO:0005783 endoplasmic reticulum C
IDA
SpoSPAC20G8.07c
ISS
SpoSPAC20G8.07c
TAS
SceS000004815
GO:0005887 integral to plasma membrane C
TAS
HsaSIGMAR1
GO:0016021 integral to membrane C
TAS
HsaSIGMAR1
GO:0000247 C-8 sterol isomerase activity F
IMP
SceS000004815
ISS
SpoSPAC20G8.07c
GO:0008144 drug binding F
TAS
HsaSIGMAR1
GO:0006066 alcohol metabolic process P
RCA
SceS000004815
GO:0006696 ergosterol biosynthetic process P
IMP
SceS000004815
SpoSPAC20G8.07c
GO:0030437 ascospore formation P
IMP
SpoSPAC20G8.07c
GO:0043094 cellular metabolic compound salvage P
RCA
SceS000004815
GO:0071210 protein insertion into membrane
raft		 P
IMP
SpoSPAC20G8.07c
GO:0090002 establishment of protein localization in plasma
membrane		 P
IMP
SpoSPAC20G8.07c

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
39965

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) SIGMAR1 GI:5032117 Q8N7H3
Pan troglodytes (Ptr) SIGMAR1 GI:114624244
Canis familiaris (Cfa) SIGMAR1 GI:73971191
Mus musculus (Mmu) Sigmar1
(MGI:1195268)		 GI:6754942 A2AMS0
Rattus norvegicus (Rno) Oprs1
(RGD:68364)		 GI:13591888
Schizosaccharomyces pombe (Spo) erg2
(SPAC20G8.07c)		 GI:19114236 P87113
Saccharomyces cerevisiae (Sce) ERG2
(S000004815)		 GI:6323858 P32352
Kluyveromyces lactis (Kla) KLLA0F06336g GI:50310691
Eremothecium gossypii (Ego) AGOS_AFL181C GI:45198340
Magnaporthe grisea (Mgr) MGG_08624 GI:39947737
Neurospora crassa (Ncr) NCU04156.1 GI:32405766


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005635 nuclear envelope C
IDA
HsaSIGMAR1
GO:0005783 endoplasmic reticulum C
IDA
SpoSPAC20G8.07c
ISS
SpoSPAC20G8.07c
TAS
SceS000004815
GO:0005887 integral to plasma membrane C
TAS
HsaSIGMAR1
GO:0016021 integral to membrane C
TAS
HsaSIGMAR1
GO:0000247 C-8 sterol isomerase activity F
IMP
SceS000004815
ISS
SpoSPAC20G8.07c
GO:0004872 receptor activity F
IDA
MmuMGI:1195268
GO:0004985 opioid receptor activity F
ISO
MmuMGI:1195268
GO:0008144 drug binding F
TAS
HsaSIGMAR1
GO:0006066 alcohol metabolic process P
RCA
SceS000004815
GO:0006696 ergosterol biosynthetic process P
IMP
SceS000004815
SpoSPAC20G8.07c
GO:0007165 signal transduction P
IDA
MmuMGI:1195268
GO:0007399 nervous system development P
ISO
MmuMGI:1195268
GO:0030437 ascospore formation P
IMP
SpoSPAC20G8.07c
GO:0043094 cellular metabolic compound salvage P
RCA
SceS000004815
GO:0071210 protein insertion into membrane
raft		 P
IMP
SpoSPAC20G8.07c
GO:0090002 establishment of protein localization in plasma
membrane		 P
IMP
SpoSPAC20G8.07c

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_5987

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Ashbya gossypii (Ago) ago3014 AFL181C
Candida glabrata (Cgl) cgl4541 CAGL0L10714g
Cryptococcus neoformans (Cne) cne2527 181.m08573
Dictyostelium discoideum (Ddi) ddi4142 DDB0190993
Debaryomyces hansenii (Dha) dha2772 DEHA0D10714g
Danio rerio (Dre) dre15142 ENSDARP00000011354
Takifugu rubripes (Fru) fru22291 SINFRUP00000133844
Homo sapiens (Hsa) hsa31186 ENSP00000277010
(SIGMAR1)		 Q99720-1
Homo sapiens (Hsa) hsa31189 ENSP00000353935
(SIGMAR1)		 Q99720-5
Kluyveromyces lactis (Kla) kla4367 KLLA0F06336g
Mus musculus (Mmu) mmu17994 ENSMUSP00000056027
(MGI:1195268)		 O55242-1
Neurospora crassa (Ncr) ncr4032 NCU04156.2
Rattus norvegicus (Rno) rno22994 ENSRNOP00000019795
(RGD:68364)		 Q9R0C9-1
Saccharomyces cerevisiae (Sce) sce4971 YMR202W
(S000004815)
Schizosaccharomyces pombe (Spo) spo4315 SPAC20G8.07c P87113
Yarrowia lipolytica (Yli) yli1461 YALI0B17204g
Yarrowia lipolytica (Yli) yli5195 YALI0E32065g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005783 endoplasmic reticulum C
IDA
SpoSPAC20G8.07c
ISS
SpoSPAC20G8.07c
TAS
SceS000004815
GO:0000247 C-8 sterol isomerase activity F
IMP
SceS000004815
ISS
SpoSPAC20G8.07c
GO:0004872 receptor activity F
IDA
MmuMGI:1195268
GO:0004985 opioid receptor activity F
ISO
MmuMGI:1195268
GO:0006066 alcohol metabolic process P
RCA
SceS000004815
GO:0006696 ergosterol biosynthetic process P
IMP
SceS000004815
SpoSPAC20G8.07c
GO:0007165 signal transduction P
IDA
MmuMGI:1195268
GO:0007399 nervous system development P
ISO
MmuMGI:1195268
GO:0030437 ascospore formation P
IMP
SpoSPAC20G8.07c
GO:0043094 cellular metabolic compound salvage P
RCA
SceS000004815
GO:0071210 protein insertion into membrane
raft		 P
IMP
SpoSPAC20G8.07c
GO:0090002 establishment of protein localization in plasma
membrane		 P
IMP
SpoSPAC20G8.07c

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPAC20G8.07c
(P87113)		 YMR202W
(S000004815)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005783 endoplasmic reticulum C
IDA
SpoSPAC20G8.07c
ISS
SpoSPAC20G8.07c
TAS
SceS000004815
GO:0000247 C-8 sterol isomerase activity F
IMP
SceS000004815
ISS
SpoSPAC20G8.07c
GO:0006066 alcohol metabolic process P
RCA
SceS000004815
GO:0006696 ergosterol biosynthetic process P
IMP
SceS000004815
SpoSPAC20G8.07c
GO:0030437 ascospore formation P
IMP
SpoSPAC20G8.07c
GO:0043094 cellular metabolic compound salvage P
RCA
SceS000004815
GO:0071210 protein insertion into membrane
raft		 P
IMP
SpoSPAC20G8.07c
GO:0090002 establishment of protein localization in plasma
membrane		 P
IMP
SpoSPAC20G8.07c

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GO info in one table:

s.khadayate@ucl.ac.uk