Bahler Lab

Search term: YMR208W

Gene summary:

Species Saccharomyces cerevisiae (Sce)

Primary name ERG12

SGD link S000004821

Alternative ID YMR208W

Description Mevalonate kinase, acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate

Synonyms YMR208W

Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

Search for gene by ID or name:

Query species:

Include wild-cards: Yes No

Search for GO info: Yes No

GO info in one table: Yes No

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)

KOG1511 ACDHYPE

KOGs classification KOGs description

METABOLISM Mevalonate kinase MVK/ERG12

Species KOG link NCBI link UniProt link

Arabidopsis thaliana (Ath) At5g27450 GI:15240936

Caenorhabditis elegans (Cel) CE29110
(WBGene00021534) GI:17555862

Drosophila melanogaster (Dme) 7303424 GI:19922118

Homo sapiens (Hsa) Hs4557769
(MVK) GI:4557769 Q03426

Saccharomyces cerevisiae (Sce) YMR208w
(S000004821) GI:6323864 P07277

Schizosaccharomyces pombe (Spo) SPAC13G6.11c GI:19113749 Q09780

Encephalitozoon cuniculi (Ecu) ECU09g1780 GI:19173299

GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations

GO:0005634 nucleus C
IDA
Spo SPAC13G6.11c

GO:0005737 cytoplasm C
ISS
Spo SPAC13G6.11c

GO:0005829 cytosol C
IDA
Spo SPAC13G6.11c
TAS
Sce S000004821

GO:0004496 mevalonate kinase activity F
IDA
Hsa MVK
Sce S000004821
IGI
Ath At5g27450
ISS
Ath At5g27450
Spo SPAC13G6.11c

GO:0042802 identical protein binding F
IPI
Hsa MVK

GO:0042803 protein homodimerization activity F
ISS
Spo SPAC13G6.11c

GO:0002119 nematode larval development P
IMP
Cel WBGene00021534

GO:0006066 alcohol metabolic process P
RCA
Sce S000004821

GO:0006696 ergosterol biosynthetic process P
IMP
Sce S000004821
ISS
Spo SPAC13G6.11c

GO:0008299 isoprenoid biosynthetic process P
IDA
Hsa MVK

GO:0008340 determination of adult lifespan P
IMP
Cel WBGene00021534

GO:0009792 embryo development ending in birth or egg
hatching P
IMP
Cel WBGene00021534

GO:0010142 farnesyl diphosphate biosynthetic process,
mevalonate pathway P
IMP
Sce S000004821

GO:0019287 isopentenyl diphosphate biosynthetic process,
mevalonate pathway P
IMP
Sce S000004821

GO:0040007 growth P
IMP
Cel WBGene00021534

GO:0040011 locomotion P
IMP
Cel WBGene00021534

GO:0043094 cellular metabolic compound salvage P
RCA
Sce S000004821

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern

372

Species Gene ID NCBI link UniProt link

Homo sapiens (Hsa) MVK GI:4557769 Q03426

Canis familiaris (Cfa) MVK GI:73995337

Mus musculus (Mmu) Mvk
(MGI:107624) GI:12963731 Q3UEB4

Gallus gallus (Gga) MVK GI:118098609

Caenorhabditis elegans (Cel) Y42G9A.4
(CE29110;
WBGene00021534) GI:71993795

Schizosaccharomyces pombe (Spo) erg12
(SPAC13G6.11c) GI:19113749 Q09780

Saccharomyces cerevisiae (Sce) ERG12
(S000004821) GI:6323864 P07277

Kluyveromyces lactis (Kla) KLLA0C07469g GI:50305147

Eremothecium gossypii (Ego) AGOS_AER335W GI:45190937

Magnaporthe grisea (Mgr) MGG_06946 GI:39978123

Neurospora crassa (Ncr) NCU03633.1 GI:32404644

Arabidopsis thaliana (Ath) MK GI:15240936

Oryza sativa (Osa) Os10g0329300 GI:115481534

GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations

GO:0005575 cellular_component C
ND
Ath MK

GO:0005576 extracellular region C
ISS
Ath MK

GO:0005625 soluble fraction C
ISO
Mmu MGI:107624

GO:0005634 nucleus C
IDA
Ath MK
Spo SPAC13G6.11c

GO:0005737 cytoplasm C
IDA
Ath MK
ISS
Spo SPAC13G6.11c

GO:0005739 mitochondrion C
IDA
Ath MK

GO:0005777 peroxisome C
ISO
Mmu MGI:107624

GO:0005829 cytosol C
IDA
Spo SPAC13G6.11c
ISO
Mmu MGI:107624
TAS
Sce S000004821

GO:0005840 ribosome C
ISS
Ath MK

GO:0005886 plasma membrane C
IDA
Ath MK

GO:0009505 plant-type cell wall C
IDA
Ath MK

GO:0009507 chloroplast C
IDA
Ath MK

GO:0016020 membrane C
NAS
Ath MK

GO:0022625 cytosolic large ribosomal subunit C
IDA
Ath MK

GO:0080008 CUL4 RING ubiquitin ligase complex C
ISS
Ath MK

GO:0003674 molecular_function F
ND
Ath MK

GO:0003676 nucleic acid binding F
ISS
Ath MK

GO:0003700 transcription factor activity F
ISS
Ath MK

GO:0003729 mRNA binding F
ISO
Mmu MGI:107624

GO:0003735 structural constituent of ribosome F
ISS
Ath MK

GO:0004017 adenylate kinase activity F
ISS
Ath MK

GO:0004496 mevalonate kinase activity F
IDA
Hsa MVK
Mmu MGI:107624
Sce S000004821
IGI
Ath MK
ISO
Mmu MGI:107624
ISS
Ath MK
Spo SPAC13G6.11c

GO:0004519 endonuclease activity F
ISS
Ath MK

GO:0004650 polygalacturonase activity F
ISS
Ath MK

GO:0004657 proline dehydrogenase activity F
ISS
Ath MK

GO:0004672 protein kinase activity F
NAS
Ath MK

GO:0004674 protein serine/threonine kinase
activity F
ISS
Ath MK

GO:0004675 transmembrane receptor protein serine/threonine
kinase activity F
IDA
Ath MK

GO:0004708 MAP kinase kinase activity F
IDA
Ath MK
ISS
Ath MK
TAS
Ath MK

GO:0004776 succinate-CoA ligase (GDP-forming)
activity F
ISS
Ath MK

GO:0005507 copper ion binding F
IDA
Ath MK

GO:0005515 protein binding F
IPI
Ath MK
ISS
Ath MK

GO:0005524 ATP binding F
ISO
Mmu MGI:107624
ISS
Ath MK

GO:0008138 protein tyrosine/serine/threonine phosphatase
activity F
ISS
Ath MK

GO:0008757 S-adenosylmethionine-dependent methyltransferase
activity F
ISS
Ath MK

GO:0016301 kinase activity F
IDA
Ath MK
ISS
Ath MK

GO:0016740 transferase activity F
ISS
Ath MK

GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase
activity F
ISS
Ath MK

GO:0030247 polysaccharide binding F
IDA
Ath MK

GO:0030295 protein kinase activator activity F
IDA
Ath MK

GO:0033549 MAP kinase phosphatase activity F
IDA
Ath MK

GO:0042802 identical protein binding F
IPI
Hsa MVK

GO:0042803 protein homodimerization activity F
ISS
Spo SPAC13G6.11c

GO:0050566 asparaginyl-tRNA synthase (glutamine-hydrolyzing)
activity F
ISS
Ath MK

GO:0000165 MAPKKK cascade P
IC
Ath MK
IGI
Ath MK
ISS
Ath MK

GO:0002119 nematode larval development P
IMP
Cel WBGene00021534

GO:0002229 defense response to oomycetes P
IMP
Ath MK

GO:0005975 carbohydrate metabolic process P
ISS
Ath MK

GO:0006066 alcohol metabolic process P
RCA
Sce S000004821

GO:0006281 DNA repair P
ISS
Ath MK

GO:0006412 translation P
ISS
Ath MK

GO:0006457 protein folding P
ISS
Ath MK

GO:0006468 protein amino acid phosphorylation P
ISS
Ath MK

GO:0006506 GPI anchor biosynthetic process P
ISS
Ath MK

GO:0006537 glutamate biosynthetic process P
ISS
Ath MK

GO:0006562 proline catabolic process P
ISS
Ath MK

GO:0006696 ergosterol biosynthetic process P
IMP
Sce S000004821
ISS
Spo SPAC13G6.11c

GO:0006950 response to stress P
IMP
Ath MK

GO:0007165 signal transduction P
IC
Ath MK
IDA
Ath MK

GO:0007169 transmembrane receptor protein tyrosine kinase
signaling pathway P
ISS
Ath MK

GO:0007243 intracellular protein kinase cascade P
IC
Ath MK

GO:0008150 biological_process P
ND
Ath MK

GO:0008152 metabolic process P
ISS
Ath MK

GO:0008299 isoprenoid biosynthetic process P
IDA
Hsa MVK
ISO
Mmu MGI:107624

GO:0008340 determination of adult lifespan P
IMP
Cel WBGene00021534

GO:0009409 response to cold P
IDA
Ath MK
IMP
Ath MK

GO:0009611 response to wounding P
IEP
Ath MK

GO:0009631 cold acclimation P
IMP
Ath MK

GO:0009651 response to salt stress P
IDA
Ath MK
IGI
Ath MK
IMP
Ath MK

GO:0009693 ethylene biosynthetic process P
IDA
Ath MK

GO:0009792 embryo development ending in birth or egg
hatching P
IMP
Cel WBGene00021534

GO:0009793 embryo development ending in seed
dormancy P
ISS
Ath MK

GO:0009814 defense response, incompatible
interaction P
IGI
Ath MK
IMP
Ath MK

GO:0009862 systemic acquired resistance, salicylic acid
mediated signaling pathway P
IMP
Ath MK

GO:0009864 induced systemic resistance, jasmonic acid
mediated signaling pathway P
IEP
Ath MK

GO:0009866 induced systemic resistance, ethylene mediated
signaling pathway P
IEP
Ath MK

GO:0009870 defense response signaling pathway, resistance
gene-dependent P
IMP
Ath MK
TAS
Ath MK

GO:0009873 ethylene mediated signaling pathway P
IMP
Ath MK

GO:0009926 auxin polar transport P
IMP
Ath MK

GO:0010120 camalexin biosynthetic process P
IDA
Ath MK

GO:0010142 farnesyl diphosphate biosynthetic process,
mevalonate pathway P
IMP
Sce S000004821

GO:0010193 response to ozone P
IMP
Ath MK

GO:0010225 response to UV-C P
IMP
Ath MK

GO:0010227 floral organ abscission P
IMP
Ath MK

GO:0016310 phosphorylation P
IDA
Mmu MGI:107624

GO:0017148 negative regulation of translation P
ISO
Mmu MGI:107624

GO:0019287 isopentenyl diphosphate biosynthetic process,
mevalonate pathway P
IMP
Sce S000004821
ISO
Mmu MGI:107624

GO:0040007 growth P
IMP
Cel WBGene00021534

GO:0040011 locomotion P
IMP
Cel WBGene00021534

GO:0042254 ribosome biogenesis P
ISS
Ath MK

GO:0042742 defense response to bacterium P
IMP
Ath MK

GO:0043094 cellular metabolic compound salvage P
RCA
Sce S000004821

GO:0043407 negative regulation of MAP kinase
activity P
IMP
Ath MK

GO:0045449 regulation of transcription P
TAS
Ath MK

GO:0045941 positive regulation of transcription P
IEP
Ath MK

GO:0046777 protein amino acid autophosphorylation P
IDA
Ath MK

GO:2000037 regulation of stomatal complex
patterning P
IGI
Ath MK

GO:2000038 regulation of stomatal complex
development P
IGI
Ath MK

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern

OG1_2829

Species OrthoMCL
sequence Model organism
protein page UniProt link

Anopheles gambiae (Aga) aga11034 ENSANGP00000021364

Ashbya gossypii (Ago) ago2836 AER335W

Arabidopsis thaliana (Ath) ath25018 At5g27450.1

Arabidopsis thaliana (Ath) ath25019 At5g27450.2

Caenorhabditis elegans (Cel) cel18763 Y42G9A.4a
(CE29110;
WBGene00021534)

Caenorhabditis elegans (Cel) cel18764 Y42G9A.4b
(CE37427)

Caenorhabditis elegans (Cel) cel18765 Y42G9A.4c
(CE37428)

Caenorhabditis elegans (Cel) cel18766 Y42G9A.4d
(CE37569)

Candida glabrata (Cgl) cgl1396 CAGL0F03861g

Dictyostelium discoideum (Ddi) ddi2783 DDB0168621

Debaryomyces hansenii (Dha) dha4925 DEHA0F12188g

Drosophila melanogaster (Dme) dme4741 CG33009-PA

Danio rerio (Dre) dre18997 ENSDARP00000019792
(zgc:103473) Q5U3I7

Encephalitozoon cuniculi (Ecu) ecu1450 19173299

Takifugu rubripes (Fru) fru10167 SINFRUP00000155076

Gallus gallus (Gga) gga26834 ENSGALP00000022427

Gallus gallus (Gga) gga26835 ENSGALP00000022428
(MVK)

Homo sapiens (Hsa) hsa8156 ENSP00000228510
(MVK) Q03426

Kluyveromyces lactis (Kla) kla1531 KLLA0C07469g

Mus musculus (Mmu) mmu20728 ENSMUSP00000036971
(MGI:107624) Q9R008

Neurospora crassa (Ncr) ncr3524 NCU03633.2

Oryza sativa (Osa) osa5192 2178.m00134

Saccharomyces cerevisiae (Sce) sce4977 YMR208W
(S000004821)

Schizosaccharomyces pombe (Spo) spo2526 SPAC13G6.11c Q09780

Yarrowia lipolytica (Yli) yli1411 YALI0B16038g

GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations

GO:0005625 soluble fraction C
ISO
Mmu MGI:107624

GO:0005634 nucleus C
IDA
Spo SPAC13G6.11c

GO:0005737 cytoplasm C
ISS
Spo SPAC13G6.11c

GO:0005777 peroxisome C
ISO
Mmu MGI:107624

GO:0005829 cytosol C
IDA
Spo SPAC13G6.11c
ISO
Mmu MGI:107624
TAS
Sce S000004821

GO:0003729 mRNA binding F
ISO
Mmu MGI:107624

GO:0004496 mevalonate kinase activity F
IDA
Mmu MGI:107624
Sce S000004821
IGI
Ath At5g27450
ISO
Mmu MGI:107624
ISS
Ath At5g27450
Spo SPAC13G6.11c

GO:0005524 ATP binding F
ISO
Mmu MGI:107624

GO:0042803 protein homodimerization activity F
ISS
Spo SPAC13G6.11c

GO:0002119 nematode larval development P
IMP
Cel WBGene00021534

GO:0006066 alcohol metabolic process P
RCA
Sce S000004821

GO:0006696 ergosterol biosynthetic process P
IMP
Sce S000004821
ISS
Spo SPAC13G6.11c

GO:0008299 isoprenoid biosynthetic process P
ISO
Mmu MGI:107624

GO:0008340 determination of adult lifespan P
IMP
Cel WBGene00021534

GO:0009792 embryo development ending in birth or egg
hatching P
IMP
Cel WBGene00021534

GO:0010142 farnesyl diphosphate biosynthetic process,
mevalonate pathway P
IMP
Sce S000004821

GO:0016310 phosphorylation P
IDA
Mmu MGI:107624

GO:0017148 negative regulation of translation P
ISO
Mmu MGI:107624

GO:0019287 isopentenyl diphosphate biosynthetic process,
mevalonate pathway P
IMP
Sce S000004821
ISO
Mmu MGI:107624

GO:0040007 growth P
IMP
Cel WBGene00021534

GO:0040011 locomotion P
IMP
Cel WBGene00021534

GO:0043094 cellular metabolic compound salvage P
RCA
Sce S000004821

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Curated yeast ortholog results:

S. pombe
systematic ID S. cerevisiae
systematic ID

SPAC13G6.11c
(Q09780) YMR208W
(S000004821)

GO terms for curated homolog results:

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YOGY Home

YOGY Help

Search for gene by ID or name:

Query species:

Include wild-cards: Yes No

Search for GO info: Yes No

GO info in one table: Yes No

s.khadayate@ucl.ac.uk

KOG name	Phylogenetic pattern (and link to KOGs with this pattern)
KOG1511	ACDHYPE

KOGs classification	KOGs description
METABOLISM	Mevalonate kinase MVK/ERG12

Species	KOG link	NCBI link	UniProt link
Arabidopsis thaliana (Ath)	At5g27450	GI:15240936
Caenorhabditis elegans (Cel)	CE29110 (WBGene00021534)	GI:17555862
Drosophila melanogaster (Dme)	7303424	GI:19922118
Homo sapiens (Hsa)	Hs4557769 (MVK)	GI:4557769	Q03426
Saccharomyces cerevisiae (Sce)	YMR208w (S000004821)	GI:6323864	P07277
Schizosaccharomyces pombe (Spo)	SPAC13G6.11c	GI:19113749	Q09780
Encephalitozoon cuniculi (Ecu)	ECU09g1780	GI:19173299

Species	Gene ID	NCBI link	UniProt link
Homo sapiens (Hsa)	MVK	GI:4557769	Q03426
Canis familiaris (Cfa)	MVK	GI:73995337
Mus musculus (Mmu)	Mvk (MGI:107624)	GI:12963731	Q3UEB4
Gallus gallus (Gga)	MVK	GI:118098609
Caenorhabditis elegans (Cel)	Y42G9A.4 (CE29110; WBGene00021534)	GI:71993795
Schizosaccharomyces pombe (Spo)	erg12 (SPAC13G6.11c)	GI:19113749	Q09780
Saccharomyces cerevisiae (Sce)	ERG12 (S000004821)	GI:6323864	P07277
Kluyveromyces lactis (Kla)	KLLA0C07469g	GI:50305147
Eremothecium gossypii (Ego)	AGOS_AER335W	GI:45190937
Magnaporthe grisea (Mgr)	MGG_06946	GI:39978123
Neurospora crassa (Ncr)	NCU03633.1	GI:32404644
Arabidopsis thaliana (Ath)	MK	GI:15240936
Oryza sativa (Osa)	Os10g0329300	GI:115481534

Species	OrthoMCL sequence	Model organism protein page	UniProt link
Anopheles gambiae (Aga)	aga11034	ENSANGP00000021364
Ashbya gossypii (Ago)	ago2836	AER335W
Arabidopsis thaliana (Ath)	ath25018	At5g27450.1
Arabidopsis thaliana (Ath)	ath25019	At5g27450.2
Caenorhabditis elegans (Cel)	cel18763	Y42G9A.4a (CE29110; WBGene00021534)
Caenorhabditis elegans (Cel)	cel18764	Y42G9A.4b (CE37427)
Caenorhabditis elegans (Cel)	cel18765	Y42G9A.4c (CE37428)
Caenorhabditis elegans (Cel)	cel18766	Y42G9A.4d (CE37569)
Candida glabrata (Cgl)	cgl1396	CAGL0F03861g
Dictyostelium discoideum (Ddi)	ddi2783	DDB0168621
Debaryomyces hansenii (Dha)	dha4925	DEHA0F12188g
Drosophila melanogaster (Dme)	dme4741	CG33009-PA
Danio rerio (Dre)	dre18997	ENSDARP00000019792 (zgc:103473)	Q5U3I7
Encephalitozoon cuniculi (Ecu)	ecu1450	19173299
Takifugu rubripes (Fru)	fru10167	SINFRUP00000155076
Gallus gallus (Gga)	gga26834	ENSGALP00000022427
Gallus gallus (Gga)	gga26835	ENSGALP00000022428 (MVK)
Homo sapiens (Hsa)	hsa8156	ENSP00000228510 (MVK)	Q03426
Kluyveromyces lactis (Kla)	kla1531	KLLA0C07469g
Mus musculus (Mmu)	mmu20728	ENSMUSP00000036971 (MGI:107624)	Q9R008
Neurospora crassa (Ncr)	ncr3524	NCU03633.2
Oryza sativa (Osa)	osa5192	2178.m00134
Saccharomyces cerevisiae (Sce)	sce4977	YMR208W (S000004821)
Schizosaccharomyces pombe (Spo)	spo2526	SPAC13G6.11c	Q09780
Yarrowia lipolytica (Yli)	yli1411	YALI0B16038g

S. pombe systematic ID	S. cerevisiae systematic ID
SPAC13G6.11c (Q09780)	YMR208W (S000004821)