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Search term: YMR281W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name GPI12
SGD link S000004894
Alternative ID YMR281W
Description ER membrane protein involved in the second step of glycosylphosphatidylinositol (GPI) anchor assembly, the de-N-acetylation of the N-acetylglucosaminylphosphatidylinositol intermediate; functional homolog of human PIG-Lp
Synonyms YMR281W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG3332 ACDHYPE

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALING N-acetylglucosaminyl phosphatidylinositol de-N-acetylase

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At2g27340 GI:18401395
Arabidopsis thaliana (Ath) At3g58130 GI:15230965
Caenorhabditis elegans (Cel) CE19222 GI:17510221
Drosophila melanogaster (Dme) 7300580 GI:7300580
Homo sapiens (Hsa) Hs4758922
(PIGL)		 GI:4758922 Q9Y2B2
Saccharomyces cerevisiae (Sce) YMR281w
(S000004894)		 GI:6323937 P23797
Schizosaccharomyces pombe (Spo) SPAPB2B4.01c GI:19114799 Q9HDW9
Encephalitozoon cuniculi (Ecu) ECU08g0300 GI:19173356 Q8SUT3


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005783 endoplasmic reticulum C
IDA
SpoSPAPB2B4.01c
NAS
HsaPIGL
GO:0005789 endoplasmic reticulum membrane C
ISS
SceS000004894
SpoSPAPB2B4.01c
GO:0000225 N-acetylglucosaminylphosphatidylinositol
deacetylase activity		 F
ISS
SceS000004894
SpoSPAPB2B4.01c
NAS
HsaPIGL
GO:0003674 molecular_function F
ND
AthAt3g58130
At2g27340
GO:0006506 GPI anchor biosynthetic process P
ISS
SceS000004894
SpoSPAPB2B4.01c
NAS
HsaPIGL
GO:0008150 biological_process P
ND
AthAt2g27340
At3g58130
GO:0016254 preassembly of GPI anchor in ER
membrane		 P
EXP
HsaPIGL

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
3159

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) PIGL GI:4758922 Q9Y2B2
Pan troglodytes (Ptr) PIGL GI:114671705
Canis familiaris (Cfa) PIGL GI:57086435
Mus musculus (Mmu) Pigl
(MGI:2681271)		 GI:88014552 Q4V9U8
Rattus norvegicus (Rno) Pigl
(RGD:620437)		 GI:20302097
Gallus gallus (Gga) PIGL GI:118100255
Drosophila melanogaster (Dme) CG4433
(FBgn0038763)		 GI:45550772
Anopheles gambiae (Aga) AgaP_AGAP001955 GI:158301403
Schizosaccharomyces pombe (Spo) gpi12
(SPAPB2B4.01c)		 GI:19114799 Q9HDW9
Saccharomyces cerevisiae (Sce) GPI12
(S000004894)		 GI:6323937 P23797
Kluyveromyces lactis (Kla) KLLA0D01430g GI:50306317
Eremothecium gossypii (Ego) AGOS_ABL120W GI:45185110
Magnaporthe grisea (Mgr) MGG_05020 GI:39940440
Neurospora crassa (Ncr) NCU09510.1 GI:32418782
Arabidopsis thaliana (Ath) AT3G58130 GI:79315492
Arabidopsis thaliana (Ath) AT2G27340 GI:79323249
Oryza sativa (Osa) Os04g0678800 GI:115461350


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
MmuMGI:2681271
GO:0005783 endoplasmic reticulum C
IDA
SpoSPAPB2B4.01c
NAS
HsaPIGL
GO:0005789 endoplasmic reticulum membrane C
ISS
SceS000004894
SpoSPAPB2B4.01c
GO:0000225 N-acetylglucosaminylphosphatidylinositol
deacetylase activity		 F
ISO
MmuMGI:2681271
ISS
SceS000004894
SpoSPAPB2B4.01c
NAS
HsaPIGL
GO:0003674 molecular_function F
ND
AthAt3g58130
At2g27340
GO:0006506 GPI anchor biosynthetic process P
ISO
MmuMGI:2681271
ISS
SceS000004894
SpoSPAPB2B4.01c
NAS
HsaPIGL
GO:0008150 biological_process P
ND
AthAt2g27340
At3g58130
GO:0016254 preassembly of GPI anchor in ER
membrane		 P
EXP
HsaPIGL

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_2133

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga4056 ENSANGP00000007885
Ashbya gossypii (Ago) ago472 ABL120W
Arabidopsis thaliana (Ath) ath9678 At2g27340.1
Arabidopsis thaliana (Ath) ath9679 At2g27340.2
Arabidopsis thaliana (Ath) ath17218 At3g58130.1
Caenorhabditis elegans (Cel) cel19576 Y52B11C.1
Candida glabrata (Cgl) cgl4789 CAGL0M03047g
Cryptococcus neoformans (Cne) cne5742 179.m00616
Dictyostelium discoideum (Ddi) ddi11081 DDB0191808
Debaryomyces hansenii (Dha) dha4596 DEHA0F04664g
Drosophila melanogaster (Dme) dme13453 CG4433-PA
(FBgn0038763)
Drosophila melanogaster (Dme) dme13452 CG4433-PB
(FBgn0038763)
Encephalitozoon cuniculi (Ecu) ecu187 19173356
Takifugu rubripes (Fru) fru9975 SINFRUP00000137631
Gallus gallus (Gga) gga8944 ENSGALP00000007144
(PIGL)
Gallus gallus (Gga) gga8945 ENSGALP00000007145
Homo sapiens (Hsa) hsa13120 ENSP00000225609
(PIGL)		 Q9Y2B2
Kluyveromyces lactis (Kla) kla2131 KLLA0D01430g
Mus musculus (Mmu) mmu3898 ENSMUSP00000014389
(MGI:2681271)		 Q5SX19
Neurospora crassa (Ncr) ncr9258 NCU09510.2
Oryza sativa (Osa) osa47117 5770.m00106
Oryza sativa (Osa) osa47224 5774.m00029
Oryza sativa (Osa) osa85207 8326.m00143
Plasmodium falciparum (Pfa) pfa3132 PFF1190c
Rattus norvegicus (Rno) rno5230 ENSRNOP00000004113
(RGD:620437)		 O35790
Saccharomyces cerevisiae (Sce) sce5055 YMR281W
(S000004894)
Schizosaccharomyces pombe (Spo) spo386 SPAPB2B4.01c Q9HDW9
Yarrowia lipolytica (Yli) yli4767 YALI0E21934g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
MmuMGI:2681271
GO:0005783 endoplasmic reticulum C
IDA
SpoSPAPB2B4.01c
GO:0005789 endoplasmic reticulum membrane C
ISS
SceS000004894
SpoSPAPB2B4.01c
GO:0000225 N-acetylglucosaminylphosphatidylinositol
deacetylase activity		 F
ISO
MmuMGI:2681271
ISS
PfaPFF1190c
SceS000004894
SpoSPAPB2B4.01c
GO:0003674 molecular_function F
ND
AthAt3g58130
At2g27340
GO:0006506 GPI anchor biosynthetic process P
ISO
MmuMGI:2681271
ISS
PfaPFF1190c
SceS000004894
SpoSPAPB2B4.01c
GO:0008150 biological_process P
ND
AthAt2g27340
At3g58130

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPAPB2B4.01c
(Q9HDW9)		 YMR281W
(S000004894)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005783 endoplasmic reticulum C
IDA
SpoSPAPB2B4.01c
GO:0005789 endoplasmic reticulum membrane C
ISS
SceS000004894
SpoSPAPB2B4.01c
GO:0000225 N-acetylglucosaminylphosphatidylinositol
deacetylase activity		 F
ISS
SceS000004894
SpoSPAPB2B4.01c
GO:0006506 GPI anchor biosynthetic process P
ISS
SceS000004894
SpoSPAPB2B4.01c

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s.khadayate@ucl.ac.uk