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Search term: YMR284W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name YKU70
SGD link S000004897
Alternative ID YMR284W
Description Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair
Synonyms YMR284W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG2327 ACDHYP-

KOGs classification KOGs description
INFORMATION STORAGE AND PROCESSING DNA-binding subunit of a DNA-dependent protein kinase (Ku70 autoantigen)

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At1g16970 GI:15219967
Caenorhabditis elegans (Cel) CE28984
(WBGene00000519)		 GI:17555930
Drosophila melanogaster (Dme) 7299442
(FBgn0011774)		 GI:17985997
Homo sapiens (Hsa) Hs17437153_2 GI:17437153
Homo sapiens (Hsa) Hs22050378 GI:22050378
Homo sapiens (Hsa) Hs22056613 GI:22056613
Homo sapiens (Hsa) Hs4503841
(XRCC6)		 GI:4503841 P12956
Saccharomyces cerevisiae (Sce) YMR284w
(S000004897)		 GI:6323940 P32807
Schizosaccharomyces pombe (Spo) SPCC126.02c GI:19075945 O94395


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000781 chromosome, telomeric region C
IDA
SpoSPCC126.02c
GO:0000783 nuclear telomere cap complex C
TAS
HsaXRCC6
GO:0000790 nuclear chromatin C
TAS
SceS000004897
GO:0005624 membrane fraction C
TAS
HsaXRCC6
GO:0005634 nucleus C
IDA
SpoSPCC126.02c
NAS
DmeFBgn0011774
GO:0005635 nuclear envelope C
IDA
SceS000004897
GO:0005654 nucleoplasm C
EXP
HsaXRCC6
GO:0005667 transcription factor complex C
IDA
HsaXRCC6
GO:0005724 nuclear telomeric heterochromatin C
TAS
SceS000004897
GO:0043564 Ku70:Ku80 complex C
IDA
DmeFBgn0011774
HsaXRCC6
SceS000004897
GO:0070419 nonhomologous end joining complex C
IDA
HsaXRCC6
GO:0003677 DNA binding F
IDA
DmeFBgn0011774
FBgn0011774
ISS
DmeFBgn0011774
NAS
DmeFBgn0011774
HsaXRCC6
GO:0003684 damaged DNA binding F
TAS
SceS000004897
GO:0003690 double-stranded DNA binding F
IDA
AthAt1g16970
TAS
HsaXRCC6
GO:0003691 double-stranded telomeric DNA binding F
IDA
HsaXRCC6
GO:0003723 RNA binding F
IDA
SceS000004897
GO:0004003 ATP-dependent DNA helicase activity F
ISS
SpoSPCC126.02c
NAS
DmeFBgn0011774
GO:0004677 DNA-dependent protein kinase activity F
NAS
DmeFBgn0011774
GO:0005515 protein binding F
IPI
AthAt1g16970
HsaXRCC6
GO:0008022 protein C-terminus binding F
IPI
HsaXRCC6
GO:0010843 promoter binding F
IDA
HsaXRCC6
GO:0016563 transcription activator activity F
IMP
HsaXRCC6
GO:0042162 telomeric DNA binding F
IDA
SpoSPCC126.02c
RCA
SceS000004897
GO:0043565 sequence-specific DNA binding F
RCA
SceS000004897
GO:0046982 protein heterodimerization activity F
IDA
DmeFBgn0011774
IPI
SpoSPCC126.02c
GO:0051575 5'-deoxyribose-5-phosphate lyase
activity		 F
IMP
HsaXRCC6
GO:0000084 S phase of mitotic cell cycle P
IMP
SpoSPCC126.02c
GO:0000723 telomere maintenance P
IMP
DmeFBgn0011774
SceS000004897
SpoSPCC126.02c
TAS
AthAt1g16970
HsaXRCC6
GO:0000724 double-strand break repair via homologous
recombination		 P
IMP
SceS000004897
GO:0000727 double-strand break repair via break-induced
replication		 P
IGI
SceS000004897
IMP
SceS000004897
GO:0006266 DNA ligation P
TAS
HsaXRCC6
GO:0006281 DNA repair P
TAS
AthAt1g16970
GO:0006303 double-strand break repair via nonhomologous end
joining		 P
IDA
SceS000004897
IMP
HsaXRCC6
SpoSPCC126.02c
TAS
HsaXRCC6
GO:0006333 chromatin assembly or disassembly P
IDA
SceS000004897
GO:0006342 chromatin silencing P
IDA
SceS000004897
IMP
SceS000004897
GO:0006950 response to stress P
IMP
CelWBGene00000519
GO:0008340 determination of adult lifespan P
IMP
CelWBGene00000519
GO:0009408 response to heat P
IEP
AthAt1g16970
GO:0010552 positive regulation of gene-specific transcription
from RNA polymerase II promoter		 P
IMP
HsaXRCC6
GO:0019047 provirus integration P
EXP
HsaXRCC6
GO:0019059 initiation of viral infection P
EXP
HsaXRCC6
GO:0030466 chromatin silencing at silent mating-type
cassette		 P
IGI
SceS000004897
IMP
SceS000004897
GO:0045893 positive regulation of transcription,
DNA-dependent		 P
IDA
HsaXRCC6

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
37483

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) XRCC6 GI:4503841 P12956
Pan troglodytes (Ptr) XRCC6 GI:114686702
Canis familiaris (Cfa) XRCC6 GI:57092715
Mus musculus (Mmu) Xrcc6
(MGI:95606)		 GI:149266761 P23475
Rattus norvegicus (Rno) Xrcc6
(RGD:2643)		 GI:21717799 36380
Gallus gallus (Gga) XRCC6 GI:45382537
Drosophila melanogaster (Dme) Irbp
(FBgn0011774)		 GI:17985997
Anopheles gambiae (Aga) AgaP_AGAP002690 GI:158290648
Caenorhabditis elegans (Cel) cku-70
(CE28984;
WBGene00000519)		 GI:17555930
Schizosaccharomyces pombe (Spo) pku70
(SPCC126.02c)		 GI:19075945 O94395
Saccharomyces cerevisiae (Sce) YKU70
(S000004897)		 GI:6323940 P32807
Kluyveromyces lactis (Kla) KLLA0C06226g GI:50305035
Magnaporthe grisea (Mgr) MGG_01512 GI:39951739
Neurospora crassa (Ncr) NCU08290.1 GI:32417036
Arabidopsis thaliana (Ath) KU70 GI:18394425
Oryza sativa (Osa) Os07g0184900 GI:115470925


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000781 chromosome, telomeric region C
IDA
SpoSPCC126.02c
GO:0000783 nuclear telomere cap complex C
TAS
HsaXRCC6
GO:0000790 nuclear chromatin C
TAS
SceS000004897
GO:0005624 membrane fraction C
TAS
HsaXRCC6
GO:0005634 nucleus C
IDA
MmuMGI:95606
SpoSPCC126.02c
ISO
MmuMGI:95606
NAS
DmeFBgn0011774
GO:0005635 nuclear envelope C
IDA
SceS000004897
GO:0005654 nucleoplasm C
EXP
HsaXRCC6
GO:0005667 transcription factor complex C
IDA
HsaXRCC6
GO:0005724 nuclear telomeric heterochromatin C
TAS
SceS000004897
GO:0005730 nucleolus C
ISO
MmuMGI:95606
GO:0005737 cytoplasm C
IDA
MmuMGI:95606
ISO
MmuMGI:95606
GO:0043234 protein complex C
ISO
MmuMGI:95606
GO:0043564 Ku70:Ku80 complex C
IDA
DmeFBgn0011774
HsaXRCC6
SceS000004897
GO:0070419 nonhomologous end joining complex C
IDA
HsaXRCC6
GO:0003677 DNA binding F
IDA
DmeFBgn0011774
FBgn0011774
ISS
DmeFBgn0011774
NAS
DmeFBgn0011774
HsaXRCC6
GO:0003684 damaged DNA binding F
TAS
SceS000004897
GO:0003690 double-stranded DNA binding F
IDA
AthKU70
ISO
MmuMGI:95606
TAS
HsaXRCC6
GO:0003691 double-stranded telomeric DNA binding F
IDA
HsaXRCC6
GO:0003723 RNA binding F
IDA
SceS000004897
GO:0004003 ATP-dependent DNA helicase activity F
ISS
SpoSPCC126.02c
NAS
DmeFBgn0011774
GO:0004677 DNA-dependent protein kinase activity F
NAS
DmeFBgn0011774
GO:0005515 protein binding F
IPI
AthKU70
HsaXRCC6
GO:0008022 protein C-terminus binding F
IPI
HsaXRCC6
GO:0010843 promoter binding F
IDA
HsaXRCC6
GO:0016563 transcription activator activity F
IMP
HsaXRCC6
GO:0042162 telomeric DNA binding F
IDA
SpoSPCC126.02c
RCA
SceS000004897
GO:0043565 sequence-specific DNA binding F
RCA
SceS000004897
GO:0046982 protein heterodimerization activity F
IDA
DmeFBgn0011774
IPI
SpoSPCC126.02c
GO:0051575 5'-deoxyribose-5-phosphate lyase
activity		 F
IMP
HsaXRCC6
GO:0000084 S phase of mitotic cell cycle P
IMP
SpoSPCC126.02c
GO:0000723 telomere maintenance P
IMP
DmeFBgn0011774
SceS000004897
SpoSPCC126.02c
TAS
AthKU70
HsaXRCC6
GO:0000724 double-strand break repair via homologous
recombination		 P
IMP
SceS000004897
GO:0000727 double-strand break repair via break-induced
replication		 P
IGI
SceS000004897
IMP
SceS000004897
GO:0006266 DNA ligation P
TAS
HsaXRCC6
GO:0006281 DNA repair P
TAS
AthKU70
GO:0006302 double-strand break repair P
IMP
MmuMGI:95606
GO:0006303 double-strand break repair via nonhomologous end
joining		 P
IDA
SceS000004897
IMP
HsaXRCC6
MmuMGI:95606
SpoSPCC126.02c
TAS
HsaXRCC6
GO:0006333 chromatin assembly or disassembly P
IDA
SceS000004897
GO:0006342 chromatin silencing P
IDA
SceS000004897
IMP
SceS000004897
GO:0006950 response to stress P
IMP
CelWBGene00000519
GO:0006974 response to DNA damage stimulus P
IMP
MmuMGI:95606
GO:0008340 determination of adult lifespan P
IMP
CelWBGene00000519
GO:0009408 response to heat P
IEP
AthKU70
GO:0010212 response to ionizing radiation P
IMP
MmuMGI:95606
GO:0010552 positive regulation of gene-specific transcription
from RNA polymerase II promoter		 P
IMP
HsaXRCC6
GO:0019047 provirus integration P
EXP
HsaXRCC6
GO:0019059 initiation of viral infection P
EXP
HsaXRCC6
GO:0030466 chromatin silencing at silent mating-type
cassette		 P
IGI
SceS000004897
IMP
SceS000004897
GO:0033151 V(D)J recombination P
IMP
MmuMGI:95606
GO:0045893 positive regulation of transcription,
DNA-dependent		 P
IDA
HsaXRCC6
GO:0050769 positive regulation of neurogenesis P
IMP
MmuMGI:95606
GO:0071475 cellular hyperosmotic salinity
response		 P
ISO
MmuMGI:95606
GO:0071481 cellular response to X-ray P
ISO
MmuMGI:95606

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_3087

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga4911 ENSANGP00000010850
Ashbya gossypii (Ago) ago475 ABL117C
Ashbya gossypii (Ago) ago3635 AFR443C
Arabidopsis thaliana (Ath) ath1815 At1g16970.1
Caenorhabditis elegans (Cel) cel19077 Y47D3A.4
(CE28984;
WBGene00000519)
Candida glabrata (Cgl) cgl2637 CAGL0I02662g
Cryptococcus neoformans (Cne) cne429 162.m04563
Dictyostelium discoideum (Ddi) ddi9269 DDB0186801
Debaryomyces hansenii (Dha) dha4878 DEHA0F11165g
Drosophila melanogaster (Dme) dme12032 CG5247-PA
(FBgn0011774)
Danio rerio (Dre) dre3350 ENSDARP00000006156
Takifugu rubripes (Fru) fru26206 SINFRUP00000149116
Gallus gallus (Gga) gga815 ENSGALP00000019436
(XRCC6)
Homo sapiens (Hsa) hsa21751 ENSP00000352257
(XRCC6)		 P12956
Homo sapiens (Hsa) hsa21752 ENSP00000353192
(XRCC6)		 P12956
Kluyveromyces lactis (Kla) kla1474 KLLA0C06226g
Mus musculus (Mmu) mmu9374 ENSMUSP00000023108
Mus musculus (Mmu) mmu9375 ENSMUSP00000068559
(MGI:95606)		 P23475
Neurospora crassa (Ncr) ncr8079 NCU08290.2
Oryza sativa (Osa) osa69168 6926.m00152
Oryza sativa (Osa) osa69172 6926.m00154
Rattus norvegicus (Rno) rno27467 ENSRNOP00000008819
(RGD:2643)		 Q6AZ64
Saccharomyces cerevisiae (Sce) sce5058 YMR284W
(S000004897)
Schizosaccharomyces pombe (Spo) spo250 SPCC126.02c O94395
Yarrowia lipolytica (Yli) yli2073 YALI0C08701g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000781 chromosome, telomeric region C
IDA
SpoSPCC126.02c
GO:0000790 nuclear chromatin C
TAS
SceS000004897
GO:0005634 nucleus C
IDA
MmuMGI:95606
SpoSPCC126.02c
ISO
MmuMGI:95606
NAS
DmeFBgn0011774
GO:0005635 nuclear envelope C
IDA
SceS000004897
GO:0005724 nuclear telomeric heterochromatin C
TAS
SceS000004897
GO:0005730 nucleolus C
ISO
MmuMGI:95606
GO:0005737 cytoplasm C
IDA
MmuMGI:95606
ISO
MmuMGI:95606
GO:0043234 protein complex C
ISO
MmuMGI:95606
GO:0043564 Ku70:Ku80 complex C
IDA
DmeFBgn0011774
SceS000004897
GO:0003677 DNA binding F
IDA
DmeFBgn0011774
FBgn0011774
ISS
DmeFBgn0011774
NAS
DmeFBgn0011774
GO:0003684 damaged DNA binding F
TAS
SceS000004897
GO:0003690 double-stranded DNA binding F
IDA
AthAt1g16970
ISO
MmuMGI:95606
GO:0003723 RNA binding F
IDA
SceS000004897
GO:0004003 ATP-dependent DNA helicase activity F
ISS
SpoSPCC126.02c
NAS
DmeFBgn0011774
GO:0004677 DNA-dependent protein kinase activity F
NAS
DmeFBgn0011774
GO:0005515 protein binding F
IPI
AthAt1g16970
GO:0042162 telomeric DNA binding F
IDA
SpoSPCC126.02c
RCA
SceS000004897
GO:0043565 sequence-specific DNA binding F
RCA
SceS000004897
GO:0046982 protein heterodimerization activity F
IDA
DmeFBgn0011774
IPI
SpoSPCC126.02c
GO:0000084 S phase of mitotic cell cycle P
IMP
SpoSPCC126.02c
GO:0000723 telomere maintenance P
IMP
DmeFBgn0011774
SceS000004897
SpoSPCC126.02c
TAS
AthAt1g16970
GO:0000724 double-strand break repair via homologous
recombination		 P
IMP
SceS000004897
GO:0000727 double-strand break repair via break-induced
replication		 P
IGI
SceS000004897
IMP
SceS000004897
GO:0006281 DNA repair P
TAS
AthAt1g16970
GO:0006302 double-strand break repair P
IMP
MmuMGI:95606
GO:0006303 double-strand break repair via nonhomologous end
joining		 P
IDA
SceS000004897
IMP
MmuMGI:95606
SpoSPCC126.02c
GO:0006333 chromatin assembly or disassembly P
IDA
SceS000004897
GO:0006342 chromatin silencing P
IDA
SceS000004897
IMP
SceS000004897
GO:0006950 response to stress P
IMP
CelWBGene00000519
GO:0006974 response to DNA damage stimulus P
IMP
MmuMGI:95606
GO:0008340 determination of adult lifespan P
IMP
CelWBGene00000519
GO:0009408 response to heat P
IEP
AthAt1g16970
GO:0010212 response to ionizing radiation P
IMP
MmuMGI:95606
GO:0030466 chromatin silencing at silent mating-type
cassette		 P
IGI
SceS000004897
IMP
SceS000004897
GO:0033151 V(D)J recombination P
IMP
MmuMGI:95606
GO:0050769 positive regulation of neurogenesis P
IMP
MmuMGI:95606
GO:0071475 cellular hyperosmotic salinity
response		 P
ISO
MmuMGI:95606
GO:0071481 cellular response to X-ray P
ISO
MmuMGI:95606

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPCC126.02c
(O94395)		 YMR284W
(S000004897)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000781 chromosome, telomeric region C
IDA
SpoSPCC126.02c
GO:0000790 nuclear chromatin C
TAS
SceS000004897
GO:0005634 nucleus C
IDA
SpoSPCC126.02c
GO:0005635 nuclear envelope C
IDA
SceS000004897
GO:0005724 nuclear telomeric heterochromatin C
TAS
SceS000004897
GO:0043564 Ku70:Ku80 complex C
IDA
SceS000004897
GO:0003684 damaged DNA binding F
TAS
SceS000004897
GO:0003723 RNA binding F
IDA
SceS000004897
GO:0004003 ATP-dependent DNA helicase activity F
ISS
SpoSPCC126.02c
GO:0042162 telomeric DNA binding F
IDA
SpoSPCC126.02c
RCA
SceS000004897
GO:0043565 sequence-specific DNA binding F
RCA
SceS000004897
GO:0046982 protein heterodimerization activity F
IPI
SpoSPCC126.02c
GO:0000084 S phase of mitotic cell cycle P
IMP
SpoSPCC126.02c
GO:0000723 telomere maintenance P
IMP
SceS000004897
SpoSPCC126.02c
GO:0000724 double-strand break repair via homologous
recombination		 P
IMP
SceS000004897
GO:0000727 double-strand break repair via break-induced
replication		 P
IGI
SceS000004897
IMP
SceS000004897
GO:0006303 double-strand break repair via nonhomologous end
joining		 P
IDA
SceS000004897
IMP
SpoSPCC126.02c
GO:0006333 chromatin assembly or disassembly P
IDA
SceS000004897
GO:0006342 chromatin silencing P
IDA
SceS000004897
IMP
SceS000004897
GO:0030466 chromatin silencing at silent mating-type
cassette		 P
IGI
SceS000004897
IMP
SceS000004897

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Query species:

Include wild-cards:   

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GO info in one table:

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