Bahler Lab

Search term: YMR297W

Gene summary:

Species Saccharomyces cerevisiae (Sce)

Primary name PRC1

SGD link S000004912

Alternative ID YMR297W

Description Vacuolar carboxypeptidase Y (proteinase C; CPY), broad-specificity C-terminal exopeptidase involved in non-specific protein degradation in the vacuole; member of the serine carboxypeptidase family

Synonyms YMR297W

Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

Search for gene by ID or name:

Query species:

Include wild-cards: Yes No

Search for GO info: Yes No

GO info in one table: Yes No

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)

KOG1282 ACDHYP-

KOGs classification KOGs description

CELLULAR PROCESSES AND SIGNALINGMETABOLISM Serine carboxypeptidases (lysosomal cathepsin A)

GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations

GO:0000324 fungal-type vacuole C
IDA
Sce YBR139w
S000004912
Spo SPAC19G12.10c
SPBC16G5.09

GO:0000328 fungal-type vacuole lumen C
TAS
Sce S000004912

GO:0005615 extracellular space C
IDA
Ath At4g30610

GO:0005618 cell wall C
IDA
Ath At5g42240

GO:0005634 nucleus C
IDA
Spo SPAC1296.03c

GO:0005737 cytoplasm C
IDA
Sce S000004912
ISS
Spo SPAC19G12.10c

GO:0005773 vacuole C
IDA
Ath At1g15000
At2g35780
At3g10410
At4g12910
At4g30810
At5g23210

GO:0005783 endoplasmic reticulum C
IDA
Sce S000004912

GO:0005802 trans-Golgi network C
IDA
Sce S000003171
ISS
Spo SPBC16G5.09

GO:0005829 cytosol C
IDA
Spo SPAC1296.03c

GO:0009505 plant-type cell wall C
IDA
Ath At2g22970
At1g28110
At2g33530
At2g22920
At5g23210

GO:0004185 serine-type carboxypeptidase activity F
IDA
Ath At4g30610
Sce S000004912
IMP
Sce S000004912
Spo SPAC19G12.10c
ISA
Sce YBR139w
ISS
Ath At1g73280
At1g33540
At2g12480
At1g73270
At1g15000
At1g73300
At1g28110
At2g35780
At3g17180
At1g61130
At3g56540
At2g33530
At2g24010
At2g23010
At2g22970
At3g07990
At2g24000
At3g52010
At3g12240
At3g10410
At2g05850
At2g22920
At1g73310
At2g35770
At3g63470
At1g11080
At1g43780
At1g73290
At4g12910
At2g22980
At2g23000
At3g52020
At3g12203
At3g52000
At2g22990
At3g12230
At3g02110
At3g25420
At3g45010
At3g10450
At3g12220
At5g09640
At4g15100
At4g30810
At5g08260
At5g22960
At5g23210
At5g22980
At5g36180
At5g42240
At5g42230
Spo SPBC16G5.09
TAS
Sce S000003171
Spo SPAC1296.03c

GO:0016752 sinapoyltransferase activity F
IMP
Ath At5g09640

GO:0016754 sinapoylglucose-malate O-sinapoyltransferase
activity F
IDA
Ath At2g22990

GO:0017171 serine hydrolase activity F
IDA
Sce YBR139w

GO:0046982 protein heterodimerization activity F
IDA
Spo SPAC19G12.10c

GO:0000747 conjugation with cellular fusion P
IMP
Spo SPAC1296.03c

GO:0002119 nematode larval development P
IMP
Cel WBGene00021503

GO:0006508 proteolysis P
IDA
Ath At4g30610
ISS
Ath At2g23000
At2g22970
At2g22920
At2g22990
At2g22980
At1g28110
At1g73270
At2g24010
At2g33530
At1g43780
At1g11080
At1g73280
At1g61130
At2g12480
At2g24000
At2g23010
At2g05850
At1g33540
At1g73290
At1g73300
At1g73310
At2g35770
At2g35780
At1g15000
At3g02110
At3g07990
At4g30610
At3g10410
At3g10450
At3g12203
At3g12220
At3g12230
At3g12240
At3g17180
At3g25420
At3g45010
At3g52000
At3g52010
At3g52020
At3g56540
At3g63470
At4g12910
At4g15100
At4g30810
At5g08260
At5g09640
At5g22960
At5g42230
At5g22980
At5g23210
At5g36180
At5g42240

GO:0007039 vacuolar protein catabolic process P
ISS
Spo SPAC19G12.10c
RCA
Sce S000004912
TAS
Sce S000004912

GO:0009698 phenylpropanoid metabolic process P
IDA
Ath At2g22990

GO:0009742 brassinosteroid mediated signaling
pathway P
IGI
Ath At4g30610

GO:0016485 protein processing P
TAS
Sce S000003171

GO:0019748 secondary metabolic process P
IMP
Ath At5g09640

GO:0019915 lipid storage P
IMP
Cel WBGene00008741

GO:0030163 protein catabolic process P
ISS
Spo SPBC16G5.09

GO:0040007 growth P
IMP
Cel WBGene00021503

GO:0046938 phytochelatin biosynthetic process P
IDA
Sce S000004912
IGI
Sce YBR139w
IMP
Sce S000004912

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern

80163

Species Gene ID NCBI link UniProt link

Homo sapiens (Hsa) CTSA GI:119395729

Pan troglodytes (Ptr) CTSA GI:114682296

Canis familiaris (Cfa) CTSA GI:73992530

Mus musculus (Mmu) Ctsa
(MGI:97748) GI:84042525 P16675

Rattus norvegicus (Rno) Ppgb
(RGD:1309070) GI:58865488

Gallus gallus (Gga) CTSA GI:71895603

Caenorhabditis elegans (Cel) F13D12.6
(CE02185;
WBGene00008741) GI:17533155 P52715

Caenorhabditis elegans (Cel) F41C3.5
(CE02733;
WBGene00018271) GI:17533883 P52717

Schizosaccharomyces pombe (Spo) cpy1
(SPAC19G12.10c) GI:19115337 O13849

Saccharomyces cerevisiae (Sce) PRC1
(S000004912) GI:6323955 P00729

Kluyveromyces lactis (Kla) KLLA0A09977g GI:50302997

Eremothecium gossypii (Ego) AGOS_AGL328C GI:45200769

Magnaporthe grisea (Mgr) MGG_05663 GI:39941504

Neurospora crassa (Ncr) NCU00477.1 GI:32403900

Arabidopsis thaliana (Ath) scpl20 GI:30682276

Arabidopsis thaliana (Ath) scpl21 GI:15230836

Oryza sativa (Osa) Os12g0257000 GI:115488046

Oryza sativa (Osa) Os04g0321700 GI:115457728

GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations

GO:0000324 fungal-type vacuole C
IDA
Sce S000004912
Spo SPAC19G12.10c

GO:0000328 fungal-type vacuole lumen C
TAS
Sce S000004912

GO:0005737 cytoplasm C
IDA
Sce S000004912
ISS
Spo SPAC19G12.10c

GO:0005739 mitochondrion C
IDA
Mmu MGI:97748

GO:0005764 lysosome C
NAS
Hsa CTSA

GO:0005773 vacuole C
IDA
Ath scpl20

GO:0005783 endoplasmic reticulum C
IDA
Sce S000004912
TAS
Hsa CTSA

GO:0004180 carboxypeptidase activity F
TAS
Hsa CTSA

GO:0004185 serine-type carboxypeptidase activity F
IDA
Sce S000004912
IMP
Sce S000004912
Spo SPAC19G12.10c
ISS
Ath scpl20
scpl21

GO:0005515 protein binding F
IPI
Hsa CTSA
Mmu MGI:97748

GO:0008047 enzyme activator activity F
TAS
Hsa CTSA

GO:0046982 protein heterodimerization activity F
IDA
Spo SPAC19G12.10c

GO:0006508 proteolysis P
ISS
Ath scpl20
scpl21

GO:0006886 intracellular protein transport P
TAS
Hsa CTSA

GO:0007039 vacuolar protein catabolic process P
ISS
Spo SPAC19G12.10c
RCA
Sce S000004912
TAS
Sce S000004912

GO:0019915 lipid storage P
IMP
Cel WBGene00008741

GO:0046938 phytochelatin biosynthetic process P
IDA
Sce S000004912
IMP
Sce S000004912

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern

OG1_789

GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations

GO:0000324 fungal-type vacuole C
IDA
Sce YBR139w
S000004912
Spo SPAC19G12.10c

GO:0000328 fungal-type vacuole lumen C
TAS
Sce S000004912

GO:0005737 cytoplasm C
IDA
Sce S000004912
ISS
Spo SPAC19G12.10c

GO:0005739 mitochondrion C
IDA
Mmu MGI:97748

GO:0005773 vacuole C
IDA
Ath At3g10410
At4g12910

GO:0005783 endoplasmic reticulum C
IDA
Sce S000004912

GO:0004185 serine-type carboxypeptidase activity F
IDA
Sce S000004912
IMP
Sce S000004912
Spo SPAC19G12.10c
ISA
Sce YBR139w
ISS
Ath At3g10410
At4g12910
At3g25420
At3g45010
At5g22980

GO:0005515 protein binding F
IPI
Mmu MGI:97748

GO:0017171 serine hydrolase activity F
IDA
Sce YBR139w

GO:0046982 protein heterodimerization activity F
IDA
Spo SPAC19G12.10c

GO:0006508 proteolysis P
ISS
Ath At3g10410
At3g25420
At3g45010
At4g12910
At5g22980

GO:0007039 vacuolar protein catabolic process P
ISS
Spo SPAC19G12.10c
RCA
Sce S000004912
TAS
Sce S000004912

GO:0046938 phytochelatin biosynthetic process P
IDA
Sce S000004912
IGI
Sce YBR139w
IMP
Sce S000004912

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Curated yeast ortholog results:

S. pombe
systematic ID S. cerevisiae
systematic ID

SPAC19G12.10c
(O13849) YMR297W
(S000004912)

GO terms for curated homolog results:

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YOGY Home

YOGY Help

Search for gene by ID or name:

Query species:

Include wild-cards: Yes No

Search for GO info: Yes No

GO info in one table: Yes No

s.khadayate@ucl.ac.uk

KOG name	Phylogenetic pattern (and link to KOGs with this pattern)
KOG1282	ACDHYP-

KOGs classification	KOGs description
CELLULAR PROCESSES AND SIGNALINGMETABOLISM	Serine carboxypeptidases (lysosomal cathepsin A)

Species	KOG link	NCBI link	UniProt link
Arabidopsis thaliana (Ath)	At1g11080	GI:15220282
Arabidopsis thaliana (Ath)	At1g15000	GI:15223991
Arabidopsis thaliana (Ath)	At1g28110	GI:12322985
Arabidopsis thaliana (Ath)	At1g33540	GI:15217581
Arabidopsis thaliana (Ath)	At1g43780	GI:15218514
Arabidopsis thaliana (Ath)	At1g61130	GI:15219869
Arabidopsis thaliana (Ath)	At1g73270	GI:15219427
Arabidopsis thaliana (Ath)	At1g73280	GI:15219429
Arabidopsis thaliana (Ath)	At1g73290	GI:15219431
Arabidopsis thaliana (Ath)	At1g73300	GI:15219433
Arabidopsis thaliana (Ath)	At1g73310	GI:15219435
Arabidopsis thaliana (Ath)	At2g05850	GI:15224995
Arabidopsis thaliana (Ath)	At2g12480	GI:15224454
Arabidopsis thaliana (Ath)	At2g22920	GI:15227765
Arabidopsis thaliana (Ath)	At2g22970	GI:15227769
Arabidopsis thaliana (Ath)	At2g22980	GI:15227770
Arabidopsis thaliana (Ath)	At2g22990	GI:8699619
Arabidopsis thaliana (Ath)	At2g23000	GI:15227772
Arabidopsis thaliana (Ath)	At2g23010	GI:15227773
Arabidopsis thaliana (Ath)	At2g24000	GI:15224082
Arabidopsis thaliana (Ath)	At2g24010	GI:15224083
Arabidopsis thaliana (Ath)	At2g33530	GI:15226124
Arabidopsis thaliana (Ath)	At2g35770	GI:15227492
Arabidopsis thaliana (Ath)	At2g35780	GI:15227493
Arabidopsis thaliana (Ath)	At3g02110	GI:15232847
Arabidopsis thaliana (Ath)	At3g07990	GI:15231911
Arabidopsis thaliana (Ath)	At3g10410	GI:15228281
Arabidopsis thaliana (Ath)	At3g10450	GI:15228300
Arabidopsis thaliana (Ath)	At3g12203	GI:15230430
Arabidopsis thaliana (Ath)	At3g12220	GI:12322057
Arabidopsis thaliana (Ath)	At3g12230	GI:15230438
Arabidopsis thaliana (Ath)	At3g12240	GI:15230440
Arabidopsis thaliana (Ath)	At3g17180	GI:15228988
Arabidopsis thaliana (Ath)	At3g25420	GI:15230836
Arabidopsis thaliana (Ath)	At3g45010	GI:15230577
Arabidopsis thaliana (Ath)	At3g52000	GI:15231099
Arabidopsis thaliana (Ath)	At3g52010	GI:15231101
Arabidopsis thaliana (Ath)	At3g52020	GI:15231103
Arabidopsis thaliana (Ath)	At3g56540	GI:15228953
Arabidopsis thaliana (Ath)	At3g63470	GI:15229439
Arabidopsis thaliana (Ath)	At4g12910	GI:15235525
Arabidopsis thaliana (Ath)	At4g15100	GI:15233683
Arabidopsis thaliana (Ath)	At4g30610	GI:15234795
Arabidopsis thaliana (Ath)	At4g30810	GI:2980785
Arabidopsis thaliana (Ath)	At5g08260	GI:15241571
Arabidopsis thaliana (Ath)	At5g09640	GI:11357219
Arabidopsis thaliana (Ath)	At5g22960	GI:15237176
Arabidopsis thaliana (Ath)	At5g22980	GI:15237178
Arabidopsis thaliana (Ath)	At5g23210	GI:15237254
Arabidopsis thaliana (Ath)	At5g36180	GI:15239316
Arabidopsis thaliana (Ath)	At5g42230	GI:15238327
Arabidopsis thaliana (Ath)	At5g42240	GI:15238328
Caenorhabditis elegans (Cel)	CE01273 (WBGene00017969)	GI:17533609	P52716
Caenorhabditis elegans (Cel)	CE02009 (WBGene00019605)	GI:17535025	Q09991
Caenorhabditis elegans (Cel)	CE02185 (WBGene00008741)	GI:17533155	P52715
Caenorhabditis elegans (Cel)	CE02733 (WBGene00018271)	GI:17533883	P52717
Caenorhabditis elegans (Cel)	CE02987 (WBGene00007462)	GI:17531675	P52714
Caenorhabditis elegans (Cel)	CE04747	GI:17568857
Caenorhabditis elegans (Cel)	CE19621 (WBGene00021503)	GI:17555824	O76725
Caenorhabditis elegans (Cel)	CE21374 (WBGene00012445)	GI:17570337
Drosophila melanogaster (Dme)	7300553	GI:7300553
Homo sapiens (Hsa)	Hs22027516	GI:16877133	O75225
Homo sapiens (Hsa)	Hs4505989	GI:4505989
Homo sapiens (Hsa)	HsM13786125	GI:13786125
Saccharomyces cerevisiae (Sce)	YBR139w	GI:6319615	P38109
Saccharomyces cerevisiae (Sce)	YGL203c (S000003171)	GI:6321235	P09620
Saccharomyces cerevisiae (Sce)	YMR297w (S000004912)	GI:6323955	P00729
Schizosaccharomyces pombe (Spo)	SPAC1296.03c	GI:19113955	P32825
Schizosaccharomyces pombe (Spo)	SPAC19G12.10c	GI:19115337	O13849
Schizosaccharomyces pombe (Spo)	SPBC16G5.09	GI:19113550	O60123

Species	Gene ID	NCBI link	UniProt link
Homo sapiens (Hsa)	CTSA	GI:119395729
Pan troglodytes (Ptr)	CTSA	GI:114682296
Canis familiaris (Cfa)	CTSA	GI:73992530
Mus musculus (Mmu)	Ctsa (MGI:97748)	GI:84042525	P16675
Rattus norvegicus (Rno)	Ppgb (RGD:1309070)	GI:58865488
Gallus gallus (Gga)	CTSA	GI:71895603
Caenorhabditis elegans (Cel)	F13D12.6 (CE02185; WBGene00008741)	GI:17533155	P52715
Caenorhabditis elegans (Cel)	F41C3.5 (CE02733; WBGene00018271)	GI:17533883	P52717
Schizosaccharomyces pombe (Spo)	cpy1 (SPAC19G12.10c)	GI:19115337	O13849
Saccharomyces cerevisiae (Sce)	PRC1 (S000004912)	GI:6323955	P00729
Kluyveromyces lactis (Kla)	KLLA0A09977g	GI:50302997
Eremothecium gossypii (Ego)	AGOS_AGL328C	GI:45200769
Magnaporthe grisea (Mgr)	MGG_05663	GI:39941504
Neurospora crassa (Ncr)	NCU00477.1	GI:32403900
Arabidopsis thaliana (Ath)	scpl20	GI:30682276
Arabidopsis thaliana (Ath)	scpl21	GI:15230836
Oryza sativa (Osa)	Os12g0257000	GI:115488046
Oryza sativa (Osa)	Os04g0321700	GI:115457728

Species	OrthoMCL sequence	Model organism protein page	UniProt link
Ashbya gossypii (Ago)	ago2527	AER022W
Ashbya gossypii (Ago)	ago3984	AGL328C
Arabidopsis thaliana (Ath)	ath13134	At3g10410.1
Arabidopsis thaliana (Ath)	ath14859	At3g25420.1
Arabidopsis thaliana (Ath)	ath15775	At3g45010.1
Arabidopsis thaliana (Ath)	ath19042	At4g12910.1
Arabidopsis thaliana (Ath)	ath24538	At5g22980.1
Caenorhabditis elegans (Cel)	cel8755	F41C3.5 (CE02733; WBGene00018271)
Caenorhabditis elegans (Cel)	cel12477	K10B2.2a (CE02009; WBGene00019605)
Candida glabrata (Cgl)	cgl5251	CAGL0M13651g
Cryptococcus neoformans (Cne)	cne3622	176.m02356
Cryptococcus neoformans (Cne)	cne1465	180.m00419
Dictyostelium discoideum (Ddi)	ddi10065	DDB0184133
Debaryomyces hansenii (Dha)	dha2051	DEHA0C14069g
Debaryomyces hansenii (Dha)	dha2426	DEHA0D02937g
Danio rerio (Dre)	dre26622	ENSDARP00000029143
Danio rerio (Dre)	dre26621	ENSDARP00000032613
Takifugu rubripes (Fru)	fru18135	SINFRUP00000135907
Takifugu rubripes (Fru)	fru32821	SINFRUP00000162660
Takifugu rubripes (Fru)	fru32822	SINFRUP00000167234
Takifugu rubripes (Fru)	fru32820	SINFRUP00000168933
Takifugu rubripes (Fru)	fru18136	SINFRUP00000169298
Gallus gallus (Gga)	gga12150	ENSGALP00000011123
Gallus gallus (Gga)	gga12148	ENSGALP00000011124 (CTSA)	Q5ZIJ5
Gallus gallus (Gga)	gga12149	ENSGALP00000011125
Homo sapiens (Hsa)	hsa20337	ENSP00000191018 (CTSA)	P10619
Homo sapiens (Hsa)	hsa20336	ENSP00000346952 (CTSA)	P10619
Kluyveromyces lactis (Kla)	kla433	KLLA0A09977g
Mus musculus (Mmu)	mmu16014	ENSMUSP00000017904 (MGI:97748)	Q9D2D1
Neurospora crassa (Ncr)	ncr463	NCU00477.2
Oryza sativa (Osa)	osa7219	2498.m00146
Oryza sativa (Osa)	osa26714	4137.m00137
Oryza sativa (Osa)	osa26715	4137.m00138
Oryza sativa (Osa)	osa29141	4270.m00120
Oryza sativa (Osa)	osa68215	6904.m00138
Oryza sativa (Osa)	osa73604	7123.m00180
Oryza sativa (Osa)	osa70361	7140.m00175
Oryza sativa (Osa)	osa83665	8298.m00148
Oryza sativa (Osa)	osa86662	9208.m00101
Oryza sativa (Osa)	osa86663	9208.m00102
Oryza sativa (Osa)	osa87732	9239.m00099
Oryza sativa (Osa)	osa87733	9239.m00100
Rattus norvegicus (Rno)	rno20268	ENSRNOP00000022011 (RGD:1309070)
Saccharomyces cerevisiae (Sce)	sce404	YBR139W
Saccharomyces cerevisiae (Sce)	sce5073	YMR297W (S000004912)
Schizosaccharomyces pombe (Spo)	spo3872	SPAC19G12.10c	O13849
Yarrowia lipolytica (Yli)	yli630	YALI0A18810g
Yarrowia lipolytica (Yli)	yli1608	YALI0B20812g
Yarrowia lipolytica (Yli)	yli1756	YALI0C00803g
Yarrowia lipolytica (Yli)	yli5839	YALI0F11803g

S. pombe systematic ID	S. cerevisiae systematic ID
SPAC19G12.10c (O13849)	YMR297W (S000004912)