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Search term: YNL045W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name LAP2
SGD link S000004990
Alternative ID YNL045W
Description Leucyl aminopeptidase yscIV (leukotriene A4 hydrolase) with epoxide hydrolase activity, metalloenzyme containing one zinc atom; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
Synonyms YNL045W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG1047 ACDHYP-

KOGs classification KOGs description
METABOLISMCELLULAR PROCESSES AND SIGNALINGCELLULAR PROCESSES AND SIGNALINGMETABOLISM Bifunctional leukotriene A4 hydrolase/aminopeptidase LTA4H

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At5g13520 GI:15240645
Caenorhabditis elegans (Cel) CE24840
(WBGene00016589)		 GI:17539128
Caenorhabditis elegans (Cel) CE28160
(WBGene00022610)		 GI:17544504 O44183
Drosophila melanogaster (Dme) 7298498 GI:7298498
Homo sapiens (Hsa) Hs13443031 GI:13443031
Homo sapiens (Hsa) Hs20070296 GI:20070296
Homo sapiens (Hsa) Hs20537652 GI:20537652
Homo sapiens (Hsa) Hs21361893 GI:18044927 Q8N6M6
Homo sapiens (Hsa) Hs4505029
(LTA4H)		 GI:4505029 P09960
Homo sapiens (Hsa) HsM14249522 GI:14249522
Saccharomyces cerevisiae (Sce) YNL045w
(S000004990)		 GI:6324283 Q10740
Schizosaccharomyces pombe (Spo) SPCC1322.05c GI:19075633 O94544
Arabidopsis thaliana (Ath) At5g13520 GI:15240645
Caenorhabditis elegans (Cel) CE24840
(WBGene00016589)		 GI:17539128
Caenorhabditis elegans (Cel) CE28160
(WBGene00022610)		 GI:17544504 O44183
Drosophila melanogaster (Dme) 7298498 GI:7298498
Homo sapiens (Hsa) Hs13443031 GI:13443031
Homo sapiens (Hsa) Hs20070296 GI:20070296
Homo sapiens (Hsa) Hs20537652 GI:20537652
Homo sapiens (Hsa) Hs21361893 GI:18044927 Q8N6M6
Homo sapiens (Hsa) Hs4505029
(LTA4H)		 GI:4505029 P09960
Homo sapiens (Hsa) HsM14249522 GI:14249522
Saccharomyces cerevisiae (Sce) YNL045w
(S000004990)		 GI:6324283 Q10740
Schizosaccharomyces pombe (Spo) SPCC1322.05c GI:19075633 O94544


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
AthAt5g13520
GO:0005634 nucleus C
IDA
SceS000004990
SpoSPCC1322.05c
ISS
SpoSPCC1322.05c
GO:0005737 cytoplasm C
IDA
HsaLTA4H
SceS000004990
ISS
SpoSPCC1322.05c
GO:0005829 cytosol C
IDA
SpoSPCC1322.05c
GO:0004177 aminopeptidase activity F
IDA
SceS000004990
ISS
SpoSPCC1322.05c
GO:0004301 epoxide hydrolase activity F
IDA
SceS000004990
ISS
SpoSPCC1322.05c
TAS
HsaLTA4H
GO:0004463 leukotriene-A4 hydrolase activity F
ISS
SceS000004990
SpoSPCC1322.05c
GO:0005515 protein binding F
IPI
HsaLTA4H
GO:0000003 reproduction P
IMP
CelWBGene00016589
GO:0006508 proteolysis P
ISS
AthAt5g13520
GO:0006629 lipid metabolic process P
ISS
SpoSPCC1322.05c
GO:0006691 leukotriene metabolic process P
IC
SpoSPCC1322.05c
GO:0006954 inflammatory response P
NAS
HsaLTA4H
GO:0030163 protein catabolic process P
IDA
SceS000004990
ISS
SpoSPCC1322.05c
GO:0044255 cellular lipid metabolic process P
IDA
SceS000004990
IMP
SceS000004990

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
6820

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) LTA4H GI:4505029 P09960
Pan troglodytes (Ptr) LTA4H GI:114646359
Canis familiaris (Cfa) LTA4H GI:73978215
Mus musculus (Mmu) Lta4h
(MGI:96836)		 GI:116734870 P24527
Rattus norvegicus (Rno) Lta4h
(RGD:1311333)		 GI:71795621
Gallus gallus (Gga) LTA4H GI:57525373
Drosophila melanogaster (Dme) CG10602
(FBgn0032721)		 GI:45550350
Anopheles gambiae (Aga) AgaP_AGAP009907 GI:158298885
Caenorhabditis elegans (Cel) protease GI:17544504 O44183
Caenorhabditis elegans (Cel) peptidase GI:71984339
Schizosaccharomyces pombe (Spo) SPCC1322.05c GI:19075633 O94544
Saccharomyces cerevisiae (Sce) YNL045W
(S000004990)		 GI:6324283 Q10740
Kluyveromyces lactis (Kla) KLLA0F03883g GI:50310473
Magnaporthe grisea (Mgr) MGG_09481 GI:39960895
Neurospora crassa (Ncr) NCU06732.1 GI:32413076
Arabidopsis thaliana (Ath) AT5G13520 GI:15240645
Oryza sativa (Osa) Os03g0819100 GI:115456219


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
AthAt5g13520
GO:0005634 nucleus C
IDA
SceS000004990
SpoSPCC1322.05c
ISO
MmuMGI:96836
ISS
SpoSPCC1322.05c
GO:0005737 cytoplasm C
IDA
HsaLTA4H
SceS000004990
ISO
MmuMGI:96836
ISS
SpoSPCC1322.05c
GO:0005829 cytosol C
IDA
SpoSPCC1322.05c
GO:0004177 aminopeptidase activity F
IDA
SceS000004990
ISS
SpoSPCC1322.05c
GO:0004301 epoxide hydrolase activity F
IDA
SceS000004990
ISS
SpoSPCC1322.05c
TAS
HsaLTA4H
GO:0004463 leukotriene-A4 hydrolase activity F
ISO
MmuMGI:96836
ISS
DmeFBgn0032721
SceS000004990
SpoSPCC1322.05c
GO:0005515 protein binding F
IPI
HsaLTA4H
GO:0006508 proteolysis P
ISS
AthAt5g13520
GO:0006629 lipid metabolic process P
ISS
SpoSPCC1322.05c
GO:0006691 leukotriene metabolic process P
IC
SpoSPCC1322.05c
ISO
MmuMGI:96836
GO:0006954 inflammatory response P
NAS
HsaLTA4H
GO:0030163 protein catabolic process P
IDA
SceS000004990
ISS
SpoSPCC1322.05c
GO:0044255 cellular lipid metabolic process P
IDA
SceS000004990
IMP
SceS000004990

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_2700

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga12193 ENSANGP00000013312
Ashbya gossypii (Ago) ago1508 ADL233W
Arabidopsis thaliana (Ath) ath23544 At5g13520.1
Caenorhabditis elegans (Cel) cel3875 C42C1.11a
(CE24840;
WBGene00016589)
Caenorhabditis elegans (Cel) cel3877 C42C1.11c
(CE33565)
Caenorhabditis elegans (Cel) cel21342 ZC416.6
(CE28160;
WBGene00022610)
Candida glabrata (Cgl) cgl1685 CAGL0G01430g
Cryptococcus neoformans (Cne) cne3251 167.m03599
Dictyostelium discoideum (Ddi) ddi11376 DDB0191291
Debaryomyces hansenii (Dha) dha1338 DEHA0B15070g
Debaryomyces hansenii (Dha) dha6433 DEHA0G16449
Drosophila melanogaster (Dme) dme2883 CG10602-PA
(FBgn0032721)
Drosophila melanogaster (Dme) dme2886 CG10602-PB
(FBgn0032721)
Drosophila melanogaster (Dme) dme2885 CG10602-PC
(FBgn0032721)
Drosophila melanogaster (Dme) dme2884 CG10602-PD
(FBgn0032721)
Danio rerio (Dre) dre17971 ENSDARP00000011882
(zgc:85809)		 Q5RIF1
Takifugu rubripes (Fru) fru3331 SINFRUP00000147984
Gallus gallus (Gga) gga638 ENSGALP00000018616
(LTA4H)		 Q5ZJJ6
Homo sapiens (Hsa) hsa8015 ENSP00000228740
(LTA4H)		 P09960-1
Kluyveromyces lactis (Kla) kla4256 KLLA0F03883g
Mus musculus (Mmu) mmu2741 ENSMUSP00000016033
(MGI:96836)		 Q3UY71
Neurospora crassa (Ncr) ncr6548 NCU06732.2
Oryza sativa (Osa) osa63123 6700.m00186
Rattus norvegicus (Rno) rno26638 ENSRNOP00000005930
(RGD:1311333)		 Q499P2
Saccharomyces cerevisiae (Sce) sce5155 YNL045W
(S000004990)
Schizosaccharomyces pombe (Spo) spo4511 SPCC1322.05c O94544
Yarrowia lipolytica (Yli) yli5348 YALI0F00396g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
AthAt5g13520
GO:0005634 nucleus C
IDA
SceS000004990
SpoSPCC1322.05c
ISO
MmuMGI:96836
ISS
SpoSPCC1322.05c
GO:0005737 cytoplasm C
IDA
SceS000004990
ISO
MmuMGI:96836
ISS
SpoSPCC1322.05c
GO:0005829 cytosol C
IDA
SpoSPCC1322.05c
GO:0004177 aminopeptidase activity F
IDA
SceS000004990
ISS
SpoSPCC1322.05c
GO:0004301 epoxide hydrolase activity F
IDA
SceS000004990
ISS
SpoSPCC1322.05c
GO:0004463 leukotriene-A4 hydrolase activity F
ISO
MmuMGI:96836
ISS
DmeFBgn0032721
SceS000004990
SpoSPCC1322.05c
GO:0000003 reproduction P
IMP
CelWBGene00016589
GO:0006508 proteolysis P
ISS
AthAt5g13520
GO:0006629 lipid metabolic process P
ISS
SpoSPCC1322.05c
GO:0006691 leukotriene metabolic process P
IC
SpoSPCC1322.05c
ISO
MmuMGI:96836
GO:0030163 protein catabolic process P
IDA
SceS000004990
ISS
SpoSPCC1322.05c
GO:0044255 cellular lipid metabolic process P
IDA
SceS000004990
IMP
SceS000004990

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPCC1322.05c
(O94544)		 YNL045W
(S000004990)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SceS000004990
SpoSPCC1322.05c
ISS
SpoSPCC1322.05c
GO:0005737 cytoplasm C
IDA
SceS000004990
ISS
SpoSPCC1322.05c
GO:0005829 cytosol C
IDA
SpoSPCC1322.05c
GO:0004177 aminopeptidase activity F
IDA
SceS000004990
ISS
SpoSPCC1322.05c
GO:0004301 epoxide hydrolase activity F
IDA
SceS000004990
ISS
SpoSPCC1322.05c
GO:0004463 leukotriene-A4 hydrolase activity F
ISS
SceS000004990
SpoSPCC1322.05c
GO:0006629 lipid metabolic process P
ISS
SpoSPCC1322.05c
GO:0006691 leukotriene metabolic process P
IC
SpoSPCC1322.05c
GO:0030163 protein catabolic process P
IDA
SceS000004990
ISS
SpoSPCC1322.05c
GO:0044255 cellular lipid metabolic process P
IDA
SceS000004990
IMP
SceS000004990

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Query species:

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GO info in one table:

s.khadayate@ucl.ac.uk