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Search term: YNL082W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name PMS1
SGD link S000005026
Alternative ID YNL082W
Description ATP-binding protein required for mismatch repair in mitosis and meiosis; functions as a heterodimer with Mlh1p, binds double- and single-stranded DNA via its N-terminal domain, similar to E. coli MutL
Synonyms YNL082W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG1978 ACDHYPE

KOGs classification KOGs description
INFORMATION STORAGE AND PROCESSING DNA mismatch repair protein - MLH2/PMS1/Pms2 family

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At4g02460 GI:7487015
Caenorhabditis elegans (Cel) CE19915
(WBGene00004064)		 GI:17562796 Q9TVL8
Drosophila melanogaster (Dme) 7303075
(FBgn0011660)		 GI:17136970 A1ZA03
Homo sapiens (Hsa) Hs18568033 GI:18568033
Homo sapiens (Hsa) Hs22046253 GI:22046253
Homo sapiens (Hsa) Hs22046611 GI:22046611
Homo sapiens (Hsa) Hs22049531 GI:22049531
Homo sapiens (Hsa) Hs4505911
(PMS1)		 GI:4505911 P54277
Homo sapiens (Hsa) Hs4505913
(PMS2)		 GI:4505913 P54278
Homo sapiens (Hsa) Hs4885551 GI:4885551
Homo sapiens (Hsa) Hs4885553 GI:4885553
Saccharomyces cerevisiae (Sce) YLR035c
(S000004025)		 GI:6323063 Q07980
Saccharomyces cerevisiae (Sce) YNL082w
(S000005026)		 GI:6324247
Schizosaccharomyces pombe (Spo) SPAC19G12.02c GI:19115329 P54280
Encephalitozoon cuniculi (Ecu) ECU11g1260 GI:19074926 Q8SQV0


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000228 nuclear chromosome C
ISS
SpoSPAC19G12.02c
GO:0005634 nucleus C
IC
AthAt4g02460
HsaPMS2
IDA
SceS000005026
SpoSPAC19G12.02c
IPI
SceS000004025
GO:0005737 cytoplasm C
IDA
SceS000005026
GO:0005875 microtubule associated complex C
IDA
DmeFBgn0011660
GO:0032389 MutLalpha complex C
IPI
SceS000005026
GO:0000166 nucleotide binding F
RCA
SceS000004025
GO:0000217 DNA secondary structure binding F
RCA
SceS000004025
GO:0000404 loop DNA binding F
IDA
SceS000005026
RCA
SceS000004025
GO:0001882 nucleoside binding F
RCA
SceS000004025
GO:0001883 purine nucleoside binding F
RCA
SceS000004025
GO:0003674 molecular_function F
ND
SceS000004025
GO:0003677 DNA binding F
IDA
HsaPMS2
ISS
SpoSPAC19G12.02c
GO:0003690 double-stranded DNA binding F
IDA
SceS000005026
RCA
SceS000004025
GO:0003697 single-stranded DNA binding F
IDA
HsaPMS2
SceS000005026
RCA
SceS000004025
GO:0005515 protein binding F
IPI
HsaPMS2
GO:0005524 ATP binding F
IMP
SceS000005026
ISS
AthAt4g02460
SpoSPAC19G12.02c
RCA
SceS000004025
GO:0016887 ATPase activity F
IDA
SceS000005026
IMP
SceS000005026
ISS
SpoSPAC19G12.02c
RCA
SceS000004025
GO:0017076 purine nucleotide binding F
RCA
SceS000004025
GO:0030554 adenyl nucleotide binding F
RCA
SceS000004025
GO:0030983 mismatched DNA binding F
NAS
SpoSPAC19G12.02c
RCA
SceS000004025
GO:0032135 DNA insertion or deletion binding F
IDA
SceS000005026
RCA
SceS000004025
GO:0032138 single base insertion or deletion
binding		 F
IDA
HsaPMS2
GO:0032139 dinucleotide insertion or deletion
binding		 F
IDA
SceS000005026
RCA
SceS000004025
GO:0032407 MutSalpha complex binding F
IDA
HsaPMS2
GO:0032553 ribonucleotide binding F
RCA
SceS000004025
GO:0032555 purine ribonucleotide binding F
RCA
SceS000004025
GO:0032559 adenyl ribonucleotide binding F
RCA
SceS000004025
GO:0043566 structure-specific DNA binding F
RCA
SceS000004025
GO:0000710 meiotic mismatch repair P
IMP
SceS000005026
GO:0006200 ATP catabolic process P
ISS
SpoSPAC19G12.02c
GO:0006298 mismatch repair P
IDA
HsaPMS2
IGI
SpoSPAC19G12.02c
IMP
AthAt4g02460
SceS000004025
S000005026
SpoSPAC19G12.02c
ISS
AthAt4g02460
DmeFBgn0011660
GO:0006310 DNA recombination P
IMP
AthAt4g02460
GO:0006974 response to DNA damage stimulus P
IMP
CelWBGene00004064
GO:0007131 reciprocal meiotic recombination P
IMP
SceS000004025
RCA
SceS000005026
GO:0009555 pollen development P
IMP
AthAt4g02460
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00004064
GO:0010154 fruit development P
IMP
AthAt4g02460
GO:0043570 maintenance of DNA repeat elements P
IMP
SpoSPAC19G12.02c
GO:0048316 seed development P
IMP
AthAt4g02460

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
450

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) PMS2 GI:4505913 P54278
Pan troglodytes (Ptr) PMS2 GI:114612035
Canis familiaris (Cfa) PMS2 GI:73958129
Mus musculus (Mmu) Pms2
(MGI:104288)		 GI:121583910 A4QPD7
Rattus norvegicus (Rno) Pms2 GI:109495145
Drosophila melanogaster (Dme) Pms2
(FBgn0011660)		 GI:17136970 A1ZA03
Anopheles gambiae (Aga) AgaP_AGAP007126 GI:158286232
Caenorhabditis elegans (Cel) pms-2
(CE19915;
WBGene00004064)		 GI:17562796 Q9TVL8
Schizosaccharomyces pombe (Spo) pms1
(SPAC19G12.02c)		 GI:19115329 P54280
Saccharomyces cerevisiae (Sce) PMS1
(S000005026)		 GI:46562124
Kluyveromyces lactis (Kla) KLLA0C11319g GI:50305491
Eremothecium gossypii (Ego) AGOS_AER421W GI:45191022
Magnaporthe grisea (Mgr) MGG_01716 GI:39952147
Neurospora crassa (Ncr) NCU08020.1 GI:32416496
Arabidopsis thaliana (Ath) PMS1 GI:18411951
Oryza sativa (Osa) Os02g0592300 GI:115447025


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000228 nuclear chromosome C
ISS
SpoSPAC19G12.02c
GO:0005634 nucleus C
IC
HsaPMS2
IDA
SceS000005026
SpoSPAC19G12.02c
GO:0005737 cytoplasm C
IDA
SceS000005026
GO:0005875 microtubule associated complex C
IDA
DmeFBgn0011660
GO:0032389 MutLalpha complex C
IDA
MmuMGI:104288
IPI
SceS000005026
GO:0000404 loop DNA binding F
IDA
SceS000005026
GO:0003677 DNA binding F
IDA
HsaPMS2
ISS
SpoSPAC19G12.02c
GO:0003690 double-stranded DNA binding F
IDA
SceS000005026
GO:0003697 single-stranded DNA binding F
IDA
HsaPMS2
SceS000005026
GO:0005515 protein binding F
IPI
HsaPMS2
GO:0005524 ATP binding F
IMP
SceS000005026
ISS
SpoSPAC19G12.02c
GO:0016887 ATPase activity F
IDA
SceS000005026
IMP
SceS000005026
ISS
SpoSPAC19G12.02c
GO:0030983 mismatched DNA binding F
NAS
SpoSPAC19G12.02c
GO:0032135 DNA insertion or deletion binding F
IDA
SceS000005026
GO:0032138 single base insertion or deletion
binding		 F
IDA
HsaPMS2
GO:0032139 dinucleotide insertion or deletion
binding		 F
IDA
SceS000005026
GO:0032407 MutSalpha complex binding F
IDA
HsaPMS2
GO:0000710 meiotic mismatch repair P
IMP
SceS000005026
GO:0006200 ATP catabolic process P
ISS
SpoSPAC19G12.02c
GO:0006281 DNA repair P
IMP
MmuMGI:104288
GO:0006298 mismatch repair P
IDA
HsaPMS2
IGI
MmuMGI:104288
SpoSPAC19G12.02c
IMP
MmuMGI:104288
SceS000005026
SpoSPAC19G12.02c
ISS
DmeFBgn0011660
TAS
MmuMGI:104288
GO:0006974 response to DNA damage stimulus P
IGI
MmuMGI:104288
IMP
CelWBGene00004064
MmuMGI:104288
GO:0007126 meiosis P
TAS
MmuMGI:104288
GO:0007131 reciprocal meiotic recombination P
RCA
SceS000005026
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00004064
GO:0016446 somatic hypermutation of immunoglobulin
genes		 P
IMP
MmuMGI:104288
GO:0016447 somatic recombination of immunoglobulin gene
segments		 P
IMP
MmuMGI:104288
GO:0043570 maintenance of DNA repeat elements P
IMP
SpoSPAC19G12.02c

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_1441

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga2581 ENSANGP00000007566
Ashbya gossypii (Ago) ago2921 AER421W
Arabidopsis thaliana (Ath) ath18131 At4g02460.1
Caenorhabditis elegans (Cel) cel11279 H12C20.2a
(CE19915;
WBGene00004064)
Candida glabrata (Cgl) cgl3229 CAGL0J05500g
Cryptococcus neoformans (Cne) cne5377 179.m00229
Dictyostelium discoideum (Ddi) ddi9805 DDB0185791
Debaryomyces hansenii (Dha) dha506 DEHA0A11297g
Debaryomyces hansenii (Dha) dha507 DEHA0A11319g
Debaryomyces hansenii (Dha) dha509 DEHA0A11363g
Drosophila melanogaster (Dme) dme5228 CG8169-PA
(FBgn0011660)
Danio rerio (Dre) dre29532 ENSDARP00000002039
(pms1)		 Q7SXD5
Danio rerio (Dre) dre19727 ENSDARP00000022765
Danio rerio (Dre) dre19725 ENSDARP00000032329
Danio rerio (Dre) dre19726 ENSDARP00000039354
Encephalitozoon cuniculi (Ecu) ecu1014 19074926
Takifugu rubripes (Fru) fru32082 SINFRUP00000129001
Takifugu rubripes (Fru) fru32083 SINFRUP00000167653
Gallus gallus (Gga) gga6330 ENSGALP00000005417 Q5ZJ94
Gallus gallus (Gga) gga6331 ENSGALP00000005418
Gallus gallus (Gga) gga6329 ENSGALP00000005419
Homo sapiens (Hsa) hsa28212 ENSP00000265849
(PMS2)		 P54278-1
Homo sapiens (Hsa) hsa28237 ENSP00000341112
Kluyveromyces lactis (Kla) kla1704 KLLA0C11319g
Mus musculus (Mmu) mmu21270 ENSMUSP00000051168
Neurospora crassa (Ncr) ncr7812 NCU08020.2
Oryza sativa (Osa) osa58046 6456.m00249
Plasmodium falciparum (Pfa) pfa2505 MAL7P1.145
Rattus norvegicus (Rno) rno8071 ENSRNOP00000001374
(RGD:1305483)		 B1H246
Saccharomyces cerevisiae (Sce) sce5195 YNL082W
(S000005026)
Schizosaccharomyces pombe (Spo) spo2378 SPAC19G12.02c P54280
Yarrowia lipolytica (Yli) yli4308 YALI0E10769g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000228 nuclear chromosome C
ISS
SpoSPAC19G12.02c
GO:0005634 nucleus C
IC
AthAt4g02460
IDA
SceS000005026
SpoSPAC19G12.02c
GO:0005737 cytoplasm C
IDA
SceS000005026
GO:0005875 microtubule associated complex C
IDA
DmeFBgn0011660
GO:0032389 MutLalpha complex C
IPI
SceS000005026
GO:0000404 loop DNA binding F
IDA
SceS000005026
GO:0003677 DNA binding F
ISS
SpoSPAC19G12.02c
GO:0003684 damaged DNA binding F
ISS
PfaMAL7P1.145
GO:0003690 double-stranded DNA binding F
IDA
SceS000005026
GO:0003697 single-stranded DNA binding F
IDA
SceS000005026
GO:0005524 ATP binding F
IMP
SceS000005026
ISS
AthAt4g02460
SpoSPAC19G12.02c
GO:0016887 ATPase activity F
IDA
SceS000005026
IMP
SceS000005026
ISS
SpoSPAC19G12.02c
GO:0030983 mismatched DNA binding F
NAS
SpoSPAC19G12.02c
GO:0032135 DNA insertion or deletion binding F
IDA
SceS000005026
GO:0032139 dinucleotide insertion or deletion
binding		 F
IDA
SceS000005026
GO:0000710 meiotic mismatch repair P
IMP
SceS000005026
GO:0006200 ATP catabolic process P
ISS
SpoSPAC19G12.02c
GO:0006298 mismatch repair P
IGI
SpoSPAC19G12.02c
IMP
AthAt4g02460
SceS000005026
SpoSPAC19G12.02c
ISS
AthAt4g02460
DmeFBgn0011660
GO:0006310 DNA recombination P
IMP
AthAt4g02460
GO:0006974 response to DNA damage stimulus P
IMP
CelWBGene00004064
GO:0007131 reciprocal meiotic recombination P
RCA
SceS000005026
GO:0009555 pollen development P
IMP
AthAt4g02460
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00004064
GO:0010154 fruit development P
IMP
AthAt4g02460
GO:0043570 maintenance of DNA repeat elements P
IMP
SpoSPAC19G12.02c
GO:0048316 seed development P
IMP
AthAt4g02460

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPAC19G12.02c
(P54280)		 YNL082W
(S000005026)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000228 nuclear chromosome C
ISS
SpoSPAC19G12.02c
GO:0005634 nucleus C
IDA
SceS000005026
SpoSPAC19G12.02c
GO:0005737 cytoplasm C
IDA
SceS000005026
GO:0032389 MutLalpha complex C
IPI
SceS000005026
GO:0000404 loop DNA binding F
IDA
SceS000005026
GO:0003677 DNA binding F
ISS
SpoSPAC19G12.02c
GO:0003690 double-stranded DNA binding F
IDA
SceS000005026
GO:0003697 single-stranded DNA binding F
IDA
SceS000005026
GO:0005524 ATP binding F
IMP
SceS000005026
ISS
SpoSPAC19G12.02c
GO:0016887 ATPase activity F
IDA
SceS000005026
IMP
SceS000005026
ISS
SpoSPAC19G12.02c
GO:0030983 mismatched DNA binding F
NAS
SpoSPAC19G12.02c
GO:0032135 DNA insertion or deletion binding F
IDA
SceS000005026
GO:0032139 dinucleotide insertion or deletion
binding		 F
IDA
SceS000005026
GO:0000710 meiotic mismatch repair P
IMP
SceS000005026
GO:0006200 ATP catabolic process P
ISS
SpoSPAC19G12.02c
GO:0006298 mismatch repair P
IGI
SpoSPAC19G12.02c
IMP
SceS000005026
SpoSPAC19G12.02c
GO:0007131 reciprocal meiotic recombination P
RCA
SceS000005026
GO:0043570 maintenance of DNA repeat elements P
IMP
SpoSPAC19G12.02c

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