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Search term: YNL088W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name TOP2
SGD link S000005032
Alternative ID YNL088W
Description Essential type II topoisomerase, relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone of both positively and negatively supercoiled DNA; cleaves complementary strands; localizes to axial cores in meiosis
Synonyms YNL088W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG0355 ACDHYPE

KOGs classification KOGs description
INFORMATION STORAGE AND PROCESSING DNA topoisomerase type II

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At2g13720 GI:15225481
Arabidopsis thaliana (Ath) At3g10270 GI:15228245
Arabidopsis thaliana (Ath) At3g10690 GI:15228353
Arabidopsis thaliana (Ath) At3g23890 GI:15229538
Arabidopsis thaliana (Ath) At5g04110 GI:15237631
Arabidopsis thaliana (Ath) At5g04130 GI:9955568
Arabidopsis thaliana (Ath) At5g53960 GI:15238884
Caenorhabditis elegans (Cel) CE01933 GI:17533601
Caenorhabditis elegans (Cel) CE06184
(WBGene00010785)		 GI:17535065 Q23670
Caenorhabditis elegans (Cel) CE07645 GI:17538047
Caenorhabditis elegans (Cel) CE17740 GI:17533625
Caenorhabditis elegans (Cel) CE18656 GI:17533627
Caenorhabditis elegans (Cel) CE24315 GI:17565806
Caenorhabditis elegans (Cel) CE25068 GI:17554464
Drosophila melanogaster (Dme) 7298585 GI:7298585
Homo sapiens (Hsa) Hs19913406
(TOP2A)		 GI:19913406 Q9UQP9
Homo sapiens (Hsa) Hs19913408
(TOP2B)		 GI:19913408 Q02880
Saccharomyces cerevisiae (Sce) YNL088w
(S000005032)		 GI:6324241 P06786
Schizosaccharomyces pombe (Spo) SPBC1A4.03c GI:19112597 P08096
Encephalitozoon cuniculi (Ecu) ECU04g0350 GI:19074112 Q8SS63
Arabidopsis thaliana (Ath) At2g13720 GI:15225481
Arabidopsis thaliana (Ath) At3g10270 GI:15228245
Arabidopsis thaliana (Ath) At3g10690 GI:15228353
Arabidopsis thaliana (Ath) At3g23890 GI:15229538
Arabidopsis thaliana (Ath) At5g04110 GI:15237631
Arabidopsis thaliana (Ath) At5g04130 GI:9955568
Arabidopsis thaliana (Ath) At5g53960 GI:15238884
Caenorhabditis elegans (Cel) CE01933 GI:17533601
Caenorhabditis elegans (Cel) CE06184
(WBGene00010785)		 GI:17535065 Q23670
Caenorhabditis elegans (Cel) CE07645 GI:17538047
Caenorhabditis elegans (Cel) CE17740 GI:17533625
Caenorhabditis elegans (Cel) CE18656 GI:17533627
Caenorhabditis elegans (Cel) CE24315 GI:17565806
Caenorhabditis elegans (Cel) CE25068 GI:17554464
Drosophila melanogaster (Dme) 7298585 GI:7298585
Homo sapiens (Hsa) Hs19913406
(TOP2A)		 GI:19913406 Q9UQP9
Homo sapiens (Hsa) Hs19913408
(TOP2B)		 GI:19913408 Q02880
Saccharomyces cerevisiae (Sce) YNL088w
(S000005032)		 GI:6324241 P06786
Schizosaccharomyces pombe (Spo) SPBC1A4.03c GI:19112597 P08096
Encephalitozoon cuniculi (Ecu) ECU04g0350 GI:19074112 Q8SS63
Arabidopsis thaliana (Ath) At2g13720 GI:15225481
Arabidopsis thaliana (Ath) At3g10270 GI:15228245
Arabidopsis thaliana (Ath) At3g10690 GI:15228353
Arabidopsis thaliana (Ath) At3g23890 GI:15229538
Arabidopsis thaliana (Ath) At5g04110 GI:15237631
Arabidopsis thaliana (Ath) At5g04130 GI:9955568
Arabidopsis thaliana (Ath) At5g53960 GI:15238884
Caenorhabditis elegans (Cel) CE01933 GI:17533601
Caenorhabditis elegans (Cel) CE06184
(WBGene00010785)		 GI:17535065 Q23670
Caenorhabditis elegans (Cel) CE07645 GI:17538047
Caenorhabditis elegans (Cel) CE17740 GI:17533625
Caenorhabditis elegans (Cel) CE18656 GI:17533627
Caenorhabditis elegans (Cel) CE24315 GI:17565806
Caenorhabditis elegans (Cel) CE25068 GI:17554464
Drosophila melanogaster (Dme) 7298585 GI:7298585
Homo sapiens (Hsa) Hs19913406
(TOP2A)		 GI:19913406 Q9UQP9
Homo sapiens (Hsa) Hs19913408
(TOP2B)		 GI:19913408 Q02880
Saccharomyces cerevisiae (Sce) YNL088w
(S000005032)		 GI:6324241 P06786
Schizosaccharomyces pombe (Spo) SPBC1A4.03c GI:19112597 P08096
Encephalitozoon cuniculi (Ecu) ECU04g0350 GI:19074112 Q8SS63


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000228 nuclear chromosome C
IDA
HsaTOP2A
NAS
SpoSPBC1A4.03c
GO:0000792 heterochromatin C
IDA
HsaTOP2B
GO:0000795 synaptonemal complex C
IDA
SceS000005032
GO:0005634 nucleus C
IDA
AthAt3g23890
HsaTOP2B
TOP2A
SceS000005032
SpoSPBC1A4.03c
GO:0005654 nucleoplasm C
IDA
HsaTOP2B
TOP2A
GO:0005737 cytoplasm C
IDA
AthAt3g10270
HsaTOP2A
GO:0005739 mitochondrion C
IDA
AthAt3g10690
At5g04130
At3g10270
SceS000005032
GO:0005814 centriole C
IDA
HsaTOP2A
GO:0005829 cytosol C
IDA
HsaTOP2B
GO:0005886 plasma membrane C
IDA
AthAt5g53960
GO:0009295 nucleoid C
IDA
AthAt3g10690
At3g10270
GO:0009330 DNA topoisomerase complex (ATP-hydrolyzing) C
IDA
HsaTOP2A
ISS
AthAt3g23890
GO:0009507 chloroplast C
IDA
AthAt3g10690
At3g10270
GO:0019035 viral integration complex C
NAS
HsaTOP2A
GO:0043234 protein complex C
IPI
HsaTOP2A
GO:0070603 SWI/SNF-type complex C
IDA
HsaTOP2B
GO:0003677 DNA binding F
IDA
HsaTOP2A
ISS
AthAt5g04130
At3g10270
At3g23890
At5g04110
GO:0003682 chromatin binding F
IDA
HsaTOP2B
TOP2A
GO:0003824 catalytic activity F
ISS
AthAt3g10690
GO:0003916 DNA topoisomerase activity F
IGI
AthAt5g04130
At5g04110
At3g10690
ISS
AthAt3g23890
GO:0003918 DNA topoisomerase (ATP-hydrolyzing)
activity		 F
IDA
HsaTOP2A
SceS000005032
SpoSPBC1A4.03c
IGI
SpoSPBC1A4.03c
IMP
SpoSPBC1A4.03c
ISS
AthAt3g10270
At5g04130
At5g04110
At3g23890
GO:0005080 protein kinase C binding F
IPI
HsaTOP2B
TOP2A
GO:0005515 protein binding F
IPI
HsaTOP2A
GO:0005524 ATP binding F
IC
SpoSPBC1A4.03c
ISS
AthAt3g10690
At5g04130
At3g23890
At3g10270
At5g04110
GO:0008022 protein C-terminus binding F
IPI
HsaTOP2B
TOP2A
GO:0008094 DNA-dependent ATPase activity F
IDA
HsaTOP2A
ISS
AthAt3g23890
GO:0008144 drug binding F
IDA
HsaTOP2A
GO:0019899 enzyme binding F
IPI
HsaTOP2A
GO:0042803 protein homodimerization activity F
IPI
HsaTOP2A
GO:0042826 histone deacetylase binding F
IPI
HsaTOP2A
TOP2B
GO:0043130 ubiquitin binding F
IMP
HsaTOP2A
GO:0046982 protein heterodimerization activity F
IPI
HsaTOP2A
TOP2B
GO:0000019 regulation of mitotic recombination P
IMP
SceS000005032
GO:0000712 resolution of meiotic recombination
intermediates		 P
IMP
SpoSPBC1A4.03c
GO:0000910 cytokinesis P
IMP
CelWBGene00010785
GO:0006259 DNA metabolic process P
ISS
AthAt3g10270
At5g04110
At5g04130
At3g23890
GO:0006260 DNA replication P
NAS
HsaTOP2A
GO:0006265 DNA topological change P
IDA
SceS000005032
SpoSPBC1A4.03c
IGI
SpoSPBC1A4.03c
IMP
SpoSPBC1A4.03c
ISS
AthAt3g10270
At5g04130
At3g23890
At5g04110
GO:0006266 DNA ligation P
IDA
HsaTOP2A
GO:0006271 DNA strand elongation involved in DNA
replication		 P
IMP
SceS000005032
ISS
SpoSPBC1A4.03c
GO:0006281 DNA repair P
NAS
HsaTOP2A
GO:0006325 chromatin organization P
IGI
SpoSPBC1A4.03c
GO:0006333 chromatin assembly or disassembly P
IMP
SceS000005032
GO:0006406 mRNA export from nucleus P
IMP
SpoSPBC1A4.03c
GO:0006974 response to DNA damage stimulus P
IDA
HsaTOP2A
GO:0007059 chromosome segregation P
IMP
HsaTOP2A
ISS
AthAt3g23890
GO:0007076 mitotic chromosome condensation P
IMP
SpoSPBC1A4.03c
GO:0007131 reciprocal meiotic recombination P
IMP
SceS000005032
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00010785
GO:0030263 apoptotic chromosome condensation P
IDA
HsaTOP2A
GO:0031055 chromatin remodeling at centromere P
IMP
SceS000005032
GO:0042790 transcription of nuclear rRNA large RNA polymerase
I transcript		 P
IGI
SpoSPBC1A4.03c
GO:0043065 positive regulation of apoptosis P
IDA
HsaTOP2A
GO:0045070 positive regulation of viral genome
replication		 P
IMP
HsaTOP2A
GO:0045870 positive regulation of retroviral genome
replication		 P
IMP
HsaTOP2A
GO:0048015 phosphoinositide-mediated signaling P
NAS
HsaTOP2A
GO:0051301 cell division P
IMP
CelWBGene00010785
GO:0070683 decatenation checkpoint P
IMP
SceS000005032

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
830

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) TOP2A GI:19913406 Q9UQP9
Canis familiaris (Cfa) TOP2A GI:73966009
Mus musculus (Mmu) Top2a
(MGI:98790)		 GI:6755849 Q01320
Rattus norvegicus (Rno) Top2a
(RGD:62048)		 GI:38259192
Gallus gallus (Gga) TOP2A GI:45382161
Caenorhabditis elegans (Cel) top-2
(CE06184;
WBGene00010785)		 GI:17535065 Q23670
Schizosaccharomyces pombe (Spo) ptr11 GI:19112597
Saccharomyces cerevisiae (Sce) TOP2
(S000005032)		 GI:6324241 P06786
Kluyveromyces lactis (Kla) KLLA0C13838g GI:50305715
Eremothecium gossypii (Ego) AGOS_AER410W GI:45191011
Magnaporthe grisea (Mgr) MGG_06162 GI:39975823
Neurospora crassa (Ncr) NCU06338.1 GI:32411425
Arabidopsis thaliana (Ath) TOPII GI:15229538
Oryza sativa (Osa) Os02g0699700 GI:115448107
Plasmodium falciparum (Pfa) PF14_0316 GI:124809097