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Search term: YNL104C

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name LEU4
SGD link S000005048
Alternative ID YNL104C
Description Alpha-isopropylmalate synthase (2-isopropylmalate synthase); the main isozyme responsible for the first step in the leucine biosynthesis pathway
Synonyms YNL104C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG2367 A---YP-

KOGs classification KOGs description
METABOLISM Alpha-isopropylmalate synthase/homocitrate synthase

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At1g18500 GI:15221794
Arabidopsis thaliana (Ath) At1g74040 GI:15221125
Arabidopsis thaliana (Ath) At5g23010 GI:15237194
Arabidopsis thaliana (Ath) At5g23020 GI:15237196
Saccharomyces cerevisiae (Sce) YDL131w
(S000002289)		 GI:6320071 Q12122
Saccharomyces cerevisiae (Sce) YDL182w
(S000002341)		 GI:6320019 P48570
Saccharomyces cerevisiae (Sce) YNL104c
(S000005048)		 GI:6324225 P06208
Saccharomyces cerevisiae (Sce) YOR108w
(S000005634)		 GI:6324682 Q12166
Schizosaccharomyces pombe (Spo) SPBC1105.02c GI:19113250 Q9Y823
Schizosaccharomyces pombe (Spo) SPBC3E7.16c GI:19112895 O59736


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SceS000002341
S000002289
ISS
SpoSPBC1105.02c
GO:0005737 cytoplasm C
IDA
SceS000005048
ISS
SpoSPBC3E7.16c
GO:0005739 mitochondrion C
IDA
SceS000005048
S000005634
S000002341
SpoSPBC3E7.16c
ISS
SpoSPBC3E7.16c
SPBC1105.02c
GO:0005829 cytosol C
IDA
SpoSPBC1105.02c
GO:0009507 chloroplast C
IDA
AthAt5g23020
At1g74040
At5g23010
At1g18500
ISS
AthAt5g23010
GO:0009941 chloroplast envelope C
IDA
AthAt1g74040
GO:0003852 2-isopropylmalate synthase activity F
IDA
AthAt1g74040
At1g18500
SceS000005634
S000005048
IGI
AthAt1g74040
SceS000005634
ISS
AthAt1g74040
SceS000005634
SpoSPBC3E7.16c
NAS
AthAt5g23020
GO:0004410 homocitrate synthase activity F
IEP
SceS000002341
IGI
SceS000002341
IMP
SceS000002341
SpoSPBC1105.02c
ISS
SceS000002341
S000002289
GO:0010177 methylthioalkylmalate synthase
activity		 F
IDA
AthAt5g23010
At5g23020
GO:0006082 organic acid metabolic process P
RCA
SceS000002341
S000005048
S000002289
S000005634
GO:0006091 generation of precursor metabolites and
energy		 P
NAS
SpoSPBC1105.02c
GO:0006414 translational elongation P
RCA
SceS000002341
S000005048
GO:0006519 cellular amino acid and derivative metabolic
process		 P
RCA
SceS000002289
S000002341
S000005048
S000005634
GO:0006725 cellular aromatic compound metabolic
process		 P
RCA
SceS000002289
S000002341
S000005048
S000005634
GO:0006807 nitrogen compound metabolic process P
RCA
SceS000005048
S000002341
S000002289
S000005634
GO:0009098 leucine biosynthetic process P
IDA
AthAt1g18500
At1g74040
IGI
AthAt1g74040
SceS000005634
IMP
SceS000005048
ISS
SpoSPBC3E7.16c
TAS
AthAt5g23020
GO:0019761 glucosinolate biosynthetic process P
IDA
AthAt5g23010
At5g23020
IGI
AthAt5g23010
At5g23020
IMP
AthAt5g23010
At5g23020
GO:0019878 lysine biosynthetic process via aminoadipic
acid		 P
IGI
SceS000002289
S000002341
IMP
SceS000002289
SpoSPBC1105.02c

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
48994

Species Gene ID NCBI link UniProt link
Saccharomyces cerevisiae (Sce) LEU4
(S000005048)		 GI:6324225 P06208
Saccharomyces cerevisiae (Sce) LEU9
(S000005634)		 GI:6324682 Q12166
Kluyveromyces lactis (Kla) KLLA0F23529g GI:50312193


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005737 cytoplasm C
IDA
SceS000005048
GO:0005739 mitochondrion C
IDA
SceS000005048
S000005634
GO:0003852 2-isopropylmalate synthase activity F
IDA
SceS000005634
S000005048
IGI
SceS000005634
ISS
SceS000005634
GO:0006082 organic acid metabolic process P
RCA
SceS000005048
S000005634
GO:0006414 translational elongation P
RCA
SceS000005048
GO:0006519 cellular amino acid and derivative metabolic
process		 P
RCA
SceS000005048
S000005634
GO:0006725 cellular aromatic compound metabolic
process		 P
RCA
SceS000005048
S000005634
GO:0006807 nitrogen compound metabolic process P
RCA
SceS000005048
S000005634
GO:0009098 leucine biosynthetic process P
IGI
SceS000005634
IMP
SceS000005048

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_6383

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Ashbya gossypii (Ago) ago1727 ADL015C
Ashbya gossypii (Ago) ago2966 AFL229W
Candida glabrata (Cgl) cgl1827 CAGL0G04741g
Candida glabrata (Cgl) cgl1914 CAGL0G06732g
Debaryomyces hansenii (Dha) dha607 DEHA0A13585g
Debaryomyces hansenii (Dha) dha1261 DEHA0B13387g
Kluyveromyces lactis (Kla) kla2695 KLLA0D14201g
Kluyveromyces lactis (Kla) kla5128 KLLA0F23529g
Neurospora crassa (Ncr) ncr1954 NCU02010.2
Saccharomyces cerevisiae (Sce) sce5220 YNL104C
(S000005048)
Saccharomyces cerevisiae (Sce) sce5845 YOR108W
(S000005634)
Schizosaccharomyces pombe (Spo) spo2648 SPBC3E7.16c O59736
Yarrowia lipolytica (Yli) yli1041 YALI0B07447g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005737 cytoplasm C
IDA
SceS000005048
ISS
SpoSPBC3E7.16c
GO:0005739 mitochondrion C
IDA
SceS000005048
S000005634
SpoSPBC3E7.16c
ISS
SpoSPBC3E7.16c
GO:0003852 2-isopropylmalate synthase activity F
IDA
SceS000005634
S000005048
IGI
SceS000005634
ISS
SceS000005634
SpoSPBC3E7.16c
GO:0006082 organic acid metabolic process P
RCA
SceS000005048
S000005634
GO:0006414 translational elongation P
RCA
SceS000005048
GO:0006519 cellular amino acid and derivative metabolic
process		 P
RCA
SceS000005048
S000005634
GO:0006725 cellular aromatic compound metabolic
process		 P
RCA
SceS000005048
S000005634
GO:0006807 nitrogen compound metabolic process P
RCA
SceS000005048
S000005634
GO:0009098 leucine biosynthetic process P
IGI
SceS000005634
IMP
SceS000005048
ISS
SpoSPBC3E7.16c

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPBC3E7.16c
(O59736)		 YNL104C
(S000005048)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005737 cytoplasm C
IDA
SceS000005048
ISS
SpoSPBC3E7.16c
GO:0005739 mitochondrion C
IDA
SceS000005048
SpoSPBC3E7.16c
ISS
SpoSPBC3E7.16c
GO:0003852 2-isopropylmalate synthase activity F
IDA
SceS000005048
ISS
SpoSPBC3E7.16c
GO:0006082 organic acid metabolic process P
RCA
SceS000005048
GO:0006414 translational elongation P
RCA
SceS000005048
GO:0006519 cellular amino acid and derivative metabolic
process		 P
RCA
SceS000005048
GO:0006725 cellular aromatic compound metabolic
process		 P
RCA
SceS000005048
GO:0006807 nitrogen compound metabolic process P
RCA
SceS000005048
GO:0009098 leucine biosynthetic process P
IMP
SceS000005048
ISS
SpoSPBC3E7.16c

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