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Search term: YNL121C


Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name TOM70
SGD link S000005065
Alternative ID YNL121C
Description Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; acts as a receptor for incoming precursor proteins
Synonyms YNL121C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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Query species:

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Search for GO info:  

GO info in one table:


KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG0547 --DHYP-

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALING Translocase of outer mitochondrial membrane complex, subunit TOM70/TOM72

Species KOG link NCBI link UniProt link
Drosophila melanogaster (Dme) 7297902 GI:7297902
Homo sapiens (Hsa) Hs7662673 GI:7662673
Saccharomyces cerevisiae (Sce) YHR117w
(S000001159)
GI:6321909 P38825
Saccharomyces cerevisiae (Sce) YNL121c
(S000005065)
GI:6324208 P07213
Schizosaccharomyces pombe (Spo) SPAC6B12.12 GI:19114679 O14217
Drosophila melanogaster (Dme) 7297902 GI:7297902
Homo sapiens (Hsa) Hs7662673 GI:7662673
Saccharomyces cerevisiae (Sce) YHR117w
(S000001159)
GI:6321909 P38825
Saccharomyces cerevisiae (Sce) YNL121c
(S000005065)
GI:6324208 P07213
Schizosaccharomyces pombe (Spo) SPAC6B12.12 GI:19114679 O14217


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005739 mitochondrion C
IDA
SceS000005065
S000001159
SpoSPAC6B12.12
GO:0005741 mitochondrial outer membrane C
IDA
SceS000001159
S000005065
GO:0005742 mitochondrial outer membrane translocase
complex
C
IDA
SceS000005065
ISS
SpoSPAC6B12.12
GO:0005743 mitochondrial inner membrane C
RCA
SceS000005065
GO:0019866 organelle inner membrane C
RCA
SceS000005065
GO:0031307 integral to mitochondrial outer
membrane
C
IDA
SceS000001159
S000005065
GO:0005047 signal recognition particle binding F
ISS
SpoSPAC6B12.12
GO:0008565 protein transporter activity F
IDA
SceS000001159
ISS
SceS000001159
SpoSPAC6B12.12
GO:0015266 protein channel activity F
IMP
SceS000005065
GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane
transporter activity
F
ISS
SpoSPAC6B12.12
GO:0030943 mitochondrion targeting sequence
binding
F
IMP
SceS000005065
GO:0008150 biological_process P
IMP
SceS000001159
GO:0030150 protein import into mitochondrial
matrix
P
IMP
SceS000005065
GO:0045039 protein import into mitochondrial inner
membrane
P
IDA
SceS000005065
IMP
SceS000005065
ISS
SpoSPAC6B12.12

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
40112

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) TOMM70A GI:54607135
Pan troglodytes (Ptr) TOMM70A GI:114588180
Canis familiaris (Cfa) TOMM70A GI:74002556
Mus musculus (Mmu) Tomm70a
(MGI:106295)
GI:27552760 Q3TSX8
Rattus norvegicus (Rno) Tomm70a
(RGD:1303049)
GI:47058988
Gallus gallus (Gga) TOMM70A GI:50729660
Drosophila melanogaster (Dme) Tom70
(FBgn0032397)
GI:24583793
Anopheles gambiae (Aga) AgaP_AGAP009497 GI:158288319
Schizosaccharomyces pombe (Spo) tom70
(SPAC6B12.12)
GI:19114679 O14217
Saccharomyces cerevisiae (Sce) TOM70
(S000005065)
GI:6324208 P07213
Kluyveromyces lactis (Kla) KLLA0F24046g GI:50312239
Eremothecium gossypii (Ego) AGOS_ABR131W GI:45185361
Magnaporthe grisea (Mgr) MGG_00979 GI:39973749
Neurospora crassa (Ncr) NCU04245.1 GI:32405944


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005737 cytoplasm C
IDA
HsaTOMM70A
GO:0005739 mitochondrion C
IDA
HsaTOMM70A
MmuMGI:106295
SceS000005065
SpoSPAC6B12.12
GO:0005741 mitochondrial outer membrane C
IDA
SceS000005065
GO:0005742 mitochondrial outer membrane translocase
complex
C
IDA
SceS000005065
ISS
DmeFBgn0032397
SpoSPAC6B12.12
TAS
HsaTOMM70A
GO:0005743 mitochondrial inner membrane C
RCA
SceS000005065
GO:0019866 organelle inner membrane C
RCA
SceS000005065
GO:0031307 integral to mitochondrial outer
membrane
C
IDA
SceS000005065
GO:0005047 signal recognition particle binding F
ISS
SpoSPAC6B12.12
GO:0005515 protein binding F
IPI
HsaTOMM70A
MmuMGI:106295
GO:0008320 protein transmembrane transporter
activity
F
TAS
HsaTOMM70A
GO:0008565 protein transporter activity F
ISS
SpoSPAC6B12.12
GO:0015266 protein channel activity F
IMP
SceS000005065
GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane
transporter activity
F
ISS
DmeFBgn0032397
SpoSPAC6B12.12
GO:0030943 mitochondrion targeting sequence
binding
F
IMP
SceS000005065
GO:0006626 protein targeting to mitochondrion P
ISS
DmeFBgn0032397
TAS
HsaTOMM70A
GO:0030150 protein import into mitochondrial
matrix
P
IMP
SceS000005065
GO:0045039 protein import into mitochondrial inner
membrane
P
IDA
SceS000005065
IMP
SceS000005065
ISS
SpoSPAC6B12.12

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_3454

Species OrthoMCL
sequence
Model organism
protein page
UniProt link
Anopheles gambiae (Aga) aga11653 ENSANGP00000011046
Ashbya gossypii (Ago) ago723 ABR131W
Candida glabrata (Cgl) cgl4254 CAGL0L04048g
Candida glabrata (Cgl) cgl4639 CAGL0L12936g
Cryptococcus neoformans (Cne) cne5326 179.m00177
Debaryomyces hansenii (Dha) dha950 DEHA0B05962g
Drosophila melanogaster (Dme) dme2071 CG6756-PA
(FBgn0032397)
Drosophila melanogaster (Dme) dme2070 CG6756-PB
(FBgn0032397)
Drosophila melanogaster (Dme) dme2072 CG6756-PC
(FBgn0032397)
Danio rerio (Dre) dre20460 ENSDARP00000040375
(tomm70a)
Q6PBY6
Danio rerio (Dre) dre20450 ENSDARP00000041997
(tomm70a)
Q6PBY6
Takifugu rubripes (Fru) fru32495 SINFRUP00000165621
Gallus gallus (Gga) gga1816 ENSGALP00000024624
(TOMM70A)
Gallus gallus (Gga) gga1817 ENSGALP00000024625
Homo sapiens (Hsa) hsa22844 ENSP00000284320
(TOMM70A)
O94826
Kluyveromyces lactis (Kla) kla5151 KLLA0F24046g
Mus musculus (Mmu) mmu10481 ENSMUSP00000023433
(MGI:106295)
Q3TSX8
Neurospora crassa (Ncr) ncr4121 NCU04245.2
Oryza sativa (Osa) osa59483 6523.m00196
Rattus norvegicus (Rno) rno6974 ENSRNOP00000002238
(RGD:1303049)
Q75Q39
Rattus norvegicus (Rno) rno6973 ENSRNOP00000039713
Saccharomyces cerevisiae (Sce) sce2883 YHR117W
(S000001159)
Saccharomyces cerevisiae (Sce) sce5237 YNL121C
(S000005065)
Schizosaccharomyces pombe (Spo) spo533 SPAC6B12.12 O14217
Yarrowia lipolytica (Yli) yli1164 YALI0B10362g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005739 mitochondrion C
IDA
MmuMGI:106295
SceS000005065
S000001159
SpoSPAC6B12.12
GO:0005741 mitochondrial outer membrane C
IDA
SceS000001159
S000005065
GO:0005742 mitochondrial outer membrane translocase
complex
C
IDA
SceS000005065
ISS
DmeFBgn0032397
SpoSPAC6B12.12
GO:0005743 mitochondrial inner membrane C
RCA
SceS000005065
GO:0019866 organelle inner membrane C
RCA
SceS000005065
GO:0031307 integral to mitochondrial outer
membrane
C
IDA
SceS000001159
S000005065
GO:0005047 signal recognition particle binding F
ISS
SpoSPAC6B12.12
GO:0005515 protein binding F
IPI
MmuMGI:106295
GO:0008565 protein transporter activity F
IDA
SceS000001159
ISS
SceS000001159
SpoSPAC6B12.12
GO:0015266 protein channel activity F
IMP
SceS000005065
GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane
transporter activity
F
ISS
DmeFBgn0032397
SpoSPAC6B12.12
GO:0030943 mitochondrion targeting sequence
binding
F
IMP
SceS000005065
GO:0006626 protein targeting to mitochondrion P
ISS
DmeFBgn0032397
GO:0008150 biological_process P
IMP
SceS000001159
GO:0030150 protein import into mitochondrial
matrix
P
IMP
SceS000005065
GO:0045039 protein import into mitochondrial inner
membrane
P
IDA
SceS000005065
IMP
SceS000005065
ISS
SpoSPAC6B12.12

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Curated yeast ortholog results:

S. pombe
systematic ID
S. cerevisiae
systematic ID
SPAC6B12.12
(O14217)
YNL121C
(S000005065)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005739 mitochondrion C
IDA
SceS000005065
SpoSPAC6B12.12
GO:0005741 mitochondrial outer membrane C
IDA
SceS000005065
GO:0005742 mitochondrial outer membrane translocase
complex
C
IDA
SceS000005065
ISS
SpoSPAC6B12.12
GO:0005743 mitochondrial inner membrane C
RCA
SceS000005065
GO:0019866 organelle inner membrane C
RCA
SceS000005065
GO:0031307 integral to mitochondrial outer
membrane
C
IDA
SceS000005065
GO:0005047 signal recognition particle binding F
ISS
SpoSPAC6B12.12
GO:0008565 protein transporter activity F
ISS
SpoSPAC6B12.12
GO:0015266 protein channel activity F
IMP
SceS000005065
GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane
transporter activity
F
ISS
SpoSPAC6B12.12
GO:0030943 mitochondrion targeting sequence
binding
F
IMP
SceS000005065
GO:0030150 protein import into mitochondrial
matrix
P
IMP
SceS000005065
GO:0045039 protein import into mitochondrial inner
membrane
P
IDA
SceS000005065
IMP
SceS000005065
ISS
SpoSPAC6B12.12

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Search for gene by ID or name:

Query species:

Include wild-cards:   

Search for GO info:  

GO info in one table:

s.khadayate@ucl.ac.uk