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Search term: YNL135C

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name FPR1
SGD link S000005079
Alternative ID YNL135C
Description Peptidyl-prolyl cis-trans isomerase (PPIase), binds to the drugs FK506 and rapamycin; also binds to the nonhistone chromatin binding protein Hmo1p and may regulate its assembly or function
Synonyms YNL135C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG0544 ACDHYP-

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALING FKBP-type peptidyl-prolyl cis-trans isomerase

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At5g64350 GI:15237679
Caenorhabditis elegans (Cel) CE21415
(WBGene00001433)		 GI:17507843
Caenorhabditis elegans (Cel) CE21416 GI:17507845
Caenorhabditis elegans (Cel) CE21417
(WBGene00001427)		 GI:7509457 Q9U2Q8
Drosophila melanogaster (Dme) 7302498 GI:7302498
Homo sapiens (Hsa) Hs17149839 GI:17149839 P68106
Homo sapiens (Hsa) Hs17464200 GI:17464200
Homo sapiens (Hsa) Hs17489110 GI:17489110
Homo sapiens (Hsa) Hs22043701_2 GI:22043701
Homo sapiens (Hsa) Hs4503725
(FKBP1A)		 GI:4503725 Q9UH88
Homo sapiens (Hsa) Hs4503727
(FKBP3)		 GI:4503727 Q00688
Homo sapiens (Hsa) Hs4758380
(FKBP1B)		 GI:4758380 P68106
Saccharomyces cerevisiae (Sce) YNL135c
(S000005079)		 GI:6324194 P20081
Schizosaccharomyces pombe (Spo) SPBC839.17c GI:19112049 O42993
Arabidopsis thaliana (Ath) At5g64350 GI:15237679
Caenorhabditis elegans (Cel) CE21415
(WBGene00001433)		 GI:17507843
Caenorhabditis elegans (Cel) CE21416 GI:17507845
Caenorhabditis elegans (Cel) CE21417
(WBGene00001427)		 GI:7509457 Q9U2Q8
Drosophila melanogaster (Dme) 7302498 GI:7302498
Homo sapiens (Hsa) Hs17149839 GI:17149839 P68106
Homo sapiens (Hsa) Hs17464200 GI:17464200
Homo sapiens (Hsa) Hs17489110 GI:17489110
Homo sapiens (Hsa) Hs22043701_2 GI:22043701
Homo sapiens (Hsa) Hs4503725
(FKBP1A)		 GI:4503725 Q9UH88
Homo sapiens (Hsa) Hs4503727
(FKBP3)		 GI:4503727 Q00688
Homo sapiens (Hsa) Hs4758380
(FKBP1B)		 GI:4758380 P68106
Saccharomyces cerevisiae (Sce) YNL135c
(S000005079)		 GI:6324194 P20081
Schizosaccharomyces pombe (Spo) SPBC839.17c GI:19112049 O42993


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SceS000005079
SpoSPBC839.17c
GO:0005737 cytoplasm C
IDA
SceS000005079
GO:0005739 mitochondrion C
IDA
SceS000005079
GO:0005829 cytosol C
IDA
HsaFKBP1A
SpoSPBC839.17c
GO:0009543 chloroplast thylakoid lumen C
ISS
AthAt5g64350
GO:0014802 terminal cisterna C
ISS
HsaFKBP1A
GO:0003755 peptidyl-prolyl cis-trans isomerase
activity		 F
IDA
HsaFKBP1A
SceS000005079
ISS
AthAt5g64350
CelWBGene00001433
SceS000005079
TAS
HsaFKBP1A
GO:0004871 signal transducer activity F
IMP
HsaFKBP1A
GO:0004872 receptor activity F
TAS
HsaFKBP3
GO:0005024 transforming growth factor beta receptor
activity		 F
TAS
HsaFKBP1A
GO:0005160 transforming growth factor beta receptor
binding		 F
ISS
HsaFKBP1A
GO:0005219 ryanodine-sensitive calcium-release channel
activity		 F
TAS
HsaFKBP1A
GO:0005515 protein binding F
IPI
HsaFKBP1A
GO:0005527 macrolide binding F
IDA
SceS000005079
NAS
HsaFKBP1A
GO:0005528 FK506 binding F
IDA
HsaFKBP1A
ISS
AthAt5g64350
NAS
HsaFKBP1A
TAS
HsaFKBP3
GO:0034713 type I transforming growth factor beta receptor
binding		 F
ISS
HsaFKBP1A
GO:0046332 SMAD binding F
IPI
HsaFKBP1A
GO:0048185 activin binding F
IPI
HsaFKBP1A
GO:0000747 conjugation with cellular fusion P
IMP
SpoSPBC839.17c
GO:0003007 heart morphogenesis P
ISS
HsaFKBP1A
GO:0006325 chromatin organization P
IGI
SceS000005079
GO:0006457 protein folding P
IMP
SceS000005079
NAS
HsaFKBP1A
SpoSPBC839.17c
GO:0006458 'de novo' protein folding P
TAS
HsaFKBP1A
GO:0007183 SMAD protein complex assembly P
IDA
HsaFKBP1A
GO:0009092 homoserine metabolic process P
IGI
SceS000005079
GO:0022417 protein maturation by protein folding P
TAS
HsaFKBP1A
GO:0031398 positive regulation of protein
ubiquitination		 P
IDA
HsaFKBP1A
GO:0032092 positive regulation of protein
binding		 P
IDA
HsaFKBP1A
GO:0032513 negative regulation of protein phosphatase type 2B
activity		 P
IDA
HsaFKBP1A
GO:0032925 regulation of activin receptor signaling
pathway		 P
IDA
HsaFKBP1A
GO:0034205 beta-amyloid formation P
IDA
HsaFKBP1A
GO:0042026 protein refolding P
TAS
HsaFKBP1A
GO:0042110 T cell activation P
NAS
HsaFKBP1A
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB
cascade		 P
IMP
HsaFKBP1A
GO:0043206 fibril organization P
IDA
HsaFKBP1A
GO:0050776 regulation of immune response P
IMP
HsaFKBP1A
GO:0055010 ventricular cardiac muscle tissue
morphogenesis		 P
ISS
HsaFKBP1A
GO:0060314 regulation of ryanodine-sensitive calcium-release
channel activity		 P
IDA
HsaFKBP1A
ISS
HsaFKBP1A
GO:0060347 heart trabecula formation P
ISS
HsaFKBP1A

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
105284

Species Gene ID NCBI link UniProt link
Drosophila melanogaster (Dme) FK506-bp2
(FBgn0013954)		 GI:24655568
Anopheles gambiae (Aga) AgaP_AGAP012184 GI:31239875
Caenorhabditis elegans (Cel) fkb-2
(CE21417;
WBGene00001427)		 GI:71993519
Caenorhabditis elegans (Cel) fkb-8
(CE21415;
WBGene00001433)		 GI:71993555
Schizosaccharomyces pombe (Spo) fkh1
(SPBC839.17c)		 GI:19112049 O42993
Saccharomyces cerevisiae (Sce) FPR1
(S000005079)		 GI:6324194 P20081
Kluyveromyces lactis (Kla) KLLA0A11704g GI:50303143
Eremothecium gossypii (Ego) AGOS_AFR064C GI:45198582


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SceS000005079
SpoSPBC839.17c
GO:0005737 cytoplasm C
IDA
SceS000005079
ISS
DmeFBgn0013954
NAS
DmeFBgn0013954
GO:0005739 mitochondrion C
IDA
SceS000005079
GO:0005829 cytosol C
IDA
SpoSPBC839.17c
GO:0003755 peptidyl-prolyl cis-trans isomerase
activity		 F
IDA
SceS000005079
ISS
CelWBGene00001433
DmeFBgn0013954
SceS000005079
NAS
DmeFBgn0013954
GO:0005527 macrolide binding F
IDA
SceS000005079
GO:0005528 FK506 binding F
ISS
DmeFBgn0013954
NAS
DmeFBgn0013954
GO:0000747 conjugation with cellular fusion P
IMP
SpoSPBC839.17c
GO:0006325 chromatin organization P
IGI
SceS000005079
GO:0006457 protein folding P
IMP
SceS000005079
ISS
DmeFBgn0013954
NAS
DmeFBgn0013954
SpoSPBC839.17c
GO:0006974 response to DNA damage stimulus P
IMP
DmeFBgn0013954
GO:0009092 homoserine metabolic process P
IGI
SceS000005079

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_183

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga9373 ENSANGP00000014046
Anopheles gambiae (Aga) aga14145 ENSANGP00000014683
Anopheles gambiae (Aga) aga11505 ENSANGP00000025947
Ashbya gossypii (Ago) ago3256 AFR064C
Arabidopsis thaliana (Ath) ath14850 At3g25230.1
Arabidopsis thaliana (Ath) ath26420 At5g45680.1
Arabidopsis thaliana (Ath) ath26758 At5g48570.1
Caenorhabditis elegans (Cel) cel7766 F31D4.3
(CE15929;
WBGene00001431)
Caenorhabditis elegans (Cel) cel17905 Y18D10A.19
(CE21417;
WBGene00001427)
Candida glabrata (Cgl) cgl3938 CAGL0K09724g
Cryptococcus neoformans (Cne) cne5145 186.m04097
Dictyostelium discoideum (Ddi) ddi5542 DDB0185700
Dictyostelium discoideum (Ddi) ddi2323 DDB0203130
Dictyostelium discoideum (Ddi) ddi5608 DDB0204309
Dictyostelium discoideum (Ddi) ddi6533 DDB0205465
Debaryomyces hansenii (Dha) dha948 DEHA0B05918g
Drosophila melanogaster (Dme) dme6012 CG11001-PA
(FBgn0013954)
Drosophila melanogaster (Dme) dme1661 CG4535-PA
(FBgn0029174)
Danio rerio (Dre) dre28482 ENSDARP00000013076
(LOC555160)
Danio rerio (Dre) dre15212 ENSDARP00000018380
Danio rerio (Dre) dre26137 ENSDARP00000036607
(zgc:73373)		 Q6PBJ8
Danio rerio (Dre) dre20670 ENSDARP00000038578
(fkbp5)		 Q801U5
Escherichia coli (Eco) eco3229 16131226
Takifugu rubripes (Fru) fru19944 SINFRUP00000129987
Takifugu rubripes (Fru) fru3698 SINFRUP00000147444
Takifugu rubripes (Fru) fru32973 SINFRUP00000162512
Takifugu rubripes (Fru) fru19278 SINFRUP00000168334
Gallus gallus (Gga) gga16411 ENSGALP00000001395
(FKBP5)
Gallus gallus (Gga) gga16410 ENSGALP00000001396
(FKBP5)
Gallus gallus (Gga) gga16412 ENSGALP00000001397
Gallus gallus (Gga) gga16057 ENSGALP00000026566
(FKBP1B)		 Q8QGU2
Homo sapiens (Hsa) hsa6901 ENSP00000001008
(FKBP4)		 Q02790
Homo sapiens (Hsa) hsa17534 ENSP00000238793
Homo sapiens (Hsa) hsa19660 ENSP00000262925
Homo sapiens (Hsa) hsa27012 ENSP00000338160
(FKBP5)		 Q13451
Homo sapiens (Hsa) hsa31314 ENSP00000347352
Homo sapiens (Hsa) hsa27013 ENSP00000349811
(FKBP5)		 Q13451
Kluyveromyces lactis (Kla) kla506 KLLA0A11704g
Mus musculus (Mmu) mmu5429 ENSMUSP00000020964
(MGI:1336205)		 Q9Z2I2
Mus musculus (Mmu) mmu22798 ENSMUSP00000032508
(MGI:95543)		 P30416
Mus musculus (Mmu) mmu15721 ENSMUSP00000037206
(MGI:95541)		 P26883
Mus musculus (Mmu) mmu11281 ENSMUSP00000061503
(MGI:104670)		 Q64378
Mus musculus (Mmu) mmu11282 ENSMUSP00000078382
(MGI:104670)		 Q64378
Neurospora crassa (Ncr) ncr4016 NCU04140.2
Oryza sativa (Osa) osa23542 3775.m00181
Oryza sativa (Osa) osa29285 4267.m00162
Oryza sativa (Osa) osa37961 4883.m00176
Oryza sativa (Osa) osa73731 7278.m00096
Oryza sativa (Osa) osa73768 7278.m00124
Oryza sativa (Osa) osa81846 8171.m00143
Plasmodium falciparum (Pfa) pfa5236 PFL2275c
Rattus norvegicus (Rno) rno22293 ENSRNOP00000008737
(RGD:628729)		 Q9QVC8
Rattus norvegicus (Rno) rno19959 ENSRNOP00000012608
(RGD:2617)		 Q62658
Rattus norvegicus (Rno) rno17596 ENSRNOP00000034024
(RGD:1309155)		 Q5U2T9
Saccharomyces cerevisiae (Sce) sce5252 YNL135C
(S000005079)
Schizosaccharomyces pombe (Spo) spo4597 SPBC839.17c O42993
Yarrowia lipolytica (Yli) yli1168 YALI0B10450g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
PfaPFL2275c
GO:0005624 membrane fraction C
IDA
MmuMGI:95541
GO:0005634 nucleus C
IDA
AthAt3g25230
MmuMGI:95543
SceS000005079
SpoSPBC839.17c
GO:0005737 cytoplasm C
IDA
AthAt3g25230
SceS000005079
ISS
DmeFBgn0013954
NAS
DmeFBgn0013954
GO:0005739 mitochondrion C
IDA
SceS000005079
GO:0005773 vacuole C
IDA
AthAt5g48570
GO:0005792 microsome C
ISO
MmuMGI:95541
MGI:1336205
GO:0005829 cytosol C
IDA
SpoSPBC839.17c
ISO
MmuMGI:95543
GO:0009507 chloroplast C
IDA
AthAt5g45680
GO:0009543 chloroplast thylakoid lumen C
IDA
AthAt5g45680
ISS
AthAt5g45680
GO:0016027 inaD signaling complex C
IPI
DmeFBgn0029174
GO:0031977 thylakoid lumen C
IDA
AthAt5g45680
GO:0033017 sarcoplasmic reticulum membrane C
IDA
MmuMGI:1336205
MGI:95541
GO:0043679 axon terminus C
ISO
MmuMGI:95541
GO:0044295 axonal growth cone C
ISO
MmuMGI:95543
GO:0003755 peptidyl-prolyl cis-trans isomerase
activity		 F
IDA
AthAt5g45680
MmuMGI:1336205
SceS000005079
ISS
AthAt5g45680
At3g25230
At5g48570
DmeFBgn0013954
FBgn0029174
PfaPFL2275c
SceS000005079
NAS
DmeFBgn0013954
GO:0005160 transforming growth factor beta receptor
binding		 F
ISO
MmuMGI:95541
GO:0005515 protein binding F
IPI
DmeFBgn0029174
MmuMGI:95541
MGI:95543
MGI:1336205
MGI:104670
GO:0005516 calmodulin binding F
ISS
AthAt3g25230
At5g48570
GO:0005524 ATP binding F
IDA
MmuMGI:95543
GO:0005525 GTP binding F
IDA
MmuMGI:95543
GO:0005527 macrolide binding F
IDA
SceS000005079
GO:0005528 FK506 binding F
IDA
MmuMGI:95541
MGI:1336205
ISA
MmuMGI:95541
ISO
MmuMGI:95541
MGI:1336205
ISS
AthAt3g25230
At5g45680
At5g48570
DmeFBgn0013954
FBgn0029174
PfaPFL2275c
NAS
DmeFBgn0013954
GO:0008144 drug binding F
IDA
MmuMGI:95541
GO:0031072 heat shock protein binding F
IDA
MmuMGI:95543
GO:0034713 type I transforming growth factor beta receptor
binding		 F
ISO
MmuMGI:95541
GO:0035259 glucocorticoid receptor binding F
IDA
MmuMGI:95543
GO:0048156 tau protein binding F
ISO
MmuMGI:95543
GO:0051219 phosphoprotein binding F
IDA
MmuMGI:95543
GO:0000003 reproduction P
IMP
CelWBGene00001431
GO:0000747 conjugation with cellular fusion P
IMP
SpoSPBC839.17c
GO:0001933 negative regulation of protein amino acid
phosphorylation		 P
IDA
MmuMGI:95541
GO:0002009 morphogenesis of an epithelium P
IMP
CelWBGene00001431
GO:0002027 regulation of heart rate P
IMP
MmuMGI:1336205
GO:0003007 heart morphogenesis P
IMP
MmuMGI:95541
GO:0006325 chromatin organization P
IGI
SceS000005079
GO:0006457 protein folding P
IMP
SceS000005079
ISS
DmeFBgn0013954
NAS
DmeFBgn0013954
SpoSPBC839.17c
GO:0006463 steroid hormone receptor complex
assembly		 P
IDA
MmuMGI:95543
GO:0006825 copper ion transport P
ISO
MmuMGI:95543
GO:0006936 muscle contraction P
IMP
MmuMGI:95541
GO:0006939 smooth muscle contraction P
IMP
MmuMGI:1336205
GO:0006974 response to DNA damage stimulus P
IMP
DmeFBgn0013954
GO:0007204 elevation of cytosolic calcium ion
concentration		 P
ISO
MmuMGI:1336205
GO:0007422 peripheral nervous system development P
TAS
DmeFBgn0029174
GO:0007566 embryo implantation P
IMP
MmuMGI:95543
GO:0008152 metabolic process P
IDA
MmuMGI:1336205
GO:0009092 homoserine metabolic process P
IGI
SceS000005079
GO:0009408 response to heat P
IMP
AthAt3g25230
GO:0009611 response to wounding P
IEP
AthAt3g25230
GO:0009749 response to glucose stimulus P
IMP
MmuMGI:1336205
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00001431
GO:0010459 negative regulation of heart rate P
IMP
MmuMGI:1336205
GO:0010881 regulation of cardiac muscle contraction by
regulation of the release of sequestered calcium
ion		 P
IMP
MmuMGI:1336205
GO:0014808 release of sequestered calcium ion into cytosol by
sarcoplasmic reticulum		 P
IMP
MmuMGI:1336205
GO:0019221 cytokine-mediated signaling pathway P
IMP
MmuMGI:95541
GO:0019227 neuronal action potential propagation P
IMP
MmuMGI:1336205
GO:0030073 insulin secretion P
IMP
MmuMGI:1336205
GO:0030521 androgen receptor signaling pathway P
IMP
MmuMGI:95543
GO:0030850 prostate gland development P
IMP
MmuMGI:95543
GO:0031000 response to caffeine P
IMP
MmuMGI:95541
GO:0031503 protein complex localization P
IDA
MmuMGI:95543
GO:0040011 locomotion P
IMP
CelWBGene00001431
GO:0042098 T cell proliferation P
IMP
MmuMGI:95541
MGI:1336205
GO:0046661 male sex differentiation P
IMP
MmuMGI:95543
GO:0046686 response to cadmium ion P
IEP
AthAt3g25230
GO:0048608 reproductive structure development P
IMP
MmuMGI:95543
GO:0050908 detection of light stimulus involved in visual
perception		 P
IPI
DmeFBgn0029174
GO:0051209 release of sequestered calcium ion into
cytosol		 P
IDA
MmuMGI:95541
IMP
MmuMGI:1336205
MGI:95541
GO:0051924 regulation of calcium ion transport P
IDA
DmeFBgn0029174
GO:0055010 ventricular cardiac muscle tissue
morphogenesis		 P
IMP
MmuMGI:95541
GO:0060314 regulation of ryanodine-sensitive calcium-release
channel activity		 P
IMP
MmuMGI:95541
MGI:1336205
GO:0060347 heart trabecula formation P
IMP
MmuMGI:95541

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPBC839.17c
(O42993)		 YNL135C
(S000005079)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SceS000005079
SpoSPBC839.17c
GO:0005737 cytoplasm C
IDA
SceS000005079
GO:0005739 mitochondrion C
IDA
SceS000005079
GO:0005829 cytosol C
IDA
SpoSPBC839.17c
GO:0003755 peptidyl-prolyl cis-trans isomerase
activity		 F
IDA
SceS000005079
ISS
SceS000005079
GO:0005527 macrolide binding F
IDA
SceS000005079
GO:0000747 conjugation with cellular fusion P
IMP
SpoSPBC839.17c
GO:0006325 chromatin organization P
IGI
SceS000005079
GO:0006457 protein folding P
IMP
SceS000005079
NAS
SpoSPBC839.17c
GO:0009092 homoserine metabolic process P
IGI
SceS000005079

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Query species:

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GO info in one table:

s.khadayate@ucl.ac.uk