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Search term: YNL141W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name AAH1
SGD link S000005085
Alternative ID YNL141W
Description Adenine deaminase (adenine aminohydrolase), converts adenine to hypoxanthine; involved in purine salvage; transcriptionally regulated by nutrient levels and growth phase; Aah1p degraded upon entry into quiescence via SCF and the proteasome
Synonyms YNL141W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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Search for GO info:  

GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG1097 ACDHYP-

KOGs classification KOGs description
METABOLISM Adenine deaminase/adenosine deaminase

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At4g04880 GI:15234484
Caenorhabditis elegans (Cel) CE02538_1 GI:17532413
Caenorhabditis elegans (Cel) CE26867
(WBGene00015551)		 GI:17538512 Q17747
Drosophila melanogaster (Dme) 7293947
(FBgn0036752)		 GI:17737615 Q9VVK5
Drosophila melanogaster (Dme) 7293948 GI:7293948 Q9VVK4
Drosophila melanogaster (Dme) 7299138 GI:7299138
Drosophila melanogaster (Dme) 7299800 GI:7299800
Drosophila melanogaster (Dme) 7299801 GI:7299801
Drosophila melanogaster (Dme) 7303159
(FBgn0033952)		 GI:19922262
Homo sapiens (Hsa) Hs8393093 GI:8393093
Homo sapiens (Hsa) Hs14770999 GI:14770999
Homo sapiens (Hsa) Hs22057407 GI:22057407
Homo sapiens (Hsa) Hs4557249 GI:4557249
Saccharomyces cerevisiae (Sce) YNL141w
(S000005085)		 GI:6324188 P53909
Schizosaccharomyces pombe (Spo) SPBC1198.02 GI:19111863 Q9P6I7
Schizosaccharomyces pombe (Spo) SPBC1683.02 GI:19111850 Q9P6J8
Arabidopsis thaliana (Ath) At4g04880 GI:15234484
Caenorhabditis elegans (Cel) CE02538_1 GI:17532413
Caenorhabditis elegans (Cel) CE26867
(WBGene00015551)		 GI:17538512 Q17747
Drosophila melanogaster (Dme) 7293947
(FBgn0036752)		 GI:17737615 Q9VVK5
Drosophila melanogaster (Dme) 7293948 GI:7293948 Q9VVK4
Drosophila melanogaster (Dme) 7299138 GI:7299138
Drosophila melanogaster (Dme) 7299800 GI:7299800
Drosophila melanogaster (Dme) 7299801 GI:7299801
Drosophila melanogaster (Dme) 7303159
(FBgn0033952)		 GI:19922262
Homo sapiens (Hsa) Hs8393093 GI:8393093
Homo sapiens (Hsa) Hs14770999 GI:14770999
Homo sapiens (Hsa) Hs22057407 GI:22057407
Homo sapiens (Hsa) Hs4557249 GI:4557249
Saccharomyces cerevisiae (Sce) YNL141w
(S000005085)		 GI:6324188 P53909
Schizosaccharomyces pombe (Spo) SPBC1198.02 GI:19111863 Q9P6I7
Schizosaccharomyces pombe (Spo) SPBC1683.02 GI:19111850 Q9P6J8


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
AthAt4g04880
GO:0005576 extracellular region C
ISS
DmeFBgn0033952
GO:0005615 extracellular space C
NAS
DmeFBgn0036752
GO:0005634 nucleus C
IDA
SceS000005085
SpoSPBC1198.02
SPBC1683.02
ISS
SpoSPBC1198.02
GO:0005737 cytoplasm C
IDA
SceS000005085
ISS
SpoSPBC1198.02
GO:0005829 cytosol C
IDA
SpoSPBC1198.02
SPBC1683.02
GO:0000034 adenine deaminase activity F
IDA
SceS000005085
SpoSPBC1198.02
IMP
SceS000005085
GO:0003674 molecular_function F
ND
SpoSPBC1683.02
GO:0004000 adenosine deaminase activity F
IDA
DmeFBgn0036752
NAS
DmeFBgn0033952
GO:0008083 growth factor activity F
IDA
DmeFBgn0036752
ISS
DmeFBgn0033952
NAS
DmeFBgn0033952
GO:0019239 deaminase activity F
ISS
AthAt4g04880
GO:0006146 adenine catabolic process P
IDA
SceS000005085
SpoSPBC1198.02
IMP
SceS000005085
GO:0006163 purine nucleotide metabolic process P
NAS
SpoSPBC1683.02
SPBC1198.02
GO:0008283 cell proliferation P
IDA
DmeFBgn0036752
GO:0009168 purine ribonucleoside monophosphate biosynthetic
process		 P
ISS
AthAt4g04880
GO:0009451 RNA modification P
RCA
SceS000005085
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00015551
GO:0018193 peptidyl-amino acid modification P
RCA
SceS000005085
GO:0042386 hemocyte differentiation P
IMP
DmeFBgn0036752
GO:0043094 cellular metabolic compound salvage P
RCA
SceS000005085
GO:0043101 purine salvage P
IDA
SceS000005085
SpoSPBC1198.02
IMP
SceS000005085
GO:0043103 hypoxanthine salvage P
IDA
SceS000005085
IMP
SceS000005085

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
37249

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) ADA GI:47078295
Pan troglodytes (Ptr) ADA GI:114682264
Canis familiaris (Cfa) ADA GI:73992038
Mus musculus (Mmu) Ada
(MGI:87916)		 GI:6680636 P03958
Rattus norvegicus (Rno) Ada
(RGD:2031)		 GI:18426812 23
Gallus gallus (Gga) ADA GI:57529377
Caenorhabditis elegans (Cel) C06G3.5
(CE26867;
WBGene00015551)		 GI:17538512 Q17747
Schizosaccharomyces pombe (Spo) dea2
(SPBC1198.02)		 GI:19111863 Q9P6I7
Saccharomyces cerevisiae (Sce) AAH1
(S000005085)		 GI:6324188 P53909
Kluyveromyces lactis (Kla) KLLA0E23254g GI:50309967
Plasmodium falciparum (Pfa) PF10_0289 GI:124802718


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
PfaPF10_0289
GO:0005615 extracellular space C
ISO
MmuMGI:87916
GO:0005634 nucleus C
IDA
SceS000005085
SpoSPBC1198.02
ISS
SpoSPBC1198.02
GO:0005737 cytoplasm C
IDA
HsaADA
MmuMGI:87916
SceS000005085
ISO
MmuMGI:87916
ISS
SpoSPBC1198.02
GO:0005764 lysosome C
IDA
HsaADA
GO:0005829 cytosol C
EXP
HsaADA
IDA
SpoSPBC1198.02
GO:0005886 plasma membrane C
IDA
HsaADA
GO:0009897 external side of plasma membrane C
IDA
HsaADA
GO:0009986 cell surface C
IDA
HsaADA
GO:0016020 membrane C
IDA
HsaADA
GO:0032839 dendrite cytoplasm C
ISO
MmuMGI:87916
GO:0043025 neuronal cell body C
ISO
MmuMGI:87916
GO:0000034 adenine deaminase activity F
IDA
SceS000005085
SpoSPBC1198.02
IMP
SceS000005085
GO:0001883 purine nucleoside binding F
ISO
MmuMGI:87916
GO:0004000 adenosine deaminase activity F
EXP
HsaADA
IDA
HsaADA
MmuMGI:87916
IMP
MmuMGI:87916
ISO
MmuMGI:87916
ISS
HsaADA
PfaPF10_0289
GO:0005515 protein binding F
IPI
HsaADA
GO:0008270 zinc ion binding F
IMP
HsaADA
ISS
HsaADA
GO:0001666 response to hypoxia P
IDA
HsaADA
GO:0001701 in utero embryonic development P
IMP
MmuMGI:87916
GO:0001829 trophectodermal cell differentiation P
IMP
MmuMGI:87916
GO:0001889 liver development P
IMP
MmuMGI:87916
GO:0001890 placenta development P
IMP
MmuMGI:87916
GO:0002314 germinal center B cell differentiation P
IMP
MmuMGI:87916
GO:0002636 positive regulation of germinal center
formation		 P
IMP
MmuMGI:87916
GO:0002686 negative regulation of leukocyte
migration		 P
IGI
MmuMGI:87916
IMP
MmuMGI:87916
GO:0002906 negative regulation of mature B cell
apoptosis		 P
IMP
MmuMGI:87916
GO:0006146 adenine catabolic process P
IDA
SceS000005085
SpoSPBC1198.02
IMP
SceS000005085
GO:0006154 adenosine catabolic process P
IDA
HsaADA
MmuMGI:87916
IMP
MmuMGI:87916
ISO
MmuMGI:87916
ISS
HsaADA
GO:0006157 deoxyadenosine catabolic process P
IDA
MmuMGI:87916
IMP
MmuMGI:87916
GO:0006163 purine nucleotide metabolic process P
NAS
SpoSPBC1198.02
GO:0009451 RNA modification P
RCA
SceS000005085
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00015551
GO:0010460 positive regulation of heart rate P
IMP
MmuMGI:87916
GO:0018193 peptidyl-amino acid modification P
RCA
SceS000005085
GO:0030324 lung development P
IMP
MmuMGI:87916
GO:0030890 positive regulation of B cell proliferation P
IMP
MmuMGI:87916
GO:0032261 purine nucleotide salvage P
IMP
HsaADA
GO:0033089 positive regulation of T cell differentiation in
the thymus		 P
IMP
MmuMGI:87916
GO:0033632 regulation of cell-cell adhesion mediated by
integrin		 P
IDA
HsaADA
GO:0042110 T cell activation P
IDA
HsaADA
GO:0043066 negative regulation of apoptosis P
IMP
MmuMGI:87916
GO:0043094 cellular metabolic compound salvage P
RCA
SceS000005085
GO:0043101 purine salvage P
IDA
SceS000005085
SpoSPBC1198.02
IMP
SceS000005085
GO:0043103 hypoxanthine salvage P
IDA
SceS000005085
IMP
SceS000005085
GO:0045580 regulation of T cell differentiation P
IMP
MmuMGI:87916
GO:0045582 positive regulation of T cell differentiation P
IMP
MmuMGI:87916
GO:0045987 positive regulation of smooth muscle
contraction		 P
IMP
MmuMGI:87916
GO:0046061 dATP catabolic process P
IDA
MmuMGI:87916
IMP
MmuMGI:87916
GO:0046085 adenosine metabolic process P
ISO
MmuMGI:87916
GO:0046101 hypoxanthine biosynthetic process P
IMP
MmuMGI:87916
GO:0046103 inosine biosynthetic process P
IDA
HsaADA
MmuMGI:87916
IMP
MmuMGI:87916
ISO
MmuMGI:87916
ISS
HsaADA
GO:0046111 xanthine biosynthetic process P
IMP
MmuMGI:87916
GO:0046638 positive regulation of alpha-beta T cell
differentiation		 P
IMP
MmuMGI:87916
GO:0048286 lung alveolus development P
IMP
MmuMGI:87916
GO:0048541 Peyer's patch development P
IMP
MmuMGI:87916
GO:0048566 embryonic digestive tract development P
IMP
MmuMGI:87916
GO:0050728 negative regulation of inflammatory
response		 P
IGI
MmuMGI:87916
IMP
MmuMGI:87916
GO:0050850 positive regulation of calcium-mediated
signaling		 P
IMP
MmuMGI:87916
GO:0050862 positive regulation of T cell receptor signaling
pathway		 P
IMP
MmuMGI:87916
GO:0050870 positive regulation of T cell activation P
IMP
MmuMGI:87916
GO:0060169 negative regulation of adenosine receptor
signaling pathway		 P
IDA
HsaADA
GO:0060407 negative regulation of penile erection P
IMP
MmuMGI:87916
GO:0070244 negative regulation of thymocyte
apoptosis		 P
IMP
MmuMGI:87916
GO:0070256 negative regulation of mucus secretion P
IGI
MmuMGI:87916
IMP
MmuMGI:87916

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_2474

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Caenorhabditis elegans (Cel) cel1341 C06G3.5a
(CE26867;
WBGene00015551)
Caenorhabditis elegans (Cel) cel1342 C06G3.5b
(CE07981)
Candida glabrata (Cgl) cgl3251 CAGL0J05984g
Dictyostelium discoideum (Ddi) ddi13088 DDB0230171
Drosophila melanogaster (Dme) dme10027 CG32178-PA
(FBgn0043025)
Danio rerio (Dre) dre15576 ENSDARP00000005284
(ada)		 Q6DG22
Escherichia coli (Eco) eco1582 16129581
Takifugu rubripes (Fru) fru2538 SINFRUP00000132496
Gallus gallus (Gga) gga11874 ENSGALP00000006619
Gallus gallus (Gga) gga11873 ENSGALP00000006620
(ADA)		 Q5ZKP6
Homo sapiens (Hsa) hsa21132 ENSP00000332871
(CECR1)		 Q8NCJ2
Homo sapiens (Hsa) hsa20256 ENSP00000352331
Kluyveromyces lactis (Kla) kla3996 KLLA0E23254g
Mus musculus (Mmu) mmu15963 ENSMUSP00000017841
(MGI:87916)		 P03958
Plasmodium falciparum (Pfa) pfa507 PF10_0289
Rattus norvegicus (Rno) rno20213 ENSRNOP00000014151
(RGD:2031)		 Q920P6
Saccharomyces cerevisiae (Sce) sce5259 YNL141W
(S000005085)
Schizosaccharomyces pombe (Spo) spo247 SPBC1198.02 Q9P6I7
Schizosaccharomyces pombe (Spo) spo254 SPBC1683.02 Q9P6J8


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
PfaPF10_0289
GO:0005615 extracellular space C
ISO
MmuMGI:87916
GO:0005624 membrane fraction C
IDA
DmeFBgn0043025
GO:0005634 nucleus C
IDA
SceS000005085
SpoSPBC1198.02
SPBC1683.02
ISS
SpoSPBC1198.02
GO:0005737 cytoplasm C
IDA
MmuMGI:87916
SceS000005085
ISO
MmuMGI:87916
ISS
SpoSPBC1198.02
GO:0005829 cytosol C
IDA
SpoSPBC1198.02
SPBC1683.02
GO:0016020 membrane C
IDA
DmeFBgn0043025
GO:0016021 integral to membrane C
ISS
DmeFBgn0043025
GO:0032839 dendrite cytoplasm C
ISO
MmuMGI:87916
GO:0043025 neuronal cell body C
ISO
MmuMGI:87916
GO:0000034 adenine deaminase activity F
IDA
SceS000005085
SpoSPBC1198.02
IMP
SceS000005085
GO:0001883 purine nucleoside binding F
ISO
MmuMGI:87916
GO:0003674 molecular_function F
ND
SpoSPBC1683.02
GO:0004000 adenosine deaminase activity F
IDA
MmuMGI:87916
IMP
MmuMGI:87916
ISO
MmuMGI:87916
ISS
PfaPF10_0289
GO:0008083 growth factor activity F
IDA
DmeFBgn0043025
ISS
DmeFBgn0043025
NAS
DmeFBgn0043025
GO:0001701 in utero embryonic development P
IMP
MmuMGI:87916
GO:0001829 trophectodermal cell differentiation P
IMP
MmuMGI:87916
GO:0001889 liver development P
IMP
MmuMGI:87916
GO:0001890 placenta development P
IMP
MmuMGI:87916
GO:0002314 germinal center B cell differentiation P
IMP
MmuMGI:87916
GO:0002636 positive regulation of germinal center
formation		 P
IMP
MmuMGI:87916
GO:0002686 negative regulation of leukocyte
migration		 P
IGI
MmuMGI:87916
IMP
MmuMGI:87916
GO:0002906 negative regulation of mature B cell
apoptosis		 P
IMP
MmuMGI:87916
GO:0006146 adenine catabolic process P
IDA
SceS000005085
SpoSPBC1198.02
IMP
SceS000005085
GO:0006154 adenosine catabolic process P
IDA
MmuMGI:87916
IMP
MmuMGI:87916
ISO
MmuMGI:87916
GO:0006157 deoxyadenosine catabolic process P
IDA
MmuMGI:87916
IMP
MmuMGI:87916
GO:0006163 purine nucleotide metabolic process P
NAS
SpoSPBC1683.02
SPBC1198.02
GO:0007286 spermatid development P
IEP
DmeFBgn0043025
GO:0009451 RNA modification P
RCA
SceS000005085
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00015551
GO:0010460 positive regulation of heart rate P
IMP
MmuMGI:87916
GO:0018193 peptidyl-amino acid modification P
RCA
SceS000005085
GO:0030324 lung development P
IMP
MmuMGI:87916
GO:0030890 positive regulation of B cell proliferation P
IMP
MmuMGI:87916
GO:0033089 positive regulation of T cell differentiation in
the thymus		 P
IMP
MmuMGI:87916
GO:0043066 negative regulation of apoptosis P
IMP
MmuMGI:87916
GO:0043094 cellular metabolic compound salvage P
RCA
SceS000005085
GO:0043101 purine salvage P
IDA
SceS000005085
SpoSPBC1198.02
IMP
SceS000005085
GO:0043103 hypoxanthine salvage P
IDA
SceS000005085
IMP
SceS000005085
GO:0045580 regulation of T cell differentiation P
IMP
MmuMGI:87916
GO:0045582 positive regulation of T cell differentiation P
IMP
MmuMGI:87916
GO:0045987 positive regulation of smooth muscle
contraction		 P
IMP
MmuMGI:87916
GO:0046061 dATP catabolic process P
IDA
MmuMGI:87916
IMP
MmuMGI:87916
GO:0046085 adenosine metabolic process P
ISO
MmuMGI:87916
GO:0046101 hypoxanthine biosynthetic process P
IMP
MmuMGI:87916
GO:0046103 inosine biosynthetic process P
IDA
MmuMGI:87916
IMP
MmuMGI:87916
ISO
MmuMGI:87916
GO:0046111 xanthine biosynthetic process P
IMP
MmuMGI:87916
GO:0046638 positive regulation of alpha-beta T cell
differentiation		 P
IMP
MmuMGI:87916
GO:0048286 lung alveolus development P
IMP
MmuMGI:87916
GO:0048541 Peyer's patch development P
IMP
MmuMGI:87916
GO:0048566 embryonic digestive tract development P
IMP
MmuMGI:87916
GO:0050728 negative regulation of inflammatory
response		 P
IGI
MmuMGI:87916
IMP
MmuMGI:87916
GO:0050850 positive regulation of calcium-mediated
signaling		 P
IMP
MmuMGI:87916
GO:0050862 positive regulation of T cell receptor signaling
pathway		 P
IMP
MmuMGI:87916
GO:0050870 positive regulation of T cell activation P
IMP
MmuMGI:87916
GO:0060407 negative regulation of penile erection P
IMP
MmuMGI:87916
GO:0070244 negative regulation of thymocyte
apoptosis		 P
IMP
MmuMGI:87916
GO:0070256 negative regulation of mucus secretion P
IGI
MmuMGI:87916
IMP
MmuMGI:87916

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPBC1198.02
(Q9P6I7)		 YNL141W
(S000005085)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SceS000005085
SpoSPBC1198.02
ISS
SpoSPBC1198.02
GO:0005737 cytoplasm C
IDA
SceS000005085
ISS
SpoSPBC1198.02
GO:0005829 cytosol C
IDA
SpoSPBC1198.02
GO:0000034 adenine deaminase activity F
IDA
SceS000005085
SpoSPBC1198.02
IMP
SceS000005085
GO:0006146 adenine catabolic process P
IDA
SceS000005085
SpoSPBC1198.02
IMP
SceS000005085
GO:0006163 purine nucleotide metabolic process P
NAS
SpoSPBC1198.02
GO:0009451 RNA modification P
RCA
SceS000005085
GO:0018193 peptidyl-amino acid modification P
RCA
SceS000005085
GO:0043094 cellular metabolic compound salvage P
RCA
SceS000005085
GO:0043101 purine salvage P
IDA
SceS000005085
SpoSPBC1198.02
IMP
SceS000005085
GO:0043103 hypoxanthine salvage P
IDA
SceS000005085
IMP
SceS000005085

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GO info in one table:

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