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Search term: YNL172W


Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name APC1
SGD link S000005116
Alternative ID YNL172W
Description Largest subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
Synonyms YNL172W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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Query species:

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GO info in one table:


KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG1858 ACDHYPE

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALINGCELLULAR PROCESSES AND SIGNALING Anaphase-promoting complex (APC), subunit 1 (meiotic check point regulator/Tsg24)

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At5g05560 GI:15239171
Caenorhabditis elegans (Cel) CE21288
(WBGene00003133)
GI:17536831
Drosophila melanogaster (Dme) 7293070 GI:7293070 Q9VXV3
Homo sapiens (Hsa) Hs22040869 GI:22040869
Homo sapiens (Hsa) Hs12056971
(ANAPC1)
GI:12056971 Q9H1A4
Saccharomyces cerevisiae (Sce) YNL172w
(S000005116)
GI:6324157 P53886
Schizosaccharomyces pombe (Spo) SPBC106.09 GI:19111950 Q9URV2
Encephalitozoon cuniculi (Ecu) ECU10g1160 GI:19074725 Q8SUD1


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000151 ubiquitin ligase complex C
TAS
AthAt5g05560
GO:0005634 nucleus C
IDA
SpoSPBC106.09
GO:0005654 nucleoplasm C
EXP
HsaANAPC1
GO:0005680 anaphase-promoting complex C
IDA
HsaANAPC1
SceS000005116
SpoSPBC106.09
IMP
CelWBGene00003133
ISS
CelWBGene00003133
GO:0005829 cytosol C
EXP
HsaANAPC1
IDA
SpoSPBC106.09
GO:0004842 ubiquitin-protein ligase activity F
IC
SpoSPBC106.09
ISS
AthAt5g05560
TAS
SceS000005116
GO:0005488 binding F
ISS
CelWBGene00003133
GO:0005515 protein binding F
TAS
SceS000005116
GO:0000003 reproduction P
IMP
CelWBGene00003133
GO:0000022 mitotic spindle elongation P
TAS
SceS000005116
GO:0000070 mitotic sister chromatid segregation P
TAS
SceS000005116
GO:0000278 mitotic cell cycle P
RCA
SceS000005116
GO:0000279 M phase P
RCA
SceS000005116
GO:0006511 ubiquitin-dependent protein catabolic
process
P
TAS
AthAt5g05560
GO:0007091 mitotic metaphase/anaphase transition P
IMP
CelWBGene00003133
TAS
SceS000005116
GO:0007126 meiosis P
IMP
CelWBGene00003133
GO:0007132 meiotic metaphase I P
IMP
CelWBGene00003133
GO:0008054 cyclin catabolic process P
IC
SpoSPBC106.09
TAS
SceS000005116
GO:0009792 embryo development ending in birth or egg
hatching
P
IMP
CelWBGene00003133
GO:0009949 polarity specification of anterior/posterior
axis
P
IMP
CelWBGene00003133
GO:0016567 protein ubiquitination P
IC
SpoSPBC106.09
IPI
SceS000005116
GO:0030071 regulation of mitotic metaphase/anaphase
transition
P
IC
SpoSPBC106.09
GO:0031145 anaphase-promoting complex-dependent proteasomal
ubiquitin-dependent protein catabolic
process
P
EXP
HsaANAPC1
IC
SpoSPBC106.09
IDA
SceS000005116
IPI
SceS000005116
GO:0051295 establishment of meiotic spindle
localization
P
IGI
CelWBGene00003133
GO:0051436 negative regulation of ubiquitin-protein ligase
activity involved in mitotic cell
cycle
P
EXP
HsaANAPC1
GO:0051437 positive regulation of ubiquitin-protein ligase
activity involved in mitotic cell
cycle
P
EXP
HsaANAPC1
GO:0070979 protein K11-linked ubiquitination P
IDA
HsaANAPC1

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
40090

Species Gene ID NCBI link UniProt link
Saccharomyces cerevisiae (Sce) APC1
(S000005116)
GI:6324157 P53886
Kluyveromyces lactis (Kla) KLLA0D08118g GI:50306899
Eremothecium gossypii (Ego) AGOS_AFR021W GI:45198539


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005680 anaphase-promoting complex C
IDA
SceS000005116
GO:0004842 ubiquitin-protein ligase activity F
TAS
SceS000005116
GO:0005515 protein binding F
TAS
SceS000005116
GO:0000022 mitotic spindle elongation P
TAS
SceS000005116
GO:0000070 mitotic sister chromatid segregation P
TAS
SceS000005116
GO:0000278 mitotic cell cycle P
RCA
SceS000005116
GO:0000279 M phase P
RCA
SceS000005116
GO:0007091 mitotic metaphase/anaphase transition P
TAS
SceS000005116
GO:0008054 cyclin catabolic process P
TAS
SceS000005116
GO:0016567 protein ubiquitination P
IPI
SceS000005116
GO:0031145 anaphase-promoting complex-dependent proteasomal
ubiquitin-dependent protein catabolic
process
P
IDA
SceS000005116
IPI
SceS000005116

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_2053

Species OrthoMCL
sequence
Model organism
protein page
UniProt link
Anopheles gambiae (Aga) aga14977 ENSANGP00000007497
Ashbya gossypii (Ago) ago3213 AFR021W
Arabidopsis thaliana (Ath) ath22736 At5g05560.1
Caenorhabditis elegans (Cel) cel17346 W10C6.1
(CE21288;
WBGene00003133)
Candida glabrata (Cgl) cgl3263 CAGL0J06248g
Cryptococcus neoformans (Cne) cne3163 167.m03500
Dictyostelium discoideum (Ddi) ddi7928 DDB0186456
Debaryomyces hansenii (Dha) dha2732 DEHA0D09856g
Debaryomyces hansenii (Dha) dha2733 DEHA0D09867g
Drosophila melanogaster (Dme) dme17938 CG9198-PA
(FBgn0004391)
Drosophila melanogaster (Dme) dme17939 CG9198-PB
(FBgn0004391)
Danio rerio (Dre) dre4672 ENSDARP00000020694
Danio rerio (Dre) dre4671 ENSDARP00000044262
Takifugu rubripes (Fru) fru1922 SINFRUP00000129375
Takifugu rubripes (Fru) fru1923 SINFRUP00000129376
Gallus gallus (Gga) gga14328 ENSGALP00000013420
(ANAPC1)
Homo sapiens (Hsa) hsa18436 ENSP00000339109
(ANAPC1)
Q9H1A4
Kluyveromyces lactis (Kla) kla2424 KLLA0D08118g
Mus musculus (Mmu) mmu15471 ENSMUSP00000014499
(MGI:103097)
A2ATQ4
Neurospora crassa (Ncr) ncr5737 NCU05901.2
Oryza sativa (Osa) osa17761 3318.m00135
Oryza sativa (Osa) osa18359 3337.m00152
Saccharomyces cerevisiae (Sce) sce5293 YNL172W
(S000005116)
Schizosaccharomyces pombe (Spo) spo4654 SPBC106.09 Q9URV2
Yarrowia lipolytica (Yli) yli3402 YALI0D16885g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000151 ubiquitin ligase complex C
TAS
AthAt5g05560
GO:0005634 nucleus C
IDA
MmuMGI:103097
SpoSPBC106.09
GO:0005680 anaphase-promoting complex C
IDA
SceS000005116
SpoSPBC106.09
IMP
CelWBGene00003133
ISS
CelWBGene00003133
TAS
DmeFBgn0004391
GO:0005829 cytosol C
IDA
SpoSPBC106.09
GO:0004842 ubiquitin-protein ligase activity F
IC
SpoSPBC106.09
ISS
AthAt5g05560
TAS
SceS000005116
GO:0005488 binding F
ISS
CelWBGene00003133
GO:0005515 protein binding F
IPI
MmuMGI:103097
TAS
SceS000005116
GO:0000003 reproduction P
IMP
CelWBGene00003133
GO:0000022 mitotic spindle elongation P
TAS
SceS000005116
GO:0000070 mitotic sister chromatid segregation P
TAS
SceS000005116
GO:0000278 mitotic cell cycle P
RCA
SceS000005116
GO:0000279 M phase P
RCA
SceS000005116
GO:0006511 ubiquitin-dependent protein catabolic
process
P
TAS
AthAt5g05560
GO:0007091 mitotic metaphase/anaphase transition P
IMP
CelWBGene00003133
TAS
SceS000005116
GO:0007126 meiosis P
IMP
CelWBGene00003133
GO:0007132 meiotic metaphase I P
IMP
CelWBGene00003133
GO:0008054 cyclin catabolic process P
IC
SpoSPBC106.09
TAS
SceS000005116
GO:0009792 embryo development ending in birth or egg
hatching
P
IMP
CelWBGene00003133
GO:0009949 polarity specification of anterior/posterior
axis
P
IMP
CelWBGene00003133
GO:0016567 protein ubiquitination P
IC
SpoSPBC106.09
IPI
SceS000005116
GO:0030071 regulation of mitotic metaphase/anaphase
transition
P
IC
SpoSPBC106.09
GO:0031145 anaphase-promoting complex-dependent proteasomal
ubiquitin-dependent protein catabolic
process
P
IC
SpoSPBC106.09
IDA
SceS000005116
IPI
SceS000005116
GO:0051295 establishment of meiotic spindle
localization
P
IGI
CelWBGene00003133

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Curated yeast ortholog results:

S. pombe
systematic ID
S. cerevisiae
systematic ID
SPBC106.09
(Q9URV2)
YNL172W
(S000005116)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SpoSPBC106.09
GO:0005680 anaphase-promoting complex C
IDA
SceS000005116
SpoSPBC106.09
GO:0005829 cytosol C
IDA
SpoSPBC106.09
GO:0004842 ubiquitin-protein ligase activity F
IC
SpoSPBC106.09
TAS
SceS000005116
GO:0005515 protein binding F
TAS
SceS000005116
GO:0000022 mitotic spindle elongation P
TAS
SceS000005116
GO:0000070 mitotic sister chromatid segregation P
TAS
SceS000005116
GO:0000278 mitotic cell cycle P
RCA
SceS000005116
GO:0000279 M phase P
RCA
SceS000005116
GO:0007091 mitotic metaphase/anaphase transition P
TAS
SceS000005116
GO:0008054 cyclin catabolic process P
IC
SpoSPBC106.09
TAS
SceS000005116
GO:0016567 protein ubiquitination P
IC
SpoSPBC106.09
IPI
SceS000005116
GO:0030071 regulation of mitotic metaphase/anaphase
transition
P
IC
SpoSPBC106.09
GO:0031145 anaphase-promoting complex-dependent proteasomal
ubiquitin-dependent protein catabolic
process
P
IC
SpoSPBC106.09
IDA
SceS000005116
IPI
SceS000005116

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Search for gene by ID or name:

Query species:

Include wild-cards:   

Search for GO info:  

GO info in one table:

s.khadayate@ucl.ac.uk