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Search term: YNL243W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name SLA2
SGD link S000005187
Alternative ID YNL243W
Description Transmembrane actin-binding protein involved in membrane cytoskeleton assembly and cell polarization; adaptor protein that links actin to clathrin and endocytosis; present in the actin cortical patch of the emerging bud tip; dimer in vivo
Synonyms YNL243W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG0980 -CDHYP-

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALING Actin-binding protein SLA2/Huntingtin-interacting protein Hip1

Species KOG link NCBI link UniProt link
Caenorhabditis elegans (Cel) CE00540
(WBGene00022717)		 GI:17556913
Caenorhabditis elegans (Cel) CE17638
(WBGene00006484)		 GI:17506539 O62142
Caenorhabditis elegans (Cel) CE29640 GI:17556911 Q02328
Drosophila melanogaster (Dme) 7294543 GI:7294543 Q86BS5
Homo sapiens (Hsa) Hs14760485 GI:14760485
Homo sapiens (Hsa) Hs7427515 GI:7427515
Saccharomyces cerevisiae (Sce) YNL243w
(S000005187)		 GI:6324086 P33338
Schizosaccharomyces pombe (Spo) SPAC688.11 GI:19114981 Q9P6L5
Caenorhabditis elegans (Cel) CE00540
(WBGene00022717)		 GI:17556913
Caenorhabditis elegans (Cel) CE17638
(WBGene00006484)		 GI:17506539 O62142
Caenorhabditis elegans (Cel) CE29640 GI:17556911 Q02328
Drosophila melanogaster (Dme) 7294543 GI:7294543 Q86BS5
Homo sapiens (Hsa) Hs14760485 GI:14760485
Homo sapiens (Hsa) Hs7427515 GI:7427515
Saccharomyces cerevisiae (Sce) YNL243w
(S000005187)		 GI:6324086 P33338
Schizosaccharomyces pombe (Spo) SPAC688.11 GI:19114981 Q9P6L5


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000131 incipient cellular bud site C
IDA
SceS000005187
GO:0005737 cytoplasm C
IDA
SpoSPAC688.11
GO:0030479 actin cortical patch C
IDA
SceS000005187
SpoSPAC688.11
GO:0032153 cell division site C
IDA
SpoSPAC688.11
GO:0043332 mating projection tip C
IDA
SceS000005187
GO:0051285 cell cortex of cell tip C
IDA
SpoSPAC688.11
GO:0003779 actin binding F
ISS
SpoSPAC688.11
GO:0005515 protein binding F
IPI
SpoSPAC688.11
GO:0005546 phosphatidylinositol-4,5-bisphosphate
binding		 F
ISS
SpoSPAC688.11
GO:0030276 clathrin binding F
RCA
SceS000005187
GO:0030674 protein binding, bridging F
IGI
SceS000005187
IPI
SceS000005187
ISS
SpoSPAC688.11
GO:0000003 reproduction P
IMP
CelWBGene00022717
GO:0006887 exocytosis P
TAS
SceS000005187
GO:0006897 endocytosis P
IMP
SceS000005187
SpoSPAC688.11
GO:0007015 actin filament organization P
IMP
SceS000005187
GO:0007121 bipolar cellular bud site selection P
TAS
SceS000005187
GO:0007269 neurotransmitter secretion P
IMP
CelWBGene00022717
GO:0007624 ultradian rhythm P
IMP
CelWBGene00022717
GO:0007638 mechanosensory behavior P
IMP
CelWBGene00022717
GO:0008104 protein localization P
IMP
CelWBGene00022717
GO:0009612 response to mechanical stimulus P
IMP
CelWBGene00022717
GO:0016192 vesicle-mediated transport P
RCA
SceS000005187
GO:0030036 actin cytoskeleton organization P
IMP
SpoSPAC688.11
GO:0030421 defecation P
IMP
CelWBGene00022717
GO:0030866 cortical actin cytoskeleton organization P
IMP
SpoSPAC688.11
GO:0030950 establishment or maintenance of actin cytoskeleton
polarity		 P
IMP
SpoSPAC688.11
GO:0031505 fungal-type cell wall organization P
IMP
SpoSPAC688.11
TAS
SceS000005187
GO:0031580 membrane raft distribution P
IMP
SpoSPAC688.11
GO:0032502 developmental process P
IMP
CelWBGene00022717
GO:0034613 cellular protein localization P
IGI
SpoSPAC688.11
GO:0050954 sensory perception of mechanical
stimulus		 P
IMP
CelWBGene00022717
GO:0051049 regulation of transport P
RCA
SceS000005187
GO:0061161 positive regulation of establishment of bipolar
cell polarity resulting in cell
shape		 P
IMP
SpoSPAC688.11
GO:0070314 G1 to G0 transition P
IMP
SpoSPAC688.11

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
68463

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) HIP1 GI:38045919
Pan troglodytes (Ptr) HIP1 GI:114618446
Canis familiaris (Cfa) HIP1 GI:73957772
Mus musculus (Mmu) Hip1
(MGI:1099804)		 GI:22122461 Q8C303
Rattus norvegicus (Rno) Hip1
(RGD:620305)		 GI:109495576
Gallus gallus (Gga) HIP1 GI:118100027
Drosophila melanogaster (Dme) CG10971
(FBgn0036309)		 GI:28574920
Anopheles gambiae (Aga) AgaP_AGAP004801 GI:158297830
Caenorhabditis elegans (Cel) hipr-1
(CE00540;
WBGene00022717)		 GI:25152671
Schizosaccharomyces pombe (Spo) end4
(SPAC688.11)		 GI:19114981 Q9P6L5
Saccharomyces cerevisiae (Sce) SLA2
(S000005187)		 GI:6324086 P33338
Kluyveromyces lactis (Kla) KLLA0C03113g GI:50304761
Magnaporthe grisea (Mgr) MGG_02949 GI:39970965
Neurospora crassa (Ncr) NCU01956.1 GI:32417336


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000131 incipient cellular bud site C
IDA
SceS000005187
GO:0005624 membrane fraction C
TAS
HsaHIP1
GO:0005737 cytoplasm C
IDA
HsaHIP1
SpoSPAC688.11
ISO
MmuMGI:1099804
GO:0005794 Golgi apparatus C
IDA
HsaHIP1
ISO
MmuMGI:1099804
GO:0005856 cytoskeleton C
TAS
HsaHIP1
GO:0030136 clathrin-coated vesicle C
IDA
HsaHIP1
ISO
MmuMGI:1099804
GO:0030479 actin cortical patch C
IDA
SceS000005187
SpoSPAC688.11
GO:0032153 cell division site C
IDA
SpoSPAC688.11
GO:0043332 mating projection tip C
IDA
SceS000005187
GO:0051285 cell cortex of cell tip C
IDA
SpoSPAC688.11
GO:0003779 actin binding F
ISS
DmeFBgn0036309
SpoSPAC688.11
GO:0005200 structural constituent of cytoskeleton F
TAS
HsaHIP1
GO:0005515 protein binding F
IPI
HsaHIP1
MmuMGI:1099804
SpoSPAC688.11
GO:0005546 phosphatidylinositol-4,5-bisphosphate
binding		 F
ISS
SpoSPAC688.11
GO:0030276 clathrin binding F
IDA
HsaHIP1
ISO
MmuMGI:1099804
RCA
SceS000005187
GO:0030674 protein binding, bridging F
IGI
SceS000005187
IPI
SceS000005187
ISS
SpoSPAC688.11
GO:0035091 phosphoinositide binding F
IDA
HsaHIP1
GO:0000003 reproduction P
IMP
CelWBGene00022717
GO:0006887 exocytosis P
TAS
SceS000005187
GO:0006897 endocytosis P
IDA
MmuMGI:1099804
IMP
SceS000005187
SpoSPAC688.11
GO:0006915 apoptosis P
IDA
HsaHIP1
ISO
MmuMGI:1099804
GO:0006917 induction of apoptosis P
IDA
HsaHIP1
GO:0006919 activation of caspase activity P
IDA
HsaHIP1
ISO
MmuMGI:1099804
GO:0007010 cytoskeleton organization P
ISS
DmeFBgn0036309
GO:0007015 actin filament organization P
IMP
SceS000005187
GO:0007121 bipolar cellular bud site selection P
TAS
SceS000005187
GO:0007269 neurotransmitter secretion P
IMP
CelWBGene00022717
GO:0007624 ultradian rhythm P
IMP
CelWBGene00022717
GO:0007638 mechanosensory behavior P
IMP
CelWBGene00022717
GO:0008104 protein localization P
IMP
CelWBGene00022717
GO:0009612 response to mechanical stimulus P
IMP
CelWBGene00022717
GO:0016192 vesicle-mediated transport P
RCA
SceS000005187
GO:0030036 actin cytoskeleton organization P
IMP
SpoSPAC688.11
GO:0030421 defecation P
IMP
CelWBGene00022717
GO:0030866 cortical actin cytoskeleton organization P
IMP
SpoSPAC688.11
GO:0030950 establishment or maintenance of actin cytoskeleton
polarity		 P
IMP
SpoSPAC688.11
GO:0031505 fungal-type cell wall organization P
IMP
SpoSPAC688.11
TAS
SceS000005187
GO:0031580 membrane raft distribution P
IMP
SpoSPAC688.11
GO:0032502 developmental process P
IMP
CelWBGene00022717
GO:0034613 cellular protein localization P
IGI
SpoSPAC688.11
GO:0042981 regulation of apoptosis P
IDA
HsaHIP1
ISO
MmuMGI:1099804
GO:0048260 positive regulation of receptor-mediated
endocytosis		 P
IMP
HsaHIP1
MmuMGI:1099804
GO:0048268 clathrin coat assembly P
IDA
HsaHIP1
ISO
MmuMGI:1099804
GO:0050954 sensory perception of mechanical
stimulus		 P
IMP
CelWBGene00022717
GO:0051049 regulation of transport P
RCA
SceS000005187
GO:0061161 positive regulation of establishment of bipolar
cell polarity resulting in cell
shape		 P
IMP
SpoSPAC688.11
GO:0070314 G1 to G0 transition P
IMP
SpoSPAC688.11

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_1947

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga137 ENSANGP00000010722
Anopheles gambiae (Aga) aga138 ENSANGP00000029241
Caenorhabditis elegans (Cel) cel5605 F08A8.6
(CE17638;
WBGene00006484)
Caenorhabditis elegans (Cel) cel21857 ZK370.3a
(CE00540;
WBGene00022717)
Caenorhabditis elegans (Cel) cel21858 ZK370.3b
(CE29640)
Candida glabrata (Cgl) cgl3325 CAGL0J07656g
Cryptococcus neoformans (Cne) cne3121 167.m03451
Dictyostelium discoideum (Ddi) ddi7046 DDB0186667
Debaryomyces hansenii (Dha) dha6243 DEHA0G12243g
Drosophila melanogaster (Dme) dme9281 CG10971-PA
(FBgn0036309)
Drosophila melanogaster (Dme) dme9282 CG10971-PB
(FBgn0036309)
Danio rerio (Dre) dre23173 ENSDARP00000002285
Danio rerio (Dre) dre20149 ENSDARP00000006142
Danio rerio (Dre) dre20150 ENSDARP00000044301
Danio rerio (Dre) dre24197 ENSDARP00000047630
Takifugu rubripes (Fru) fru4731 SINFRUP00000148289
Takifugu rubripes (Fru) fru4732 SINFRUP00000148290
Takifugu rubripes (Fru) fru9920 SINFRUP00000150724
Takifugu rubripes (Fru) fru9921 SINFRUP00000150725
Gallus gallus (Gga) gga8638 ENSGALP00000001363
Gallus gallus (Gga) gga8636 ENSGALP00000001364
Gallus gallus (Gga) gga8637 ENSGALP00000001365
(HIP1)
Gallus gallus (Gga) gga7197 ENSGALP00000006004
(RCJMB04_14f2)		 Q5ZJZ1
Homo sapiens (Hsa) hsa8386 ENSP00000253083
(HIP1R)		 O75146
Homo sapiens (Hsa) hsa28827 ENSP00000336747
(HIP1)		 O00291
Kluyveromyces lactis (Kla) kla1335 KLLA0C03113g
Mus musculus (Mmu) mmu20929 ENSMUSP00000000939
(MGI:1352504)		 Q3UJ14
Mus musculus (Mmu) mmu21065 ENSMUSP00000059033
(MGI:1099804)		 Q8VD75
Neurospora crassa (Ncr) ncr10453 NCU10938.2
Rattus norvegicus (Rno) rno8544 ENSRNOP00000001461
(RGD:621615)		 B5DFK5
Rattus norvegicus (Rno) rno8391 ENSRNOP00000001967
Rattus norvegicus (Rno) rno8545 ENSRNOP00000029635
(RGD:621615)
Saccharomyces cerevisiae (Sce) sce5364 YNL243W
(S000005187)
Schizosaccharomyces pombe (Spo) spo2192 SPAC688.11 Q9P6L5
Yarrowia lipolytica (Yli) yli2021 YALI0C07502g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000131 incipient cellular bud site C
IDA
SceS000005187
GO:0005624 membrane fraction C
ISO
MmuMGI:1352504
GO:0005737 cytoplasm C
IDA
SpoSPAC688.11
ISO
MmuMGI:1099804
GO:0005794 Golgi apparatus C
ISO
MmuMGI:1099804
GO:0005856 cytoskeleton C
IDA
MmuMGI:1352504
GO:0005905 coated pit C
IDA
MmuMGI:1352504
GO:0030136 clathrin-coated vesicle C
ISO
MmuMGI:1099804
GO:0030479 actin cortical patch C
IDA
SceS000005187
SpoSPAC688.11
GO:0032153 cell division site C
IDA
SpoSPAC688.11
GO:0043332 mating projection tip C
IDA
SceS000005187
GO:0051285 cell cortex of cell tip C
IDA
SpoSPAC688.11
GO:0003779 actin binding F
IDA
MmuMGI:1352504
ISS
DmeFBgn0036309
SpoSPAC688.11
GO:0005515 protein binding F
IPI
MmuMGI:1099804
SpoSPAC688.11
GO:0005546 phosphatidylinositol-4,5-bisphosphate
binding		 F
ISS
SpoSPAC688.11
GO:0030276 clathrin binding F
ISO
MmuMGI:1099804
RCA
SceS000005187
GO:0030674 protein binding, bridging F
IGI
SceS000005187
IPI
SceS000005187
ISS
SpoSPAC688.11
GO:0000003 reproduction P
IMP
CelWBGene00022717
GO:0006887 exocytosis P
TAS
SceS000005187
GO:0006897 endocytosis P
IDA
MmuMGI:1099804
IMP
SceS000005187
SpoSPAC688.11
GO:0006898 receptor-mediated endocytosis P
IDA
MmuMGI:1352504
GO:0006915 apoptosis P
ISO
MmuMGI:1099804
GO:0006919 activation of caspase activity P
ISO
MmuMGI:1099804
GO:0007010 cytoskeleton organization P
ISS
DmeFBgn0036309
GO:0007015 actin filament organization P
IMP
SceS000005187
GO:0007121 bipolar cellular bud site selection P
TAS
SceS000005187
GO:0007269 neurotransmitter secretion P
IMP
CelWBGene00022717
GO:0007624 ultradian rhythm P
IMP
CelWBGene00022717
GO:0007638 mechanosensory behavior P
IMP
CelWBGene00022717
GO:0008104 protein localization P
IMP
CelWBGene00022717
GO:0009612 response to mechanical stimulus P
IMP
CelWBGene00022717
GO:0016192 vesicle-mediated transport P
RCA
SceS000005187
GO:0030036 actin cytoskeleton organization P
IMP
SpoSPAC688.11
GO:0030421 defecation P
IMP
CelWBGene00022717
GO:0030866 cortical actin cytoskeleton organization P
IMP
SpoSPAC688.11
GO:0030950 establishment or maintenance of actin cytoskeleton
polarity		 P
IMP
SpoSPAC688.11
GO:0031505 fungal-type cell wall organization P
IMP
SpoSPAC688.11
TAS
SceS000005187
GO:0031580 membrane raft distribution P
IMP
SpoSPAC688.11
GO:0032502 developmental process P
IMP
CelWBGene00022717
GO:0034613 cellular protein localization P
IGI
SpoSPAC688.11
GO:0042981 regulation of apoptosis P
ISO
MmuMGI:1099804
GO:0048260 positive regulation of receptor-mediated
endocytosis		 P
IMP
MmuMGI:1099804
GO:0048268 clathrin coat assembly P
ISO
MmuMGI:1099804
GO:0050954 sensory perception of mechanical
stimulus		 P
IMP
CelWBGene00022717
GO:0051049 regulation of transport P
RCA
SceS000005187
GO:0061161 positive regulation of establishment of bipolar
cell polarity resulting in cell
shape		 P
IMP
SpoSPAC688.11
GO:0070314 G1 to G0 transition P
IMP
SpoSPAC688.11

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPAC688.11
(Q9P6L5)		 YNL243W
(S000005187)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000131 incipient cellular bud site C
IDA
SceS000005187
GO:0005737 cytoplasm C
IDA
SpoSPAC688.11
GO:0030479 actin cortical patch C
IDA
SceS000005187
SpoSPAC688.11
GO:0032153 cell division site C
IDA
SpoSPAC688.11
GO:0043332 mating projection tip C
IDA
SceS000005187
GO:0051285 cell cortex of cell tip C
IDA
SpoSPAC688.11
GO:0003779 actin binding F
ISS
SpoSPAC688.11
GO:0005515 protein binding F
IPI
SpoSPAC688.11
GO:0005546 phosphatidylinositol-4,5-bisphosphate
binding		 F
ISS
SpoSPAC688.11
GO:0030276 clathrin binding F
RCA
SceS000005187
GO:0030674 protein binding, bridging F
IGI
SceS000005187
IPI
SceS000005187
ISS
SpoSPAC688.11
GO:0006887 exocytosis P
TAS
SceS000005187
GO:0006897 endocytosis P
IMP
SceS000005187
SpoSPAC688.11
GO:0007015 actin filament organization P
IMP
SceS000005187
GO:0007121 bipolar cellular bud site selection P
TAS
SceS000005187
GO:0016192 vesicle-mediated transport P
RCA
SceS000005187
GO:0030036 actin cytoskeleton organization P
IMP
SpoSPAC688.11
GO:0030866 cortical actin cytoskeleton organization P
IMP
SpoSPAC688.11
GO:0030950 establishment or maintenance of actin cytoskeleton
polarity		 P
IMP
SpoSPAC688.11
GO:0031505 fungal-type cell wall organization P
IMP
SpoSPAC688.11
TAS
SceS000005187
GO:0031580 membrane raft distribution P
IMP
SpoSPAC688.11
GO:0034613 cellular protein localization P
IGI
SpoSPAC688.11
GO:0051049 regulation of transport P
RCA
SceS000005187
GO:0061161 positive regulation of establishment of bipolar
cell polarity resulting in cell
shape		 P
IMP
SpoSPAC688.11
GO:0070314 G1 to G0 transition P
IMP
SpoSPAC688.11

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GO info in one table:

s.khadayate@ucl.ac.uk