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Search term: YNL262W


Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name POL2
SGD link S000005206
Alternative ID YNL262W
Description Catalytic subunit of DNA polymerase (II) epsilon, a chromosomal DNA replication polymerase that exhibits processivity and proofreading exonuclease activity; also involved in DNA synthesis during DNA repair; interacts extensively with Mrc1p
Synonyms YNL262W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

Search for gene by ID or name:

Query species:

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Search for GO info:  

GO info in one table:


KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG1798 AC-HYPE

KOGs classification KOGs description
INFORMATION STORAGE AND PROCESSING DNA polymerase epsilon, catalytic subunit A

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At1g08260 GI:15223158
Arabidopsis thaliana (Ath) At2g27120 GI:15225849
Caenorhabditis elegans (Cel) CE17767
(WBGene00009368)
GI:17507143 O62218
Homo sapiens (Hsa) Hs5453926 GI:5453926
Saccharomyces cerevisiae (Sce) YNL262w
(S000005206)
GI:6324067 P21951
Schizosaccharomyces pombe (Spo) SPBC25H2.13c GI:19113146 P87154
Encephalitozoon cuniculi (Ecu) ECU10g1210 GI:19074730 Q8SR23


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IC
SpoSPBC25H2.13c
GO:0005657 replication fork C
IDA
SceS000005206
GO:0008622 epsilon DNA polymerase complex C
IDA
SceS000005206
IPI
AthAt1g08260
TAS
SpoSPBC25H2.13c
GO:0031261 DNA replication preinitiation complex C
IC
SpoSPBC25H2.13c
GO:0043596 nuclear replication fork C
IC
SpoSPBC25H2.13c
GO:0048046 apoplast C
IDA
AthAt1g08260
GO:0003690 double-stranded DNA binding F
IDA
SceS000005206
GO:0003887 DNA-directed DNA polymerase activity F
IMP
SceS000005206
SpoSPBC25H2.13c
ISS
AthAt2g27120
At1g08260
GO:0000003 reproduction P
IMP
CelWBGene00009368
GO:0000723 telomere maintenance P
IMP
SpoSPBC25H2.13c
GO:0000731 DNA synthesis involved in DNA repair P
IMP
SceS000005206
GO:0002009 morphogenesis of an epithelium P
IMP
CelWBGene00009368
GO:0006270 DNA-dependent DNA replication initiation P
IMP
SpoSPBC25H2.13c
GO:0006272 leading strand elongation P
TAS
SceS000005206
GO:0006273 lagging strand elongation P
TAS
SceS000005206
GO:0006289 nucleotide-excision repair P
TAS
SceS000005206
GO:0006298 mismatch repair P
TAS
SceS000005206
GO:0006303 double-strand break repair via nonhomologous end
joining
P
IGI
SceS000005206
IMP
SceS000005206
GO:0006348 chromatin silencing at telomere P
IMP
SceS000005206
GO:0006997 nucleus organization P
IMP
CelWBGene00009368
GO:0007064 mitotic sister chromatid cohesion P
IMP
SceS000005206
GO:0007090 regulation of S phase of mitotic cell
cycle
P
IMP
SpoSPBC25H2.13c
GO:0009792 embryo development ending in birth or egg
hatching
P
IMP
CelWBGene00009368
GO:0009793 embryo development ending in seed
dormancy
P
IMP
AthAt1g08260
NAS
AthAt1g08260
GO:0033260 DNA replication involved in S phase P
IEP
SceS000005206
IMP
SceS000005206
GO:0040011 locomotion P
IMP
CelWBGene00009368
GO:0040035 hermaphrodite genitalia development P
IMP
CelWBGene00009368
GO:0045750 positive regulation of S phase of mitotic cell
cycle
P
IMP
AthAt1g08260
GO:0048579 negative regulation of long-day photoperiodism,
flowering
P
IMP
AthAt1g08260

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
4539

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) POLE GI:62198237
Pan troglodytes (Ptr) POLE GI:114647908
Canis familiaris (Cfa) POLE GI:73994933
Mus musculus (Mmu) Pole
(MGI:1196391)
GI:6755124 Q3TBY2
Rattus norvegicus (Rno) Pole GI:62659079
Gallus gallus (Gga) POLE GI:118098794
Drosophila melanogaster (Dme) DNApol-epsilon GI:24649301
Anopheles gambiae (Aga) AgaP_AGAP004615 GI:158293870
Caenorhabditis elegans (Cel) F33H2.5
(CE17767;
WBGene00009368)
GI:17507143 O62218
Schizosaccharomyces pombe (Spo) cdc20
(SPBC25H2.13c)
GI:19113146 P87154
Saccharomyces cerevisiae (Sce) POL2
(S000005206)
GI:6324067 P21951
Kluyveromyces lactis (Kla) KLLA0C02585g GI:50304713
Eremothecium gossypii (Ego) AGOS_AFR657C GI:45199176
Magnaporthe grisea (Mgr) MGG_03850 GI:145606913
Neurospora crassa (Ncr) NCU04548.1 GI:32406576
Arabidopsis thaliana (Ath) TIL2 GI:42569372
Arabidopsis thaliana (Ath) TIL1 GI:186478264
Oryza sativa (Osa) Os02g0511900 GI:115446319


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IC
SpoSPBC25H2.13c
IDA
DmeDNApol-epsilon
HsaPOLE
GO:0005654 nucleoplasm C
EXP
HsaPOLE
GO:0005657 replication fork C
IDA
SceS000005206
GO:0008622 epsilon DNA polymerase complex C
IDA
SceS000005206
IPI
AthTIL1
ISS
DmeDNApol-epsilon
TAS
SpoSPBC25H2.13c
GO:0031261 DNA replication preinitiation complex C
IC
SpoSPBC25H2.13c
GO:0043596 nuclear replication fork C
IC
SpoSPBC25H2.13c
GO:0048046 apoplast C
IDA
AthTIL1
GO:0003677 DNA binding F
IDA
HsaPOLE
GO:0003682 chromatin binding F
IDA
HsaPOLE
GO:0003690 double-stranded DNA binding F
IDA
SceS000005206
GO:0003887 DNA-directed DNA polymerase activity F
IDA
DmeDNApol-epsilon
IMP
HsaPOLE
SceS000005206
SpoSPBC25H2.13c
ISS
AthTIL1
TIL2
DmeDNApol-epsilon
NAS
DmeDNApol-epsilon
GO:0005515 protein binding F
IPI
HsaPOLE
GO:0008296 3'-5'-exodeoxyribonuclease activity F
IDA
DmeDNApol-epsilon
GO:0000003 reproduction P
IMP
CelWBGene00009368
GO:0000082 G1/S transition of mitotic cell
cycle
P
IMP
HsaPOLE
GO:0000723 telomere maintenance P
IMP
SpoSPBC25H2.13c
GO:0000731 DNA synthesis involved in DNA repair P
IMP
HsaPOLE
SceS000005206
GO:0002009 morphogenesis of an epithelium P
IMP
CelWBGene00009368
GO:0006260 DNA replication P
IMP
HsaPOLE
GO:0006261 DNA-dependent DNA replication P
IDA
DmeDNApol-epsilon
GO:0006270 DNA-dependent DNA replication initiation P
IMP
SpoSPBC25H2.13c
GO:0006272 leading strand elongation P
TAS
SceS000005206
GO:0006273 lagging strand elongation P
TAS
SceS000005206
GO:0006289 nucleotide-excision repair P
TAS
SceS000005206
GO:0006297 nucleotide-excision repair, DNA gap
filling
P
EXP
HsaPOLE
GO:0006298 mismatch repair P
TAS
SceS000005206
GO:0006303 double-strand break repair via nonhomologous end
joining
P
IGI
SceS000005206
IMP
SceS000005206
GO:0006348 chromatin silencing at telomere P
IMP
SceS000005206
GO:0006974 response to DNA damage stimulus P
IMP
DmeDNApol-epsilon
GO:0006997 nucleus organization P
IMP
CelWBGene00009368
GO:0007064 mitotic sister chromatid cohesion P
IMP
SceS000005206
GO:0007090 regulation of S phase of mitotic cell
cycle
P
IMP
SpoSPBC25H2.13c
GO:0009792 embryo development ending in birth or egg
hatching
P
IMP
CelWBGene00009368
GO:0009793 embryo development ending in seed
dormancy
P
IMP
AthTIL1
NAS
AthTIL1
GO:0033260 DNA replication involved in S phase P
IEP
SceS000005206
IMP
SceS000005206
GO:0040011 locomotion P
IMP
CelWBGene00009368
GO:0040035 hermaphrodite genitalia development P
IMP
CelWBGene00009368
GO:0045750 positive regulation of S phase of mitotic cell
cycle
P
IMP
AthTIL1
GO:0048579 negative regulation of long-day photoperiodism,
flowering
P
IMP
AthTIL1

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_1347

Species OrthoMCL
sequence
Model organism
protein page
UniProt link
Anopheles gambiae (Aga) aga7178 ENSANGP00000020949
Anopheles gambiae (Aga) aga7179 ENSANGP00000029590
Ashbya gossypii (Ago) ago3850 AFR657C
Arabidopsis thaliana (Ath) ath830 At1g08260.1
Arabidopsis thaliana (Ath) ath9653 At2g27120.1
Caenorhabditis elegans (Cel) cel8034 F33H2.5
(CE17767;
WBGene00009368)
Candida glabrata (Cgl) cgl3342 CAGL0J08030g
Cryptococcus neoformans (Cne) cne3550 176.m02283
Dictyostelium discoideum (Ddi) ddi12758 DDB0216320
Debaryomyces hansenii (Dha) dha4263 DEHA0E23254g
Drosophila melanogaster (Dme) dme14004 CG6768-PA
(FBgn0020756)
Danio rerio (Dre) dre18705 ENSDARP00000017072
(LOC569704)
Encephalitozoon cuniculi (Ecu) ecu646 19074730
Takifugu rubripes (Fru) fru10139 SINFRUP00000155041
Takifugu rubripes (Fru) fru10143 SINFRUP00000167809
Takifugu rubripes (Fru) fru10140 SINFRUP00000172423
Takifugu rubripes (Fru) fru10141 SINFRUP00000173681
Takifugu rubripes (Fru) fru10142 SINFRUP00000176512
Gallus gallus (Gga) gga7572 ENSGALP00000012408
(POLE)
Gallus gallus (Gga) gga7574 ENSGALP00000012409
Gallus gallus (Gga) gga7576 ENSGALP00000012410
Gallus gallus (Gga) gga7575 ENSGALP00000012411
Gallus gallus (Gga) gga7577 ENSGALP00000012412
Homo sapiens (Hsa) hsa8484 ENSP00000322570
(POLE)
Q07864
Kluyveromyces lactis (Kla) kla1311 KLLA0C02585g
Mus musculus (Mmu) mmu20644 ENSMUSP00000007296
(MGI:1196391)
Q3UPI9
Neurospora crassa (Ncr) ncr4417 NCU04548.2
Oryza sativa (Osa) osa29165 4264.m00199
Oryza sativa (Osa) osa37468 4866.m00083
Oryza sativa (Osa) osa38684 4901.m00111
Plasmodium falciparum (Pfa) pfa3189 PFF1470c
Saccharomyces cerevisiae (Sce) sce5383 YNL262W
(S000005206)
Schizosaccharomyces pombe (Spo) spo4807 SPBC25H2.13c P87154
Yarrowia lipolytica (Yli) yli4946 YALI0E26367g