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Search term: YNL273W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name TOF1
SGD link S000005217
Alternative ID YNL273W
Description Subunit of a replication-pausing checkpoint complex (Tof1p-Mrc1p-Csm3p) that acts at the stalled replication fork to promote sister chromatid cohesion after DNA damage, facilitating gap repair of damaged DNA; interacts with the MCM helicase
Synonyms YNL273W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG1974 ACDHYP-

KOGs classification KOGs description
INFORMATION STORAGE AND PROCESSING DNA topoisomerase I-interacting protein

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At5g52910 GI:15237300
Caenorhabditis elegans (Cel) CE28860 GI:17556520
Drosophila melanogaster (Dme) 7295795 GI:7295795 Q59E16
Drosophila melanogaster (Dme) 7295796 GI:7295796
Drosophila melanogaster (Dme) 7299721 GI:7299721
Drosophila melanogaster (Dme) 7299722 GI:7299722
Drosophila melanogaster (Dme) 7299723 GI:7299723
Drosophila melanogaster (Dme) 7299727 GI:7299727
Homo sapiens (Hsa) Hs4507507 GI:4507507
Saccharomyces cerevisiae (Sce) YNL273w
(S000005217)		 GI:6324056 P53840
Schizosaccharomyces pombe (Spo) SPBC216.06c GI:19112150 Q9UUM2


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000228 nuclear chromosome C
IPI
SceS000005217
GO:0005634 nucleus C
IDA
SpoSPBC216.06c
NAS
AthAt5g52910
GO:0005816 spindle pole body C
IDA
SpoSPBC216.06c
GO:0031298 replication fork protection complex C
IDA
SceS000005217
TAS
SpoSPBC216.06c
GO:0043596 nuclear replication fork C
IDA
SceS000005217
GO:0003674 molecular_function F
ND
SceS000005217
GO:0005515 protein binding F
IPI
SpoSPBC216.06c
GO:0046982 protein heterodimerization activity F
IPI
SpoSPBC216.06c
GO:0000076 DNA replication checkpoint P
IGI
SpoSPBC216.06c
IMP
SceS000005217
IPI
SceS000005217
GO:0006260 DNA replication P
IMP
SceS000005217
RCA
SceS000005217
GO:0006281 DNA repair P
IGI
SceS000005217
IMP
SceS000005217
RCA
SceS000005217
GO:0006974 response to DNA damage stimulus P
RCA
SceS000005217
GO:0007064 mitotic sister chromatid cohesion P
IGI
SceS000005217
IMP
SceS000005217
GO:0007531 mating type determination P
IMP
SpoSPBC216.06c
GO:0042752 regulation of circadian rhythm P
NAS
AthAt5g52910
GO:0043111 replication fork arrest P
IDA
SpoSPBC216.06c
IMP
SceS000005217
GO:0043570 maintenance of DNA repeat elements P
IMP
SceS000005217
GO:0045950 negative regulation of mitotic
recombination		 P
IDA
SpoSPBC216.06c
GO:0048478 replication fork protection P
IDA
SpoSPBC216.06c
IMP
SceS000005217

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
40053

Species Gene ID NCBI link UniProt link
Schizosaccharomyces pombe (Spo) swi1
(SPBC216.06c)		 GI:19112150 Q9UUM2
Saccharomyces cerevisiae (Sce) TOF1
(S000005217)		 GI:6324056 P53840
Kluyveromyces lactis (Kla) KLLA0C02255g GI:50304683
Magnaporthe grisea (Mgr) MGG_03991 GI:39943960
Neurospora crassa (Ncr) NCU09552.1 GI:32418866


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000228 nuclear chromosome C
IPI
SceS000005217
GO:0005634 nucleus C
IDA
SpoSPBC216.06c
GO:0005816 spindle pole body C
IDA
SpoSPBC216.06c
GO:0031298 replication fork protection complex C
IDA
SceS000005217
TAS
SpoSPBC216.06c
GO:0043596 nuclear replication fork C
IDA
SceS000005217
GO:0003674 molecular_function F
ND
SceS000005217
GO:0005515 protein binding F
IPI
SpoSPBC216.06c
GO:0046982 protein heterodimerization activity F
IPI
SpoSPBC216.06c
GO:0000076 DNA replication checkpoint P
IGI
SpoSPBC216.06c
IMP
SceS000005217
IPI
SceS000005217
GO:0006260 DNA replication P
IMP
SceS000005217
RCA
SceS000005217
GO:0006281 DNA repair P
IGI
SceS000005217
IMP
SceS000005217
RCA
SceS000005217
GO:0006974 response to DNA damage stimulus P
RCA
SceS000005217
GO:0007064 mitotic sister chromatid cohesion P
IGI
SceS000005217
IMP
SceS000005217
GO:0007531 mating type determination P
IMP
SpoSPBC216.06c
GO:0043111 replication fork arrest P
IDA
SpoSPBC216.06c
IMP
SceS000005217
GO:0043570 maintenance of DNA repeat elements P
IMP
SceS000005217
GO:0045950 negative regulation of mitotic
recombination		 P
IDA
SpoSPBC216.06c
GO:0048478 replication fork protection P
IDA
SpoSPBC216.06c
IMP
SceS000005217

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_13189

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Ashbya gossypii (Ago) ago3865 AFR672C
Candida glabrata (Cgl) cgl3352 CAGL0J08250g
Cryptococcus neoformans (Cne) cne1325 180.m00272
Debaryomyces hansenii (Dha) dha3852 DEHA0E13860g
Kluyveromyces lactis (Kla) kla1296 KLLA0C02255g
Neurospora crassa (Ncr) ncr9299 NCU09552.2
Saccharomyces cerevisiae (Sce) sce5394 YNL273W
(S000005217)
Schizosaccharomyces pombe (Spo) spo1735 SPBC216.06c Q9UUM2
Yarrowia lipolytica (Yli) yli1003 YALI0B06512g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000228 nuclear chromosome C
IPI
SceS000005217
GO:0005634 nucleus C
IDA
SpoSPBC216.06c
GO:0005816 spindle pole body C
IDA
SpoSPBC216.06c
GO:0031298 replication fork protection complex C
IDA
SceS000005217
TAS
SpoSPBC216.06c
GO:0043596 nuclear replication fork C
IDA
SceS000005217
GO:0003674 molecular_function F
ND
SceS000005217
GO:0005515 protein binding F
IPI
SpoSPBC216.06c
GO:0046982 protein heterodimerization activity F
IPI
SpoSPBC216.06c
GO:0000076 DNA replication checkpoint P
IGI
SpoSPBC216.06c
IMP
SceS000005217
IPI
SceS000005217
GO:0006260 DNA replication P
IMP
SceS000005217
RCA
SceS000005217
GO:0006281 DNA repair P
IGI
SceS000005217
IMP
SceS000005217
RCA
SceS000005217
GO:0006974 response to DNA damage stimulus P
RCA
SceS000005217
GO:0007064 mitotic sister chromatid cohesion P
IGI
SceS000005217
IMP
SceS000005217
GO:0007531 mating type determination P
IMP
SpoSPBC216.06c
GO:0043111 replication fork arrest P
IDA
SpoSPBC216.06c
IMP
SceS000005217
GO:0043570 maintenance of DNA repeat elements P
IMP
SceS000005217
GO:0045950 negative regulation of mitotic
recombination		 P
IDA
SpoSPBC216.06c
GO:0048478 replication fork protection P
IDA
SpoSPBC216.06c
IMP
SceS000005217

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPBC216.06c
(Q9UUM2)		 YNL273W
(S000005217)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000228 nuclear chromosome C
IPI
SceS000005217
GO:0005634 nucleus C
IDA
SpoSPBC216.06c
GO:0005816 spindle pole body C
IDA
SpoSPBC216.06c
GO:0031298 replication fork protection complex C
IDA
SceS000005217
TAS
SpoSPBC216.06c
GO:0043596 nuclear replication fork C
IDA
SceS000005217
GO:0003674 molecular_function F
ND
SceS000005217
GO:0005515 protein binding F
IPI
SpoSPBC216.06c
GO:0046982 protein heterodimerization activity F
IPI
SpoSPBC216.06c
GO:0000076 DNA replication checkpoint P
IGI
SpoSPBC216.06c
IMP
SceS000005217
IPI
SceS000005217
GO:0006260 DNA replication P
IMP
SceS000005217
RCA
SceS000005217
GO:0006281 DNA repair P
IGI
SceS000005217
IMP
SceS000005217
RCA
SceS000005217
GO:0006974 response to DNA damage stimulus P
RCA
SceS000005217
GO:0007064 mitotic sister chromatid cohesion P
IGI
SceS000005217
IMP
SceS000005217
GO:0007531 mating type determination P
IMP
SpoSPBC216.06c
GO:0043111 replication fork arrest P
IDA
SpoSPBC216.06c
IMP
SceS000005217
GO:0043570 maintenance of DNA repeat elements P
IMP
SceS000005217
GO:0045950 negative regulation of mitotic
recombination		 P
IDA
SpoSPBC216.06c
GO:0048478 replication fork protection P
IDA
SpoSPBC216.06c
IMP
SceS000005217

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Search for GO info:  

GO info in one table:

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