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Search term: YNL280C

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name ERG24
SGD link S000005224
Alternative ID YNL280C
Description C-14 sterol reductase, acts in ergosterol biosynthesis; mutants accumulate the abnormal sterol ignosterol (ergosta-8,14 dienol), and are viable under anaerobic growth conditions but inviable on rich medium under aerobic conditions
Synonyms YNL280C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG1435 ACDHYP-

KOGs classification KOGs description
METABOLISMCELLULAR PROCESSES AND SIGNALING Sterol reductase/lamin B receptor

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At1g50430 GI:15222967
Arabidopsis thaliana (Ath) At3g52940 GI:11358585
Caenorhabditis elegans (Cel) CE19655_2 GI:17557324
Drosophila melanogaster (Dme) 7291331 GI:7291331
Homo sapiens (Hsa) Hs4504961 GI:4504961
Homo sapiens (Hsa) Hs4503321 GI:4503321
Homo sapiens (Hsa) Hs4507547 GI:4507547
Homo sapiens (Hsa) Hs20537133 GI:20537133
Saccharomyces cerevisiae (Sce) YGL012w
(S000002980)		 GI:6321426 P25340
Saccharomyces cerevisiae (Sce) YNL280c
(S000005224)		 GI:6324049 P32462
Schizosaccharomyces pombe (Spo) SPAC20G4.07c GI:19115654 P36209
Schizosaccharomyces pombe (Spo) SPBC16G5.18 GI:19113559 Q09195


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005783 endoplasmic reticulum C
IDA
SceS000002980
S000005224
SpoSPBC16G5.18
GO:0005789 endoplasmic reticulum membrane C
ISS
SpoSPAC20G4.07c
SPBC16G5.18
GO:0005886 plasma membrane C
IDA
AthAt1g50430
GO:0030176 integral to endoplasmic reticulum
membrane		 C
IDA
AthAt1g50430
GO:0000246 delta24(24-1) sterol reductase
activity		 F
IDA
SceS000002980
ISS
SpoSPAC20G4.07c
GO:0009918 sterol delta7 reductase activity F
IMP
AthAt1g50430
GO:0050613 delta14-sterol reductase activity F
IDA
SceS000005224
IGI
AthAt3g52940
IMP
AthAt3g52940
SceS000005224
ISS
SpoSPBC16G5.18
GO:0006066 alcohol metabolic process P
RCA
SceS000005224
GO:0006696 ergosterol biosynthetic process P
IMP
SceS000005224
S000002980
SpoSPAC20G4.07c
ISS
SpoSPBC16G5.18
GO:0006970 response to osmotic stress P
IMP
SpoSPAC20G4.07c
GO:0009793 embryo development ending in seed
dormancy		 P
IMP
AthAt3g52940
GO:0016126 sterol biosynthetic process P
TAS
AthAt3g52940
At1g50430
GO:0016132 brassinosteroid biosynthetic process P
IMP
AthAt1g50430
GO:0030437 ascospore formation P
IMP
SpoSPAC20G4.07c
GO:0042493 response to drug P
IMP
SpoSPAC20G4.07c
GO:0043094 cellular metabolic compound salvage P
RCA
SceS000005224
GO:0043157 response to cation stress P
IMP
SpoSPAC20G4.07c
GO:0044255 cellular lipid metabolic process P
RCA
SceS000005224
GO:0071210 protein insertion into membrane
raft		 P
IMP
SpoSPAC20G4.07c
GO:0090002 establishment of protein localization in plasma
membrane		 P
IMP
SpoSPAC20G4.07c

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
2455

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) LBR GI:37595750
Pan troglodytes (Ptr) LBR GI:114572887
Canis familiaris (Cfa) LBR GI:73961491
Mus musculus (Mmu) Lbr
(MGI:2138281)		 GI:19527034 Q3U9G9
Rattus norvegicus (Rno) Lbr
(RGD:620813)		 GI:19745168
Gallus gallus (Gga) RCJMB04_11a8 GI:45384396
Schizosaccharomyces pombe (Spo) erg24
(SPBC16G5.18)		 GI:19113559 Q09195
Saccharomyces cerevisiae (Sce) ERG24
(S000005224)		 GI:6324049 P32462
Kluyveromyces lactis (Kla) KLLA0C12265g GI:50305569
Eremothecium gossypii (Ego) AGOS_AFR346W GI:45198864
Magnaporthe grisea (Mgr) MGG_13986 GI:145604380
Neurospora crassa (Ncr) NCU08762.1 GI:32420871


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005635 nuclear envelope C
EXP
HsaLBR
GO:0005637 nuclear inner membrane C
TAS
MmuMGI:2138281
GO:0005639 integral to nuclear inner membrane C
TAS
HsaLBR
GO:0005643 nuclear pore C
ISO
MmuMGI:2138281
GO:0005652 nuclear lamina C
TAS
MmuMGI:2138281
GO:0005783 endoplasmic reticulum C
IDA
SceS000005224
SpoSPBC16G5.18
GO:0005789 endoplasmic reticulum membrane C
ISS
SpoSPBC16G5.18
GO:0016021 integral to membrane C
IDA
HsaLBR
ISO
MmuMGI:2138281
GO:0005515 protein binding F
IPI
HsaLBR
GO:0005521 lamin binding F
TAS
HsaLBR
GO:0050613 delta14-sterol reductase activity F
EXP
HsaLBR
IDA
SceS000005224
IMP
SceS000005224
ISS
SpoSPBC16G5.18
GO:0070087 chromo shadow domain binding F
IPI
HsaLBR
GO:0006066 alcohol metabolic process P
RCA
SceS000005224
GO:0006696 ergosterol biosynthetic process P
IMP
SceS000005224
ISS
SpoSPBC16G5.18
GO:0043094 cellular metabolic compound salvage P
RCA
SceS000005224
GO:0044255 cellular lipid metabolic process P
RCA
SceS000005224

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_1206

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga6220 ENSANGP00000015268
Ashbya gossypii (Ago) ago3538 AFR346W
Arabidopsis thaliana (Ath) ath16633 At3g52940.1
Caenorhabditis elegans (Cel) cel240 B0250.9
(CE36579;
WBGene00007126)
Candida glabrata (Cgl) cgl2651 CAGL0I02970g
Cryptococcus neoformans (Cne) cne1916 181.m08700
Dictyostelium discoideum (Ddi) ddi9848 DDB0185998
Dictyostelium discoideum (Ddi) ddi11431 DDB0191312
Debaryomyces hansenii (Dha) dha2182 DEHA0C16984g
Drosophila melanogaster (Dme) dme6418 CG17952-PA
(FBgn0034657)
Drosophila melanogaster (Dme) dme6417 CG17952-PB
(FBgn0034657)
Drosophila melanogaster (Dme) dme6419 CG17952-PC
(FBgn0034657)
Danio rerio (Dre) dre12684 ENSDARP00000004824
Danio rerio (Dre) dre12682 ENSDARP00000006221
Danio rerio (Dre) dre12683 ENSDARP00000015055
(lbr)		 Q5RJ97
Danio rerio (Dre) dre12685 ENSDARP00000024180
Danio rerio (Dre) dre1891 ENSDARP00000039592
Danio rerio (Dre) dre1901 ENSDARP00000042161
(LOC572818)
Danio rerio (Dre) dre1890 ENSDARP00000044060
Danio rerio (Dre) dre12681 ENSDARP00000044289
Danio rerio (Dre) dre1900 ENSDARP00000046331
Takifugu rubripes (Fru) fru29652 SINFRUP00000138821
Takifugu rubripes (Fru) fru29651 SINFRUP00000138827
Takifugu rubripes (Fru) fru7048 SINFRUP00000164378
Takifugu rubripes (Fru) fru7047 SINFRUP00000164379
Gallus gallus (Gga) gga14556 ENSGALP00000015128
(RCJMB04_11a8)		 P23913
Homo sapiens (Hsa) hsa3133 ENSP00000272163
(LBR)		 Q14739
Homo sapiens (Hsa) hsa5935 ENSP00000279263
(TM7SF2)		 O76062-1
Homo sapiens (Hsa) hsa5934 ENSP00000329520
(TM7SF2)		 O76062-2
Homo sapiens (Hsa) hsa3134 ENSP00000339883
(LBR)		 Q14739
Kluyveromyces lactis (Kla) kla1743 KLLA0C12265g
Mus musculus (Mmu) mmu1652 ENSMUSP00000005003
(MGI:2138281)		 Q3U9G9
Mus musculus (Mmu) mmu13183 ENSMUSP00000062603
Neurospora crassa (Ncr) ncr8541 NCU08762.2
Oryza sativa (Osa) osa8141 2592.m00188
Oryza sativa (Osa) osa9208 2698.m00114
Oryza sativa (Osa) osa66018 6773.m00148
Rattus norvegicus (Rno) rno3544 ENSRNOP00000028485
(RGD:1311205)		 Q5BK21
Rattus norvegicus (Rno) rno9698 ENSRNOP00000031360
(RGD:620813)		 O08984
Saccharomyces cerevisiae (Sce) sce5402 YNL280C
(S000005224)
Schizosaccharomyces pombe (Spo) spo4043 SPBC16G5.18 Q09195
Yarrowia lipolytica (Yli) yli1715 YALI0B23298g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005635 nuclear envelope C
IDA
DmeFBgn0034657
GO:0005637 nuclear inner membrane C
IDA
DmeFBgn0034657
NAS
DmeFBgn0034657
TAS
MmuMGI:2138281
GO:0005643 nuclear pore C
ISO
MmuMGI:2138281
GO:0005652 nuclear lamina C
TAS
MmuMGI:2138281
GO:0005783 endoplasmic reticulum C
IDA
SceS000005224
SpoSPBC16G5.18
GO:0005789 endoplasmic reticulum membrane C
ISS
SpoSPBC16G5.18
GO:0016021 integral to membrane C
ISO
MmuMGI:2138281
GO:0004872 receptor activity F
NAS
DmeFBgn0034657
GO:0005521 lamin binding F
NAS
DmeFBgn0034657
GO:0050613 delta14-sterol reductase activity F
IDA
SceS000005224
IGI
AthAt3g52940
IMP
AthAt3g52940
SceS000005224
ISS
SpoSPBC16G5.18
GO:0006066 alcohol metabolic process P
RCA
SceS000005224
GO:0006696 ergosterol biosynthetic process P
IMP
SceS000005224
ISS
SpoSPBC16G5.18
GO:0009793 embryo development ending in seed
dormancy		 P
IMP
AthAt3g52940
GO:0016126 sterol biosynthetic process P
TAS
AthAt3g52940
GO:0043094 cellular metabolic compound salvage P
RCA
SceS000005224
GO:0044255 cellular lipid metabolic process P
RCA
SceS000005224

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPBC16G5.18
(Q09195)		 YNL280C
(S000005224)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005783 endoplasmic reticulum C
IDA
SceS000005224
SpoSPBC16G5.18
GO:0005789 endoplasmic reticulum membrane C
ISS
SpoSPBC16G5.18
GO:0050613 delta14-sterol reductase activity F
IDA
SceS000005224
IMP
SceS000005224
ISS
SpoSPBC16G5.18
GO:0006066 alcohol metabolic process P
RCA
SceS000005224
GO:0006696 ergosterol biosynthetic process P
IMP
SceS000005224
ISS
SpoSPBC16G5.18
GO:0043094 cellular metabolic compound salvage P
RCA
SceS000005224
GO:0044255 cellular lipid metabolic process P
RCA
SceS000005224

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Query species:

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GO info in one table:

s.khadayate@ucl.ac.uk