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Search term: YNL312W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name RFA2
SGD link S000005256
Alternative ID YNL312W
Description Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination
Synonyms YNL312W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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Search for GO info:  

GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG3108 ACDHYPE

KOGs classification KOGs description
INFORMATION STORAGE AND PROCESSING Single-stranded DNA-binding replication protein A (RPA), medium (30 kD) subunit

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At2g24490 GI:15224151
Arabidopsis thaliana (Ath) At3g02920 GI:6728969
Caenorhabditis elegans (Cel) CE11424 GI:17507807
Caenorhabditis elegans (Cel) CE11426
(WBGene00019079)		 GI:17507809 P91356
Caenorhabditis elegans (Cel) CE12414
(WBGene00019767)		 GI:17508391 Q95Y97
Drosophila melanogaster (Dme) 7298736 GI:7298736
Homo sapiens (Hsa) Hs4506585
(RPA2)		 GI:4506585 P15927
Homo sapiens (Hsa) Hs9558731
(RPA4)		 GI:9558731 Q13156
Homo sapiens (Hsa) Hs20470549 GI:20470549
Homo sapiens (Hsa) Hs13487923 GI:13487923
Saccharomyces cerevisiae (Sce) YNL312w
(S000005256)		 GI:6324017 P26754
Schizosaccharomyces pombe (Spo) SPCC1753.01c GI:19075727 Q92373
Encephalitozoon cuniculi (Ecu) ECU06g0360 GI:19074286 Q8SRS2


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000781 chromosome, telomeric region C
IMP
SceS000005256
GO:0000794 condensed nuclear chromosome C
IDA
SceS000005256
GO:0005634 nucleus C
IDA
AthAt2g24490
HsaRPA4
SpoSPCC1753.01c
GO:0005654 nucleoplasm C
EXP
HsaRPA2
GO:0005662 DNA replication factor A complex C
IDA
HsaRPA4
SceS000005256
SpoSPCC1753.01c
IPI
HsaRPA2
GO:0005829 cytosol C
IDA
SpoSPCC1753.01c
GO:0003690 double-stranded DNA binding F
IDA
SceS000005256
GO:0003697 single-stranded DNA binding F
IDA
SceS000005256
SpoSPCC1753.01c
TAS
HsaRPA2
RPA4
GO:0005515 protein binding F
IPI
AthAt2g24490
HsaRPA2
GO:0043565 sequence-specific DNA binding F
IDA
SceS000005256
GO:0000003 reproduction P
IMP
CelWBGene00019767
GO:0000077 DNA damage checkpoint P
IDA
HsaRPA4
GO:0000718 nucleotide-excision repair, DNA damage
removal		 P
EXP
HsaRPA2
GO:0000722 telomere maintenance via recombination P
IPI
SceS000005256
GO:0000724 double-strand break repair via homologous
recombination		 P
IGI
SceS000005256
GO:0002009 morphogenesis of an epithelium P
IMP
CelWBGene00019767
GO:0006260 DNA replication P
EXP
HsaRPA2
IGI
AthAt2g24490
IMP
SceS000005256
ISS
AthAt2g24490
GO:0006261 DNA-dependent DNA replication P
TAS
HsaRPA2
GO:0006268 DNA unwinding involved in replication P
IDA
SceS000005256
GO:0006269 DNA replication, synthesis of RNA
primer		 P
ISS
SpoSPCC1753.01c
GO:0006270 DNA-dependent DNA replication initiation P
TAS
HsaRPA4
GO:0006281 DNA repair P
IMP
AthAt2g24490
SceS000005256
ISS
SpoSPCC1753.01c
GO:0006289 nucleotide-excision repair P
IDA
HsaRPA4
SceS000005256
IMP
SceS000005256
GO:0006297 nucleotide-excision repair, DNA gap
filling		 P
EXP
HsaRPA2
GO:0006310 DNA recombination P
ISS
SpoSPCC1753.01c
GO:0006312 mitotic recombination P
IPI
SceS000005256
GO:0006974 response to DNA damage stimulus P
IMP
CelWBGene00019767
GO:0007004 telomere maintenance via telomerase P
IMP
SceS000005256
GO:0007126 meiosis P
IMP
CelWBGene00019767
GO:0007131 reciprocal meiotic recombination P
IPI
SceS000005256
GO:0008150 biological_process P
ND
AthAt3g02920
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00019767
GO:0016458 gene silencing P
IMP
AthAt2g24490
GO:0016567 protein ubiquitination P
IPI
SceS000005256
GO:0018991 oviposition P
IMP
CelWBGene00019767
GO:0030491 heteroduplex formation P
IDA
SceS000005256
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00019767
GO:0040011 locomotion P
IMP
CelWBGene00019767
GO:0040035 hermaphrodite genitalia development P
IMP
CelWBGene00019767
GO:0045132 meiotic chromosome segregation P
IMP
CelWBGene00019767
GO:0045184 establishment of protein localization P
IMP
SceS000005256
GO:0065007 biological regulation P
NAS
SpoSPCC1753.01c

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
37712

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) RPA2 GI:4506585 P15927
Pan troglodytes (Ptr) RPA2 GI:114555089
Canis familiaris (Cfa) RPA2 GI:73950517
Mus musculus (Mmu) Rpa2
(MGI:1339939)		 GI:110625961 Q3TE40
Rattus norvegicus (Rno) Rpa2
(RGD:619714)		 GI:51036584
Gallus gallus (Gga) RCJMB04_6d17 GI:71894737
Drosophila melanogaster (Dme) RPA2 GI:19921606
Anopheles gambiae (Aga) AgaP_AGAP008332 GI:158296779
Schizosaccharomyces pombe (Spo) ssb2
(SPCC1753.01c)		 GI:63054444 Q92373
Saccharomyces cerevisiae (Sce) RFA2
(S000005256)		 GI:6324017 P26754
Kluyveromyces lactis (Kla) KLLA0E07348g GI:50308557
Eremothecium gossypii (Ego) AGOS_ADL176W GI:45187697
Magnaporthe grisea (Mgr) MGG_07124 GI:145612441
Neurospora crassa (Ncr) NCU07717.1 GI:32415890
Arabidopsis thaliana (Ath) RPA2 GI:186502765
Arabidopsis thaliana (Ath) AT3G02920 GI:18396383
Oryza sativa (Osa) Os02g0633400 GI:115447461
Oryza sativa (Osa) Os02g0829100 GI:115450003
Oryza sativa (Osa) Os06g0693300 GI:115469668


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000781 chromosome, telomeric region C
IMP
SceS000005256
GO:0000794 condensed nuclear chromosome C
IDA
SceS000005256
GO:0005634 nucleus C
IDA
SpoSPCC1753.01c
GO:0005654 nucleoplasm C
EXP
HsaRPA2
GO:0005662 DNA replication factor A complex C
IDA
SceS000005256
SpoSPCC1753.01c
IPI
HsaRPA2
ISO
MmuMGI:1339939
GO:0005829 cytosol C
IDA
SpoSPCC1753.01c
GO:0003677 DNA binding F
IDA
MmuMGI:1339939
GO:0003690 double-stranded DNA binding F
IDA
SceS000005256
GO:0003697 single-stranded DNA binding F
IDA
SceS000005256
SpoSPCC1753.01c
ISO
MmuMGI:1339939
TAS
HsaRPA2
GO:0005515 protein binding F
IPI
HsaRPA2
MmuMGI:1339939
GO:0043565 sequence-specific DNA binding F
IDA
SceS000005256
GO:0047485 protein N-terminus binding F
ISO
MmuMGI:1339939
GO:0000718 nucleotide-excision repair, DNA damage
removal		 P
EXP
HsaRPA2
GO:0000722 telomere maintenance via recombination P
IPI
SceS000005256
GO:0000724 double-strand break repair via homologous
recombination		 P
IGI
SceS000005256
GO:0006260 DNA replication P
EXP
HsaRPA2
IMP
SceS000005256
GO:0006261 DNA-dependent DNA replication P
TAS
HsaRPA2
GO:0006268 DNA unwinding involved in replication P
IDA
SceS000005256
GO:0006269 DNA replication, synthesis of RNA
primer		 P
ISS
SpoSPCC1753.01c
GO:0006281 DNA repair P
IMP
SceS000005256
ISS
SpoSPCC1753.01c
GO:0006289 nucleotide-excision repair P
IDA
SceS000005256
IMP
SceS000005256
GO:0006297 nucleotide-excision repair, DNA gap
filling		 P
EXP
HsaRPA2
GO:0006310 DNA recombination P
ISS
SpoSPCC1753.01c
GO:0006312 mitotic recombination P
IPI
SceS000005256
GO:0007004 telomere maintenance via telomerase P
IMP
SceS000005256
GO:0007131 reciprocal meiotic recombination P
IPI
SceS000005256
GO:0008150 biological_process P
ND
AthAt3g02920
MmuMGI:1339939
GO:0016567 protein ubiquitination P
IPI
SceS000005256
GO:0030491 heteroduplex formation P
IDA
SceS000005256
GO:0045184 establishment of protein localization P
IMP
SceS000005256
GO:0065007 biological regulation P
NAS
SpoSPCC1753.01c

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_3153

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga10321 ENSANGP00000018307
Anopheles gambiae (Aga) aga10320 ENSANGP00000023457
Ashbya gossypii (Ago) ago1565 ADL176W
Arabidopsis thaliana (Ath) ath9366 At2g24490.1
Arabidopsis thaliana (Ath) ath12314 At3g02920.1
Caenorhabditis elegans (Cel) cel12948 M04F3.1
(CE12414;
WBGene00019767)
Candida glabrata (Cgl) cgl4830 CAGL0M03993g
Cryptococcus neoformans (Cne) cne1039 163.m06560
Debaryomyces hansenii (Dha) dha5517 DEHA0F25322g
Drosophila melanogaster (Dme) dme3199 CG9273-PA
(FBgn0032906)
Danio rerio (Dre) dre28714 ENSDARP00000022787
Encephalitozoon cuniculi (Ecu) ecu1513 19074286
Takifugu rubripes (Fru) fru16154 SINFRUP00000150797
Gallus gallus (Gga) gga12788 ENSGALP00000001048
(RCJMB04_6d17)		 Q5ZLH1
Homo sapiens (Hsa) hsa671 ENSP00000263698
Kluyveromyces lactis (Kla) kla3280 KLLA0E07348g
Mus musculus (Mmu) mmu19032 ENSMUSP00000030705
Neurospora crassa (Ncr) ncr7513 NCU07717.2
Oryza sativa (Osa) osa3775 1978.m00157
Oryza sativa (Osa) osa6627 2458.m00097
Oryza sativa (Osa) osa8277 2541.m00148
Rattus norvegicus (Rno) rno24083 ENSRNOP00000017549
(RGD:619714)		 Q63528
Rattus norvegicus (Rno) rno24084 ENSRNOP00000043962
Saccharomyces cerevisiae (Sce) sce5436 YNL312W
(S000005256)
Schizosaccharomyces pombe (Spo) spo2608 SPCC1753.01c Q92373
Yarrowia lipolytica (Yli) yli5509 YALI0F03993g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000781 chromosome, telomeric region C
IMP
SceS000005256
GO:0000794 condensed nuclear chromosome C
IDA
SceS000005256
GO:0005634 nucleus C
IDA
AthAt2g24490
SpoSPCC1753.01c
GO:0005662 DNA replication factor A complex C
IDA
SceS000005256
SpoSPCC1753.01c
ISS
DmeFBgn0032906
GO:0005829 cytosol C
IDA
SpoSPCC1753.01c
GO:0003677 DNA binding F
ISS
DmeFBgn0032906
GO:0003690 double-stranded DNA binding F
IDA
SceS000005256
GO:0003697 single-stranded DNA binding F
IDA
SceS000005256
SpoSPCC1753.01c
GO:0005515 protein binding F
IPI
AthAt2g24490
GO:0043565 sequence-specific DNA binding F
IDA
SceS000005256
GO:0000003 reproduction P
IMP
CelWBGene00019767
GO:0000722 telomere maintenance via recombination P
IPI
SceS000005256
GO:0000724 double-strand break repair via homologous
recombination		 P
IGI
SceS000005256
GO:0002009 morphogenesis of an epithelium P
IMP
CelWBGene00019767
GO:0006260 DNA replication P
IGI
AthAt2g24490
IMP
SceS000005256
ISS
AthAt2g24490
GO:0006261 DNA-dependent DNA replication P
ISS
DmeFBgn0032906
GO:0006268 DNA unwinding involved in replication P
IDA
SceS000005256
GO:0006269 DNA replication, synthesis of RNA
primer		 P
ISS
SpoSPCC1753.01c
GO:0006281 DNA repair P
IMP
AthAt2g24490
SceS000005256
ISS
SpoSPCC1753.01c
GO:0006289 nucleotide-excision repair P
IDA
SceS000005256
IMP
SceS000005256
GO:0006310 DNA recombination P
ISS
SpoSPCC1753.01c
GO:0006312 mitotic recombination P
IPI
SceS000005256
GO:0006974 response to DNA damage stimulus P
IMP
CelWBGene00019767
GO:0007004 telomere maintenance via telomerase P
IMP
SceS000005256
GO:0007126 meiosis P
IMP
CelWBGene00019767
GO:0007131 reciprocal meiotic recombination P
IPI
SceS000005256
GO:0008150 biological_process P
ND
AthAt3g02920
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00019767
GO:0016458 gene silencing P
IMP
AthAt2g24490
GO:0016567 protein ubiquitination P
IPI
SceS000005256
GO:0018991 oviposition P
IMP
CelWBGene00019767
GO:0030491 heteroduplex formation P
IDA
SceS000005256
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00019767
GO:0040011 locomotion P
IMP
CelWBGene00019767
GO:0040035 hermaphrodite genitalia development P
IMP
CelWBGene00019767
GO:0045132 meiotic chromosome segregation P
IMP
CelWBGene00019767
GO:0045184 establishment of protein localization P
IMP
SceS000005256
GO:0065007 biological regulation P
NAS
SpoSPCC1753.01c

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPCC1753.01c
(Q92373)		 YNL312W
(S000005256)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000781 chromosome, telomeric region C
IMP
SceS000005256
GO:0000794 condensed nuclear chromosome C
IDA
SceS000005256
GO:0005634 nucleus C
IDA
SpoSPCC1753.01c
GO:0005662 DNA replication factor A complex C
IDA
SceS000005256
SpoSPCC1753.01c
GO:0005829 cytosol C
IDA
SpoSPCC1753.01c
GO:0003690 double-stranded DNA binding F
IDA
SceS000005256
GO:0003697 single-stranded DNA binding F
IDA
SceS000005256
SpoSPCC1753.01c
GO:0043565 sequence-specific DNA binding F
IDA
SceS000005256
GO:0000722 telomere maintenance via recombination P
IPI
SceS000005256
GO:0000724 double-strand break repair via homologous
recombination		 P
IGI
SceS000005256
GO:0006260 DNA replication P
IMP
SceS000005256
GO:0006268 DNA unwinding involved in replication P
IDA
SceS000005256
GO:0006269 DNA replication, synthesis of RNA
primer		 P
ISS
SpoSPCC1753.01c
GO:0006281 DNA repair P
IMP
SceS000005256
ISS
SpoSPCC1753.01c
GO:0006289 nucleotide-excision repair P
IDA
SceS000005256
IMP
SceS000005256
GO:0006310 DNA recombination P
ISS
SpoSPCC1753.01c
GO:0006312 mitotic recombination P
IPI
SceS000005256
GO:0007004 telomere maintenance via telomerase P
IMP
SceS000005256
GO:0007131 reciprocal meiotic recombination P
IPI
SceS000005256
GO:0016567 protein ubiquitination P
IPI
SceS000005256
GO:0030491 heteroduplex formation P
IDA
SceS000005256
GO:0045184 establishment of protein localization P
IMP
SceS000005256
GO:0065007 biological regulation P
NAS
SpoSPCC1753.01c

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Query species:

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GO info in one table:

s.khadayate@ucl.ac.uk