Search term: YNL330C

Gene summary:

KOG results:

KOG name	Phylogenetic pattern (and link to KOGs with this pattern)
KOG1342	ACDHYPE

KOGs classification	KOGs description
INFORMATION STORAGE AND PROCESSING	Histone deacetylase complex, catalytic component RPD3

Species	KOG link	NCBI link	UniProt link
Arabidopsis thaliana (Ath)	At3g44490	GI:15229981
Arabidopsis thaliana (Ath)	At3g44660	GI:15230469
Arabidopsis thaliana (Ath)	At3g44680	GI:15230483
Arabidopsis thaliana (Ath)	At4g38130	GI:15233694
Arabidopsis thaliana (Ath)	At5g35600	GI:15238556
Arabidopsis thaliana (Ath)	At5g63110	GI:15242626
Caenorhabditis elegans (Cel)	CE01472 (WBGene00001835)	GI:17534739	Q09440
Caenorhabditis elegans (Cel)	CE08952 (WBGene00001834)	GI:17561978	O17695
Caenorhabditis elegans (Cel)	CE18116 (WBGene00001836)	GI:17508561	O62339
Drosophila melanogaster (Dme)	7292522	GI:7292522
Drosophila melanogaster (Dme)	7296744	GI:7296744
Homo sapiens (Hsa)	Hs13128862 (HDAC3)	GI:13128862	O15379
Homo sapiens (Hsa)	Hs13128860 (HDAC1)	GI:13128860	Q13547
Homo sapiens (Hsa)	Hs4557641	GI:4557641
Homo sapiens (Hsa)	Hs8923769 (HDAC8)	GI:8923769	Q9BY41
Homo sapiens (Hsa)	Hs20551695	GI:20551695
Saccharomyces cerevisiae (Sce)	YGL194c (S000003162)	GI:6321244	P53096
Saccharomyces cerevisiae (Sce)	YNL330c (S000005274)	GI:6323999	P32561
Saccharomyces cerevisiae (Sce)	YPR068c (S000006272)	GI:6325325	Q12214
Schizosaccharomyces pombe (Spo)	SPAC3G9.07c	GI:19114991	O13298
Schizosaccharomyces pombe (Spo)	SPBC36.05c	GI:19112125	O59702
Encephalitozoon cuniculi (Ecu)	ECU03g1370	GI:19173094	Q8SS80
Encephalitozoon cuniculi (Ecu)	ECU09g0670	GI:19173189

GO terms for KOG results:

GO ID	GO term	GO aspect	Evidence codes and associations
GO:0000118	histone deacetylase complex	C	IDA Sce S000005274 IPI Cel WBGene00001834 ISS Cel WBGene00001835 WBGene00001836 TAS Hsa HDAC3 HDAC1 HDAC8 Sce S000006272
GO:0000228	nuclear chromosome	C	TAS Hsa HDAC8
GO:0000790	nuclear chromatin	C	IDA Spo SPBC36.05c
GO:0005634	nucleus	C	IDA Ath At4g38130 At5g63110 Cel WBGene00001836 WBGene00001834 Hsa HDAC3 HDAC1 Spo SPAC3G9.07c ISS Ath At4g38130 At3g44680 At5g63110 At5g35600 TAS Hsa HDAC3 HDAC8
GO:0005737	cytoplasm	C	IDA Cel WBGene00001834 Spo SPAC3G9.07c TAS Hsa HDAC3 HDAC1 HDAC8
GO:0005829	cytosol	C	IDA Hsa HDAC1 Spo SPAC3G9.07c SPBC36.05c
GO:0005876	spindle microtubule	C	IDA Hsa HDAC3
GO:0009941	chloroplast envelope	C	IDA Ath At5g63110
GO:0016580	Sin3 complex	C	IDA Hsa HDAC1
GO:0016581	NuRD complex	C	IDA Hsa HDAC1 IPI Cel WBGene00001834
GO:0017053	transcriptional repressor complex	C	IDA Hsa HDAC3
GO:0032221	Rpd3S complex	C	IDA Sce S000005274 Spo SPBC36.05c
GO:0033698	Rpd3L complex	C	IDA Sce S000005274 Spo SPBC36.05c
GO:0034967	Set3 complex	C	IDA Sce S000003162 Spo SPAC3G9.07c
GO:0043073	germ cell nucleus	C	IDA Cel WBGene00001834
GO:0070210	Rpd3L-Expanded complex	C	IDA Sce S000003162 S000005274 Spo SPBC36.05c SPAC3G9.07c
GO:0070211	Snt2C complex	C	IDA Sce S000005274
GO:0070822	Sin3-type complex	C	IDA Sce S000005274
GO:0003700	transcription factor activity	F	TAS Hsa HDAC1
GO:0003713	transcription coactivator activity	F	IMP Sce S000005274 IPI Sce S000005274
GO:0003714	transcription corepressor activity	F	IMP Hsa HDAC3 Sce S000005274 IPI Cel WBGene00001834 Sce S000005274 ISS Cel WBGene00001836 WBGene00001835
GO:0004407	histone deacetylase activity	F	IDA Ath At4g38130 Cel WBGene00001834 Hsa HDAC1 Sce S000005274 Spo SPAC3G9.07c IMP Ath At4g38130 Hsa HDAC3 HDAC1 Sce S000005274 Spo SPBC36.05c ISS Ath At3g44660 At4g38130 At3g44490 At3g44680 At5g35600 At5g63110 Cel WBGene00001836 WBGene00001835 Sce S000006272 TAS Hsa HDAC1 HDAC8 HDAC3
GO:0005515	protein binding	F	IPI Ath At4g38130 Hsa HDAC3 HDAC1 Spo SPBC36.05c
GO:0008134	transcription factor binding	F	IPI Hsa HDAC1 TAS Hsa HDAC1 HDAC8 HDAC3
GO:0016563	transcription activator activity	F	IDA Hsa HDAC1
GO:0016564	transcription repressor activity	F	IMP Hsa HDAC3
GO:0016566	specific transcriptional repressor activity	F	IDA Hsa HDAC1
GO:0017136	NAD-dependent histone deacetylase activity	F	IDA Sce S000003162
GO:0017163	basal transcription repressor activity	F	TAS Ath At4g38130
GO:0019899	enzyme binding	F	IPI Hsa HDAC1
GO:0032129	histone deacetylase activity (H3-K9 specific)	F	NAS Spo SPBC36.05c
GO:0033558	protein deacetylase activity	F	IDA Hsa HDAC3 HDAC1 IMP Hsa HDAC1
GO:0034739	histone deacetylase activity (H3-K16 specific)	F	IDA Spo SPAC3G9.07c
GO:0042802	identical protein binding	F	IPI Hsa HDAC1
GO:0042826	histone deacetylase binding	F	IPI Hsa HDAC3 HDAC1
GO:0043565	sequence-specific DNA binding	F	RCA Sce S000005274
GO:0045129	NAD-independent histone deacetylase activity	F	IDA Sce S000003162
GO:0000003	reproduction	P	IMP Cel WBGene00001834 WBGene00001835 WBGene00001836
GO:0000083	regulation of transcription involved in G1/S phase of mitotic cell cycle	P	IGI Sce S000005274 IPI Sce S000005274
GO:0000115	regulation of transcription involved in S phase of mitotic cell cycle	P	IMP Sce S000005274
GO:0000117	regulation of transcription involved in G2/M-phase of mitotic cell cycle	P	IGI Sce S000005274
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	P	IMP Cel WBGene00001834 ISS Cel WBGene00001835 WBGene00001836 TAS Hsa HDAC8
GO:0001302	replicative cell aging	P	IMP Sce S000005274
GO:0002119	nematode larval development	P	IMP Cel WBGene00001835
GO:0006323	DNA packaging	P	RCA Sce S000005274
GO:0006325	chromatin organization	P	ISS Sce S000003162 S000006272
GO:0006333	chromatin assembly or disassembly	P	TAS Hsa HDAC8
GO:0006338	chromatin remodeling	P	IC Hsa HDAC1 Spo SPAC3G9.07c NAS Spo SPAC3G9.07c SPBC36.05c
GO:0006348	chromatin silencing at telomere	P	IMP Spo SPAC3G9.07c
GO:0006355	regulation of transcription, DNA-dependent	P	ISS Sce S000006272 S000003162
GO:0006357	regulation of transcription from RNA polymerase II promoter	P	IEP Spo SPAC3G9.07c SPBC36.05c
GO:0006368	RNA elongation from RNA polymerase II promoter	P	IGI Sce S000005274
GO:0006476	protein amino acid deacetylation	P	IDA Hsa HDAC3 HDAC1 ISS Sce S000006272
GO:0006898	receptor-mediated endocytosis	P	IMP Cel WBGene00001834
GO:0006916	anti-apoptosis	P	TAS Hsa HDAC3 HDAC1
GO:0006974	response to DNA damage stimulus	P	IMP Cel WBGene00001835 WBGene00001834 WBGene00001836
GO:0007059	chromosome segregation	P	TAS Spo SPBC36.05c
GO:0008284	positive regulation of cell proliferation	P	IMP Hsa HDAC1
GO:0008406	gonad development	P	IMP Cel WBGene00001834
GO:0009294	DNA mediated transformation	P	IMP Ath At4g38130
GO:0009651	response to salt stress	P	IMP Ath At5g63110
GO:0009737	response to abscisic acid stimulus	P	IMP Ath At5g63110
GO:0009792	embryo development ending in birth or egg hatching	P	IMP Cel WBGene00001835 WBGene00001834
GO:0009861	jasmonic acid and ethylene-dependent systemic resistance	P	IMP Ath At4g38130
GO:0009890	negative regulation of biosynthetic process	P	RCA Sce S000005274
GO:0009891	positive regulation of biosynthetic process	P	RCA Sce S000003162
GO:0009893	positive regulation of metabolic process	P	RCA Sce S000003162
GO:0010552	positive regulation of gene-specific transcription from RNA polymerase II promoter	P	IDA Hsa HDAC1 IGI Sce S000005274 IMP Sce S000006272 S000005274
GO:0010553	negative regulation of gene-specific transcription from RNA polymerase II promoter	P	IDA Hsa HDAC3 HDAC1 IMP Hsa HDAC3 HDAC1 Sce S000005274
GO:0010557	positive regulation of macromolecule biosynthetic process	P	RCA Sce S000003162
GO:0010604	positive regulation of macromolecule metabolic process	P	RCA Sce S000003162
GO:0010628	positive regulation of gene expression	P	RCA Sce S000003162
GO:0010870	positive regulation of receptor biosynthetic process	P	IMP Hsa HDAC1
GO:0016246	RNA interference	P	IMP Cel WBGene00001836
GO:0016441	posttranscriptional gene silencing	P	IMP Ath At5g63110
GO:0016458	gene silencing	P	IMP Ath At5g63110
GO:0016479	negative regulation of transcription from RNA polymerase I promoter	P	IMP Sce S000005274
GO:0016481	negative regulation of transcription	P	IDA Ath At4g38130 RCA Sce S000005274
GO:0016568	chromatin modification	P	ISS Cel WBGene00001835 WBGene00001836 TAS Hsa HDAC3 HDAC1 HDAC8
GO:0016573	histone acetylation	P	IDA Ath At4g38130
GO:0016575	histone deacetylation	P	IDA Cel WBGene00001834 Sce S000003162 Spo SPAC3G9.07c IMP Ath At5g63110 Hsa HDAC1 Spo SPBC36.05c ISS Ath At4g38130 At5g35600 At5g63110 At3g44680 Cel WBGene00001835 WBGene00001836
GO:0018991	oviposition	P	IMP Cel WBGene00001836
GO:0030174	regulation of DNA-dependent DNA replication initiation	P	IGI Sce S000005274 IMP Sce S000005274
GO:0030261	chromosome condensation	P	IMP Spo SPBC36.05c
GO:0030435	sporulation resulting in formation of a cellular spore	P	RCA Sce S000003162
GO:0030466	chromatin silencing at silent mating-type cassette	P	IGI Spo SPBC36.05c IMP Spo SPAC3G9.07c
GO:0030702	chromatin silencing at centromere	P	IMP Spo SPBC36.05c SPAC3G9.07c
GO:0031325	positive regulation of cellular metabolic process	P	RCA Sce S000003162
GO:0031328	positive regulation of cellular biosynthetic process	P	RCA Sce S000003162
GO:0031939	negative regulation of chromatin silencing at telomere	P	IMP Sce S000005274
GO:0032582	negative regulation of gene-specific transcription	P	IMP Hsa HDAC3
GO:0032874	positive regulation of stress-activated MAPK cascade	P	IMP Sce S000003162
GO:0034401	regulation of transcription by chromatin organization	P	IMP Sce S000005274
GO:0034503	protein localization to nucleolar rDNA repeats	P	IMP Sce S000005274
GO:0040007	growth	P	IMP Cel WBGene00001835
GO:0040010	positive regulation of growth rate	P	IMP Cel WBGene00001834
GO:0040011	locomotion	P	IMP Cel WBGene00001835
GO:0040017	positive regulation of locomotion	P	IMP Cel WBGene00001835
GO:0040027	negative regulation of vulval development	P	IGI Cel WBGene00001834 IMP Cel WBGene00001834
GO:0040035	hermaphrodite genitalia development	P	IMP Cel WBGene00001834
GO:0042262	DNA protection	P	IMP Cel WBGene00001835 WBGene00001836
GO:0043922	negative regulation by host of viral transcription	P	IMP Hsa HDAC1
GO:0045128	negative regulation of reciprocal meiotic recombination	P	IMP Sce S000005274
GO:0045138	tail tip morphogenesis	P	IMP Cel WBGene00001834 WBGene00001835
GO:0045449	regulation of transcription	P	IMP Sce S000003162
GO:0045595	regulation of cell differentiation	P	IGI Cel WBGene00001834
GO:0045746	negative regulation of Notch signaling pathway	P	IMP Cel WBGene00001834
GO:0045786	negative regulation of cell cycle	P	EXP Hsa HDAC3 HDAC1
GO:0045816	negative regulation of transcription from RNA polymerase II promoter, global	P	IGI Sce S000005274 IPI Sce S000005274
GO:0045835	negative regulation of meiosis	P	IMP Sce S000003162
GO:0045893	positive regulation of transcription, DNA-dependent	P	RCA Sce S000003162
GO:0045935	positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	P	RCA Sce S000003162
GO:0045941	positive regulation of transcription	P	RCA Sce S000003162
GO:0046329	negative regulation of JNK cascade	P	IMP Hsa HDAC3
GO:0046580	negative regulation of Ras protein signal transduction	P	IGI Cel WBGene00001834
GO:0048557	embryonic digestive tract morphogenesis	P	IGI Cel WBGene00001834
GO:0051038	negative regulation of transcription, meiotic	P	IMP Sce S000005274
GO:0051173	positive regulation of nitrogen compound metabolic process	P	RCA Sce S000003162
GO:0051225	spindle assembly	P	IMP Hsa HDAC3
GO:0051254	positive regulation of RNA metabolic process	P	RCA Sce S000003162
GO:0051570	regulation of histone H3-K9 methylation	P	NAS Spo SPBC36.05c
GO:0060303	regulation of nucleosome density	P	IEP Spo SPAC3G9.07c
GO:0061186	negative regulation of chromatin silencing at silent mating-type cassette	P	IMP Sce S000005274
GO:0061188	negative regulation of chromatin silencing at rDNA	P	IMP Sce S000005274
GO:0070932	histone H3 deacetylation	P	IDA Hsa HDAC1 IMP Sce S000005274
GO:0070933	histone H4 deacetylation	P	IDA Hsa HDAC1 IMP Sce S000005274
GO:2000026	regulation of multicellular organismal development	P	IMP Ath At4g38130

HomoloGene results:

HomoloGene cluster	Phylogenetic pattern
68426

Species	Gene ID	NCBI link	UniProt link
Homo sapiens (Hsa)	HDAC1	GI:13128860	Q13547
Pan troglodytes (Ptr)	LOC464259	GI:114555331
Canis familiaris (Cfa)	LOC487309	GI:73949981
Mus musculus (Mmu)	Hdac1 (MGI:108086)	GI:6680193	O09106
Rattus norvegicus (Rno)	Hdac1 (RGD:619975)	GI:70794768
Gallus gallus (Gga)	HDAC1	GI:118101764
Drosophila melanogaster (Dme)	Rpd3 (FBgn0015805)	GI:24657891
Anopheles gambiae (Aga)	AgaP_AGAP006511	GI:158295965
Caenorhabditis elegans (Cel)	hda-1 (CE08952; WBGene00001834)	GI:17561978	O17695
Schizosaccharomyces pombe (Spo)	clr6 (SPBC36.05c)	GI:19112125	O59702
Saccharomyces cerevisiae (Sce)	RPD3 (S000005274)	GI:6323999	P32561
Kluyveromyces lactis (Kla)	KLLA0E01980g	GI:50308073
Eremothecium gossypii (Ego)	AGOS_AGR395W	GI:45201491
Magnaporthe grisea (Mgr)	MGG_05857	GI:145603739
Neurospora crassa (Ncr)	NCU00824.1	GI:32409047
Arabidopsis thaliana (Ath)	HDA9	GI:30692236
Plasmodium falciparum (Pfa)	PFI1260c	GI:124507060

GO terms for Homologene results:

GO ID	GO term	GO aspect	Evidence codes and associations
GO:0000118	histone deacetylase complex	C	IDA Sce S000005274 IPI Cel WBGene00001834 Mmu MGI:108086 TAS Hsa HDAC1 Mmu MGI:108086
GO:0000785	chromatin	C	IDA Dme FBgn0015805 ISO Mmu MGI:108086
GO:0000790	nuclear chromatin	C	IDA Spo SPBC36.05c
GO:0000792	heterochromatin	C	IDA Mmu MGI:108086
GO:0005634	nucleus	C	IDA Cel WBGene00001834 Dme FBgn0015805 Hsa HDAC1 ISO Mmu MGI:108086 ISS Ath HDA9 NAS Dme FBgn0015805 TAS Mmu MGI:108086
GO:0005705	polytene chromosome interband	C	IDA Dme FBgn0015805
GO:0005737	cytoplasm	C	IDA Cel WBGene00001834 TAS Hsa HDAC1 Mmu MGI:108086
GO:0005829	cytosol	C	IDA Hsa HDAC1 Spo SPBC36.05c
GO:0016580	Sin3 complex	C	IDA Hsa HDAC1 NAS Dme FBgn0015805
GO:0016581	NuRD complex	C	IDA Hsa HDAC1 IPI Cel WBGene00001834 Dme FBgn0015805 Mmu MGI:108086 NAS Dme FBgn0015805
GO:0031523	Myb complex	C	IDA Dme FBgn0015805
GO:0032221	Rpd3S complex	C	IDA Sce S000005274 Spo SPBC36.05c
GO:0033698	Rpd3L complex	C	IDA Sce S000005274 Spo SPBC36.05c
GO:0035098	ESC/E(Z) complex	C	IDA Dme FBgn0015805 TAS Dme FBgn0015805
GO:0043025	neuronal cell body	C	IDA Mmu MGI:108086
GO:0043073	germ cell nucleus	C	IDA Cel WBGene00001834
GO:0043234	protein complex	C	ISO Mmu MGI:108086
GO:0070210	Rpd3L-Expanded complex	C	IDA Sce S000005274 Spo SPBC36.05c
GO:0070211	Snt2C complex	C	IDA Sce S000005274
GO:0070822	Sin3-type complex	C	IDA Sce S000005274
GO:0003677	DNA binding	F	IDA Mmu MGI:108086
GO:0003682	chromatin binding	F	IDA Mmu MGI:108086
GO:0003700	transcription factor activity	F	IDA Mmu MGI:108086 TAS Hsa HDAC1
GO:0003713	transcription coactivator activity	F	IMP Sce S000005274 IPI Sce S000005274
GO:0003714	transcription corepressor activity	F	IDA Mmu MGI:108086 IMP Sce S000005274 IPI Cel WBGene00001834 Sce S000005274 NAS Dme FBgn0015805
GO:0004407	histone deacetylase activity	F	IDA Cel WBGene00001834 Dme FBgn0015805 Hsa HDAC1 Mmu MGI:108086 Sce S000005274 IMP Hsa HDAC1 Sce S000005274 Spo SPBC36.05c ISO Mmu MGI:108086 ISS Ath HDA9 Dme FBgn0015805 NAS Dme FBgn0015805 TAS Hsa HDAC1
GO:0005515	protein binding	F	IPI Dme FBgn0015805 Hsa HDAC1 Mmu MGI:108086 Spo SPBC36.05c
GO:0008134	transcription factor binding	F	IPI Hsa HDAC1 TAS Hsa HDAC1 Mmu MGI:108086
GO:0016563	transcription activator activity	F	IDA Hsa HDAC1
GO:0016564	transcription repressor activity	F	IDA Mmu MGI:108086 ISO Mmu MGI:108086
GO:0016566	specific transcriptional repressor activity	F	IDA Hsa HDAC1
GO:0019899	enzyme binding	F	IPI Hsa HDAC1
GO:0032129	histone deacetylase activity (H3-K9 specific)	F	NAS Spo SPBC36.05c
GO:0032403	protein complex binding	F	ISO Mmu MGI:108086
GO:0033558	protein deacetylase activity	F	IDA Hsa HDAC1 IMP Hsa HDAC1
GO:0042802	identical protein binding	F	IPI Hsa HDAC1
GO:0042826	histone deacetylase binding	F	IPI Hsa HDAC1
GO:0043565	sequence-specific DNA binding	F	RCA Sce S000005274
GO:0000003	reproduction	P	IMP Cel WBGene00001834
GO:0000083	regulation of transcription involved in G1/S phase of mitotic cell cycle	P	IGI Sce S000005274 IPI Sce S000005274
GO:0000115	regulation of transcription involved in S phase of mitotic cell cycle	P	IMP Sce S000005274
GO:0000117	regulation of transcription involved in G2/M-phase of mitotic cell cycle	P	IGI Sce S000005274
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	P	IMP Cel WBGene00001834
GO:0001302	replicative cell aging	P	IMP Sce S000005274
GO:0006099	tricarboxylic acid cycle	P	IDA Dme FBgn0015805
GO:0006323	DNA packaging	P	RCA Sce S000005274
GO:0006338	chromatin remodeling	P	IC Hsa HDAC1 NAS Spo SPBC36.05c
GO:0006342	chromatin silencing	P	IGI Dme FBgn0015805 IMP Dme FBgn0015805 IPI Dme FBgn0015805
GO:0006357	regulation of transcription from RNA polymerase II promoter	P	IEP Spo SPBC36.05c
GO:0006368	RNA elongation from RNA polymerase II promoter	P	IGI Sce S000005274
GO:0006476	protein amino acid deacetylation	P	IDA Hsa HDAC1
GO:0006898	receptor-mediated endocytosis	P	IMP Cel WBGene00001834
GO:0006916	anti-apoptosis	P	TAS Hsa HDAC1
GO:0006974	response to DNA damage stimulus	P	IMP Cel WBGene00001834
GO:0007059	chromosome segregation	P	TAS Spo SPBC36.05c
GO:0007350	blastoderm segmentation	P	IMP Dme FBgn0015805
GO:0007492	endoderm development	P	IDA Mmu MGI:108086 IMP Mmu MGI:108086
GO:0007517	muscle organ development	P	IMP Dme FBgn0015805
GO:0008284	positive regulation of cell proliferation	P	IMP Hsa HDAC1
GO:0008285	negative regulation of cell proliferation	P	ISO Mmu MGI:108086
GO:0008340	determination of adult lifespan	P	IMP Dme FBgn0015805 TAS Dme FBgn0015805
GO:0008406	gonad development	P	IMP Cel WBGene00001834
GO:0009792	embryo development ending in birth or egg hatching	P	IMP Cel WBGene00001834
GO:0009890	negative regulation of biosynthetic process	P	RCA Sce S000005274
GO:0010552	positive regulation of gene-specific transcription from RNA polymerase II promoter	P	IDA Hsa HDAC1 IGI Sce S000005274 IMP Sce S000005274
GO:0010553	negative regulation of gene-specific transcription from RNA polymerase II promoter	P	IDA Hsa HDAC1 Mmu MGI:108086 IMP Hsa HDAC1 Sce S000005274
GO:0010870	positive regulation of receptor biosynthetic process	P	IMP Hsa HDAC1
GO:0016458	gene silencing	P	IMP Dme FBgn0015805
GO:0016479	negative regulation of transcription from RNA polymerase I promoter	P	IMP Sce S000005274
GO:0016481	negative regulation of transcription	P	IEP Dme FBgn0015805 ISO Mmu MGI:108086 NAS Dme FBgn0015805 RCA Sce S000005274
GO:0016568	chromatin modification	P	TAS Hsa HDAC1 Mmu MGI:108086
GO:0016575	histone deacetylation	P	IDA Cel WBGene00001834 IMP Dme FBgn0015805 Hsa HDAC1 Spo SPBC36.05c ISS Ath HDA9 NAS Dme FBgn0015805
GO:0021766	hippocampus development	P	IGI Mmu MGI:108086
GO:0022904	respiratory electron transport chain	P	IDA Dme FBgn0015805
GO:0030174	regulation of DNA-dependent DNA replication initiation	P	IGI Sce S000005274 IMP Sce S000005274
GO:0030182	neuron differentiation	P	IGI Mmu MGI:108086
GO:0030261	chromosome condensation	P	IMP Spo SPBC36.05c
GO:0030466	chromatin silencing at silent mating-type cassette	P	IGI Spo SPBC36.05c
GO:0030702	chromatin silencing at centromere	P	IMP Spo SPBC36.05c
GO:0031939	negative regulation of chromatin silencing at telomere	P	IMP Sce S000005274
GO:0034401	regulation of transcription by chromatin organization	P	IMP Sce S000005274
GO:0034503	protein localization to nucleolar rDNA repeats	P	IMP Sce S000005274
GO:0034599	cellular response to oxidative stress	P	ISO Mmu MGI:108086
GO:0040010	positive regulation of growth rate	P	IMP Cel WBGene00001834
GO:0040027	negative regulation of vulval development	P	IGI Cel WBGene00001834 IMP Cel WBGene00001834
GO:0040035	hermaphrodite genitalia development	P	IMP Cel WBGene00001834
GO:0043524	negative regulation of neuron apoptosis	P	ISO Mmu MGI:108086
GO:0043922	negative regulation by host of viral transcription	P	IMP Hsa HDAC1
GO:0045128	negative regulation of reciprocal meiotic recombination	P	IMP Sce S000005274
GO:0045138	tail tip morphogenesis	P	IMP Cel WBGene00001834
GO:0045449	regulation of transcription	P	IDA Dme FBgn0015805
GO:0045595	regulation of cell differentiation	P	IGI Cel WBGene00001834
GO:0045746	negative regulation of Notch signaling pathway	P	IMP Cel WBGene00001834
GO:0045786	negative regulation of cell cycle	P	EXP Hsa HDAC1
GO:0045816	negative regulation of transcription from RNA polymerase II promoter, global	P	IGI Sce S000005274 IPI Sce S000005274
GO:0046580	negative regulation of Ras protein signal transduction	P	IGI Cel WBGene00001834
GO:0048477	oogenesis	P	TAS Dme FBgn0015805
GO:0048557	embryonic digestive tract morphogenesis	P	IGI Cel WBGene00001834
GO:0048813	dendrite morphogenesis	P	IMP Dme FBgn0015805
GO:0051038	negative regulation of transcription, meiotic	P	IMP Sce S000005274
GO:0051570	regulation of histone H3-K9 methylation	P	NAS Spo SPBC36.05c
GO:0061186	negative regulation of chromatin silencing at silent mating-type cassette	P	IMP Sce S000005274
GO:0061188	negative regulation of chromatin silencing at rDNA	P	IMP Sce S000005274
GO:0070932	histone H3 deacetylation	P	IDA Hsa HDAC1 IMP Sce S000005274 ISO Mmu MGI:108086
GO:0070933	histone H4 deacetylation	P	IDA Hsa HDAC1 IMP Sce S000005274

OrthoMCL results:

OrthoMCL cluster	Phylogenetic pattern
OG1_434

Species	OrthoMCL sequence	Model organism protein page	UniProt link
Anopheles gambiae (Aga)	aga1962	ENSANGP00000004321
Anopheles gambiae (Aga)	aga3214	ENSANGP00000012089
Ashbya gossypii (Ago)	ago4706	AGR395W
Arabidopsis thaliana (Ath)	ath15735	At3g44680.1
Arabidopsis thaliana (Ath)	ath21999	At4g38130.1
Arabidopsis thaliana (Ath)	ath28429	At5g63110.1
Caenorhabditis elegans (Cel)	cel4630	C53A5.3 (CE08952; WBGene00001834)
Caenorhabditis elegans (Cel)	cel13431	R06C1.1 (CE18116; WBGene00001836)
Candida glabrata (Cgl)	cgl266	CAGL0B01441g
Cryptococcus neoformans (Cne)	cne1447	180.m00401
Dictyostelium discoideum (Ddi)	ddi534	DDB0189724
Dictyostelium discoideum (Ddi)	ddi3422	DDB0190980
Debaryomyces hansenii (Dha)	dha4505	DEHA0F02706g
Drosophila melanogaster (Dme)	dme11020	CG2128-PA (FBgn0025825)
Drosophila melanogaster (Dme)	dme8012	CG7471-PA (FBgn0015805)
Danio rerio (Dre)	dre16687	ENSDARP00000005905 (hdac1)	Q6P2A8
Danio rerio (Dre)	dre1247	ENSDARP00000025705
Encephalitozoon cuniculi (Ecu)	ecu501	19173094
Takifugu rubripes (Fru)	fru21315	SINFRUP00000133251
Takifugu rubripes (Fru)	fru8870	SINFRUP00000136977
Takifugu rubripes (Fru)	fru15	SINFRUP00000149595
Takifugu rubripes (Fru)	fru13100	SINFRUP00000153870
Takifugu rubripes (Fru)	fru16	SINFRUP00000171774
Gallus gallus (Gga)	gga5742	ENSGALP00000004141 (HDAC3)	P56520
Gallus gallus (Gga)	gga15539	ENSGALP00000024133 (HDAC2)	P56519
Homo sapiens (Hsa)	hsa765	ENSP00000271095
Homo sapiens (Hsa)	hsa25904	ENSP00000302967 (HDAC3)	O15379-1
Homo sapiens (Hsa)	hsa27637	ENSP00000347104
Kluyveromyces lactis (Kla)	kla3036	KLLA0E01980g
Mus musculus (Mmu)	mmu18963	ENSMUSP00000000423
Mus musculus (Mmu)	mmu12592	ENSMUSP00000025328
Mus musculus (Mmu)	mmu12116	ENSMUSP00000078339
Neurospora crassa (Ncr)	ncr802	NCU00824.2
Oryza sativa (Osa)	osa3336	1969.m00172
Oryza sativa (Osa)	osa6575	2456.m00157
Oryza sativa (Osa)	osa6581	2456.m00160
Oryza sativa (Osa)	osa25673	3852.m00148
Oryza sativa (Osa)	osa25679	3852.m00151
Oryza sativa (Osa)	osa25696	3852.m00181
Oryza sativa (Osa)	osa52919	5947.m00116
Oryza sativa (Osa)	osa59995	6370.m00157
Plasmodium falciparum (Pfa)	pfa4718	PFI1260c
Rattus norvegicus (Rno)	rno17995	ENSRNOP00000000742 (RGD:619976)	B1WBY8
Rattus norvegicus (Rno)	rno24004	ENSRNOP00000012854 (RGD:1309799)	Q4QQW4
Saccharomyces cerevisiae (Sce)	sce5454	YNL330C (S000005274)
Schizosaccharomyces pombe (Spo)	spo1743	SPBC36.05c	O59702
Yarrowia lipolytica (Yli)	yli4808	YALI0E22935g

GO terms for OrthoMCL results:

GO ID	GO term	GO aspect	Evidence codes and associations
GO:0000118	histone deacetylase complex	C	IDA Sce S000005274 IPI Cel WBGene00001834 ISS Cel WBGene00001836
GO:0000785	chromatin	C	IDA Dme FBgn0015805
GO:0000790	nuclear chromatin	C	IDA Spo SPBC36.05c
GO:0005634	nucleus	C	IDA Ath At4g38130 At5g63110 Cel WBGene00001836 WBGene00001834 Dme FBgn0015805 FBgn0025825 ISS Ath At4g38130 At3g44680 At5g63110 NAS Dme FBgn0015805
GO:0005705	polytene chromosome interband	C	IDA Dme FBgn0015805
GO:0005737	cytoplasm	C	IDA Cel WBGene00001834 Dme FBgn0025825
GO:0005829	cytosol	C	IDA Spo SPBC36.05c
GO:0009941	chloroplast envelope	C	IDA Ath At5g63110
GO:0016580	Sin3 complex	C	NAS Dme FBgn0015805
GO:0016581	NuRD complex	C	IPI Cel WBGene00001834 Dme FBgn0015805 NAS Dme FBgn0015805
GO:0031523	Myb complex	C	IDA Dme FBgn0015805
GO:0032221	Rpd3S complex	C	IDA Sce S000005274 Spo SPBC36.05c
GO:0033698	Rpd3L complex	C	IDA Sce S000005274 Spo SPBC36.05c
GO:0035098	ESC/E(Z) complex	C	IDA Dme FBgn0015805 TAS Dme FBgn0015805
GO:0043073	germ cell nucleus	C	IDA Cel WBGene00001834
GO:0070210	Rpd3L-Expanded complex	C	IDA Sce S000005274 Spo SPBC36.05c
GO:0070211	Snt2C complex	C	IDA Sce S000005274
GO:0070822	Sin3-type complex	C	IDA Sce S000005274
GO:0003713	transcription coactivator activity	F	IMP Sce S000005274 IPI Sce S000005274
GO:0003714	transcription corepressor activity	F	IMP Sce S000005274 IPI Cel WBGene00001834 Sce S000005274 ISS Cel WBGene00001836 NAS Dme FBgn0015805
GO:0004407	histone deacetylase activity	F	IDA Ath At4g38130 Cel WBGene00001834 Dme FBgn0025825 FBgn0015805 Sce S000005274 IMP Ath At4g38130 Sce S000005274 Spo SPBC36.05c ISS Ath At4g38130 At3g44680 At5g63110 Cel WBGene00001836 Dme FBgn0025825 FBgn0015805 NAS Dme FBgn0025825 FBgn0015805
GO:0005515	protein binding	F	IPI Ath At4g38130 Dme FBgn0015805 Spo SPBC36.05c
GO:0017163	basal transcription repressor activity	F	TAS Ath At4g38130
GO:0032129	histone deacetylase activity (H3-K9 specific)	F	NAS Spo SPBC36.05c
GO:0043565	sequence-specific DNA binding	F	RCA Sce S000005274
GO:0000003	reproduction	P	IMP Cel WBGene00001834 WBGene00001836
GO:0000083	regulation of transcription involved in G1/S phase of mitotic cell cycle	P	IGI Sce S000005274 IPI Sce S000005274
GO:0000115	regulation of transcription involved in S phase of mitotic cell cycle	P	IMP Sce S000005274
GO:0000117	regulation of transcription involved in G2/M-phase of mitotic cell cycle	P	IGI Sce S000005274
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	P	IMP Cel WBGene00001834 ISS Cel WBGene00001836
GO:0001302	replicative cell aging	P	IMP Sce S000005274
GO:0006099	tricarboxylic acid cycle	P	IDA Dme FBgn0015805
GO:0006323	DNA packaging	P	RCA Sce S000005274
GO:0006338	chromatin remodeling	P	NAS Spo SPBC36.05c
GO:0006342	chromatin silencing	P	IGI Dme FBgn0015805 FBgn0025825 IMP Dme FBgn0025825 FBgn0015805 IPI Dme FBgn0015805
GO:0006357	regulation of transcription from RNA polymerase II promoter	P	IEP Spo SPBC36.05c
GO:0006368	RNA elongation from RNA polymerase II promoter	P	IGI Sce S000005274
GO:0006898	receptor-mediated endocytosis	P	IMP Cel WBGene00001834
GO:0006974	response to DNA damage stimulus	P	IMP Cel WBGene00001834 WBGene00001836
GO:0007059	chromosome segregation	P	TAS Spo SPBC36.05c
GO:0007350	blastoderm segmentation	P	IMP Dme FBgn0015805
GO:0007517	muscle organ development	P	IMP Dme FBgn0015805
GO:0008340	determination of adult lifespan	P	IMP Dme FBgn0015805 TAS Dme FBgn0015805
GO:0008406	gonad development	P	IMP Cel WBGene00001834
GO:0009294	DNA mediated transformation	P	IMP Ath At4g38130
GO:0009651	response to salt stress	P	IMP Ath At5g63110
GO:0009737	response to abscisic acid stimulus	P	IMP Ath At5g63110
GO:0009792	embryo development ending in birth or egg hatching	P	IMP Cel WBGene00001834
GO:0009861	jasmonic acid and ethylene-dependent systemic resistance	P	IMP Ath At4g38130
GO:0009890	negative regulation of biosynthetic process	P	RCA Sce S000005274
GO:0010552	positive regulation of gene-specific transcription from RNA polymerase II promoter	P	IGI Sce S000005274 IMP Sce S000005274
GO:0010553	negative regulation of gene-specific transcription from RNA polymerase II promoter	P	IMP Sce S000005274
GO:0016246	RNA interference	P	IMP Cel WBGene00001836
GO:0016441	posttranscriptional gene silencing	P	IMP Ath At5g63110
GO:0016458	gene silencing	P	IMP Ath At5g63110 Dme FBgn0015805
GO:0016479	negative regulation of transcription from RNA polymerase I promoter	P	IMP Sce S000005274
GO:0016481	negative regulation of transcription	P	IDA Ath At4g38130 IEP Dme FBgn0015805 NAS Dme FBgn0015805 RCA Sce S000005274
GO:0016568	chromatin modification	P	ISS Cel WBGene00001836
GO:0016573	histone acetylation	P	IDA Ath At4g38130
GO:0016575	histone deacetylation	P	IDA Cel WBGene00001834 IMP Ath At5g63110 Dme FBgn0015805 Spo SPBC36.05c ISS Ath At4g38130 At5g63110 At3g44680 Cel WBGene00001836 NAS Dme FBgn0015805
GO:0018991	oviposition	P	IMP Cel WBGene00001836
GO:0022904	respiratory electron transport chain	P	IDA Dme FBgn0015805
GO:0030174	regulation of DNA-dependent DNA replication initiation	P	IGI Sce S000005274 IMP Sce S000005274
GO:0030261	chromosome condensation	P	IMP Spo SPBC36.05c
GO:0030466	chromatin silencing at silent mating-type cassette	P	IGI Spo SPBC36.05c
GO:0030702	chromatin silencing at centromere	P	IMP Spo SPBC36.05c
GO:0031939	negative regulation of chromatin silencing at telomere	P	IMP Sce S000005274
GO:0034401	regulation of transcription by chromatin organization	P	IMP Sce S000005274
GO:0034503	protein localization to nucleolar rDNA repeats	P	IMP Sce S000005274
GO:0040010	positive regulation of growth rate	P	IMP Cel WBGene00001834
GO:0040027	negative regulation of vulval development	P	IGI Cel WBGene00001834 IMP Cel WBGene00001834
GO:0040035	hermaphrodite genitalia development	P	IMP Cel WBGene00001834
GO:0042262	DNA protection	P	IMP Cel WBGene00001836
GO:0043066	negative regulation of apoptosis	P	IMP Dme FBgn0025825
GO:0045128	negative regulation of reciprocal meiotic recombination	P	IMP Sce S000005274
GO:0045138	tail tip morphogenesis	P	IMP Cel WBGene00001834
GO:0045449	regulation of transcription	P	IDA Dme FBgn0015805 FBgn0025825
GO:0045595	regulation of cell differentiation	P	IGI Cel WBGene00001834
GO:0045746	negative regulation of Notch signaling pathway	P	IMP Cel WBGene00001834
GO:0045816	negative regulation of transcription from RNA polymerase II promoter, global	P	IGI Sce S000005274 IPI Sce S000005274
GO:0046580	negative regulation of Ras protein signal transduction	P	IGI Cel WBGene00001834
GO:0048477	oogenesis	P	TAS Dme FBgn0015805
GO:0048557	embryonic digestive tract morphogenesis	P	IGI Cel WBGene00001834
GO:0048813	dendrite morphogenesis	P	IMP Dme FBgn0015805
GO:0051038	negative regulation of transcription, meiotic	P	IMP Sce S000005274
GO:0051570	regulation of histone H3-K9 methylation	P	NAS Spo SPBC36.05c
GO:0061186	negative regulation of chromatin silencing at silent mating-type cassette	P	IMP Sce S000005274
GO:0061188	negative regulation of chromatin silencing at rDNA	P	IMP Sce S000005274
GO:0070932	histone H3 deacetylation	P	IMP Sce S000005274
GO:0070933	histone H4 deacetylation	P	IMP Sce S000005274
GO:2000026	regulation of multicellular organismal development	P	IMP Ath At4g38130