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Search term: YNR006W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name VPS27
SGD link S000005289
Alternative ID YNR006W
Description Endosomal protein that forms a complex with Hse1p; required for recycling Golgi proteins, forming lumenal membranes and sorting ubiquitinated proteins destined for degradation; has Ubiquitin Interaction Motifs which bind ubiquitin (Ubi4p)
Synonyms YNR006W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

Search for gene by ID or name:

Query species:

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Search for GO info:  

GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG1818 ACDHYP-

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALINGCELLULAR PROCESSES AND SIGNALING Membrane trafficking and cell signaling protein HRS, contains VHS and FYVE domains

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At1g61690 GI:15220569
Caenorhabditis elegans (Cel) CE06781 GI:17538544
Drosophila melanogaster (Dme) 7295922 GI:7295922
Homo sapiens (Hsa) Hs4758528
(HGS)		 GI:4758528 O14964
Homo sapiens (Hsa) Hs20543659 GI:20543659
Homo sapiens (Hsa) Hs14249574 GI:14249574
Saccharomyces cerevisiae (Sce) YNR006w
(S000005289)		 GI:6324332 P40343
Schizosaccharomyces pombe (Spo) SPAC19A8.05c GI:19114699 O13821


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005628 prospore membrane C
IDA
SpoSPAC19A8.05c
GO:0005634 nucleus C
IDA
SpoSPAC19A8.05c
GO:0005737 cytoplasm C
IDA
HsaHGS
GO:0005768 endosome C
IDA
HsaHGS
SceS000005289
GO:0005769 early endosome C
IDA
HsaHGS
GO:0005829 cytosol C
EXP
HsaHGS
IDA
SpoSPAC19A8.05c
GO:0033565 ESCRT-0 complex C
IPI
SceS000005289
SpoSPAC19A8.05c
GO:0043231 intracellular membrane-bounded
organelle		 C
IDA
HsaHGS
GO:0005515 protein binding F
IPI
HsaHGS
GO:0019904 protein domain specific binding F
IPI
HsaHGS
GO:0032266 phosphatidylinositol-3-phosphate
binding		 F
IDA
SceS000005289
GO:0035091 phosphoinositide binding F
ISS
AthAt1g61690
SpoSPAC19A8.05c
GO:0043130 ubiquitin binding F
IDA
SceS000005289
IMP
SpoSPAC19A8.05c
GO:0006623 protein targeting to vacuole P
IMP
SceS000005289
IPI
SceS000005289
GO:0006897 endocytosis P
IMP
SpoSPAC19A8.05c
GO:0006914 autophagy P
RCA
SceS000005289
GO:0007165 signal transduction P
ISS
AthAt1g61690
TAS
HsaHGS
GO:0008285 negative regulation of cell proliferation P
TAS
HsaHGS
GO:0016197 endosome transport P
NAS
HsaHGS
GO:0031321 ascospore-type prospore formation P
IGI
SpoSPAC19A8.05c
GO:0042176 regulation of protein catabolic
process		 P
TAS
HsaHGS
GO:0043328 protein targeting to vacuole involved in
ubiquitin-dependent protein catabolic process via
the multivesicular body sorting
pathway		 P
IMP
SpoSPAC19A8.05c
GO:0045053 protein retention in Golgi apparatus P
IMP
SceS000005289
ISS
SpoSPAC19A8.05c
GO:0045184 establishment of protein localization P
RCA
SceS000005289
GO:0045324 late endosome to vacuole transport P
IMP
SceS000005289
SpoSPAC19A8.05c
GO:0046426 negative regulation of JAK-STAT
cascade		 P
IDA
HsaHGS

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
37954

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) HGS GI:4758528 O14964
Pan troglodytes (Ptr) HGS GI:114670944
Canis familiaris (Cfa) HGS GI:73964685
Mus musculus (Mmu) Hgs
(MGI:104681)		 GI:31982286 Q3TLL4
Rattus norvegicus (Rno) Hgs
(RGD:69225)		 GI:77539444
Gallus gallus (Gga) HGS GI:118099875
Drosophila melanogaster (Dme) Hrs
(FBgn0031450)		 GI:28574007
Anopheles gambiae (Aga) AgaP_AGAP008887 GI:158299524
Caenorhabditis elegans (Cel) hgrs-1
(CE32574;
WBGene00004101)		 GI:32565930
Schizosaccharomyces pombe (Spo) vps27
(SPAC19A8.05c)		 GI:19114699 O13821
Saccharomyces cerevisiae (Sce) VPS27
(S000005289)		 GI:6324332 P40343
Kluyveromyces lactis (Kla) KLLA0F06446g GI:50310701
Eremothecium gossypii (Ego) AGOS_AFL176C GI:45198345
Magnaporthe grisea (Mgr) MGG_04958 GI:39940564
Neurospora crassa (Ncr) NCU04015.1 GI:32405442


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005628 prospore membrane C
IDA
SpoSPAC19A8.05c
GO:0005634 nucleus C
IDA
SpoSPAC19A8.05c
GO:0005737 cytoplasm C
IDA
HsaHGS
MmuMGI:104681
NAS
DmeFBgn0031450
GO:0005768 endosome C
IDA
HsaHGS
SceS000005289
TAS
DmeFBgn0031450
GO:0005769 early endosome C
IDA
CelWBGene00004101
HsaHGS
NAS
DmeFBgn0031450
GO:0005770 late endosome C
NAS
DmeFBgn0031450
GO:0005829 cytosol C
EXP
HsaHGS
IDA
SpoSPAC19A8.05c
ISO
MmuMGI:104681
GO:0008021 synaptic vesicle C
NAS
DmeFBgn0031450
GO:0010008 endosome membrane C
IDA
CelWBGene00004101
GO:0016020 membrane C
ISO
MmuMGI:104681
GO:0030141 stored secretory granule C
ISO
MmuMGI:104681
GO:0033565 ESCRT-0 complex C
IPI
SceS000005289
SpoSPAC19A8.05c
GO:0043231 intracellular membrane-bounded
organelle		 C
IDA
HsaHGS
GO:0005515 protein binding F
IPI
HsaHGS
NAS
DmeFBgn0031450
GO:0019904 protein domain specific binding F
IPI
HsaHGS
GO:0032266 phosphatidylinositol-3-phosphate
binding		 F
IDA
SceS000005289
ISS
CelWBGene00004101
GO:0035091 phosphoinositide binding F
ISS
SpoSPAC19A8.05c
GO:0043130 ubiquitin binding F
IDA
SceS000005289
IMP
SpoSPAC19A8.05c
GO:0000003 reproduction P
IMP
CelWBGene00004101
GO:0002119 nematode larval development P
IMP
CelWBGene00004101
GO:0006623 protein targeting to vacuole P
IMP
SceS000005289
IPI
SceS000005289
GO:0006887 exocytosis P
TAS
DmeFBgn0031450
GO:0006897 endocytosis P
IMP
DmeFBgn0031450
SpoSPAC19A8.05c
NAS
DmeFBgn0031450
GO:0006914 autophagy P
IMP
CelWBGene00004101
RCA
SceS000005289
GO:0007165 signal transduction P
TAS
HsaHGS
GO:0007269 neurotransmitter secretion P
NAS
DmeFBgn0031450
GO:0007298 border follicle cell migration P
IMP
DmeFBgn0031450
GO:0008285 negative regulation of cell proliferation P
TAS
HsaHGS
GO:0008293 torso signaling pathway P
NAS
DmeFBgn0031450
GO:0008333 endosome to lysosome transport P
TAS
DmeFBgn0031450
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00004101
GO:0010171 body morphogenesis P
IMP
CelWBGene00004101
GO:0016050 vesicle organization P
NAS
DmeFBgn0031450
GO:0016079 synaptic vesicle exocytosis P
ISS
DmeFBgn0031450
GO:0016082 synaptic vesicle priming P
NAS
DmeFBgn0031450
GO:0016197 endosome transport P
NAS
HsaHGS
TAS
DmeFBgn0031450
GO:0018996 molting cycle, collagen and cuticulin-based
cuticle		 P
IMP
CelWBGene00004101
GO:0031321 ascospore-type prospore formation P
IGI
SpoSPAC19A8.05c
GO:0040007 growth P
IMP
CelWBGene00004101
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00004101
GO:0040011 locomotion P
IMP
CelWBGene00004101
GO:0042059 negative regulation of epidermal growth factor
receptor signaling pathway		 P
NAS
DmeFBgn0031450
GO:0042176 regulation of protein catabolic
process		 P
TAS
HsaHGS
GO:0043328 protein targeting to vacuole involved in
ubiquitin-dependent protein catabolic process via
the multivesicular body sorting
pathway		 P
IMP
SpoSPAC19A8.05c
GO:0045053 protein retention in Golgi apparatus P
IMP
SceS000005289
ISS
SpoSPAC19A8.05c
GO:0045184 establishment of protein localization P
RCA
SceS000005289
GO:0045324 late endosome to vacuole transport P
IMP
SceS000005289
SpoSPAC19A8.05c
GO:0046426 negative regulation of JAK-STAT
cascade		 P
IDA
HsaHGS

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_3850

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga10952 ENSANGP00000013939
Ashbya gossypii (Ago) ago3019 AFL176C
Caenorhabditis elegans (Cel) cel1433 C07G1.5
(CE32574;
WBGene00004101)
Candida glabrata (Cgl) cgl2774 CAGL0I05830g
Cryptococcus neoformans (Cne) cne3175 167.m03512
Debaryomyces hansenii (Dha) dha2765 DEHA0D10571g
Drosophila melanogaster (Dme) dme437 CG2903-PA
(FBgn0031450)
Drosophila melanogaster (Dme) dme436 CG2903-PB
(FBgn0031450)
Drosophila melanogaster (Dme) dme435 CG2903-PC
(FBgn0031450)
Danio rerio (Dre) dre31086 ENSDARP00000020905
(zgc:63492)		 Q6PH00
Takifugu rubripes (Fru) fru21773 SINFRUP00000135569
Takifugu rubripes (Fru) fru21774 SINFRUP00000169290
Takifugu rubripes (Fru) fru21775 SINFRUP00000170119
Gallus gallus (Gga) gga16471 ENSGALP00000011677
(HGS)
Gallus gallus (Gga) gga16472 ENSGALP00000011678
Gallus gallus (Gga) gga16473 ENSGALP00000011679
Homo sapiens (Hsa) hsa14516 ENSP00000327871
Homo sapiens (Hsa) hsa14515 ENSP00000331201
(HGS)		 O14964-1
Kluyveromyces lactis (Kla) kla4372 KLLA0F06446g
Mus musculus (Mmu) mmu5316 ENSMUSP00000026900
(MGI:104681)		 B1ATZ1
Neurospora crassa (Ncr) ncr3893 NCU04015.2
Saccharomyces cerevisiae (Sce) sce5473 YNR006W
(S000005289)
Schizosaccharomyces pombe (Spo) spo3601 SPAC19A8.05c O13821
Yarrowia lipolytica (Yli) yli907 YALI0B04070g