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Search term: YNR019W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name ARE2
SGD link S000005302
Alternative ID YNR019W
Description Acyl-CoA:sterol acyltransferase, isozyme of Are1p; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the presence of oxygen
Synonyms YNR019W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG0380 ACDHYPE

KOGs classification KOGs description
METABOLISM Sterol O-acyltransferase/Diacylglycerol O-acyltransferase

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At2g19450 GI:15224779
Caenorhabditis elegans (Cel) CE02943
(WBGene00007174)		 GI:17549960 Q17498
Caenorhabditis elegans (Cel) CE16185
(WBGene00010408)		 GI:17561916
Drosophila melanogaster (Dme) 7298346 GI:7298346
Drosophila melanogaster (Dme) 7298348 GI:7298348
Drosophila melanogaster (Dme) 7299071 GI:7299071
Homo sapiens (Hsa) Hs11415054 GI:11415054
Homo sapiens (Hsa) Hs4507147
(SOAT2)		 GI:4507147 O75908
Homo sapiens (Hsa) Hs6912332 GI:6912332
Homo sapiens (Hsa) Hs14744938 GI:14744938
Saccharomyces cerevisiae (Sce) YCR048w
(S000000644)		 GI:6319896 P25628
Saccharomyces cerevisiae (Sce) YNR019w
(S000005302)		 GI:6324346 P53629
Schizosaccharomyces pombe (Spo) SPAC13G7.05 GI:19114619 Q10269
Schizosaccharomyces pombe (Spo) SPCP1E11.05c GI:19076058 Q9UU82
Encephalitozoon cuniculi (Ecu) ECU10g0300 GI:19074639 Q8SR71
Arabidopsis thaliana (Ath) At2g19450 GI:15224779
Caenorhabditis elegans (Cel) CE02943
(WBGene00007174)		 GI:17549960 Q17498
Caenorhabditis elegans (Cel) CE16185
(WBGene00010408)		 GI:17561916
Drosophila melanogaster (Dme) 7298346 GI:7298346
Drosophila melanogaster (Dme) 7298348 GI:7298348
Drosophila melanogaster (Dme) 7299071 GI:7299071
Homo sapiens (Hsa) Hs11415054 GI:11415054
Homo sapiens (Hsa) Hs4507147
(SOAT2)		 GI:4507147 O75908
Homo sapiens (Hsa) Hs6912332 GI:6912332
Homo sapiens (Hsa) Hs14744938 GI:14744938
Saccharomyces cerevisiae (Sce) YCR048w
(S000000644)		 GI:6319896 P25628
Saccharomyces cerevisiae (Sce) YNR019w
(S000005302)		 GI:6324346 P53629
Schizosaccharomyces pombe (Spo) SPAC13G7.05 GI:19114619 Q10269
Schizosaccharomyces pombe (Spo) SPCP1E11.05c GI:19076058 Q9UU82
Encephalitozoon cuniculi (Ecu) ECU10g0300 GI:19074639 Q8SR71
Arabidopsis thaliana (Ath) At2g19450 GI:15224779
Caenorhabditis elegans (Cel) CE02943
(WBGene00007174)		 GI:17549960 Q17498
Caenorhabditis elegans (Cel) CE16185
(WBGene00010408)		 GI:17561916
Drosophila melanogaster (Dme) 7298346 GI:7298346
Drosophila melanogaster (Dme) 7298348 GI:7298348
Drosophila melanogaster (Dme) 7299071 GI:7299071
Homo sapiens (Hsa) Hs11415054 GI:11415054
Homo sapiens (Hsa) Hs4507147
(SOAT2)		 GI:4507147 O75908
Homo sapiens (Hsa) Hs6912332 GI:6912332
Homo sapiens (Hsa) Hs14744938 GI:14744938
Saccharomyces cerevisiae (Sce) YCR048w
(S000000644)		 GI:6319896 P25628
Saccharomyces cerevisiae (Sce) YNR019w
(S000005302)		 GI:6324346 P53629
Schizosaccharomyces pombe (Spo) SPAC13G7.05 GI:19114619 Q10269
Schizosaccharomyces pombe (Spo) SPCP1E11.05c GI:19076058 Q9UU82
Encephalitozoon cuniculi (Ecu) ECU10g0300 GI:19074639 Q8SR71


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005783 endoplasmic reticulum C
IDA
HsaSOAT2
SceS000000644
S000005302
SpoSPAC13G7.05
ISS
SpoSPCP1E11.05c
SPAC13G7.05
GO:0005789 endoplasmic reticulum membrane C
IDA
HsaSOAT2
GO:0005792 microsome C
IDA
HsaSOAT2
GO:0005903 brush border C
IDA
HsaSOAT2
GO:0009941 chloroplast envelope C
IDA
AthAt2g19450
GO:0016020 membrane C
TAS
AthAt2g19450
GO:0030176 integral to endoplasmic reticulum
membrane		 C
IC
SpoSPAC13G7.05
SPCP1E11.05c
GO:0000062 acyl-CoA binding F
IDA
HsaSOAT2
GO:0004144 diacylglycerol O-acyltransferase
activity		 F
IDA
AthAt2g19450
IMP
AthAt2g19450
ISS
AthAt2g19450
GO:0008415 acyltransferase activity F
TAS
HsaSOAT2
GO:0015485 cholesterol binding F
IDA
HsaSOAT2
GO:0034736 cholesterol O-acyltransferase activity F
IDA
HsaSOAT2
GO:0034737 ergosterol O-acyltransferase activity F
IGI
SceS000000644
S000005302
IMP
SceS000005302
ISS
SpoSPCP1E11.05c
SPAC13G7.05
GO:0034738 lanosterol O-acyltransferase activity F
IGI
SceS000000644
IMP
SceS000000644
GO:0000003 reproduction P
IMP
CelWBGene00007174
GO:0005975 carbohydrate metabolic process P
IMP
AthAt2g19450
GO:0007568 aging P
IEP
AthAt2g19450
GO:0008203 cholesterol metabolic process P
IDA
HsaSOAT2
GO:0008204 ergosterol metabolic process P
IGI
SceS000005302
IMP
SceS000005302
ISS
SpoSPAC13G7.05
SPCP1E11.05c
GO:0008340 determination of adult lifespan P
IMP
CelWBGene00007174
GO:0009409 response to cold P
IMP
AthAt2g19450
GO:0009651 response to salt stress P
IMP
AthAt2g19450
GO:0009737 response to abscisic acid stimulus P
IMP
AthAt2g19450
GO:0009749 response to glucose stimulus P
IMP
AthAt2g19450
GO:0009793 embryo development ending in seed
dormancy		 P
TAS
AthAt2g19450
GO:0010029 regulation of seed germination P
IMP
AthAt2g19450
GO:0010030 positive regulation of seed germination P
IMP
AthAt2g19450
GO:0010742 macrophage derived foam cell differentiation P
TAS
HsaSOAT2
GO:0016125 sterol metabolic process P
IMP
SceS000000644
GO:0019432 triglyceride biosynthetic process P
IMP
AthAt2g19450
TAS
AthAt2g19450
GO:0030299 intestinal cholesterol absorption P
IC
HsaSOAT2
GO:0033344 cholesterol efflux P
IMP
HsaSOAT2
GO:0034379 very-low-density lipoprotein particle
assembly		 P
IMP
HsaSOAT2
GO:0034435 cholesterol esterification P
IDA
HsaSOAT2
GO:0040011 locomotion P
IMP
CelWBGene00007174
GO:0042632 cholesterol homeostasis P
TAS
HsaSOAT2
GO:0045995 regulation of embryonic development P
IMP
AthAt2g19450

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
74804

Species Gene ID NCBI link UniProt link
Schizosaccharomyces pombe (Spo) SPAC13G7.05 GI:19114619 Q10269
Saccharomyces cerevisiae (Sce) ARE2
(S000005302)		 GI:6324346 P53629
Kluyveromyces lactis (Kla) KLLA0C09152g GI:50305295
Eremothecium gossypii (Ego) AGOS_AAR065C GI:45184888


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005783 endoplasmic reticulum C
IDA
SceS000005302
SpoSPAC13G7.05
ISS
SpoSPAC13G7.05
GO:0030176 integral to endoplasmic reticulum
membrane		 C
IC
SpoSPAC13G7.05
GO:0034737 ergosterol O-acyltransferase activity F
IGI
SceS000005302
IMP
SceS000005302
ISS
SpoSPAC13G7.05
GO:0008204 ergosterol metabolic process P
IGI
SceS000005302
IMP
SceS000005302
ISS
SpoSPAC13G7.05

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_1033

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga9765 ENSANGP00000002281
Ashbya gossypii (Ago) ago251 AAR065C
Arabidopsis thaliana (Ath) ath8802 At2g19450.1
Caenorhabditis elegans (Cel) cel11370 H19N07.4
(CE16185;
WBGene00010408)
Candida glabrata (Cgl) cgl547 CAGL0C02981g
Candida glabrata (Cgl) cgl5118 CAGL0M10571g
Cryptococcus neoformans (Cne) cne1129 180.m00055
Dictyostelium discoideum (Ddi) ddi4278 DDB0202877
Debaryomyces hansenii (Dha) dha5531 DEHA0F25652g
Debaryomyces hansenii (Dha) dha5533 DEHA0F25685g
Drosophila melanogaster (Dme) dme2694 CG31991-PA
(FBgn0004797)
Drosophila melanogaster (Dme) dme2695 CG31991-PB
(FBgn0004797)
Drosophila melanogaster (Dme) dme2696 CG31991-PC
(FBgn0004797)
Drosophila melanogaster (Dme) dme2697 CG31991-PD
(FBgn0004797)
Danio rerio (Dre) dre21492 ENSDARP00000030538
Danio rerio (Dre) dre21493 ENSDARP00000042878
Encephalitozoon cuniculi (Ecu) ecu555 19074639
Takifugu rubripes (Fru) fru28460 SINFRUP00000136629
Takifugu rubripes (Fru) fru28461 SINFRUP00000173510
Homo sapiens (Hsa) hsa30888 ENSP00000332258
(DGAT1)		 O75907
Homo sapiens (Hsa) hsa30933 ENSP00000340350
Kluyveromyces lactis (Kla) kla1606 KLLA0C09152g
Mus musculus (Mmu) mmu9191 ENSMUSP00000023214
(MGI:1333825)		 Q9Z2A7
Neurospora crassa (Ncr) ncr34 NCU00035.2
Neurospora crassa (Ncr) ncr4020 NCU04144.2
Neurospora crassa (Ncr) ncr9892 NCU10188.2
Oryza sativa (Osa) osa50350 5907.m00157
Oryza sativa (Osa) osa80690 8105.m00099
Plasmodium falciparum (Pfa) pfa2873 PFC0995c
Rattus norvegicus (Rno) rno27296 ENSRNOP00000035110
(RGD:628673)		 Q8BHI5
Saccharomyces cerevisiae (Sce) sce709 YCR048W
(S000000644)
Saccharomyces cerevisiae (Sce) sce5486 YNR019W
(S000005302)
Schizosaccharomyces pombe (Spo) spo719 SPAC13G7.05 Q10269
Schizosaccharomyces pombe (Spo) spo1334 SPCP1E11.05c Q9UU82
Yarrowia lipolytica (Yli) yli3041 YALI0D07986g
Yarrowia lipolytica (Yli) yli5622 YALI0F06578g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005624 membrane fraction C
IDA
MmuMGI:1333825
GO:0005783 endoplasmic reticulum C
IDA
SceS000000644
S000005302
SpoSPAC13G7.05
ISS
SpoSPCP1E11.05c
SPAC13G7.05
GO:0005792 microsome C
ISO
MmuMGI:1333825
GO:0009941 chloroplast envelope C
IDA
AthAt2g19450
GO:0016020 membrane C
TAS
AthAt2g19450
GO:0030176 integral to endoplasmic reticulum
membrane		 C
IC
SpoSPAC13G7.05
SPCP1E11.05c
GO:0003846 2-acylglycerol O-acyltransferase
activity		 F
IDA
MmuMGI:1333825
GO:0004144 diacylglycerol O-acyltransferase
activity		 F
IDA
AthAt2g19450
DmeFBgn0004797
IMP
AthAt2g19450
ISO
MmuMGI:1333825
ISS
AthAt2g19450
DmeFBgn0004797
PfaPFC0995c
NAS
DmeFBgn0004797
GO:0004772 sterol O-acyltransferase activity F
ISS
DmeFBgn0004797
GO:0005504 fatty acid binding F
ISO
MmuMGI:1333825
GO:0019992 diacylglycerol binding F
ISO
MmuMGI:1333825
GO:0034737 ergosterol O-acyltransferase activity F
IGI
SceS000000644
S000005302
IMP
SceS000005302
ISS
SpoSPCP1E11.05c
SPAC13G7.05
GO:0034738 lanosterol O-acyltransferase activity F
IGI
SceS000000644
IMP
SceS000000644
GO:0005975 carbohydrate metabolic process P
IMP
AthAt2g19450
GO:0007568 aging P
IEP
AthAt2g19450
GO:0008152 metabolic process P
IDA
MmuMGI:1333825
GO:0008204 ergosterol metabolic process P
IGI
SceS000005302
IMP
SceS000005302
ISS
SpoSPAC13G7.05
SPCP1E11.05c
GO:0009409 response to cold P
IMP
AthAt2g19450
GO:0009651 response to salt stress P
IMP
AthAt2g19450
GO:0009737 response to abscisic acid stimulus P
IMP
AthAt2g19450
GO:0009749 response to glucose stimulus P
IMP
AthAt2g19450
GO:0009793 embryo development ending in seed
dormancy		 P
TAS
AthAt2g19450
GO:0010029 regulation of seed germination P
IMP
AthAt2g19450
GO:0010030 positive regulation of seed germination P
IMP
AthAt2g19450
GO:0010888 negative regulation of lipid storage P
IDA
DmeFBgn0004797
GO:0016125 sterol metabolic process P
IMP
SceS000000644
GO:0019432 triglyceride biosynthetic process P
IMP
AthAt2g19450
ISO
MmuMGI:1333825
ISS
DmeFBgn0004797
PfaPFC0995c
TAS
AthAt2g19450
GO:0030073 insulin secretion P
ISO
MmuMGI:1333825
GO:0045477 regulation of nurse cell apoptosis P
IMP
DmeFBgn0004797
GO:0045995 regulation of embryonic development P
IMP
AthAt2g19450
GO:0046486 glycerolipid metabolic process P
ISO
MmuMGI:1333825
GO:0048477 oogenesis P
IMP
DmeFBgn0004797

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPCP1E11.05c
(Q9UU82)		 YNR019W
(S000005302)
SPAC13G7.05
(Q10269)		 YNR019W
(S000005302)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005783 endoplasmic reticulum C
IDA
SceS000005302
SpoSPAC13G7.05
ISS
SpoSPCP1E11.05c
SPAC13G7.05
GO:0030176 integral to endoplasmic reticulum
membrane		 C
IC
SpoSPAC13G7.05
SPCP1E11.05c
GO:0034737 ergosterol O-acyltransferase activity F
IGI
SceS000005302
IMP
SceS000005302
ISS
SpoSPCP1E11.05c
SPAC13G7.05
GO:0008204 ergosterol metabolic process P
IGI
SceS000005302
IMP
SceS000005302
ISS
SpoSPAC13G7.05
SPCP1E11.05c

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