Bahler Lab

Search term: YNR055C

Gene summary:

Species Saccharomyces cerevisiae (Sce)

Primary name HOL1

SGD link S000005338

Alternative ID YNR055C

Description Putative transporter in the major facilitator superfamily (DHA1 family) of multidrug resistance transporters; mutations in membrane-spanning domains permit cation and histidinol uptake

Synonyms YNR055C

Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

Search for gene by ID or name:

Query species:

Include wild-cards: Yes No

Search for GO info: Yes No

GO info in one table: Yes No

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)

KOG0255 ACDHYP-

KOGs classification KOGs description

POORLY CHARACTERIZED Synaptic vesicle transporter SVOP and related transporters (major facilitator superfamily)

GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations

GO:0005624 membrane fraction C
IDA
Sce S000006360
TAS
Hsa SLC22A3
SLC22A1
SLC22A2

GO:0005628 prospore membrane C
IDA
Sce S000000384

GO:0005737 cytoplasm C
IDA
Spo SPAPB1A11.01
SPCC576.17c

GO:0005739 mitochondrion C
IDA
Sce S000005338

GO:0005774 vacuolar membrane C
IMP
Sce S000003370
S000006360
S000003951
S000005799

GO:0005783 endoplasmic reticulum C
IDA
Spo SPAC11D3.05
SPAC17C9.16c
SPBC36.02c
SPBC36.03c
SPCC1529.01
SPCC569.05c
SPCC965.13

GO:0005794 Golgi apparatus C
IDA
Spo SPAC750.02c
SPCC569.05c
SPBC609.04
SPCC965.13

GO:0005886 plasma membrane C
EXP
Hsa SLC22A2
IC
Hsa SLC22A5
IDA
Ath At1g73220
Hsa SLC22A2
Sce S000000212
S000000247
S000001382
S000003370
S000005009
S000003951
S000005799
S000006360
IMP
Sce S000003951
ISS
Sce S000005338
Spo SPBC36.01c
SPAC17C9.16c
SPAC11D3.05
SPAC750.02c
SPAPB1A11.01
SPBC530.02
SPBC36.02c
SPBC409.08
SPBC36.03c
SPBC530.15c
SPBC609.04
SPBC947.06c
SPBPB2B2.16c
SPCC1529.01
SPCC576.17c
SPCC569.05c
SPCC794.04c
SPCC965.13

GO:0005887 integral to plasma membrane C
IDA
Hsa SLC22A11
Sce S000001383
ISS
Spo SPCC576.17c
SPCC965.13
TAS
Hsa SLC22A3
SLC22A1
SLC22A2

GO:0005938 cell cortex C
IDA
Spo SPBC1271.10c

GO:0009535 chloroplast thylakoid membrane C
IDA
Ath At3g20660

GO:0009897 external side of plasma membrane C
IDA
Hsa SLC22A11

GO:0016020 membrane C
ISS
Ath At1g79360
At1g79410
At1g73220
At1g16390
At3g20660
At1g16370

GO:0016021 integral to membrane C
ISS
Sce S000001090

GO:0016324 apical plasma membrane C
IDA
Hsa SLC22A11
SLC22A5

GO:0031526 brush border membrane C
IDA
Hsa SLC22A5
ISS
Hsa SLC22A5

GO:0032153 cell division site C
IDA
Spo SPCC965.13

GO:0033101 cellular bud membrane C
IDA
Sce S000003951

GO:0051286 cell tip C
IDA
Spo SPCC965.13

GO:0000297 spermine transmembrane transporter
activity F
IDA
Sce S000003951
IMP
Sce S000003370
S000005799
S000003951
S000006360
ISS
Spo SPAC17C9.16c
SPBC36.01c
SPBC36.02c
SPBC36.03c
SPBC409.08
SPBC609.04
SPBC530.15c
SPBC947.06c
SPCC569.05c

GO:0005215 transporter activity F
ISS
Ath At1g73220

GO:0005275 amine transmembrane transporter
activity F
IMP
Sce S000000384

GO:0005326 neurotransmitter transporter activity F
EXP
Hsa SLC22A2

GO:0005351 sugar:hydrogen symporter activity F
ISS
Ath At1g79360
At1g16390
At1g16370
At3g20660
At1g79410

GO:0005452 inorganic anion exchanger activity F
IDA
Hsa SLC22A11

GO:0005515 protein binding F
IPI
Hsa SLC22A3
SLC22A11
SLC22A1
SLC22A5

GO:0008028 monocarboxylic acid transmembrane transporter
activity F
IMP
Sce S000005009

GO:0008513 secondary active organic cation transmembrane
transporter activity F
ISS
Dme FBgn0032879
FBgn0034479

GO:0008514 organic anion transmembrane transporter
activity F
IDA
Hsa SLC22A11

GO:0015101 organic cation transmembrane transporter
activity F
IDA
Hsa SLC22A3
SLC22A2
TAS
Hsa SLC22A1

GO:0015144 carbohydrate transmembrane transporter
activity F
ISS
Ath At1g79360
At1g79410
At3g20660
At1g16370
At1g16390
At1g73220

GO:0015171 amino acid transmembrane transporter
activity F
ISS
Spo SPCC794.04c

GO:0015226 carnitine transporter activity F
IDA
Ath At1g73220
Hsa SLC22A5
IMP
Hsa SLC22A5

GO:0015238 drug transmembrane transporter
activity F
IC
Hsa SLC22A5
IEP
Sce S000001090
IMP
Sce S000000247
S000001382
S000001383
S000005009
ISS
Sce S000000212
RCA
Sce S000003951
S000005799

GO:0015244 fluconazole transporter activity F
ISS
Sce S000000212

GO:0015347 sodium-independent organic anion transmembrane
transporter activity F
IDA
Hsa SLC22A11

GO:0015606 spermidine transmembrane transporter
activity F
IDA
Sce S000003951
IMP
Sce S000003951
S000005799
ISS
Spo SPBC36.01c
SPBC36.02c
SPBC36.03c
SPBC530.15c
SPBC947.06c
SPCC569.05c

GO:0015651 quaternary ammonium group transmembrane
transporter activity F
IDA
Hsa SLC22A5
SLC22A3

GO:0015665 alcohol transmembrane transporter
activity F
IMP
Sce S000005338

GO:0022857 transmembrane transporter activity F
ISS
Spo SPAC11D3.05
SPAC750.02c
SPBC1271.10c
SPAPB1A11.01
SPBC409.08
SPBC530.02
SPBPB2B2.16c
SPCC1529.01

GO:0022890 inorganic cation transmembrane transporter
activity F
IMP
Sce S000005338

GO:0022891 substrate-specific transmembrane transporter
activity F
RCA
Sce S000001383

GO:0030165 PDZ domain binding F
IPI
Hsa SLC22A5

GO:0031925 pyridoxal transmembrane transporter
activity F
ISS
Spo SPCC576.17c
SPCC965.13

GO:0031927 pyridoxamine transmembrane transporter
activity F
ISS
Spo SPCC576.17c
SPCC965.13

GO:0031928 pyridoxine transmembrane transporter
activity F
ISS
Spo SPCC576.17c
SPCC965.13

GO:0000296 spermine transport P
IC
Spo SPBC36.01c
SPBC36.02c
SPBC530.15c
SPBC36.03c
SPBC947.06c
SPCC569.05c
IDA
Sce S000003951
IMP
Sce S000003370
S000003951
S000005799
S000006360
ISS
Spo SPAC17C9.16c
SPBC409.08
SPBC609.04

GO:0002119 nematode larval development P
IMP
Cel WBGene00022348
WBGene00020340

GO:0003333 amino acid transmembrane transport P
ISS
Spo SPCC794.04c

GO:0006414 translational elongation P
RCA
Sce S000003370
S000001383
S000003951
S000005009
S000006360

GO:0006810 transport P
ISS
Spo SPBC1271.10c
SPBC409.08
SPBPB2B2.16c
SPCC1529.01

GO:0006812 cation transport P
IMP
Sce S000005338

GO:0006855 drug transmembrane transport P
IGI
Sce S000000212
IMP
Sce S000000212
S000000247
S000001382
S000001383
S000005009

GO:0007589 body fluid secretion P
TAS
Hsa SLC22A2

GO:0009792 embryo development ending in birth or egg
hatching P
IMP
Cel WBGene00020340
WBGene00022348

GO:0010107 potassium ion import P
IGI
Sce S000001383
IMP
Sce S000001383

GO:0015695 organic cation transport P
IDA
Hsa SLC22A3
SLC22A2
TAS
Hsa SLC22A1

GO:0015697 quaternary ammonium group transport P
IDA
Hsa SLC22A3
SLC22A5

GO:0015711 organic anion transport P
IDA
Hsa SLC22A11

GO:0015718 monocarboxylic acid transport P
IMP
Sce S000005009

GO:0015837 amine transport P
IMP
Sce S000000384

GO:0015846 polyamine transport P
ISS
Spo SPAC17C9.16c
SPBC36.01c
SPBC36.02c
SPBC36.03c
SPBC409.08
SPBC530.15c
SPBC947.06c
SPBC609.04

GO:0015847 putrescine transport P
IMP
Sce S000003951

GO:0015848 spermidine transport P
IC
Spo SPBC36.01c
SPBC36.02c
SPBC36.03c
SPBC530.15c
SPBC947.06c
SPCC569.05c
IDA
Sce S000003951
IMP
Sce S000003951
S000005799

GO:0015849 organic acid transport P
RCA
Sce S000000212
S000005009

GO:0015850 organic alcohol transport P
IMP
Sce S000005338

GO:0015879 carnitine transport P
IDA
Hsa SLC22A5
IMP
Hsa SLC22A5

GO:0015893 drug transport P
IC
Hsa SLC22A5
IEP
Sce S000001090
RCA
Sce S000000212
S000005009

GO:0030476 ascospore wall assembly P
IMP
Sce S000000384

GO:0031920 pyridoxal transport P
ISS
Spo SPCC576.17c
SPCC965.13

GO:0031922 pyridoxamine transport P
ISS
Spo SPCC576.17c
SPCC965.13

GO:0031923 pyridoxine transport P
ISS
Spo SPCC576.17c
SPCC965.13

GO:0032973 amino acid export P
IGI
Sce S000005009
IMP
Sce S000005009

GO:0033554 cellular response to stress P
IEP
Spo SPAC11D3.05
SPBC36.02c
SPCC569.05c
SPCC576.17c

GO:0040007 growth P
IMP
Cel WBGene00022348
WBGene00020340

GO:0040010 positive regulation of growth rate P
IMP
Cel WBGene00020340

GO:0040039 inductive cell migration P
IMP
Cel WBGene00008271

GO:0052106 quorum sensing involved in interaction with
host P
IMP
Hsa SLC22A5

GO:0055085 transmembrane transport P
IMP
Sce S000000247
S000000384
ISS
Sce S000000212
Spo SPAC11D3.05
SPAC750.02c
SPAPB1A11.01
SPBC530.02

GO:0060731 positive regulation of intestinal epithelial
structure maintenance P
IMP
Hsa SLC22A5

GO:0070715 sodium-dependent organic cation
transport P
IDA
Hsa SLC22A5

GO:0071313 cellular response to caffeine P
IMP
Spo SPBC609.04

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern

56308

Species Gene ID NCBI link UniProt link

Schizosaccharomyces pombe (Spo) SPBC1271.10c GI:19111932 O94343

Saccharomyces cerevisiae (Sce) HOL1
(S000005338) GI:6324383 P53389

Kluyveromyces lactis (Kla) KLLA0E09614g GI:50308761

Eremothecium gossypii (Ego) AGOS_ADR336C GI:45188209

GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations

GO:0005739 mitochondrion C
IDA
Sce S000005338

GO:0005886 plasma membrane C
ISS
Sce S000005338

GO:0005938 cell cortex C
IDA
Spo SPBC1271.10c

GO:0015665 alcohol transmembrane transporter
activity F
IMP
Sce S000005338

GO:0022857 transmembrane transporter activity F
ISS
Spo SPBC1271.10c

GO:0022890 inorganic cation transmembrane transporter
activity F
IMP
Sce S000005338

GO:0006810 transport P
ISS
Spo SPBC1271.10c

GO:0006812 cation transport P
IMP
Sce S000005338

GO:0015850 organic alcohol transport P
IMP
Sce S000005338

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern

OG1_15261

Species OrthoMCL
sequence Model organism
protein page UniProt link

Ashbya gossypii (Ago) ago2077 ADR336C

Ashbya gossypii (Ago) ago2078 ADR337C

Debaryomyces hansenii (Dha) dha1215 DEHA0B12386g

Kluyveromyces lactis (Kla) kla3384 KLLA0E09614g

Neurospora crassa (Ncr) ncr7752 NCU07960.2

Saccharomyces cerevisiae (Sce) sce5524 YNR055C
(S000005338)

Schizosaccharomyces pombe (Spo) spo3269 SPBC1271.10c O94343

Yarrowia lipolytica (Yli) yli3739 YALI0D24651g

GO terms for OrthoMCL results:

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Curated yeast ortholog results:

S. pombe
systematic ID S. cerevisiae
systematic ID

SPBC1271.10c
(O94343) YNR055C
(S000005338)

GO terms for curated homolog results:

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YOGY Home

YOGY Help

Search for gene by ID or name:

Query species:

Include wild-cards: Yes No

Search for GO info: Yes No

GO info in one table: Yes No

s.khadayate@ucl.ac.uk

KOG name	Phylogenetic pattern (and link to KOGs with this pattern)
KOG0255	ACDHYP-

KOGs classification	KOGs description
POORLY CHARACTERIZED	Synaptic vesicle transporter SVOP and related transporters (major facilitator superfamily)

Species	Gene ID	NCBI link	UniProt link
Schizosaccharomyces pombe (Spo)	SPBC1271.10c	GI:19111932	O94343
Saccharomyces cerevisiae (Sce)	HOL1 (S000005338)	GI:6324383	P53389
Kluyveromyces lactis (Kla)	KLLA0E09614g	GI:50308761
Eremothecium gossypii (Ego)	AGOS_ADR336C	GI:45188209

Species	OrthoMCL sequence	Model organism protein page	UniProt link
Ashbya gossypii (Ago)	ago2077	ADR336C
Ashbya gossypii (Ago)	ago2078	ADR337C
Debaryomyces hansenii (Dha)	dha1215	DEHA0B12386g
Kluyveromyces lactis (Kla)	kla3384	KLLA0E09614g
Neurospora crassa (Ncr)	ncr7752	NCU07960.2
Saccharomyces cerevisiae (Sce)	sce5524	YNR055C (S000005338)
Schizosaccharomyces pombe (Spo)	spo3269	SPBC1271.10c	O94343
Yarrowia lipolytica (Yli)	yli3739	YALI0D24651g

S. pombe systematic ID	S. cerevisiae systematic ID
SPBC1271.10c (O94343)	YNR055C (S000005338)