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Search term: YNR074C


Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name AIF1
SGD link S000005357
Alternative ID YNR074C
Description Mitochondrial cell death effector that translocates to the nucleus in response to apoptotic stimuli, homolog of mammalian Apoptosis-Inducing Factor, putative reductase
Synonyms YNR074C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:


KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG1336 ACDHYP-

KOGs classification KOGs description
POORLY CHARACTERIZED Monodehydroascorbate/ferredoxin reductase

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At1g63940 GI:12325013
Arabidopsis thaliana (Ath) At3g09940 GI:18398691
Arabidopsis thaliana (Ath) At3g27820 GI:15232273
Arabidopsis thaliana (Ath) At3g52880 GI:15231702
Arabidopsis thaliana (Ath) At5g03630 GI:11280104
Caenorhabditis elegans (Cel) CE27373
(WBGene00017640)
GI:17559934 Q19655
Drosophila melanogaster (Dme) 7290253 GI:7290253
Drosophila melanogaster (Dme) 7298536 GI:7298536 Q9VJ03
Homo sapiens (Hsa) Hs21389617 GI:18593768
Homo sapiens (Hsa) Hs14318424
(AIFM2)
GI:14318424 Q9BRQ8
Saccharomyces cerevisiae (Sce) YNR074c
(S000005357)
GI:6324402 P52923
Schizosaccharomyces pombe (Spo) SPAC26F1.14c GI:19115793 Q10499


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SceS000005357
ISS
SpoSPAC26F1.14c
GO:0005737 cytoplasm C
IDA
HsaAIFM2
GO:0005739 mitochondrion C
IDA
AthAt1g63940
HsaAIFM2
SceS000005357
ISS
SpoSPAC26F1.14c
GO:0005741 mitochondrial outer membrane C
IDA
HsaAIFM2
GO:0005777 peroxisome C
IDA
AthAt3g52880
GO:0005778 peroxisomal membrane C
IDA
AthAt3g27820
GO:0005782 peroxisomal matrix C
IDA
AthAt3g52880
GO:0005829 cytosol C
IDA
AthAt3g09940
At5g03630
HsaAIFM2
SpoSPAC26F1.14c
GO:0005886 plasma membrane C
IDA
AthAt3g52880
ISS
SceS000005357
GO:0009507 chloroplast C
IDA
AthAt1g63940
At3g52880
GO:0009570 chloroplast stroma C
IDA
AthAt1g63940
GO:0009941 chloroplast envelope C
IDA
AthAt3g27820
GO:0010319 stromule C
IDA
AthAt1g63940
GO:0048046 apoplast C
IDA
AthAt3g52880
GO:0003677 DNA binding F
IDA
HsaAIFM2
GO:0004174 electron-transferring-flavoprotein dehydrogenase
activity
F
IDA
HsaAIFM2
GO:0005524 ATP binding F
IDA
AthAt1g63940
GO:0016656 monodehydroascorbate reductase (NADH)
activity
F
IDA
AthAt3g52880
At3g27820
IMP
AthAt3g27820
ISS
AthAt3g09940
At5g03630
GO:0016668 oxidoreductase activity, acting on sulfur group of
donors, NAD or NADP as acceptor
F
ISS
SceS000005357
SpoSPAC26F1.14c
GO:0050660 FAD binding F
IDA
HsaAIFM2
GO:0000304 response to singlet oxygen P
IMP
SceS000005357
ISS
SpoSPAC26F1.14c
GO:0006917 induction of apoptosis P
IDA
HsaAIFM2
IMP
HsaAIFM2
GO:0008637 apoptotic mitochondrial changes P
NAS
HsaAIFM2
GO:0009409 response to cold P
IEP
AthAt1g63940
GO:0009414 response to water deprivation P
IEP
AthAt3g09940
GO:0009610 response to symbiotic fungus P
IEP
AthAt3g09940
GO:0009651 response to salt stress P
IEP
AthAt3g09940
At5g03630
GO:0009753 response to jasmonic acid stimulus P
IEP
AthAt3g09940
GO:0010043 response to zinc ion P
IEP
AthAt5g03630
GO:0030261 chromosome condensation P
IDA
HsaAIFM2
GO:0033554 cellular response to stress P
IEP
SpoSPAC26F1.14c
GO:0042744 hydrogen peroxide catabolic process P
IMP
AthAt3g27820
TAS
AthAt3g27820
At3g52880
GO:0043065 positive regulation of apoptosis P
IMP
SceS000005357
GO:0043903 regulation of symbiosis, encompassing mutualism
through parasitism
P
IMP
AthAt3g09940
GO:0046686 response to cadmium ion P
IEP
AthAt5g03630
At3g52880
At1g63940

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_2874

Species OrthoMCL
sequence
Model organism
protein page
UniProt link
Arabidopsis thaliana (Ath) ath15687 At3g44190.1
Arabidopsis thaliana (Ath) ath24442 At5g22140.1
Arabidopsis thaliana (Ath) ath24443 At5g22140.2
Cryptococcus neoformans (Cne) cne167 162.m02606
Cryptococcus neoformans (Cne) cne5535 179.m00390
Dictyostelium discoideum (Ddi) ddi8430 DDB0186313
Dictyostelium discoideum (Ddi) ddi8431 DDB0186314
Dictyostelium discoideum (Ddi) ddi7131 DDB0186878
Debaryomyces hansenii (Dha) dha1247 DEHA0B13090g
Debaryomyces hansenii (Dha) dha1248 DEHA0B13112g
Danio rerio (Dre) dre28304 ENSDARP00000008623
Takifugu rubripes (Fru) fru24029 SINFRUP00000158126
Gallus gallus (Gga) gga20411 ENSGALP00000007614
(AIFM2)
Homo sapiens (Hsa) hsa4040 ENSP00000312370
(AIFM2)
Q9BRQ8-1
Homo sapiens (Hsa) hsa4039 ENSP00000346616
Mus musculus (Mmu) mmu2226 ENSMUSP00000070054
(MGI:1918611)
Q8BUE4-1
Neurospora crassa (Ncr) ncr9052 NCU09286.2
Oryza sativa (Osa) osa23822 3779.m00102
Oryza sativa (Osa) osa40615 5021.m00130
Rattus norvegicus (Rno) rno17898 ENSRNOP00000033692
(RGD:1304964)
Saccharomyces cerevisiae (Sce) sce5543 YNR074C
(S000005357)


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SceS000005357
GO:0005737 cytoplasm C
ISO
MmuMGI:1918611
GO:0005739 mitochondrion C
IDA
MmuMGI:1918611
SceS000005357
ISO
MmuMGI:1918611
GO:0005886 plasma membrane C
IDA
AthAt5g22140
ISS
SceS000005357
GO:0003674 molecular_function F
ND
MmuMGI:1918611
GO:0009055 electron carrier activity F
ISS
AthAt3g44190
At5g22140
GO:0016668 oxidoreductase activity, acting on sulfur group of
donors, NAD or NADP as acceptor
F
ISS
SceS000005357
GO:0000304 response to singlet oxygen P
IMP
SceS000005357
GO:0006917 induction of apoptosis P
ISO
MmuMGI:1918611
GO:0043065 positive regulation of apoptosis P
IMP
SceS000005357

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Curated yeast ortholog results:

S. pombe
systematic ID
S. cerevisiae
systematic ID
SPAC26F1.14c
(Q10499)
YNR074C
(S000005357)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SceS000005357
ISS
SpoSPAC26F1.14c
GO:0005739 mitochondrion C
IDA
SceS000005357
ISS
SpoSPAC26F1.14c
GO:0005829 cytosol C
IDA
SpoSPAC26F1.14c
GO:0005886 plasma membrane C
ISS
SceS000005357
GO:0016668 oxidoreductase activity, acting on sulfur group of
donors, NAD or NADP as acceptor
F
ISS
SceS000005357
SpoSPAC26F1.14c
GO:0000304 response to singlet oxygen P
IMP
SceS000005357
ISS
SpoSPAC26F1.14c
GO:0033554 cellular response to stress P
IEP
SpoSPAC26F1.14c
GO:0043065 positive regulation of apoptosis P
IMP
SceS000005357

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s.khadayate@ucl.ac.uk