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Search term: YOL013C

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name HRD1
SGD link S000005373
Alternative ID YOL013C
Description Ubiquitin-protein ligase required for endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger
Synonyms YOL013C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG0802 ACDHYPE

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALING E3 ubiquitin ligase

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At1g65040 GI:15217834
Arabidopsis thaliana (Ath) At3g16090 GI:15233281
Arabidopsis thaliana (Ath) At4g05350 GI:15234736
Arabidopsis thaliana (Ath) At4g12140 GI:15234446
Arabidopsis thaliana (Ath) At4g12150 GI:15234449
Arabidopsis thaliana (Ath) At4g12190 GI:15234472
Arabidopsis thaliana (Ath) At4g12210 GI:15234479
Arabidopsis thaliana (Ath) At4g25230 GI:15234976
Arabidopsis thaliana (Ath) At5g05910 GI:15239289
Arabidopsis thaliana (Ath) At5g51450 GI:9759291
Caenorhabditis elegans (Cel) CE04781_1 GI:17569179 Q21641
Caenorhabditis elegans (Cel) CE05945
(WBGene00010076)		 GI:17561408 Q20798
Caenorhabditis elegans (Cel) CE09695
(WBGene00009164)		 GI:17506885 P90859
Caenorhabditis elegans (Cel) CE27234
(WBGene00022471)		 GI:17510953 Q95Y82
Drosophila melanogaster (Dme) 7301102_2 GI:7301102
Drosophila melanogaster (Dme) 7301789 GI:7301789 A4V3L3
Drosophila melanogaster (Dme) 7302095 GI:7302095
Homo sapiens (Hsa) Hs21071001
(AMFR)		 GI:21071001 P26442
Homo sapiens (Hsa) Hs21071003 GI:21071003
Homo sapiens (Hsa) Hs21314654 GI:18204312 Q8WU17
Homo sapiens (Hsa) Hs21389515 GI:20545880
Homo sapiens (Hsa) Hs22062486 GI:20988872 Q8TEH6
Homo sapiens (Hsa) Hs8922675
(CHFR)		 GI:8922675
Homo sapiens (Hsa) HsM6005912 GI:6005912
Saccharomyces cerevisiae (Sce) YDR143c
(S000002550)		 GI:6320347 P22470
Saccharomyces cerevisiae (Sce) YOL013c
(S000005373)		 GI:6324561 Q08109
Schizosaccharomyces pombe (Spo) SPBC17D11.02c GI:19113168 O74757
Encephalitozoon cuniculi (Ecu) ECU01g0750 GI:19075085
Encephalitozoon cuniculi (Ecu) ECU11g1000 GI:19074900 Q8SU44
Arabidopsis thaliana (Ath) At1g65040 GI:15217834
Arabidopsis thaliana (Ath) At3g16090 GI:15233281
Arabidopsis thaliana (Ath) At4g05350 GI:15234736
Arabidopsis thaliana (Ath) At4g12140 GI:15234446
Arabidopsis thaliana (Ath) At4g12150 GI:15234449
Arabidopsis thaliana (Ath) At4g12190 GI:15234472
Arabidopsis thaliana (Ath) At4g12210 GI:15234479
Arabidopsis thaliana (Ath) At4g25230 GI:15234976
Arabidopsis thaliana (Ath) At5g05910 GI:15239289
Arabidopsis thaliana (Ath) At5g51450 GI:9759291
Caenorhabditis elegans (Cel) CE04781_1 GI:17569179 Q21641
Caenorhabditis elegans (Cel) CE05945
(WBGene00010076)		 GI:17561408 Q20798
Caenorhabditis elegans (Cel) CE09695
(WBGene00009164)		 GI:17506885 P90859
Caenorhabditis elegans (Cel) CE27234
(WBGene00022471)		 GI:17510953 Q95Y82
Drosophila melanogaster (Dme) 7301102_2 GI:7301102
Drosophila melanogaster (Dme) 7301789 GI:7301789 A4V3L3
Drosophila melanogaster (Dme) 7302095 GI:7302095
Homo sapiens (Hsa) Hs21071001
(AMFR)		 GI:21071001 P26442
Homo sapiens (Hsa) Hs21071003 GI:21071003
Homo sapiens (Hsa) Hs21314654 GI:18204312 Q8WU17
Homo sapiens (Hsa) Hs21389515 GI:20545880
Homo sapiens (Hsa) Hs22062486 GI:20988872 Q8TEH6
Homo sapiens (Hsa) Hs8922675
(CHFR)		 GI:8922675
Homo sapiens (Hsa) HsM6005912 GI:6005912
Saccharomyces cerevisiae (Sce) YDR143c
(S000002550)		 GI:6320347 P22470
Saccharomyces cerevisiae (Sce) YOL013c
(S000005373)		 GI:6324561 Q08109
Schizosaccharomyces pombe (Spo) SPBC17D11.02c GI:19113168 O74757
Encephalitozoon cuniculi (Ecu) ECU01g0750 GI:19075085
Encephalitozoon cuniculi (Ecu) ECU11g1000 GI:19074900 Q8SU44


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000299 integral to membrane of membrane
fraction		 C
IDA
HsaAMFR
GO:0000838 Hrd1p ubiquitin ligase ERAD-M complex C
IDA
SceS000005373
GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex C
IDA
SceS000005373
GO:0005634 nucleus C
IDA
HsaCHFR
SceS000002550
GO:0005737 cytoplasm C
IMP
SceS000002550
GO:0005789 endoplasmic reticulum membrane C
IDA
SceS000005373
ISS
SpoSPBC17D11.02c
GO:0005886 plasma membrane C
IDA
AthAt4g25230
At1g65040
GO:0005938 cell cortex C
IDA
SpoSPBC17D11.02c
GO:0016021 integral to membrane C
NAS
HsaAMFR
GO:0016605 PML body C
IDA
HsaCHFR
GO:0030176 integral to endoplasmic reticulum
membrane		 C
IDA
HsaAMFR
GO:0000166 nucleotide binding F
IDA
HsaCHFR
GO:0004842 ubiquitin-protein ligase activity F
IDA
AthAt5g51450
At4g25230
HsaAMFR
CHFR
SceS000002550
S000005373
IGI
SceS000005373
IMP
HsaAMFR
SceS000005373
IPI
SceS000005373
ISS
AthAt4g25230
At5g51450
SpoSPBC17D11.02c
GO:0004872 receptor activity F
IPI
HsaAMFR
GO:0005515 protein binding F
IPI
AthAt5g51450
At4g25230
HsaAMFR
CHFR
SpoSPBC17D11.02c
ISS
AthAt4g05350
At4g12210
At4g12140
At4g25230
At5g05910
At5g51450
At3g16090
At1g65040
At4g12190
At4g12150
GO:0008270 zinc ion binding F
ISS
AthAt1g65040
At4g12190
At4g12150
At4g12210
At4g12140
At5g05910
At4g05350
At4g25230
At5g51450
At3g16090
SpoSPBC17D11.02c
GO:0000209 protein polyubiquitination P
IDA
HsaCHFR
AMFR
GO:0006511 ubiquitin-dependent protein catabolic
process		 P
IMP
HsaAMFR
GO:0006915 apoptosis P
IMP
CelWBGene00009164
GO:0006928 cellular component movement P
TAS
HsaAMFR
GO:0006950 response to stress P
IMP
SceS000002550
GO:0007093 mitotic cell cycle checkpoint P
IMP
HsaCHFR
TAS
HsaCHFR
GO:0007165 signal transduction P
TAS
HsaAMFR
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00009164
GO:0010620 negative regulation of transcription by
transcription factor catabolism		 P
IMP
SpoSPBC17D11.02c
GO:0016567 protein ubiquitination P
ISS
SpoSPBC17D11.02c
GO:0019941 modification-dependent protein catabolic
process		 P
IDA
HsaCHFR
GO:0030433 ER-associated protein catabolic
process		 P
IDA
HsaAMFR
IMP
HsaAMFR
SceS000005373
SpoSPBC17D11.02c
IPI
SceS000005373
GO:0030968 endoplasmic reticulum unfolded protein
response		 P
IMP
HsaAMFR
GO:0031505 fungal-type cell wall organization P
IGI
SceS000005373
GO:0034052 positive regulation of plant-type hypersensitive
response		 P
IGI
AthAt5g51450
At4g25230
GO:0035264 multicellular organism growth P
IGI
CelWBGene00009164
GO:0042787 protein ubiquitination involved in
ubiquitin-dependent protein catabolic
process		 P
IDA
SceS000002550
IMP
SceS000002550
GO:0051049 regulation of transport P
RCA
SceS000005373
GO:0051259 protein oligomerization P
IDA
HsaAMFR
GO:0051788 response to misfolded protein P
IMP
SceS000002550
GO:0071630 nucleus-associated proteasomal ubiquitin-dependent
protein catabolic process		 P
IMP
SceS000002550

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
40222

Species Gene ID NCBI link UniProt link
Saccharomyces cerevisiae (Sce) HRD1
(S000005373)		 GI:6324561 Q08109
Kluyveromyces lactis (Kla) KLLA0C05874g GI:50305003


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000838 Hrd1p ubiquitin ligase ERAD-M complex C
IDA
SceS000005373
GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex C
IDA
SceS000005373
GO:0005789 endoplasmic reticulum membrane C
IDA
SceS000005373
GO:0004842 ubiquitin-protein ligase activity F
IDA
SceS000005373
IGI
SceS000005373
IMP
SceS000005373
IPI
SceS000005373
GO:0030433 ER-associated protein catabolic
process		 P
IMP
SceS000005373
IPI
SceS000005373
GO:0031505 fungal-type cell wall organization P
IGI
SceS000005373
GO:0051049 regulation of transport P
RCA
SceS000005373

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_1279

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga5471 ENSANGP00000014712
Ashbya gossypii (Ago) ago1030 ACL019C
Arabidopsis thaliana (Ath) ath5720 At1g65040.1
Arabidopsis thaliana (Ath) ath5721 At1g65040.2
Arabidopsis thaliana (Ath) ath13842 At3g16090.1
Caenorhabditis elegans (Cel) cel10307 F55A11.3
(CE05945;
WBGene00010076)
Candida glabrata (Cgl) cgl1042 CAGL0E02299g
Dictyostelium discoideum (Ddi) ddi8774 DDB0187676
Debaryomyces hansenii (Dha) dha3533 DEHA0E06633g
Debaryomyces hansenii (Dha) dha5399 DEHA0F22726g
Drosophila melanogaster (Dme) dme15431 CG1937-PA
(FBgn0039875)
Danio rerio (Dre) dre5298 ENSDARP00000013354
(syvn1)		 Q6NYA5
Encephalitozoon cuniculi (Ecu) ecu1722 19075085
Takifugu rubripes (Fru) fru18247 SINFRUP00000137852
Takifugu rubripes (Fru) fru13671 SINFRUP00000167615
Takifugu rubripes (Fru) fru18960 SINFRUP00000169382
Takifugu rubripes (Fru) fru18245 SINFRUP00000171449
Takifugu rubripes (Fru) fru18244 SINFRUP00000171880
Takifugu rubripes (Fru) fru18246 SINFRUP00000175611
Homo sapiens (Hsa) hsa5943 ENSP00000294256
(SYVN1)		 Q86TM6-3
Homo sapiens (Hsa) hsa5944 ENSP00000302035
(SYVN1)		 Q86TM6-2
Kluyveromyces lactis (Kla) kla1458 KLLA0C05874g
Mus musculus (Mmu) mmu13176 ENSMUSP00000025723
(MGI:1921376)		 Q9DBY1-1
Mus musculus (Mmu) mmu13177 ENSMUSP00000064239
(MGI:1921376)		 Q9DBY1-2
Neurospora crassa (Ncr) ncr4501 NCU04633.2
Oryza sativa (Osa) osa2423 1910.m00157
Oryza sativa (Osa) osa4043 1982.m00242
Plasmodium falciparum (Pfa) pfa1613 PF14_0215
Rattus norvegicus (Rno) rno3539 ENSRNOP00000028462
(RGD:1310488)		 B2RYC4
Saccharomyces cerevisiae (Sce) sce5560 YOL013C
(S000005373)
Schizosaccharomyces pombe (Spo) spo1461 SPBC17D11.02c O74757
Yarrowia lipolytica (Yli) yli5462 YALI0F02981g