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Search term: YOL049W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name GSH2
SGD link S000005409
Alternative ID YOL049W
Description Glutathione synthetase, catalyzes the ATP-dependent synthesis of glutathione (GSH) from gamma-glutamylcysteine and glycine; induced by oxidative stress and heat shock
Synonyms YOL049W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG0021 ACDHYP-

KOGs classification KOGs description
METABOLISM Glutathione synthetase

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At5g27380 GI:15240913
Caenorhabditis elegans (Cel) CE18087
(WBGene00010941)		 GI:17535239 Q21549
Drosophila melanogaster (Dme) 7293404 GI:7293404
Homo sapiens (Hsa) Hs4504169
(GSS)		 GI:4504169 P48637
Saccharomyces cerevisiae (Sce) YOL049w
(S000005409)		 GI:6324524 Q08220
Schizosaccharomyces pombe (Spo) SPAC13F10.04 GI:19114848
Arabidopsis thaliana (Ath) At5g27380 GI:15240913
Caenorhabditis elegans (Cel) CE18087
(WBGene00010941)		 GI:17535239 Q21549
Drosophila melanogaster (Dme) 7293404 GI:7293404
Homo sapiens (Hsa) Hs4504169
(GSS)		 GI:4504169 P48637
Saccharomyces cerevisiae (Sce) YOL049w
(S000005409)		 GI:6324524 Q08220
Schizosaccharomyces pombe (Spo) SPAC13F10.04 GI:19114848
Arabidopsis thaliana (Ath) At5g27380 GI:15240913
Caenorhabditis elegans (Cel) CE18087
(WBGene00010941)		 GI:17535239 Q21549
Drosophila melanogaster (Dme) 7293404 GI:7293404
Homo sapiens (Hsa) Hs4504169
(GSS)		 GI:4504169 P48637
Saccharomyces cerevisiae (Sce) YOL049w
(S000005409)		 GI:6324524 Q08220
Schizosaccharomyces pombe (Spo) SPAC13F10.04 GI:19114848


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005622 intracellular C
TAS
SceS000005409
GO:0005829 cytosol C
IDA
AthAt5g27380
TAS
AthAt5g27380
GO:0009507 chloroplast C
IDA
AthAt5g27380
GO:0000287 magnesium ion binding F
IDA
HsaGSS
GO:0004363 glutathione synthase activity F
IDA
AthAt5g27380
SceS000005409
IGI
AthAt5g27380
GO:0005524 ATP binding F
IDA
HsaGSS
GO:0042803 protein homodimerization activity F
IDA
HsaGSS
GO:0043295 glutathione binding F
IDA
HsaGSS
GO:0000003 reproduction P
IMP
CelWBGene00010941
GO:0002119 nematode larval development P
IMP
CelWBGene00010941
GO:0006520 cellular amino acid metabolic process P
TAS
HsaGSS
GO:0006750 glutathione biosynthetic process P
IDA
AthAt5g27380
IGI
AthAt5g27380
IMP
SceS000005409
GO:0006979 response to oxidative stress P
TAS
HsaGSS
GO:0007399 nervous system development P
TAS
HsaGSS
GO:0009753 response to jasmonic acid stimulus P
IEP
AthAt5g27380
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00010941
GO:0040007 growth P
IMP
CelWBGene00010941
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00010941

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
148

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) GSS GI:4504169 P48637
Canis familiaris (Cfa) GSS GI:73991696
Mus musculus (Mmu) Gss
(MGI:95852)		 GI:6680117 P51855
Rattus norvegicus (Rno) Gss
(RGD:2752)		 GI:25742757 41343
Gallus gallus (Gga) GSS GI:118100530
Drosophila melanogaster (Dme) CG32495
(FBgn0052495)		 GI:24642900
Drosophila melanogaster (Dme) GS
(FBgn0030882)		 GI:28571249
Anopheles gambiae (Aga) AgaP_AGAP000534 GI:158288708
Caenorhabditis elegans (Cel) M176.2
(CE18087;
WBGene00010941)		 GI:17535239 Q21549
Schizosaccharomyces pombe (Spo) gsa1
(SPAC3F10.04)		 GI:19114848 P35669
Saccharomyces cerevisiae (Sce) GSH2
(S000005409)		 GI:6324524 Q08220
Kluyveromyces lactis (Kla) KLLA0F07557g GI:50310799
Eremothecium gossypii (Ego) AGOS_ACR284C GI:45185970
Magnaporthe grisea (Mgr) MGG_06454 GI:145608682
Neurospora crassa (Ncr) NCU06191.1 GI:32411131
Arabidopsis thaliana (Ath) GSH2 GI:145358475
Oryza sativa (Osa) Os11g0642800 GI:115486425
Plasmodium falciparum (Pfa) PFE0605c GI:124506163


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005622 intracellular C
TAS
SceS000005409
GO:0005625 soluble fraction C
ISO
MmuMGI:95852
GO:0005829 cytosol C
IDA
AthGSH2
SpoSPAC3F10.04
TAS
AthGSH2
GO:0009507 chloroplast C
IDA
AthGSH2
GO:0000287 magnesium ion binding F
IDA
HsaGSS
ISS
SpoSPAC3F10.04
GO:0004363 glutathione synthase activity F
IDA
AthGSH2
MmuMGI:95852
SceS000005409
SpoSPAC3F10.04
IGI
AthGSH2
ISO
MmuMGI:95852
ISS
DmeFBgn0052495
FBgn0030882
GO:0005524 ATP binding F
IDA
HsaGSS
ISO
MmuMGI:95852
GO:0016594 glycine binding F
ISO
MmuMGI:95852
GO:0042277 peptide binding F
ISO
MmuMGI:95852
GO:0042803 protein homodimerization activity F
IDA
HsaGSS
ISO
MmuMGI:95852
ISS
SpoSPAC3F10.04
GO:0043295 glutathione binding F
IDA
HsaGSS
ISO
MmuMGI:95852
ISS
SpoSPAC3F10.04
GO:0000003 reproduction P
IMP
CelWBGene00010941
GO:0002119 nematode larval development P
IMP
CelWBGene00010941
GO:0006520 cellular amino acid metabolic process P
TAS
HsaGSS
GO:0006750 glutathione biosynthetic process P
IC
SpoSPAC3F10.04
IDA
AthGSH2
MmuMGI:95852
IGI
AthGSH2
IMP
SceS000005409
ISO
MmuMGI:95852
ISS
DmeFBgn0052495
GO:0006974 response to DNA damage stimulus P
IMP
DmeFBgn0030882
FBgn0052495
GO:0006979 response to oxidative stress P
ISS
PfaPFE0605c
TAS
HsaGSS
GO:0007399 nervous system development P
TAS
HsaGSS
GO:0009753 response to jasmonic acid stimulus P
IEP
AthGSH2
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00010941
GO:0033554 cellular response to stress P
TAS
SpoSPAC3F10.04
GO:0040007 growth P
IMP
CelWBGene00010941
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00010941
GO:0046686 response to cadmium ion P
IDA
MmuMGI:95852
GO:0046938 phytochelatin biosynthetic process P
IMP
SpoSPAC3F10.04
GO:0071276 cellular response to cadmium ion P
IMP
SpoSPAC3F10.04

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_1447

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga15171 ENSANGP00000017318
Ashbya gossypii (Ago) ago1331 ACR284C
Arabidopsis thaliana (Ath) ath25011 At5g27380.1
Caenorhabditis elegans (Cel) cel13040 M176.2
(CE18087;
WBGene00010941)
Candida glabrata (Cgl) cgl1268 CAGL0F00825g
Cryptococcus neoformans (Cne) cne3847 185.m02431
Dictyostelium discoideum (Ddi) ddi13517 DDB0231404
Debaryomyces hansenii (Dha) dha2173 DEHA0C16797g
Drosophila melanogaster (Dme) dme18406 CG32495-PA
(FBgn0052495)
Drosophila melanogaster (Dme) dme18407 CG32495-PB
(FBgn0052495)
Drosophila melanogaster (Dme) dme18408 CG32495-PC
(FBgn0052495)
Drosophila melanogaster (Dme) dme18402 CG6835-PC
(FBgn0030882)
Drosophila melanogaster (Dme) dme18403 CG6835-PD
(FBgn0030882)
Danio rerio (Dre) dre15174 ENSDARP00000008216
Takifugu rubripes (Fru) fru32151 SINFRUP00000128316
Gallus gallus (Gga) gga11782 ENSGALP00000005177
Gallus gallus (Gga) gga11783 ENSGALP00000005178
Gallus gallus (Gga) gga11784 ENSGALP00000005179
Gallus gallus (Gga) gga11780 ENSGALP00000005180
(GSS)
Gallus gallus (Gga) gga11781 ENSGALP00000005181
Homo sapiens (Hsa) hsa20088 ENSP00000216951
(GSS)		 P48637
Kluyveromyces lactis (Kla) kla4422 KLLA0F07557g
Mus musculus (Mmu) mmu15840 ENSMUSP00000078630
(MGI:95852)		 P51855
Neurospora crassa (Ncr) ncr6016 NCU06191.2
Oryza sativa (Osa) osa25764 3854.m00224
Oryza sativa (Osa) osa68666 6915.m00112
Oryza sativa (Osa) osa68847 6919.m00120
Plasmodium falciparum (Pfa) pfa3571 PFE0605c
Rattus norvegicus (Rno) rno20088 ENSRNOP00000025657
(RGD:2752)		 P46413
Saccharomyces cerevisiae (Sce) sce5600 YOL049W
(S000005409)
Schizosaccharomyces pombe (Spo) spo2230 SPAC3F10.04 P35669
Yarrowia lipolytica (Yli) yli2431 YALI0C17831g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005622 intracellular C
TAS
SceS000005409
GO:0005625 soluble fraction C
ISO
MmuMGI:95852
GO:0005829 cytosol C
IDA
AthAt5g27380
SpoSPAC3F10.04
TAS
AthAt5g27380
GO:0009507 chloroplast C
IDA
AthAt5g27380
GO:0000287 magnesium ion binding F
ISS
SpoSPAC3F10.04
GO:0004363 glutathione synthase activity F
IDA
AthAt5g27380
MmuMGI:95852
SceS000005409
SpoSPAC3F10.04
IGI
AthAt5g27380
ISO
MmuMGI:95852
ISS
DmeFBgn0052495
FBgn0030882
GO:0005524 ATP binding F
ISO
MmuMGI:95852
GO:0016594 glycine binding F
ISO
MmuMGI:95852
GO:0042277 peptide binding F
ISO
MmuMGI:95852
GO:0042803 protein homodimerization activity F
ISO
MmuMGI:95852
ISS
SpoSPAC3F10.04
GO:0043295 glutathione binding F
ISO
MmuMGI:95852
ISS
SpoSPAC3F10.04
GO:0000003 reproduction P
IMP
CelWBGene00010941
GO:0002119 nematode larval development P
IMP
CelWBGene00010941
GO:0006750 glutathione biosynthetic process P
IC
SpoSPAC3F10.04
IDA
AthAt5g27380
MmuMGI:95852
IGI
AthAt5g27380
IMP
SceS000005409
ISO
MmuMGI:95852
ISS
DmeFBgn0052495
GO:0006974 response to DNA damage stimulus P
IMP
DmeFBgn0030882
FBgn0052495
GO:0006979 response to oxidative stress P
ISS
PfaPFE0605c
GO:0009753 response to jasmonic acid stimulus P
IEP
AthAt5g27380
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00010941
GO:0033554 cellular response to stress P
TAS
SpoSPAC3F10.04
GO:0040007 growth P
IMP
CelWBGene00010941
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00010941
GO:0046686 response to cadmium ion P
IDA
MmuMGI:95852
GO:0046938 phytochelatin biosynthetic process P
IMP
SpoSPAC3F10.04
GO:0071276 cellular response to cadmium ion P
IMP
SpoSPAC3F10.04

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPAC3F10.04
(P35669)		 YOL049W
(S000005409)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005622 intracellular C
TAS
SceS000005409
GO:0005829 cytosol C
IDA
SpoSPAC3F10.04
GO:0000287 magnesium ion binding F
ISS
SpoSPAC3F10.04
GO:0004363 glutathione synthase activity F
IDA
SceS000005409
SpoSPAC3F10.04
GO:0042803 protein homodimerization activity F
ISS
SpoSPAC3F10.04
GO:0043295 glutathione binding F
ISS
SpoSPAC3F10.04
GO:0006750 glutathione biosynthetic process P
IC
SpoSPAC3F10.04
IMP
SceS000005409
GO:0033554 cellular response to stress P
TAS
SpoSPAC3F10.04
GO:0046938 phytochelatin biosynthetic process P
IMP
SpoSPAC3F10.04
GO:0071276 cellular response to cadmium ion P
IMP
SpoSPAC3F10.04

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GO info in one table:

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