Search term: YOL081W

Gene summary:

KOG results:

KOG name	Phylogenetic pattern (and link to KOGs with this pattern)
KOG1826	--DHY--

KOGs classification	KOGs description
CELLULAR PROCESSES AND SIGNALING	Ras GTPase activating protein RasGAP/neurofibromin

Species	KOG link	NCBI link	UniProt link
Drosophila melanogaster (Dme)	7301417	GI:7301417
Homo sapiens (Hsa)	Hs17477842	GI:17477842
Homo sapiens (Hsa)	Hs22042396	GI:22042396
Homo sapiens (Hsa)	Hs22055943	GI:22055943
Homo sapiens (Hsa)	Hs22055996	GI:22055996
Homo sapiens (Hsa)	Hs4505373 (NEK2)	GI:4505373	P51955
Homo sapiens (Hsa)	Hs4557793	GI:4557793	P21359
Saccharomyces cerevisiae (Sce)	YBR140c (S000000344)	GI:6319616	P18963
Saccharomyces cerevisiae (Sce)	YOL081w (S000005441)	GI:6324491	P19158

GO terms for KOG results:

GO ID	GO term	GO aspect	Evidence codes and associations
GO:0000776	kinetochore	C	IDA Hsa NEK2 NEK2
GO:0005737	cytoplasm	C	IDA Sce S000005441
GO:0005739	mitochondrion	C	IDA Sce S000005441 S000000344
GO:0005813	centrosome	C	TAS Hsa NEK2
GO:0005829	cytosol	C	EXP Hsa NEK2
GO:0016020	membrane	C	IMP Sce S000000344 IPI Sce S000000344
GO:0043234	protein complex	C	IMP Hsa NEK2
GO:0004672	protein kinase activity	F	IDA Hsa NEK2
GO:0005099	Ras GTPase activator activity	F	IDA Sce S000005441 IMP Sce S000000344 S000005441
GO:0005515	protein binding	F	IPI Hsa NEK2
GO:0019903	protein phosphatase binding	F	IPI Hsa NEK2
GO:0006950	response to stress	P	IMP Sce S000005441
GO:0007059	chromosome segregation	P	IDA Hsa NEK2
GO:0007067	mitosis	P	TAS Hsa NEK2
GO:0007088	regulation of mitosis	P	TAS Hsa NEK2
GO:0007568	aging	P	RCA Sce S000005441
GO:0019932	second-messenger-mediated signaling	P	RCA Sce S000005441
GO:0030818	negative regulation of cAMP biosynthetic process	P	IMP Sce S000005441 S000000344
GO:0032320	positive regulation of Ras GTPase activity	P	IMP Sce S000005441 S000000344
GO:0045761	regulation of adenylate cyclase activity	P	IMP Sce S000000344
GO:0046580	negative regulation of Ras protein signal transduction	P	IMP Sce S000005441 S000000344
GO:0046777	protein amino acid autophosphorylation	P	IMP Hsa NEK2
GO:0051299	centrosome separation	P	IDA Hsa NEK2

HomoloGene results:

HomoloGene cluster	Phylogenetic pattern
49034

Species	Gene ID	NCBI link	UniProt link
Saccharomyces cerevisiae (Sce)	IRA1 (S000000344)	GI:6319616	P18963
Saccharomyces cerevisiae (Sce)	IRA2 (S000005441)	GI:6324491	P19158
Kluyveromyces lactis (Kla)	KLLA0E17963g	GI:50309497
Eremothecium gossypii (Ego)	AGOS_AER025C	GI:45190631

GO terms for Homologene results:

GO ID	GO term	GO aspect	Evidence codes and associations
GO:0005737	cytoplasm	C	IDA Sce S000005441
GO:0005739	mitochondrion	C	IDA Sce S000005441 S000000344
GO:0016020	membrane	C	IMP Sce S000000344 IPI Sce S000000344
GO:0005099	Ras GTPase activator activity	F	IDA Sce S000005441 IMP Sce S000000344 S000005441
GO:0006950	response to stress	P	IMP Sce S000005441
GO:0007568	aging	P	RCA Sce S000005441
GO:0019932	second-messenger-mediated signaling	P	RCA Sce S000005441
GO:0030818	negative regulation of cAMP biosynthetic process	P	IMP Sce S000005441 S000000344
GO:0032320	positive regulation of Ras GTPase activity	P	IMP Sce S000005441 S000000344
GO:0045761	regulation of adenylate cyclase activity	P	IMP Sce S000000344
GO:0046580	negative regulation of Ras protein signal transduction	P	IMP Sce S000005441 S000000344

OrthoMCL results:

OrthoMCL cluster	Phylogenetic pattern
OG1_799

Species	OrthoMCL sequence	Model organism protein page	UniProt link
Anopheles gambiae (Aga)	aga5427	ENSANGP00000003216
Anopheles gambiae (Aga)	aga5426	ENSANGP00000025084
Ashbya gossypii (Ago)	ago2530	AER025C
Candida glabrata (Cgl)	cgl2864	CAGL0I07909g
Candida glabrata (Cgl)	cgl5093	CAGL0M09999g
Cryptococcus neoformans (Cne)	cne1156	180.m00084
Dictyostelium discoideum (Ddi)	ddi5458	DDB0185273
Dictyostelium discoideum (Ddi)	ddi8351	DDB0185880
Dictyostelium discoideum (Ddi)	ddi1223	DDB0203607
Dictyostelium discoideum (Ddi)	ddi5367	DDB0205121
Debaryomyces hansenii (Dha)	dha6164	DEHA0G10494g
Drosophila melanogaster (Dme)	dme14539	CG8318-PB (FBgn0015269)
Drosophila melanogaster (Dme)	dme14538	CG8318-PC (FBgn0015269)
Danio rerio (Dre)	dre2163	ENSDARP00000004724
Danio rerio (Dre)	dre2165	ENSDARP00000006480
Danio rerio (Dre)	dre2168	ENSDARP00000014824
Danio rerio (Dre)	dre2167	ENSDARP00000040246
Danio rerio (Dre)	dre6546	ENSDARP00000040420
Danio rerio (Dre)	dre6543	ENSDARP00000041919
Danio rerio (Dre)	dre6542	ENSDARP00000043039
Danio rerio (Dre)	dre6545	ENSDARP00000044572
Danio rerio (Dre)	dre2164	ENSDARP00000044691
Danio rerio (Dre)	dre6541	ENSDARP00000045715
Danio rerio (Dre)	dre6544	ENSDARP00000047244
Danio rerio (Dre)	dre2166	ENSDARP00000049268
Takifugu rubripes (Fru)	fru32722	SINFRUP00000145652
Gallus gallus (Gga)	gga9088	ENSGALP00000008950
Gallus gallus (Gga)	gga9096	ENSGALP00000009067 (NF1)
Gallus gallus (Gga)	gga9097	ENSGALP00000009072
Homo sapiens (Hsa)	hsa13404	ENSP00000348498 (NF1)	P21359-2
Homo sapiens (Hsa)	hsa13403	ENSP00000351015 (NF1)	P21359-1
Homo sapiens (Hsa)	hsa13405	ENSP00000352435
Kluyveromyces lactis (Kla)	kla3756	KLLA0E17963g
Mus musculus (Mmu)	mmu4351	ENSMUSP00000071289 (MGI:97306)	Q04690-1
Mus musculus (Mmu)	mmu4354	ENSMUSP00000077722
Mus musculus (Mmu)	mmu4353	ENSMUSP00000079018
Mus musculus (Mmu)	mmu4352	ENSMUSP00000079110
Neurospora crassa (Ncr)	ncr1596	NCU01642.2
Rattus norvegicus (Rno)	rno5649	ENSRNOP00000018480 (RGD:3168)
Rattus norvegicus (Rno)	rno5650	ENSRNOP00000045437 (RGD:3168)
Rattus norvegicus (Rno)	rno5647	ENSRNOP00000049106 (RGD:3168)
Rattus norvegicus (Rno)	rno5648	ENSRNOP00000050393 (RGD:3168)	P97526
Saccharomyces cerevisiae (Sce)	sce405	YBR140C (S000000344)
Saccharomyces cerevisiae (Sce)	sce5633	YOL081W (S000005441)
Yarrowia lipolytica (Yli)	yli1043	YALI0B07535g

GO terms for OrthoMCL results:

GO ID	GO term	GO aspect	Evidence codes and associations
GO:0005624	membrane fraction	C	ISO Mmu MGI:97306
GO:0005634	nucleus	C	IDA Mmu MGI:97306 ISO Mmu MGI:97306
GO:0005737	cytoplasm	C	IDA Mmu MGI:97306 Sce S000005441 ISO Mmu MGI:97306
GO:0005739	mitochondrion	C	IDA Sce S000005441 S000000344
GO:0014069	postsynaptic density	C	ISO Mmu MGI:97306
GO:0016020	membrane	C	IMP Sce S000000344 IPI Sce S000000344
GO:0019717	synaptosome	C	ISO Mmu MGI:97306
GO:0030424	axon	C	ISO Mmu MGI:97306
GO:0030425	dendrite	C	ISO Mmu MGI:97306
GO:0043234	protein complex	C	ISO Mmu MGI:97306
GO:0005096	GTPase activator activity	F	IGI Mmu MGI:97306 IMP Mmu MGI:97306
GO:0005099	Ras GTPase activator activity	F	IDA Dme FBgn0015269 Sce S000005441 IMP Sce S000000344 S000005441 ISS Dme FBgn0015269
GO:0005515	protein binding	F	IPI Mmu MGI:97306
GO:0008017	microtubule binding	F	ISO Mmu MGI:97306
GO:0045545	syndecan binding	F	ISO Mmu MGI:97306
GO:0000165	MAPKKK cascade	P	IMP Mmu MGI:97306
GO:0001649	osteoblast differentiation	P	IMP Mmu MGI:97306
GO:0001656	metanephros development	P	IMP Mmu MGI:97306
GO:0001666	response to hypoxia	P	IMP Mmu MGI:97306
GO:0001889	liver development	P	IMP Mmu MGI:97306
GO:0001937	negative regulation of endothelial cell proliferation	P	IMP Mmu MGI:97306 ISO Mmu MGI:97306
GO:0001938	positive regulation of endothelial cell proliferation	P	IGI Mmu MGI:97306
GO:0001952	regulation of cell-matrix adhesion	P	IMP Mmu MGI:97306
GO:0001953	negative regulation of cell-matrix adhesion	P	IGI Mmu MGI:97306
GO:0006469	negative regulation of protein kinase activity	P	IGI Mmu MGI:97306 IMP Mmu MGI:97306
GO:0006950	response to stress	P	IMP Sce S000005441
GO:0006979	response to oxidative stress	P	IMP Dme FBgn0015269
GO:0007154	cell communication	P	IMP Mmu MGI:97306
GO:0007265	Ras protein signal transduction	P	IGI Dme FBgn0015269 Mmu MGI:97306 IMP Mmu MGI:97306
GO:0007406	negative regulation of neuroblast proliferation	P	IMP Mmu MGI:97306
GO:0007420	brain development	P	IMP Mmu MGI:97306
GO:0007422	peripheral nervous system development	P	IMP Mmu MGI:97306
GO:0007507	heart development	P	IMP Mmu MGI:97306
GO:0007519	skeletal muscle tissue development	P	IMP Mmu MGI:97306
GO:0007568	aging	P	RCA Sce S000005441
GO:0007614	short-term memory	P	IMP Dme FBgn0015269
GO:0008285	negative regulation of cell proliferation	P	IGI Mmu MGI:97306 IMP Mmu MGI:97306
GO:0008340	determination of adult lifespan	P	IMP Dme FBgn0015269
GO:0008355	olfactory learning	P	IMP Dme FBgn0015269
GO:0008542	visual learning	P	IGI Mmu MGI:97306 IMP Mmu MGI:97306
GO:0009408	response to heat	P	IMP Dme FBgn0015269
GO:0014044	Schwann cell development	P	IMP Mmu MGI:97306
GO:0014065	phosphoinositide 3-kinase cascade	P	IMP Mmu MGI:97306
GO:0016525	negative regulation of angiogenesis	P	IGI Mmu MGI:97306
GO:0019932	second-messenger-mediated signaling	P	RCA Sce S000005441
GO:0019933	cAMP-mediated signaling	P	IMP Dme FBgn0015269
GO:0021510	spinal cord development	P	IMP Mmu MGI:97306
GO:0021897	forebrain astrocyte development	P	IMP Mmu MGI:97306
GO:0021915	neural tube development	P	IGI Mmu MGI:97306
GO:0021987	cerebral cortex development	P	IMP Mmu MGI:97306
GO:0022011	myelination in the peripheral nervous system	P	IMP Mmu MGI:97306
GO:0030036	actin cytoskeleton organization	P	IGI Mmu MGI:97306 IMP Mmu MGI:97306
GO:0030198	extracellular matrix organization	P	IMP Mmu MGI:97306
GO:0030199	collagen fibril organization	P	IMP Mmu MGI:97306
GO:0030325	adrenal gland development	P	IMP Mmu MGI:97306
GO:0030336	negative regulation of cell migration	P	IGI Mmu MGI:97306 IMP Mmu MGI:97306 ISO Mmu MGI:97306
GO:0030818	negative regulation of cAMP biosynthetic process	P	IMP Sce S000005441 S000000344
GO:0032228	regulation of synaptic transmission, GABAergic	P	IGI Mmu MGI:97306
GO:0032318	regulation of Ras GTPase activity	P	ISO Mmu MGI:97306
GO:0032320	positive regulation of Ras GTPase activity	P	IMP Mmu MGI:97306 Sce S000005441 S000000344 ISO Mmu MGI:97306
GO:0035021	negative regulation of Rac protein signal transduction	P	IGI Mmu MGI:97306
GO:0040014	regulation of multicellular organism growth	P	IMP Dme FBgn0015269
GO:0040018	positive regulation of multicellular organism growth	P	IMP Dme FBgn0015269
GO:0042060	wound healing	P	IMP Mmu MGI:97306
GO:0042066	perineurial glial growth	P	IGI Dme FBgn0015269
GO:0042127	regulation of cell proliferation	P	IGI Mmu MGI:97306
GO:0042992	negative regulation of transcription factor import into nucleus	P	IMP Mmu MGI:97306
GO:0043065	positive regulation of apoptosis	P	IGI Mmu MGI:97306 IMP Mmu MGI:97306
GO:0043407	negative regulation of MAP kinase activity	P	IGI Mmu MGI:97306 IMP Mmu MGI:97306
GO:0043409	negative regulation of MAPKKK cascade	P	IMP Mmu MGI:97306 ISO Mmu MGI:97306
GO:0043473	pigmentation	P	IGI Mmu MGI:97306 IMP Mmu MGI:97306
GO:0043525	positive regulation of neuron apoptosis	P	IGI Mmu MGI:97306 IMP Mmu MGI:97306
GO:0045124	regulation of bone resorption	P	IMP Mmu MGI:97306
GO:0045475	locomotor rhythm	P	IMP Dme FBgn0015269
GO:0045664	regulation of neuron differentiation	P	ISO Mmu MGI:97306
GO:0045671	negative regulation of osteoclast differentiation	P	IGI Mmu MGI:97306
GO:0045685	regulation of glial cell differentiation	P	IMP Mmu MGI:97306
GO:0045761	regulation of adenylate cyclase activity	P	IMP Sce S000000344
GO:0045762	positive regulation of adenylate cyclase activity	P	IMP Dme FBgn0015269 Mmu MGI:97306
GO:0045765	regulation of angiogenesis	P	IMP Mmu MGI:97306
GO:0046578	regulation of Ras protein signal transduction	P	IMP Dme FBgn0015269
GO:0046580	negative regulation of Ras protein signal transduction	P	IGI Mmu MGI:97306 IMP Mmu MGI:97306 Sce S000005441 S000000344
GO:0046929	negative regulation of neurotransmitter secretion	P	IGI Mmu MGI:97306 IMP Mmu MGI:97306
GO:0048169	regulation of long-term neuronal synaptic plasticity	P	IGI Mmu MGI:97306 IMP Mmu MGI:97306
GO:0048485	sympathetic nervous system development	P	IMP Mmu MGI:97306
GO:0048593	camera-type eye morphogenesis	P	IMP Mmu MGI:97306
GO:0048712	negative regulation of astrocyte differentiation	P	IMP Mmu MGI:97306
GO:0048715	negative regulation of oligodendrocyte differentiation	P	IMP Mmu MGI:97306
GO:0048745	smooth muscle tissue development	P	IMP Mmu MGI:97306
GO:0048844	artery morphogenesis	P	IMP Mmu MGI:97306
GO:0048853	forebrain morphogenesis	P	IMP Mmu MGI:97306