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Search term: YOL088C

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name MPD2
SGD link S000005448
Alternative ID YOL088C
Description Member of the protein disulfide isomerase (PDI) family, exhibits chaperone activity; overexpression suppresses the lethality of a pdi1 deletion but does not complement all Pdi1p functions; undergoes oxidation by Ero1p
Synonyms YOL088C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG0191 ACDHYPE

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALING Thioredoxin/protein disulfide isomerase

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At1g04980 GI:15220377
Arabidopsis thaliana (Ath) At1g07960 GI:15223058
Arabidopsis thaliana (Ath) At1g62180_2 GI:15220723
Arabidopsis thaliana (Ath) At2g32920 GI:15225757
Arabidopsis thaliana (Ath) At2g47470 GI:15226610
Arabidopsis thaliana (Ath) At4g04610_2 GI:15233591
Arabidopsis thaliana (Ath) At4g21990_2 GI:15234684
Caenorhabditis elegans (Cel) CE03880
(WBGene00015168)		 GI:17549970 Q11067
Caenorhabditis elegans (Cel) CE09103 GI:17506407
Caenorhabditis elegans (Cel) CE20265_2 GI:17510057
Caenorhabditis elegans (Cel) CE22222
(WBGene00013030)		 GI:17556044 Q9XTU8
Caenorhabditis elegans (Cel) CE26290
(WBGene00022236)		 GI:17544108 Q9GUG7
Drosophila melanogaster (Dme) 7292685 GI:7292685
Drosophila melanogaster (Dme) 7296071 GI:7296071
Drosophila melanogaster (Dme) 7298052 GI:7298052 Q9VJZ1
Drosophila melanogaster (Dme) 7298302
(FBgn0025678)		 GI:19921434
Drosophila melanogaster (Dme) 7299383 GI:7299383
Drosophila melanogaster (Dme) 7301255 GI:7301255
Drosophila melanogaster (Dme) 7302294 GI:7302294
Drosophila melanogaster (Dme) 7302295 GI:7302295
Homo sapiens (Hsa) Hs13540604 GI:13540604
Homo sapiens (Hsa) Hs17455940 GI:17455940
Homo sapiens (Hsa) Hs22044388_2 GI:14042479 Q8N4C5
Homo sapiens (Hsa) Hs22048178 GI:22048178
Homo sapiens (Hsa) Hs22069261 GI:22069261
Homo sapiens (Hsa) Hs5031973
(PDIA6)		 GI:5031973 Q15084
Homo sapiens (Hsa) Hs5803121
(PDIA5)		 GI:5803121 Q14554
Saccharomyces cerevisiae (Sce) YIL005w
(S000001267)		 GI:6322186 P40557
Saccharomyces cerevisiae (Sce) YOL088c
(S000005448)		 GI:6324484 Q99316
Saccharomyces cerevisiae (Sce) YOR288c
(S000005814)		 GI:6324862 Q12404
Schizosaccharomyces pombe (Spo) SPAC13F5.05 GI:19114565 O13704
Schizosaccharomyces pombe (Spo) SPAC17H9.14c GI:19114496 O13811
Schizosaccharomyces pombe (Spo) SPAC959.05c GI:19115084 Q9P4X1
Schizosaccharomyces pombe (Spo) SPBC3D6.13c GI:19112317 P87178
Schizosaccharomyces pombe (Spo) SPCC1840.08c GI:19076007 O74481
Encephalitozoon cuniculi (Ecu) ECU02g0850 GI:19074004 Q8SSF5
Arabidopsis thaliana (Ath) At1g04980 GI:15220377
Arabidopsis thaliana (Ath) At1g07960 GI:15223058
Arabidopsis thaliana (Ath) At1g62180_2 GI:15220723
Arabidopsis thaliana (Ath) At2g32920 GI:15225757
Arabidopsis thaliana (Ath) At2g47470 GI:15226610
Arabidopsis thaliana (Ath) At4g04610_2 GI:15233591
Arabidopsis thaliana (Ath) At4g21990_2 GI:15234684
Caenorhabditis elegans (Cel) CE03880
(WBGene00015168)		 GI:17549970 Q11067
Caenorhabditis elegans (Cel) CE09103 GI:17506407
Caenorhabditis elegans (Cel) CE20265_2 GI:17510057
Caenorhabditis elegans (Cel) CE22222
(WBGene00013030)		 GI:17556044 Q9XTU8
Caenorhabditis elegans (Cel) CE26290
(WBGene00022236)		 GI:17544108 Q9GUG7
Drosophila melanogaster (Dme) 7292685 GI:7292685
Drosophila melanogaster (Dme) 7296071 GI:7296071
Drosophila melanogaster (Dme) 7298052 GI:7298052 Q9VJZ1
Drosophila melanogaster (Dme) 7298302
(FBgn0025678)		 GI:19921434
Drosophila melanogaster (Dme) 7299383 GI:7299383
Drosophila melanogaster (Dme) 7301255 GI:7301255
Drosophila melanogaster (Dme) 7302294 GI:7302294
Drosophila melanogaster (Dme) 7302295 GI:7302295
Homo sapiens (Hsa) Hs13540604 GI:13540604
Homo sapiens (Hsa) Hs17455940 GI:17455940
Homo sapiens (Hsa) Hs22044388_2 GI:14042479 Q8N4C5
Homo sapiens (Hsa) Hs22048178 GI:22048178
Homo sapiens (Hsa) Hs22069261 GI:22069261
Homo sapiens (Hsa) Hs5031973
(PDIA6)		 GI:5031973 Q15084
Homo sapiens (Hsa) Hs5803121
(PDIA5)		 GI:5803121 Q14554
Saccharomyces cerevisiae (Sce) YIL005w
(S000001267)		 GI:6322186 P40557
Saccharomyces cerevisiae (Sce) YOL088c
(S000005448)		 GI:6324484 Q99316
Saccharomyces cerevisiae (Sce) YOR288c
(S000005814)		 GI:6324862 Q12404
Schizosaccharomyces pombe (Spo) SPAC13F5.05 GI:19114565 O13704
Schizosaccharomyces pombe (Spo) SPAC17H9.14c GI:19114496 O13811
Schizosaccharomyces pombe (Spo) SPAC959.05c GI:19115084 Q9P4X1
Schizosaccharomyces pombe (Spo) SPBC3D6.13c GI:19112317 P87178
Schizosaccharomyces pombe (Spo) SPCC1840.08c GI:19076007 O74481
Encephalitozoon cuniculi (Ecu) ECU02g0850 GI:19074004 Q8SSF5
Arabidopsis thaliana (Ath) At1g04980 GI:15220377
Arabidopsis thaliana (Ath) At1g07960 GI:15223058
Arabidopsis thaliana (Ath) At1g62180_2 GI:15220723
Arabidopsis thaliana (Ath) At2g32920 GI:15225757
Arabidopsis thaliana (Ath) At2g47470 GI:15226610
Arabidopsis thaliana (Ath) At4g04610_2 GI:15233591
Arabidopsis thaliana (Ath) At4g21990_2 GI:15234684
Caenorhabditis elegans (Cel) CE03880
(WBGene00015168)		 GI:17549970 Q11067
Caenorhabditis elegans (Cel) CE09103 GI:17506407
Caenorhabditis elegans (Cel) CE20265_2 GI:17510057
Caenorhabditis elegans (Cel) CE22222
(WBGene00013030)		 GI:17556044 Q9XTU8
Caenorhabditis elegans (Cel) CE26290
(WBGene00022236)		 GI:17544108 Q9GUG7
Drosophila melanogaster (Dme) 7292685 GI:7292685
Drosophila melanogaster (Dme) 7296071 GI:7296071
Drosophila melanogaster (Dme) 7298052 GI:7298052 Q9VJZ1
Drosophila melanogaster (Dme) 7298302
(FBgn0025678)		 GI:19921434
Drosophila melanogaster (Dme) 7299383 GI:7299383
Drosophila melanogaster (Dme) 7301255 GI:7301255
Drosophila melanogaster (Dme) 7302294 GI:7302294
Drosophila melanogaster (Dme) 7302295 GI:7302295
Homo sapiens (Hsa) Hs13540604 GI:13540604
Homo sapiens (Hsa) Hs17455940 GI:17455940
Homo sapiens (Hsa) Hs22044388_2 GI:14042479 Q8N4C5
Homo sapiens (Hsa) Hs22048178 GI:22048178
Homo sapiens (Hsa) Hs22069261 GI:22069261
Homo sapiens (Hsa) Hs5031973
(PDIA6)		 GI:5031973 Q15084
Homo sapiens (Hsa) Hs5803121
(PDIA5)		 GI:5803121 Q14554
Saccharomyces cerevisiae (Sce) YIL005w
(S000001267)		 GI:6322186 P40557
Saccharomyces cerevisiae (Sce) YOL088c
(S000005448)		 GI:6324484 Q99316
Saccharomyces cerevisiae (Sce) YOR288c
(S000005814)		 GI:6324862 Q12404
Schizosaccharomyces pombe (Spo) SPAC13F5.05 GI:19114565 O13704
Schizosaccharomyces pombe (Spo) SPAC17H9.14c GI:19114496 O13811
Schizosaccharomyces pombe (Spo) SPAC959.05c GI:19115084 Q9P4X1
Schizosaccharomyces pombe (Spo) SPBC3D6.13c GI:19112317 P87178
Schizosaccharomyces pombe (Spo) SPCC1840.08c GI:19076007 O74481
Encephalitozoon cuniculi (Ecu) ECU02g0850 GI:19074004 Q8SSF5


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000324 fungal-type vacuole C
IDA
SceS000005814
GO:0005739 mitochondrion C
IDA
SpoSPAC13F5.05
GO:0005773 vacuole C
IDA
AthAt2g32920
GO:0005783 endoplasmic reticulum C
IDA
AthAt2g47470
At2g32920
SpoSPAC959.05c
SPCC1840.08c
IGI
SceS000005448
ISS
SpoSPAC17H9.14c
TAS
HsaPDIA6
GO:0005788 endoplasmic reticulum lumen C
NAS
SpoSPAC13F5.05
TAS
HsaPDIA5
GO:0005789 endoplasmic reticulum membrane C
IDA
SceS000001267
ISS
SpoSPAC959.05c
SPBC3D6.13c
SPCC1840.08c
GO:0005793 ER-Golgi intermediate compartment C
IDA
HsaPDIA6
GO:0005794 Golgi apparatus C
IDA
SpoSPBC3D6.13c
SPCC1840.08c
GO:0005811 lipid particle C
IDA
DmeFBgn0025678
GO:0005886 plasma membrane C
IDA
AthAt2g47470
At2g32920
GO:0009505 plant-type cell wall C
IDA
AthAt1g04980
At2g47470
GO:0009507 chloroplast C
IDA
AthAt1g62180
At4g21990
ISS
AthAt4g21990
At4g04610
GO:0009536 plastid C
TAS
AthAt4g04610
GO:0009570 chloroplast stroma C
IDA
AthAt4g04610
At1g62180
GO:0003756 protein disulfide isomerase activity F
IDA
SceS000005448
S000005814
IGI
SceS000005814
S000005448
IMP
SceS000005448
S000005814
S000001267
SpoSPAC17H9.14c
ISS
AthAt2g32920
At1g04980
At2g47470
DmeFBgn0025678
SceS000005814
S000005448
S000001267
SpoSPAC13F5.05
SPBC3D6.13c
SPAC959.05c
SPCC1840.08c
TAS
HsaPDIA5
SceS000005448
GO:0004604 phosphoadenylyl-sulfate reductase (thioredoxin)
activity		 F
IDA
AthAt1g62180
IMP
AthAt1g62180
GO:0005515 protein binding F
IPI
HsaPDIA6
GO:0009973 adenylyl-sulfate reductase activity F
IDA
AthAt4g04610
At4g21990
At1g62180
GO:0015035 protein disulfide oxidoreductase
activity		 F
IDA
SceS000005814
S000005448
IGI
SceS000005814
S000005448
IMP
SpoSPAC17H9.14c
ISS
SceS000005814
S000005448
SpoSPAC13F5.05
GO:0015036 disulfide oxidoreductase activity F
RCA
SceS000001267
GO:0016491 oxidoreductase activity F
RCA
SceS000001267
TAS
HsaPDIA5
GO:0016667 oxidoreductase activity, acting on sulfur group of
donors		 F
RCA
SceS000001267
GO:0051082 unfolded protein binding F
IDA
SceS000001267
GO:0051087 chaperone binding F
IDA
SceS000001267
GO:0000103 sulfate assimilation P
IDA
AthAt4g04610
At4g21990
At1g62180
IGI
AthAt4g04610
At4g21990
At1g62180
GO:0002119 nematode larval development P
IMP
CelWBGene00015168
GO:0006457 protein folding P
IC
SpoSPAC13F5.05
IGI
SceS000005448
S000005814
IMP
SpoSPAC17H9.14c
NAS
SpoSPAC959.05c
TAS
HsaPDIA6
PDIA5
GO:0006621 protein retention in ER lumen P
IMP
SceS000001267
ISS
SpoSPAC959.05c
SPBC3D6.13c
SPCC1840.08c
GO:0006950 response to stress P
ISS
HsaPDIA5
GO:0009553 embryo sac development P
IMP
AthAt2g47470
GO:0009567 double fertilization forming a zygote and
endosperm		 P
IMP
AthAt2g47470
GO:0009793 embryo development ending in seed
dormancy		 P
IMP
AthAt2g47470
GO:0019379 sulfate assimilation, phosphoadenylyl sulfate
reduction by phosphoadenylyl-sulfate reductase
(thioredoxin)		 P
TAS
AthAt1g62180
GO:0019419 sulfate reduction P
IDA
AthAt4g04610
GO:0030433 ER-associated protein catabolic
process		 P
IMP
SceS000001267
ISS
SpoSPBC3D6.13c
SPCC1840.08c
GO:0034599 cellular response to oxidative
stress		 P
IMP
SpoSPAC17H9.14c
GO:0034605 cellular response to heat P
IEP
SpoSPAC13F5.05
GO:0034976 response to endoplasmic reticulum
stress		 P
IEP
AthAt2g47470
At2g32920
At1g04980
GO:0040007 growth P
IMP
CelWBGene00015168
GO:0040011 locomotion P
IMP
CelWBGene00015168
GO:0046686 response to cadmium ion P
IEP
AthAt2g47470
GO:0048868 pollen tube development P
IMP
AthAt2g47470
GO:0055114 oxidation reduction P
TAS
HsaPDIA5

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
49032

Species Gene ID NCBI link UniProt link
Saccharomyces cerevisiae (Sce) MPD2
(S000005448)		 GI:6324484 Q99316
Kluyveromyces lactis (Kla) KLLA0F02794g GI:50310373
Eremothecium gossypii (Ego) AGOS_AER039W GI:45190645


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005783 endoplasmic reticulum C
IGI
SceS000005448
GO:0003756 protein disulfide isomerase activity F
IDA
SceS000005448
IGI
SceS000005448
IMP
SceS000005448
ISS
SceS000005448
TAS
SceS000005448
GO:0015035 protein disulfide oxidoreductase
activity		 F
IDA
SceS000005448
IGI
SceS000005448
ISS
SceS000005448
GO:0006457 protein folding P
IGI
SceS000005448

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_31616

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Ashbya gossypii (Ago) ago2544 AER039W
Candida glabrata (Cgl) cgl2858 CAGL0I07777g
Kluyveromyces lactis (Kla) kla4206 KLLA0F02794g
Saccharomyces cerevisiae (Sce) sce5643 YOL088C
(S000005448)