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Search term: YOL136C

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name PFK27
SGD link S000005496
Alternative ID YOL136C
Description 6-phosphofructo-2-kinase, catalyzes synthesis of fructose-2,6-bisphosphate; inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate, expression induced by glucose and sucrose, transcriptional regulation involves protein kinase A
Synonyms YOL136C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG0234 ACDHYP-

KOGs classification KOGs description
METABOLISM Fructose-6-phosphate 2-kinase/fructose-2,6-biphosphatase

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At1g07110 GI:15222304
Arabidopsis thaliana (Ath) At1g12850 GI:18391446
Arabidopsis thaliana (Ath) At3g26780_1 GI:15231617
Caenorhabditis elegans (Cel) CE04687 GI:17541184
Caenorhabditis elegans (Cel) CE23252 GI:17510919
Caenorhabditis elegans (Cel) CE29606 GI:17510917 Q95Y85
Drosophila melanogaster (Dme) 7293590 GI:7293590
Homo sapiens (Hsa) Hs4758900
(PFKFB3)		 GI:4758900 O60352
Homo sapiens (Hsa) Hs5453878 GI:5453878
Homo sapiens (Hsa) Hs4758902
(PFKFB4)		 GI:4758902 Q16877
Homo sapiens (Hsa) Hs4505745 GI:4505745
Saccharomyces cerevisiae (Sce) YIL107c
(S000001369)		 GI:6322084 P40433
Saccharomyces cerevisiae (Sce) YJL155c
(S000003691)		 GI:6322306 P32604
Saccharomyces cerevisiae (Sce) YLR345w GI:6323377 Q06137
Saccharomyces cerevisiae (Sce) YOL136c
(S000005496)		 GI:6324436 Q12471
Schizosaccharomyces pombe (Spo) SPAC144.17c GI:19115590 Q9UTK9
Schizosaccharomyces pombe (Spo) SPAC222.13c GI:19114064 Q9UTE1
Schizosaccharomyces pombe (Spo) SPAC732.02c GI:19114513 Q9URZ7
Arabidopsis thaliana (Ath) At1g07110 GI:15222304
Arabidopsis thaliana (Ath) At1g12850 GI:18391446
Arabidopsis thaliana (Ath) At3g26780_1 GI:15231617
Caenorhabditis elegans (Cel) CE04687 GI:17541184
Caenorhabditis elegans (Cel) CE23252 GI:17510919
Caenorhabditis elegans (Cel) CE29606 GI:17510917 Q95Y85
Drosophila melanogaster (Dme) 7293590 GI:7293590
Homo sapiens (Hsa) Hs4758900
(PFKFB3)		 GI:4758900 O60352
Homo sapiens (Hsa) Hs5453878 GI:5453878
Homo sapiens (Hsa) Hs4758902
(PFKFB4)		 GI:4758902 Q16877
Homo sapiens (Hsa) Hs4505745 GI:4505745
Saccharomyces cerevisiae (Sce) YIL107c
(S000001369)		 GI:6322084 P40433
Saccharomyces cerevisiae (Sce) YJL155c
(S000003691)		 GI:6322306 P32604
Saccharomyces cerevisiae (Sce) YLR345w GI:6323377 Q06137
Saccharomyces cerevisiae (Sce) YOL136c
(S000005496)		 GI:6324436 Q12471
Schizosaccharomyces pombe (Spo) SPAC144.17c GI:19115590 Q9UTK9
Schizosaccharomyces pombe (Spo) SPAC222.13c GI:19114064 Q9UTE1
Schizosaccharomyces pombe (Spo) SPAC732.02c GI:19114513 Q9URZ7
Arabidopsis thaliana (Ath) At1g07110 GI:15222304
Arabidopsis thaliana (Ath) At1g12850 GI:18391446
Arabidopsis thaliana (Ath) At3g26780_1 GI:15231617
Caenorhabditis elegans (Cel) CE04687 GI:17541184
Caenorhabditis elegans (Cel) CE23252 GI:17510919
Caenorhabditis elegans (Cel) CE29606 GI:17510917 Q95Y85
Drosophila melanogaster (Dme) 7293590 GI:7293590
Homo sapiens (Hsa) Hs4758900
(PFKFB3)		 GI:4758900 O60352
Homo sapiens (Hsa) Hs5453878 GI:5453878
Homo sapiens (Hsa) Hs4758902
(PFKFB4)		 GI:4758902 Q16877
Homo sapiens (Hsa) Hs4505745 GI:4505745
Saccharomyces cerevisiae (Sce) YIL107c
(S000001369)		 GI:6322084 P40433
Saccharomyces cerevisiae (Sce) YJL155c
(S000003691)		 GI:6322306 P32604
Saccharomyces cerevisiae (Sce) YLR345w GI:6323377 Q06137
Saccharomyces cerevisiae (Sce) YOL136c
(S000005496)		 GI:6324436 Q12471
Schizosaccharomyces pombe (Spo) SPAC144.17c GI:19115590 Q9UTK9
Schizosaccharomyces pombe (Spo) SPAC222.13c GI:19114064 Q9UTE1
Schizosaccharomyces pombe (Spo) SPAC732.02c GI:19114513 Q9URZ7


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
AthAt1g12850
GO:0005634 nucleus C
IDA
SpoSPAC222.13c
GO:0005737 cytoplasm C
IC
SceS000001369
S000005496
IDA
SceYLR345w
ISS
SpoSPAC144.17c
SPAC222.13c
GO:0005739 mitochondrion C
IDA
AthAt3g26780
GO:0005829 cytosol C
EXP
HsaPFKFB4
PFKFB3
IDA
AthAt3g26780
At1g07110
SpoSPAC144.17c
SPAC222.13c
ISS
SpoSPAC732.02c
TAS
SceS000003691
GO:0005886 plasma membrane C
IDA
AthAt1g07110
GO:0003824 catalytic activity F
ISS
AthAt3g26780
At1g12850
GO:0003873 6-phosphofructo-2-kinase activity F
IDA
SceS000001369
ISS
SceS000005496
S000001369
SpoSPAC222.13c
NAS
HsaPFKFB4
PFKFB3
SceYLR345w
GO:0004331 fructose-2,6-bisphosphate 2-phosphatase
activity		 F
IMP
AthAt1g07110
SceS000003691
ISS
SpoSPAC144.17c
SPAC732.02c
GO:0005515 protein binding F
IPI
HsaPFKFB3
GO:0042802 identical protein binding F
IPI
HsaPFKFB3
GO:0006000 fructose metabolic process P
IMP
AthAt1g07110
GO:0006003 fructose 2,6-bisphosphate metabolic
process		 P
IC
SpoSPAC144.17c
IMP
SceS000005496
ISS
SpoSPAC222.13c
NAS
HsaPFKFB4
PFKFB3
SceYLR345w
S000001369
GO:0006006 glucose metabolic process P
IMP
SceS000003691
ISS
SpoSPAC732.02c
GO:0006110 regulation of glycolysis P
IMP
SceS000005496
NAS
SceYLR345w
S000001369
GO:0006914 autophagy P
RCA
SceS000001369
S000003691
GO:0007039 vacuolar protein catabolic process P
RCA
SceS000001369
GO:0008152 metabolic process P
ISS
AthAt1g12850
At3g26780
GO:0046835 carbohydrate phosphorylation P
ISS
SpoSPAC222.13c

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
40183

Species Gene ID NCBI link UniProt link
Saccharomyces cerevisiae (Sce) PFK27
(S000005496)		 GI:6324436 Q12471
Kluyveromyces lactis (Kla) KLLA0E07095g GI:50308533
Eremothecium gossypii (Ego) AGOS_ADL183C GI:45187690


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005737 cytoplasm C
IC
SceS000005496
GO:0003873 6-phosphofructo-2-kinase activity F
ISS
SceS000005496
GO:0006003 fructose 2,6-bisphosphate metabolic
process		 P
IMP
SceS000005496
GO:0006110 regulation of glycolysis P
IMP
SceS000005496

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_24782

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Ashbya gossypii (Ago) ago1558 ADL183C
Candida glabrata (Cgl) cgl1008 CAGL0E01529g
Debaryomyces hansenii (Dha) dha1370 DEHA0B15741g
Kluyveromyces lactis (Kla) kla3268 KLLA0E07095g
Saccharomyces cerevisiae (Sce) sce5694 YOL136C
(S000005496)


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005737 cytoplasm C
IC
SceS000005496
GO:0003873 6-phosphofructo-2-kinase activity F
ISS
SceS000005496
GO:0006003 fructose 2,6-bisphosphate metabolic
process		 P
IMP
SceS000005496
GO:0006110 regulation of glycolysis P
IMP
SceS000005496

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s.khadayate@ucl.ac.uk