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Search term: YOL139C

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name CDC33
SGD link S000005499
Alternative ID YOL139C
Description Cytoplasmic mRNA cap binding protein and translation initiation factor eIF4E; the eIF4E-cap complex is responsible for mediating cap-dependent mRNA translation via interactions with translation initiation factor eIF4G (Tif4631p or Tif4632p)
Synonyms YOL139C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

Search for gene by ID or name:

Query species:

Include wild-cards:   

Search for GO info:  

GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG1670 ACDHYPE

KOGs classification KOGs description
INFORMATION STORAGE AND PROCESSING Translation initiation factor 4F, cap-binding subunit (eIF-4E) and related cap-binding proteins

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At1g29550 GI:15220482
Arabidopsis thaliana (Ath) At1g29590 GI:15220489
Arabidopsis thaliana (Ath) At4g18040 GI:15236735
Arabidopsis thaliana (Ath) At5g35620 GI:15238558
Caenorhabditis elegans (Cel) CE04791
(WBGene00002060)		 GI:17568565 Q21693
Caenorhabditis elegans (Cel) CE16098 GI:17553536
Caenorhabditis elegans (Cel) CE17331
(WBGene00002061)		 GI:17557342 O61955
Caenorhabditis elegans (Cel) CE22608
(WBGene00002063)		 GI:7510229 P56570
Caenorhabditis elegans (Cel) CE25509 GI:17537625
Caenorhabditis elegans (Cel) CE27570 GI:17557340 O61955
Drosophila melanogaster (Dme) 7290120 GI:7290120
Drosophila melanogaster (Dme) 7294953 GI:17864468
Drosophila melanogaster (Dme) 7295135 GI:7295135
Drosophila melanogaster (Dme) 7295185 GI:7295185
Drosophila melanogaster (Dme) 7295331 GI:7295331
Drosophila melanogaster (Dme) 7301727 GI:7301727
Homo sapiens (Hsa) Hs20468608 GI:20468608
Homo sapiens (Hsa) Hs22047412 GI:17446939
Homo sapiens (Hsa) Hs4503535
(EIF4E)		 GI:4503535 P06730
Saccharomyces cerevisiae (Sce) YOL139c
(S000005499)		 GI:6324433 P07260
Schizosaccharomyces pombe (Spo) SPAC16E8.15 GI:19115140 P78954
Schizosaccharomyces pombe (Spo) SPBC1709.18 GI:19112243 O74743
Encephalitozoon cuniculi (Ecu) ECU08g0900 GI:19173417 Q8SRB6


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
AthAt5g35620
At4g18040
SceS000005499
SpoSPAC16E8.15
GO:0005730 nucleolus C
IDA
AthAt4g18040
GO:0005737 cytoplasm C
IDA
AthAt4g18040
At5g35620
SceS000005499
ISS
AthAt4g18040
At5g35620
At1g29590
At1g29550
TAS
AthAt4g18040
At5g35620
GO:0005829 cytosol C
EXP
HsaEIF4E
IDA
SpoSPAC16E8.15
SPBC1709.18
GO:0005840 ribosome C
TAS
SceS000005499
GO:0005845 mRNA cap binding complex C
IDA
HsaEIF4E
GO:0010494 stress granule C
IDA
SceS000005499
GO:0016281 eukaryotic translation initiation factor 4F
complex		 C
TAS
HsaEIF4E
SceS000005499
SpoSPAC16E8.15
SPBC1709.18
GO:0000339 RNA cap binding F
TAS
AthAt4g18040
HsaEIF4E
SpoSPAC16E8.15
SPBC1709.18
GO:0000340 RNA 7-methylguanosine cap binding F
TAS
AthAt5g35620
GO:0003723 RNA binding F
ISS
AthAt1g29590
At4g18040
At1g29550
At5g35620
GO:0003743 translation initiation factor activity F
ISS
AthAt1g29590
At1g29550
At5g35620
At4g18040
HsaEIF4E
SceS000005499
SpoSPAC16E8.15
SPBC1709.18
TAS
AthAt5g35620
SceS000005499
GO:0005515 protein binding F
IPI
AthAt4g18040
HsaEIF4E
GO:0032266 phosphatidylinositol-3-phosphate
binding		 F
IDA
SceS000005499
GO:0000082 G1/S transition of mitotic cell
cycle		 P
IMP
HsaEIF4E
GO:0000184 nuclear-transcribed mRNA catabolic process,
nonsense-mediated decay		 P
IDA
SceS000005499
IPI
SceS000005499
ISS
SpoSPAC16E8.15
SPBC1709.18
GO:0006412 translation P
IMP
CelWBGene00002060
GO:0006413 translational initiation P
ISS
AthAt4g18040
At1g29590
At5g35620
At1g29550
SceS000005499
TAS
AthAt4g18040
At5g35620
SceS000005499
SpoSPAC16E8.15
SPBC1709.18
GO:0006417 regulation of translation P
RCA
SceS000005499
GO:0008340 determination of adult lifespan P
IMP
CelWBGene00002060
GO:0009408 response to heat P
IMP
CelWBGene00002060
GO:0009615 response to virus P
IMP
AthAt4g18040
At5g35620
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00002061
GO:0019915 lipid storage P
IMP
CelWBGene00002060
GO:0033554 cellular response to stress P
TAS
SpoSPBC1709.18
GO:0045727 positive regulation of translation P
IMP
CelWBGene00002060
GO:0045931 positive regulation of mitotic cell
cycle		 P
IMP
HsaEIF4E
GO:0045948 positive regulation of translational
initiation		 P
ISS
SpoSPAC16E8.15
SPBC1709.18
GO:0051726 regulation of cell cycle P
IMP
SceS000005499

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
84699

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) EIF4E GI:4503535 P06730
Canis familiaris (Cfa) EIF4E GI:74001995
Mus musculus (Mmu) Eif4e
(MGI:95305)		 GI:83627717 P63073
Rattus norvegicus (Rno) Eif4e
(RGD:69647)		 GI:16758870
Gallus gallus (Gga) EIF4E GI:118090396
Drosophila melanogaster (Dme) eIF-4E
(FBgn0015218)		 GI:24661565
Drosophila melanogaster (Dme) eIF4E-4 GI:24659492
Drosophila melanogaster (Dme) eIF4E-7 GI:24639021
Drosophila melanogaster (Dme) eIF4E-5 GI:28574385
Drosophila melanogaster (Dme) eIF4E-3 GI:24660746
Anopheles gambiae (Aga) AgaP_AGAP007172 GI:158286137
Caenorhabditis elegans (Cel) ife-3
(CE17331;
WBGene00002061)		 GI:25153904
Schizosaccharomyces pombe (Spo) tif1
(SPAC1006.07)		 GI:19115140 P47943
Schizosaccharomyces pombe (Spo) tif452
(SPBC1709.18)		 GI:19112243 O74743
Saccharomyces cerevisiae (Sce) CDC33
(S000005499)		 GI:6324433 P07260
Kluyveromyces lactis (Kla) KLLA0E21087g GI:50309775
Eremothecium gossypii (Ego) AGOS_ADL188C GI:45187685
Magnaporthe grisea (Mgr) MGG_04647 GI:39945330
Neurospora crassa (Ncr) NCU02076.1 GI:32417576
Arabidopsis thaliana (Ath) EIF4E GI:15236735
Oryza sativa (Osa) Os01g0970400 GI:115442491


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000932 cytoplasmic mRNA processing body C
IDA
DmeFBgn0015218
GO:0005634 nucleus C
IDA
SceS000005499
GO:0005737 cytoplasm C
IDA
DmeFBgn0015218
MmuMGI:95305
SceS000005499
GO:0005829 cytosol C
EXP
HsaEIF4E
IDA
SpoSPBC1709.18
SPAC1006.07
ISS
DmeFBgn0015218
NAS
DmeFBgn0015218
GO:0005840 ribosome C
TAS
SceS000005499
GO:0005845 mRNA cap binding complex C
IDA
HsaEIF4E
GO:0005875 microtubule associated complex C
IDA
DmeFBgn0015218
GO:0010494 stress granule C
IDA
SceS000005499
GO:0014069 postsynaptic density C
IDA
DmeFBgn0015218
GO:0016281 eukaryotic translation initiation factor 4F
complex		 C
ISO
MmuMGI:95305
ISS
DmeFBgn0015218
eIF4E-7
eIF4E-4
eIF4E-3
eIF4E-5
SpoSPAC1006.07
NAS
DmeFBgn0015218
TAS
HsaEIF4E
SceS000005499
SpoSPBC1709.18
GO:0043234 protein complex C
ISO
MmuMGI:95305
GO:0000339 RNA cap binding F
IDA
DmeFBgn0015218
ISS
DmeFBgn0015218
eIF4E-4
eIF4E-7
eIF4E-3
eIF4E-5
NAS
DmeeIF4E-7
FBgn0015218
TAS
HsaEIF4E
SpoSPBC1709.18
GO:0003743 translation initiation factor activity F
IDA
DmeFBgn0015218
ISS
DmeeIF4E-4
eIF4E-5
eIF4E-7
FBgn0015218
eIF4E-3
HsaEIF4E
SceS000005499
SpoSPAC1006.07
SPBC1709.18
NAS
DmeFBgn0015218
eIF4E-7
TAS
SceS000005499
GO:0004004 ATP-dependent RNA helicase activity F
ISS
SpoSPAC1006.07
GO:0005515 protein binding F
IPI
HsaEIF4E
GO:0005524 ATP binding F
IC
SpoSPAC1006.07
GO:0031370 eukaryotic initiation factor 4G
binding		 F
ISO
MmuMGI:95305
GO:0032266 phosphatidylinositol-3-phosphate
binding		 F
IDA
SceS000005499
GO:0000022 mitotic spindle elongation P
IMP
DmeFBgn0015218
GO:0000082 G1/S transition of mitotic cell
cycle		 P
IMP
HsaEIF4E
GO:0000184 nuclear-transcribed mRNA catabolic process,
nonsense-mediated decay		 P
IDA
SceS000005499
IPI
SceS000005499
ISS
SpoSPBC1709.18
GO:0001558 regulation of cell growth P
IMP
DmeFBgn0015218
GO:0006200 ATP catabolic process P
ISS
SpoSPAC1006.07
GO:0006325 chromatin organization P
IMP
DmeFBgn0015218
GO:0006412 translation P
ISS
DmeFBgn0015218
NAS
DmeFBgn0015218
GO:0006413 translational initiation P
IDA
DmeFBgn0015218
ISS
DmeeIF4E-4
SceS000005499
SpoSPAC1006.07
NAS
DmeeIF4E-7
FBgn0015218
TAS
SceS000005499
SpoSPBC1709.18
GO:0006417 regulation of translation P
RCA
SceS000005499
GO:0007052 mitotic spindle organization P
IMP
DmeFBgn0015218
GO:0007067 mitosis P
IMP
DmeFBgn0015218
GO:0007076 mitotic chromosome condensation P
IMP
DmeFBgn0015218
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00002061
GO:0016070 RNA metabolic process P
IDA
DmeFBgn0015218
NAS
DmeFBgn0015218
GO:0016321 female meiosis chromosome segregation P
IMP
DmeFBgn0015218
GO:0030307 positive regulation of cell growth P
TAS
DmeFBgn0015218
GO:0033554 cellular response to stress P
TAS
SpoSPBC1709.18
GO:0035071 salivary gland cell autophagic cell
death		 P
IEP
DmeeIF4E-5
FBgn0015218
GO:0045931 positive regulation of mitotic cell
cycle		 P
IMP
HsaEIF4E
GO:0045948 positive regulation of translational
initiation		 P
ISS
SpoSPBC1709.18
SPAC1006.07
GO:0048102 autophagic cell death P
IEP
DmeeIF4E-5
FBgn0015218
GO:0051726 regulation of cell cycle P
IMP
SceS000005499

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_672

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga2623 ENSANGP00000018868
Anopheles gambiae (Aga) aga2624 ENSANGP00000027711
Ashbya gossypii (Ago) ago1553 ADL188C
Arabidopsis thaliana (Ath) ath3086 At1g29550.1
Arabidopsis thaliana (Ath) ath3090 At1g29590.1
Arabidopsis thaliana (Ath) ath19672 At4g18040.1
Arabidopsis thaliana (Ath) ath25334 At5g35620.1
Arabidopsis thaliana (Ath) ath25335 At5g35620.2
Caenorhabditis elegans (Cel) cel387 B0348.6a
(CE17331;
WBGene00002061)
Caenorhabditis elegans (Cel) cel388 B0348.6b
(CE27570)
Caenorhabditis elegans (Cel) cel389 B0348.6c
(CE30590)
Candida glabrata (Cgl) cgl1005 CAGL0E01463g
Cryptococcus neoformans (Cne) cne5432 179.m00285
Dictyostelium discoideum (Ddi) ddi838 DDB0216584
Debaryomyces hansenii (Dha) dha653 DEHA0A14586g
Drosophila melanogaster (Dme) dme8263 CG10124-PA
(FBgn0035709)
Drosophila melanogaster (Dme) dme14934 CG1442-PA
(FBgn0039622)
Drosophila melanogaster (Dme) dme16004 CG32859-PA
(FBgn0040368)
Drosophila melanogaster (Dme) dme8749 CG4035-PA
(FBgn0015218)
Drosophila melanogaster (Dme) dme8747 CG4035-PB
(FBgn0015218)
Drosophila melanogaster (Dme) dme8748 CG4035-PC
(FBgn0015218)
Drosophila melanogaster (Dme) dme8746 CG4035-PD
(FBgn0015218)
Drosophila melanogaster (Dme) dme8751 CG4035-PE
(FBgn0015218)
Drosophila melanogaster (Dme) dme8752 CG4035-PF
(FBgn0015218)
Drosophila melanogaster (Dme) dme8750 CG4035-PG
(FBgn0015218)
Drosophila melanogaster (Dme) dme8521 CG8023-PA
(FBgn0035860)
Drosophila melanogaster (Dme) dme8452 CG8277-PA
(FBgn0035823)
Danio rerio (Dre) dre4052 ENSDARP00000007117
(zgc:101581)		 Q5RKQ5
Danio rerio (Dre) dre29742 ENSDARP00000031553
(zgc:110154)		 Q568Q8
Encephalitozoon cuniculi (Ecu) ecu248 19173417
Takifugu rubripes (Fru) fru22182 SINFRUP00000139752
Takifugu rubripes (Fru) fru20210 SINFRUP00000149241
Takifugu rubripes (Fru) fru25569 SINFRUP00000155515
Gallus gallus (Gga) gga17953 ENSGALP00000019949
(EIF4E)
Homo sapiens (Hsa) hsa24436 ENSP00000280892
(EIF4E)		 B7Z6V1
Kluyveromyces lactis (Kla) kla3899 KLLA0E21087g
Mus musculus (Mmu) mmu17627 ENSMUSP00000029803
(MGI:95305)		 P63073
Neurospora crassa (Ncr) ncr2018 NCU02076.2
Oryza sativa (Osa) osa24842 3832.m00150
Oryza sativa (Osa) osa640 873.m00166
Plasmodium falciparum (Pfa) pfa2799 PFC0635c
Rattus norvegicus (Rno) rno17092 ENSRNOP00000018790
(RGD:69647)
Saccharomyces cerevisiae (Sce) sce5697 YOL139C
(S000005499)
Schizosaccharomyces pombe (Spo) spo21 SPAC16E8.15 P78954
Schizosaccharomyces pombe (Spo) spo3488 SPBC1709.18 O74743
Yarrowia lipolytica (Yli) yli3722 YALI0D24299g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000932 cytoplasmic mRNA processing body C
IDA
DmeFBgn0015218
GO:0005634 nucleus C
IDA
AthAt5g35620
At4g18040
SceS000005499
SpoSPAC16E8.15
GO:0005730 nucleolus C
IDA
AthAt4g18040
GO:0005737 cytoplasm C
IDA
AthAt4g18040
At5g35620
DmeFBgn0015218
MmuMGI:95305
SceS000005499
ISS
AthAt4g18040
At5g35620
At1g29590
At1g29550
TAS
AthAt4g18040
At5g35620
GO:0005829 cytosol C
IDA
SpoSPAC16E8.15
SPBC1709.18
ISS
DmeFBgn0015218
NAS
DmeFBgn0015218
GO:0005840 ribosome C
TAS
SceS000005499
GO:0005875 microtubule associated complex C
IDA
DmeFBgn0015218
GO:0010494 stress granule C
IDA
SceS000005499
GO:0014069 postsynaptic density C
IDA
DmeFBgn0015218
GO:0016281 eukaryotic translation initiation factor 4F
complex		 C
ISO
MmuMGI:95305
ISS
DmeFBgn0015218
FBgn0035823
FBgn0035709
FBgn0035860
FBgn0039622
FBgn0040368
PfaPFC0635c
NAS
DmeFBgn0015218
TAS
SceS000005499
SpoSPAC16E8.15
SPBC1709.18
GO:0043234 protein complex C
ISO
MmuMGI:95305
GO:0000339 RNA cap binding F
IDA
DmeFBgn0015218
ISS
DmeFBgn0015218
FBgn0035860
FBgn0040368
FBgn0039622
FBgn0035709
FBgn0035823
NAS
DmeFBgn0015218
FBgn0040368
TAS
AthAt4g18040
SpoSPAC16E8.15
SPBC1709.18
GO:0000340 RNA 7-methylguanosine cap binding F
TAS
AthAt5g35620
GO:0003723 RNA binding F
ISS
AthAt1g29590
At4g18040
At1g29550
At5g35620
GO:0003743 translation initiation factor activity F
IDA
DmeFBgn0015218
ISS
AthAt1g29590
At1g29550
At5g35620
At4g18040
DmeFBgn0040368
FBgn0035823
FBgn0035860
FBgn0015218
FBgn0035709
FBgn0039622
SceS000005499
SpoSPAC16E8.15
SPBC1709.18
NAS
DmeFBgn0015218
FBgn0040368
TAS
AthAt5g35620
SceS000005499
GO:0005515 protein binding F
IPI
AthAt4g18040
GO:0031370 eukaryotic initiation factor 4G
binding		 F
ISO
MmuMGI:95305
GO:0032266 phosphatidylinositol-3-phosphate
binding		 F
IDA
SceS000005499
GO:0000022 mitotic spindle elongation P
IMP
DmeFBgn0015218
GO:0000184 nuclear-transcribed mRNA catabolic process,
nonsense-mediated decay		 P
IDA
SceS000005499
IPI
SceS000005499
ISS
SpoSPAC16E8.15
SPBC1709.18
GO:0001558 regulation of cell growth P
IMP
DmeFBgn0015218
GO:0006325 chromatin organization P
IMP
DmeFBgn0015218
GO:0006412 translation P
ISS
DmeFBgn0015218
NAS
DmeFBgn0015218
GO:0006413 translational initiation P
IDA
DmeFBgn0015218
ISS
AthAt4g18040
At1g29590
At5g35620
At1g29550
DmeFBgn0035709
SceS000005499
NAS
DmeFBgn0015218
FBgn0040368
TAS
AthAt4g18040
At5g35620
SceS000005499
SpoSPAC16E8.15
SPBC1709.18
GO:0006417 regulation of translation P
RCA
SceS000005499
GO:0007052 mitotic spindle organization P
IMP
DmeFBgn0015218
GO:0007067 mitosis P
IMP
DmeFBgn0015218
GO:0007076 mitotic chromosome condensation P
IMP
DmeFBgn0015218
GO:0009615 response to virus P
IMP
AthAt4g18040
At5g35620
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00002061
GO:0016070 RNA metabolic process P
IDA
DmeFBgn0015218
NAS
DmeFBgn0015218
GO:0016321 female meiosis chromosome segregation P
IMP
DmeFBgn0015218
GO:0030307 positive regulation of cell growth P
TAS
DmeFBgn0015218
GO:0033554 cellular response to stress P
TAS
SpoSPBC1709.18
GO:0035071 salivary gland cell autophagic cell
death		 P
IEP
DmeFBgn0035823
FBgn0015218
GO:0045948 positive regulation of translational
initiation		 P
ISS
SpoSPAC16E8.15
SPBC1709.18
GO:0048102 autophagic cell death P
IEP
DmeFBgn0015218
FBgn0035823
GO:0051726 regulation of cell cycle P
IMP
SceS000005499

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPBC1709.18
(O74743)		 YOL139C
(S000005499)
SPAC16E8.15
(P78954)		 YOL139C
(S000005499)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SceS000005499
SpoSPAC16E8.15
GO:0005737 cytoplasm C
IDA
SceS000005499
GO:0005829 cytosol C
IDA
SpoSPAC16E8.15
SPBC1709.18
GO:0005840 ribosome C
TAS
SceS000005499
GO:0010494 stress granule C
IDA
SceS000005499
GO:0016281 eukaryotic translation initiation factor 4F
complex		 C
TAS
SceS000005499
SpoSPAC16E8.15
SPBC1709.18
GO:0000339 RNA cap binding F
TAS
SpoSPAC16E8.15
SPBC1709.18
GO:0003743 translation initiation factor activity F
ISS
SceS000005499
SpoSPAC16E8.15
SPBC1709.18
TAS
SceS000005499
GO:0032266 phosphatidylinositol-3-phosphate
binding		 F
IDA
SceS000005499
GO:0000184 nuclear-transcribed mRNA catabolic process,
nonsense-mediated decay		 P
IDA
SceS000005499
IPI
SceS000005499
ISS
SpoSPAC16E8.15
SPBC1709.18
GO:0006413 translational initiation P
ISS
SceS000005499
TAS
SceS000005499
SpoSPAC16E8.15
SPBC1709.18
GO:0006417 regulation of translation P
RCA
SceS000005499
GO:0033554 cellular response to stress P
TAS
SpoSPBC1709.18
GO:0045948 positive regulation of translational
initiation		 P
ISS
SpoSPAC16E8.15
SPBC1709.18
GO:0051726 regulation of cell cycle P
IMP
SceS000005499

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